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Volumn 1, Issue 3, 2010, Pages 77-89

Molecular mechanisms of diabetic vascular complications

Author keywords

Diabetes mellitus; Diabetic complications; Endogenous protective factors

Indexed keywords

ACTIVATED PROTEIN C; ALDOSE REDUCTASE INHIBITOR; AMINOGUANIDINE; DIACYLGLYCEROL; INSULIN; PLATELET DERIVED GROWTH FACTOR B; PROTEIN KINASE C; PROTEIN KINASE C BETA; RUBOXISTAURIN; VASCULOTROPIN A;

EID: 79953764336     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/j.2040-1124.2010.00018.x     Document Type: Review
Times cited : (141)

References (172)
  • 1
    • 79953761041 scopus 로고    scopus 로고
    • International Diabetes Foundation (Accessed 2009)
    • International Diabetes Foundation, 2009. (Accessed 2009, at http://www.diabetesatlas.org/content/foreward)
  • 2
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 3
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 4
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005; 353: 2643-2653.
    • (2005) N Engl J Med , vol.353 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3
  • 5
    • 0037986208 scopus 로고    scopus 로고
    • Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus
    • Nathan DM, Lachin J, Cleary P, et al. Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N Engl J Med 2003; 348: 2294-2303.
    • (2003) N Engl J Med , vol.348 , pp. 2294-2303
    • Nathan, D.M.1    Lachin, J.2    Cleary, P.3
  • 6
    • 73849129904 scopus 로고    scopus 로고
    • Kidney complications: Factors that protect the diabetic vasculature
    • Rask-Madsen C, King GL. Kidney complications: factors that protect the diabetic vasculature. Nat Med 2010; 16: 40-41.
    • (2010) Nat Med , vol.16 , pp. 40-41
    • Rask-Madsen, C.1    King, G.L.2
  • 9
    • 34547691507 scopus 로고    scopus 로고
    • Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: The 50-year medalist study
    • Keenan HA, Costacou T, Sun JK, et al. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care 2007; 30: 1995- 1997.
    • (2007) Diabetes Care , vol.30
    • Keenan, H.A.1    Costacou, T.2    Sun, J.K.3
  • 10
    • 58149252632 scopus 로고    scopus 로고
    • Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial
    • White NH, Sun W, Cleary PA, et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol 2008; 126: 1707-1715.
    • (2008) Arch Ophthalmol , vol.126 , pp. 1707-1715
    • White, N.H.1    Sun, W.2    Cleary, P.A.3
  • 11
    • 0142087597 scopus 로고    scopus 로고
    • Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) study
    • Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003; 290: 2159-2167.
    • (2003) JAMA , vol.290 , pp. 2159-2167
  • 12
    • 33645700675 scopus 로고    scopus 로고
    • Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
    • Martin CL, Albers J, Herman WH, et al. Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion. Diabetes Care 2006; 29: 340-344.
    • (2006) Diabetes Care , vol.29 , pp. 340-344
    • Martin, C.L.1    Albers, J.2    Herman, W.H.3
  • 13
    • 0037184495 scopus 로고    scopus 로고
    • Molecular understanding of hyper-glycemia's adverse effects for diabetic complications
    • Sheetz MJ, King GL. Molecular understanding of hyper-glycemia's adverse effects for diabetic complications. JAMA 2002; 288: 2579-2588.
    • (2002) JAMA , vol.288 , pp. 2579-2588
    • Sheetz, M.J.1    King, G.L.2
  • 14
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 15
    • 0027318772 scopus 로고
    • Hyperglycemic pseudohypoxia and diabetic complications
    • Williamson JR, Chang K, Frangos M, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 1993; 42: 801-813.
    • (1993) Diabetes , vol.42 , pp. 801-813
    • Williamson, J.R.1    Chang, K.2    Frangos, M.3
  • 16
    • 0028274304 scopus 로고
    • Free radicals in diabetic endothelial cell dysfunction
    • Tesfamariam B. Free radicals in diabetic endothelial cell dysfunction. Free Radic Biol Med 1994; 16: 383-391.
