Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: A systematic review and meta-analysis

Diabetologia

Volumn 56, Issue 4, 2013, Pages 696-708

  Kim, Y G ^a   Hahn, S ^b,c   Oh, T J ^a   Kwak, S H ^a   Park, K S ^a   Cho, Y M ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Asian; BMI; Dipeptidyl peptidase 4; Meta analysis; Systematic review; Type 2 diabetes

Indexed keywords

ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GEMIGLIPTIN; GLIBENCLAMIDE; GLIMEPIRIDE; GLITAZONE DERIVATIVE; GLUCOSE; GOSOGLIPTIN; HEMOGLOBIN A1C; LINAGLIPTIN; METFORMIN; PIOGLITAZONE; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN; VOGLIBOSE;

ASIAN; BODY MASS; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; ETHNIC DIFFERENCE; GLUCOSE BLOOD LEVEL; HUMAN; META ANALYSIS; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TREATMENT DURATION; WEIGHT CHANGE;

ADMINISTRATION, ORAL; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; BODY MASS INDEX; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HUMANS; POSTPRANDIAL PERIOD; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REGRESSION ANALYSIS; TREATMENT OUTCOME;

EID: 84876498178     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2827-3     Document Type: Review

References (84)

1. American Diabetes Association (2012) Diagnosis and classification of diabetes mellitus. Diabetes Care 35(suppl 1):S64-S71
2. Chan JC, Malik V, Jia W et al (2009) Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 301:2129-2140
3. Ramachandran A, Ma RC, Snehalatha C (2010) Diabetes in Asia. Lancet 375:408-418
4. Yoon KH, Lee JH, Kim JW et al (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet 368:1681-1688
5. Lear SA, Humphries KH, Kohli S, Chockalingam A, Frohlich JJ, Birmingham CL (2007) Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT). Am J Clin Nutr 86:353-359
6. Park YW, Allison DB, Heymsfield SB, Gallagher D (2001) Larger amounts of visceral adipose tissue in Asian Americans. Obes Res 9:381-387
7. Fukushima M, Suzuki H, Seino Y (2004) Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes. Diabetes Res Clin Pract 66(suppl 1):S37-S43
8. Matsumoto K, Miyake S, Yano M et al (1997) Glucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care 20:1562-1568
9. Rattarasarn C, Soonthornpan S, Leelawattana R, Setasuban W (2006) Decreased insulin secretion but not insulin sensitivity in normal glucose tolerant Thai subjects. Diabetes Care 29:742-743
10. Kim YI, Choi CS, Kim SW et al (1998) Changes in serum true insulin and C-peptide levels during oral glucose tolerance test in Koreans with glucose intolerance. J Korean Diabetes Assoc 22:192-198
11. Tripathy D, Carlsson M, Almgren P et al (2000) Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes 49:975-980
12. Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157
13. Cho YM, Kieffer TJ (2010) K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Vitam Horm 84:111-150
14. Bagger JI, Knop FK, Lund A, Vestergaard H, Holst JJ, Vilsboll T (2011) Impaired regulation of the incretin effect in patients with type 2 diabetes. J Clin Endocrinol Metab 96:737-745
15. Knop FK, Vilsboll T, Hojberg PV et al (2007) Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state? Diabetes 56:1951-1959
16. Nauck MA, Homberger E, Siegel EG et al (1986) Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 63:492-498
17. Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151:W65-W94
18. Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE (2007) Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care 30:1979-1987
19. Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P (2007) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab 9:733-745
20. Goodman M, Thurston H, Penman J (2009) Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Horm Metab Res 41:368-373
21. Raz I, Chen Y, Wu M et al (2008) Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin 24:537-550
22. Charbonnel B, Karasik A, Liu J, Wu M, Meininger G (2006) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 29:2638-2643
23. Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE (2006) Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 29:2632-2637
24. Mohan V, Yang W, Son HY et al (2009) Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India, and Korea. Diabetes Res Clin Pract 83:106-116
