Gastric Emptying, Glucose Responses, and Insulin Secretion after a Liquid Test Meal: Effects of Exogenous Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide in Type 2 (Noninsulin-Dependent) Diabetic Patients

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 1, 1996, Pages 327-332

  Willms, Berend ^a   Werner, Jens ^a   Holst, Jens Juul ^b   Ørskov, Cathrine ^b   Creutzfeldt, Werner ^c   Nauck, Michael A ^d  

^a Fachklinik Diabet S   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; CAPTOPRIL PLUS HYDROCHLOROTHIAZIDE; GLIBENCLAMIDE; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCOSE; INSULIN; ISOSORBIDE DINITRATE; METFORMIN; METOPROLOL; NIFEDIPINE; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DIABETIC DIET; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DRUG EFFECT; DRUG MECHANISM; FEMALE; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; HORMONE INHIBITION; HUMAN; HYPERTENSION; INSULIN RELEASE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH EMPTYING;

AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC EMPTYING; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INSULIN; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS;

EID: 0030068620     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.1.8550773     Document Type: Article

References (31)

1. Ørskov C. 1992 Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia. 35:701-711.
2. Creutzfeldt W, Nauck M. 1992 Gut hormones and diabetes mellitus. Diabetes Metab Rev. 8:149-177.
3. Eissele R, Göke R, Willemer S, et al. 1992 Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest. 22:283-291.
4. Kreymann B, Ghatei MA, Williams G, Bloom SR. 1987 Glucagon-like peptide-1-7-36: a physiological incretin in man. Lancet. 2:1300-1304.
5. Nauck M, Bartels E, Ørskov C, Ebert R, Creutzfeldt W. 1993 Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological insulinotropic hormone and glucose concentrations. J Clin Endocrinol Metab. 76: 912-917.
6. Nauck MA, Heimesaat MM, Ørskov C, Holst JJ, Ebert R, Creutzfeldt W. 1993 Preserved incretin activity of glucagon-like peptide 1 (GLP-1) [7-36 amide] but not of synthetic human gastric inhibitory polypteptide (GIP) in patients with type 2 diabetes mellitus. J Clin Invest. 91:301-307.
7. Nauck MA, Kleine N, Ørskov C, Holst JJ, WillmS B, Creutzfeldt W. 1993 Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 [7-36 amide] in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 36:741-744.
8. Gutniak M, Ørskov C, Holst JJ, Ahren B, Efendic S. 1992 Antidiabetogenic effect of glucagon-like peptide-1 [7-36 amide] in normal subjects and patients with diabetes. N Engl J Med. 326:1316-1322.
9. Wettergen A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ. 1993 Truncated GLP-1 (proglucagon 87-107-amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci. 38:665-673.
10. George JD. 1968 New clinical method for measuring the rate of gastric emptying; the double sampling test meal. Gut. 9:237-242.
11. Willms B, Werner J, Creutzfeldt W, Ørskov C, Holst JJ, Nauck M. 1994 Inhibition of gastric emptying by glucagon-like peptide 1 [7-36 amide] (GLP-1) in patients with type 2-diabetes mellitus [Abstract]. Diabetes. 43(Suppl):230 A.
12. Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA. 1985 Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest. 75:1144-1152.
13. Liddle RA, Morita ET, Conrad CK, Williams JA. 1986 Regulation of gastric emptying in humans by cholecystokinin. J Clin Invest. 77:992-996.
14. Kalorien mundgerecht. 9th edition. Frankfurt: Umschau Verlag. 1993.
15. Hurwitz A. 1981 Measuring gastric volume by dilution. Gut. 22:85-93.
16. Ørskov C, Holst JJ. 1987 Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2). Scand J Clin Lab Invest. 47:165-174.
17. Ørskov C, Rabenhoj L, Wettergren A, Kofod H, Holst JJ. 1994 Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide 1 in humans. Diabetes. 43:535-539.
18. Holst JJ. 1982 Evidence that peak II GLI or enteroglucagon is identical to the C-terminal sequence (residues 33-69) of glicentin. Biochem J. 207:381-388.
19. Nauck MA, Bartels E, Ørskov C, Ebert R, Creutzfeldt W. 1992 Lack of effect of synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological concentrations on pentagastrin-stimulated gastric acid secretion in normal human subjects. Digestion. 52: 214-221.
20. Schjoldager BTG, Mortensen PE, Christiansen J, Ørskov C, Holst JJ. 1989 GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments opf human proglucagon, inhibit gastric acid secretion in humans. Dig Dis Sci. 34:703-708.
21. O'Halloran DJ, Nikou GC, Kreymann B, Ghatei MA, Bloom SR. 1990 Glucagon-like peptide-1 (7-36)-NH2: a physiological inhibitor of gastrick acid secretion in man. J Endocrinol. 126:169-173.
22. Qualmann C, Nauck MA, Holst JJ, Ørskov C, Creutzfeldt W. 1995 Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects. Acta Diabetol. 32:13-16.
23. Weir GC, Mojsov S, Hendrick GK, Habener JF. 1989 Glucagonlike peptide 1 (7-37) actions on endocrine pancreas. Diabetes. 38:338-342.
24. Komatsu R, Matsuyama T, Namba M, et al. 1989 Glucagonostatic and insulinotropic action of glucagonlike peptide 1-(7-36)-amide. Diabetes. 38:902-905.
25. Barnett JL, Owyang C. 1980 Serum glucose concentration as a modulator of interdigestive gastric motility. Gastroenterology. 94:739-744.
26. Fraser RJ, Horowitz M, Maddox AF, Harding PE, Chatterton DE, Dent J. 1990 Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 33:675-680.
27. Nathan DM, Schreiber E, Fogel H, Mojsov S, Habener JF. 1992 Insulinotropic action of glucagon-like peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care. 15:270-276.
28. Ørskov C, Wettergren A, Holst JJ. 1993 Biological effects and metabolic rates of glucagonlike peptide-1 [7-36amide] and glucagon like peptide-1-7-37 in healthy subjects are indistinguishable. Diabetes. 42:658-661.
29. Creutzfeldt W, ed. Acarbose for the treatment of diabetes mellitus. Proc of the 2nd Int Symp on Acarbose. Berlin: Springer; 1988.
30. Kelly KA. 1980 Gastric emptying of liquids and solids: roles of the proximal and distal stomach. Am J Physiol. 239:G71-G76.
31. Ritzel R. 1995 Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-I [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships. Diabetologia. 38:720-725.