    • (1994) Free Radic Biol Med , vol.16 , pp. 383-391
    • Tesfamariam, B.1
  • 17
    • 0042867413 scopus 로고    scopus 로고
    • Contribution of polyol pathway to diabetes-induced oxidative stress
    • Chung SS, Ho EC, Lam KS, Chung SK. Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol 2003; 14(8 Suppl 3): S233-S236.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.8 SUPPL 3
    • Chung, S.S.1    Ho, E.C.2    Lam, K.S.3    Chung, S.K.4
  • 19
    • 0025140713 scopus 로고
    • Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors
    • Kador PF, Akagi Y, Takahashi Y, Ikebe H, Wyman M, Kinoshita JH. Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors. Arch Ophthalmol 1990; 108: 1301-1309.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1301-1309
    • Kador, P.F.1    Akagi, Y.2    Takahashi, Y.3    Ikebe, H.4    Wyman, M.5    Kinoshita, J.H.6
  • 20
    • 0024821312 scopus 로고
    • Effects of sorbinil on glomerular structure and function in long-term-diabetic rats
    • Mauer SM, Steffes MW, Azar S, Brown DM. Effects of sorbinil on glomerular structure and function in long-term-diabetic rats. Diabetes 1989; 38: 839-846.
    • (1989) Diabetes , vol.38 , pp. 839-846
    • Mauer, S.M.1    Steffes, M.W.2    Azar, S.3    Brown, D.M.4
  • 21
    • 0019965361 scopus 로고
    • The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats
    • Yue DK, Hanwell MA, Satchell PM, Turtle JR. The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats. Diabetes 1982; 31: 789-794.
    • (1982) Diabetes , vol.31 , pp. 789-794
    • Yue, D.K.1    Hanwell, M.A.2    Satchell, P.M.3    Turtle, J.R.4
  • 22
    • 0022640893 scopus 로고
    • The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat
    • Cameron NE, Leonard MB, Ross IS, Whiting PH. The effects of sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat. Diabetologia 1986; 29: 168-174.
    • (1986) Diabetologia , vol.29 , pp. 168-174
    • Cameron, N.E.1    Leonard, M.B.2    Ross, I.S.3    Whiting, P.H.4
  • 23
    • 0027954517 scopus 로고
    • Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs
    • Engerman RL, Kern TS, Larson ME. Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs. Diabetologia 1994; 37: 141-144.
    • (1994) Diabetologia , vol.37 , pp. 141-144
    • Engerman, R.L.1    Kern, T.S.2    Larson, M.E.3
  • 24
    • 0025073693 scopus 로고
    • A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy
    • Sorbinil Retinopathy Trial Research Group
    • Sorbinil Retinopathy Trial Research Group. A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Arch Ophthalmol 1990; 108: 1234-1244.
    • (1990) Arch Ophthalmol , vol.108 , pp. 1234-1244
  • 25
    • 0035486938 scopus 로고    scopus 로고
    • Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: A 52-week multicenter placebo-controlled double-blind parallel group study
    • Hotta N, Toyota T, Matsuoka K, et al. Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care 2001; 24: 1776-1782.
    • (2001) Diabetes Care , vol.24 , pp. 1776-1782
    • Hotta, N.1    Toyota, T.2    Matsuoka, K.3
  • 26
    • 34547678051 scopus 로고    scopus 로고
    • A long-term effect of epalrestat on motor conduction velocity of diabetic patients: ARI-Diabetes Complications Trial (ADCT)
    • Matsuoka K, Sakamoto N, Akanuma Y, et al. A long-term effect of epalrestat on motor conduction velocity of diabetic patients: ARI-Diabetes Complications Trial (ADCT). Diabetes Res Clin Pract 2007; 77(Suppl 1): S263-S268.