25. Taskinen M, Rosenstock J, Tamminen I et al (2011) Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metabol 13:65-74
26. Forst T, Uhlig-Laske B, Ring A et al (2010) Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled type 2 diabetes. Diabet Med 27:1409-1419
27. Del Prato S, Barnett AH, Huisman H, Neubacher D, Woerle HJ, Dugi KA (2011) Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab 13:258-67
28. Gomis R, Espadero RM, Jones R, Woerle HJ, Dugi KA (2011) Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab 13:653-661
29. Rosenstock J, Rendell MS, Gross JL, Fleck PR, Wilson CA, Mekki Q (2009) Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab 11:1145-1152
30. Nauck MA, Ellis GC, Fleck PR, Wilson CA, Mekki Q (2009) Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract 63:46-55
31. DeFronzo RA, Hissa MN, Garber AJ et al (2009) The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care 32:1649-1655
32. DeFronzo RA, Fleck PR, Wilson CA, Mekki Q (2008) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study. Diabetes Care 31:2315-2317
33. Pratley RE, Reusch JEB, Fleck PR, Wilson CA, Mekki Q (2009) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 25:2361-2371
34. Jadzinsky M, Pfutzner A, Paz-Pacheco E, Xu Z, Allen E, Chen R (2009) Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial. Diabetes Obes Metab 11:611-622
35. Rosenstock J, Guilar-Salinas C, Klein E, Nepal S, List J, Chen R (2009) Effect of saxagliptin monotherapy in treatment-naive patients with type 2 diabetes. Curr Med Res Opin 25:2401-2411
36. Owens DR, Swallow R, Dugi KA, Woerle HJ (2011) Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet Med 28:1352-1361
37. Yang W, Pan CY, Tou C, Zhao J, Gause-Nilsson I (2011) Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial. Diabetes Res Clin Pract 94:217-224
38. Rosenstock J, Aguilar-Salinas C, Klein E, Nepal S, List J, Chen R (2009) Effect of saxagliptin monotherapy in treatment-naive patients with type 2 diabetes. Curr Med Res Opin 25:2401-2411
39. Iwamoto Y, Taniguchi T, Nonaka K et al (2010) Dose-ranging efficacy of sitagliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus. Endocr J 57:383-394
40. Nonaka K, Kakikawa T, Sato A et al (2008) Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 79:291-298
41. Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H (2006) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 49:2564-2571
42. Dejager S, Razac S, Foley JE, Schweizer A (2007) Vildagliptin in drug-naive patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res 39:218-223
43. Pi-Sunyer FX, Schweizer A, Mills D, Dejager S (2007) Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract 76:132-138
44. Pratley RE, Kipnes MS, Fleck PR et al (2009) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. Diabetes Obes Metabol 11:167-176
45. Rosenstock J, Inzucchi SE, Seufert J, Fleck PR, Wilson CA, Mekki Q (2010) Initial combination therapy with alogliptin and pioglitazone in drug-naive patients with type 2 diabetes. Diabetes Care 33:2406-2408
46. Seino Y, Fujita T, Hiroi S, Hirayama M, Kaku K (2011) Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension. Curr Med Res Opin 27:21-29
47. Terra SG, Somayaji V, Schwartz S et al (2011) A dose-ranging study of the DPP-IV inhibitor PF-734200 added to metformin in subjects with type 2 diabetes. Exp Clin Endocrinol Diabetes 119:401-407
48. Hollander P, Li J, Allen E, Chen R (2009) Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone. J Clin Endocrinol Metab 94:4810-4819
49. Scott R, Loeys T, Davies MJ, Engel SS (2008) Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab 10:959-969
50. Yoon KH, Shockey GR, Teng R et al (2011) Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and pioglitazone on glycemic control and measures of beta-cell function in patients with type 2 diabetes. Int J Clin Pract 65:154-164
51. Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P (2006) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 28:1556-1568
52. Reasner C, Olansky L, Seck TL et al (2011) The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus. Diabetes Obes Metab 13:644-652
53. Kashiwagi A, Kadowaki T, Tajima N et al (2011) Sitagliptin added to treatment with ongoing pioglitazone for up to 52 weeks improves glycemic control in Japanese patients with type 2 diabetes. J Diabetes Investig 2:381-390
54. Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ (2007) Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 30:890-895
55. Rosenstock J, Kim SW, Baron MA et al (2007) Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 9:175-185
56. Garber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S (2007) Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab 9:166-174
57. Kikuchi M, Haneda M, Koya D et al (2010) Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 89:216-223
58. Bosi E, Dotta F, Jia Y, Goodman M (2009) Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus. Diabetes Obes Metab 11:506-515
59. Garber AJ, Foley JE, Banerji MA et al (2008) Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes Obes Metab 10:1047-1056
60. Vilsboll T, Rosenstock J, Yki-Jarvinen H et al (2010) Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab 12:167-177
61. Fonseca V, Schweizer A, Albrecht D, Baron MA, Chang I, Dejager S (2007) Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia 50:1148-1155
62. Higgins JPT, Green S (eds) (2005) Cochrane handbook for systematic reviews of interventions 5.1.0. In: The Cochrane Library (Issue 2). Wiley, Chichester
63. Aso Y, Ozeki N, Terasawa T et al (2012) Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea. Transl Res 159:25-31
64. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-846
65. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE (2002) Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes 51:2170-2178
66. European Medicine Agency (2007) Scientific discussion. http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Scientific- Discussion/human/000722/WC500039057.pdf. Accessed 8 February 2012
67. Hu P, Yin Q, Deckert F et al (2009) Pharmacokinetics and pharmacodynamics of vildagliptin in healthy Chinese volunteers. J Clin Pharmacol 49:39-49
68. DECODA Study Group; International Diabetes Epidemiology Group (2002) Cardiovascular risk profile assessment in glucose-intolerant Asian individuals - an evaluation of the World Health Organization two-step strategy: the DECODA Study (Diabetes Epidemiology: Collaborative Analysis of Diagnostic Criteria in Asia). Diabet Med 19:549-557
69. DECODE Study Group (1998) Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group. BMJ 317:371-375
70. Qiao Q, Hu G, Tuomilehto J et al (2003) Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care 26:1770-1780
71. Nakagami T (2004) Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin. Diabetologia 47:385-394
72. Deacon CF (2011) Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab 13:7-18
73. DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L (2008) Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin 24:2943-2952
74. Rosenstock J, Sankoh S, List JF (2008) Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 10:376-386
75. Hanefeld M, Herman GA, Wu M et al (2007) Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes. Curr Med Res Opin 23:1329-1339
76. Scott R, Wu M, Sanchez M, Stein P (2007) Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract 61:171-180
77. Pratley RE, Jauffret-Kamel S, Galbreath E, Holmes D (2006) Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res 38:423-428
78. Ristic S, Byiers S, Foley J, Holmes D (2005) Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response. Diabetes Obes Metab 7:692-698
79. Seino Y, Fujita T, Hiroi S, Hirayama M, Kaku K (2011) Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study. Curr Med Res Opin 27:1781-1792
80. Rhee EJ, Lee WY, Yoon KH et al (2010) A multicenter, randomized, placebo-controlled, double-blind phase II trial evaluating the optimal dose, efficacy and safety of LC 15-0444 in patients with type 2 diabetes. Diabetes Obes Metab 12:1113-1119
81. Kikuchi M, Abe N, Kato M, Terao S, Mimori N, Tachibana H (2009) Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 83:233-240
82. Ahren B, Gomis R, Standl E, Mills D, Schweizer A (2004) Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care 27:2874-2880
83. Kaku K, Itayasu T, Hiroi S, Hirayama M, Seino Y (2011) Efficacy and safety of alogliptin added to pioglitazone in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label long-term extension study. Diabetes Obes Metab 13:1028-1035
84. Chien MN, Lee CC, Chen WC, Liu SC, Leung CH, Wang CH (2011) Effect of sitagliptin as add-on therapy in elderly type 2 diabetes patients with inadequate glycemic control in Taiwan. Int J Gerontol 5:103-106