    • (2007) Diabetes Res Clin Pract , vol.77 , Issue.SUPPL 1
    • Matsuoka, K.1    Sakamoto, N.2    Akanuma, Y.3
  • 27
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
    • Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-614.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 28
    • 34250702110 scopus 로고    scopus 로고
    • The role of protein kinase C activation and the vascular complications of diabetes
    • Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res 2007; 55: 498-510.
    • (2007) Pharmacol Res , vol.55 , pp. 498-510
    • Das Evcimen, N.1    King, G.L.2
  • 29
    • 0027454103 scopus 로고
    • Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation
    • Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, King GL. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol 1993; 265(5 Pt 1): E783-E793.
    • (1993) Am J Physiol , vol.265 , Issue.5 PART 1
    • Shiba, T.1    Inoguchi, T.2    Sportsman, J.R.3    Heath, W.F.4    Bursell, S.5    King, G.L.6
  • 30
    • 0025313272 scopus 로고
    • Increase in diacyl-glycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
    • Craven PA, Davidson CM, DeRubertis FR. Increase in diacyl-glycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 1990; 39: 667-674.
    • (1990) Diabetes , vol.39 , pp. 667-674
    • Craven, P.A.1    Davidson, C.M.2    Derubertis, F.R.3
  • 31
    • 13344293711 scopus 로고    scopus 로고
    • Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
    • Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996; 272: 728-731.
    • (1996) Science , vol.272 , pp. 728-731
    • Ishii, H.1    Jirousek, M.R.2    Koya, D.3
  • 32
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A 1992; 89: 11059-11063.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3    Sportsman, J.R.4    Heath, W.5    King, G.L.6
  • 33
    • 0025990146 scopus 로고
    • High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures
    • Ayo SH, Radnik R, Garoni JA, Troyer DA, Kreisberg JI. High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am J Physiol 1991; 261(4 Pt 2): F571-F577.
    • (1991) Am J Physiol , vol.261 , Issue.4 PART 2
    • Ayo, S.H.1    Radnik, R.2    Garoni, J.A.3    Troyer, D.A.4    Kreisberg, J.I.5
  • 34
    • 0027526916 scopus 로고
    • Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium
    • Studer RK, Craven PA, DeRubertis FR. Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium. Diabetes 1993; 42: 118-126.
    • (1993) Diabetes , vol.42 , pp. 118-126
    • Studer, R.K.1    Craven, P.A.2    Derubertis, F.R.3
  • 36
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404: 787-790.
    • (2000) Nature , vol.404 , pp. 787-790
    • Nishikawa, T.1    Edelstein, D.2    Du, X.L.3
  • 37
  • 38
    • 0032543439 scopus 로고    scopus 로고
    • Effect of eicosapentaenoic acid on glucose-induced diacylglycerol synthesis in cultured bovine aortic endothelial cells
    • Kuroki T, Inoguchi T, Umeda F, Nawata H. Effect of eicosapentaenoic acid on glucose-induced diacylglycerol synthesis in cultured bovine aortic endothelial cells. Biochem Biophys Res Commun 1998; 247: 473-477.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 473-477
    • Kuroki, T.1    Inoguchi, T.2    Umeda, F.3    Nawata, H.4
  • 39
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998; 47: 859-866.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 40
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor
    • Aiello LP, Bursell SE, Clermont A, et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 1997; 46: 1473- 1480.
    • (1997) Diabetes , vol.46
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3
  • 41
    • 0034731522 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells
    • Suzuma K, Naruse K, Suzuma I, et al. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem 2000; 275: 40725-40731.
    • (2000) J Biol Chem , vol.275 , pp. 40725-40731
    • Suzuma, K.1    Naruse, K.2    Suzuma, I.3
  • 42
    • 0037154156 scopus 로고    scopus 로고
    • Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascu-larization
    • Suzuma K, Takahara N, Suzuma I, et al. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascu-larization. Proc Natl Acad Sci U S A 2002; 99: 721-726.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 721-726
    • Suzuma, K.1    Takahara, N.2    Suzuma, I.3
  • 43
    • 0033949316 scopus 로고    scopus 로고
    • Induction of endo-thelin-1 expression by glucose: An effect of protein kinase C activation
    • Park JY, Takahara N, Gabriele A, et al. Induction of endo-thelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes 2000; 49: 1239-1248.
    • (2000) Diabetes , vol.49 , pp. 1239-1248
    • Park, J.Y.1    Takahara, N.2    Gabriele, A.3
  • 44
    • 0037343260 scopus 로고    scopus 로고
    • Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes
    • Yokota T, Ma RC, Park JY, et al. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes 2003; 52: 838-845.
    • (2003) Diabetes , vol.52 , pp. 838-845
    • Yokota, T.1    Ma, R.C.2    Park, J.Y.3
  • 45
    • 0030760729 scopus 로고    scopus 로고
    • Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
    • Koya D, Jirousek MR, Lin YW, Ishii H, Kuboki K, King GL. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest 1997; 100: 115-126.
    • (1997) J Clin Invest , vol.100 , pp. 115-126
    • Koya, D.1    Jirousek, M.R.2    Lin, Y.W.3    Ishii, H.4    Kuboki, K.5    King, G.L.6
  • 46
    • 33845522286 scopus 로고    scopus 로고
    • Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice
    • Ohshiro Y, Ma RC, Yasuda Y, et al. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes 2006; 55: 3112-3120.
    • (2006) Diabetes , vol.55 , pp. 3112-3120
    • Ohshiro, Y.1    Ma, R.C.2    Yasuda, Y.3
  • 47
    • 0036724631 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes
    • Way KJ, Isshiki K, Suzuma K, et al. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes 2002; 51: 2709-2718.
    • (2002) Diabetes , vol.51 , pp. 2709-2718
    • Way, K.J.1    Isshiki, K.2    Suzuma, K.3
  • 48
    • 0029692743 scopus 로고    scopus 로고
    • Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression
    • Feener EP, Xia P, Inoguchi T, Shiba T, Kunisaki M, King GL. Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression. Contrib Nephrol 1996; 118: 180-187.
    • (1996) Contrib Nephrol , vol.118 , pp. 180-187
    • Feener, E.P.1    Xia, P.2    Inoguchi, T.3    Shiba, T.4    Kunisaki, M.5    King, G.L.6
  • 49
    • 0034843471 scopus 로고    scopus 로고
    • Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose-and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells
    • Ahn JD, Morishita R, Kaneda Y, et al. Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose-and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells. Diabetologia 2001; 44: 713-720.
    • (2001) Diabetologia , vol.44 , pp. 713-720
    • Ahn, J.D.1    Morishita, R.2    Kaneda, Y.3
  • 50
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
    • Inoguchi T, Li P, Umeda F, et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 2000; 49: 1939- 1945.
    • (2000) Diabetes , vol.49
    • Inoguchi, T.1    Li, P.2    Umeda, F.3
  • 51
    • 0141755311 scopus 로고    scopus 로고
    • Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy
    • Kitada M, Koya D, Sugimoto T, et al. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes 2003; 52: 2603-2614.
    • (2003) Diabetes , vol.52 , pp. 2603-2614
    • Kitada, M.1    Koya, D.2    Sugimoto, T.3
  • 52
    • 0030667807 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration: Prevention by calphostin C
    • Pieper GM, Riaz ul H. Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration: prevention by calphostin C. J Cardiovasc Pharmacol 1997; 30: 528-532.
    • (1997) J Cardiovasc Pharmacol , vol.30 , pp. 528-532
    • Pieper, G.M.1    Riaz ul, H.2
  • 53
    • 0033037930 scopus 로고    scopus 로고
    • Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells
    • Yerneni KK, Bai W, Khan BV, Medford RM, Natarajan R. Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells. Diabetes 1999; 48: 855-864.
    • (1999) Diabetes , vol.48 , pp. 855-864
    • Yerneni, K.K.1    Bai, W.2    Khan, B.V.3    Medford, R.M.4    Natarajan, R.5
  • 54
    • 55949109631 scopus 로고    scopus 로고
    • Structural basis of protein kinase C isoform function
    • Steinberg SF. Structural basis of protein kinase C isoform function. Physiol Rev 2008; 88: 1341-1378.
    • (2008) Physiol Rev , vol.88 , pp. 1341-1378
    • Steinberg, S.F.1
  • 55
    • 0028564935 scopus 로고
    • Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels
    • Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 1994; 43: 1372-1377.
    • (1994) Diabetes , vol.43 , pp. 1372-1377
    • Kunisaki, M.1    Bursell, S.E.2    Umeda, F.3    Nawata, H.4    King, G.L.5
  • 56
    • 0036085537 scopus 로고    scopus 로고
    • Mesangial cell filamentous actin disassembly and hypocon-tractility in high glucose are mediated by PKC-zeta
    • Dlugosz JA, Munk S, Ispanovic E, Goldberg HJ, Whiteside CI. Mesangial cell filamentous actin disassembly and hypocon-tractility in high glucose are mediated by PKC-zeta. Am J Physiol Renal Physiol 2002; 282: F151-F163.
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Dlugosz, J.A.1    Munk, S.2    Ispanovic, E.3    Goldberg, H.J.4    Whiteside, C.I.5
  • 57
    • 0034053336 scopus 로고    scopus 로고
    • Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    • Koya D, Haneda M, Nakagawa H, et al. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 2000; 14: 439-447.
    • (2000) FASEB J , vol.14 , pp. 439-447
    • Koya, D.1    Haneda, M.2    Nakagawa, H.3
  • 58
    • 0042415006 scopus 로고    scopus 로고
    • Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons
    • Kim H, Sasaki T, Maeda K, Koya D, Kashiwagi A, Yasuda H. Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. Diabetes 2003; 52: 2102- 2109.
    • (2003) Diabetes , vol.52
    • Kim, H.1    Sasaki, T.2    Maeda, K.3    Koya, D.4    Kashiwagi, A.5    Yasuda, H.6
  • 59
    • 0032836509 scopus 로고    scopus 로고
    • A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats
    • Nakamura J, Kato K, Hamada Y, et al. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes 1999; 48: 2090-2095.
    • (1999) Diabetes , vol.48 , pp. 2090-2095
    • Nakamura, J.1    Kato, K.2    Hamada, Y.3
  • 60
    • 65349083118 scopus 로고    scopus 로고
    • Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis
    • Harja E, Chang JS, Lu Y, et al. Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J 2009; 23: 1081-1091.
    • (2009) FASEB J , vol.23 , pp. 1081-1091
    • Harja, E.1    Chang, J.S.2    Lu, Y.3
  • 61
    • 0037059549 scopus 로고    scopus 로고
    • Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
    • Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Creager MA. Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res 2002; 90: 107-111.
    • (2002) Circ Res , vol.90 , pp. 107-111
    • Beckman, J.A.1    Goldfine, A.B.2    Gordon, M.B.3    Garrett, L.A.4    Creager, M.A.5
  • 62
    • 55549114670 scopus 로고    scopus 로고
    • Protein kinase C-beta inhibition for diabetic kidney disease
    • Tuttle KR. Protein kinase C-beta inhibition for diabetic kidney disease. Diabetes Res Clin Pract 2008; 82(Suppl 1): S70-S74.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL 1
    • Tuttle, K.R.1
  • 63
    • 21344435254 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe non-proliferative diabetic retinopathy: Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial
    • PKC-DRS Study Group
    • PKC-DRS Study Group. The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe non-proliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes 2005; 54: 2188-2197.
    • (2005) Diabetes , vol.54 , pp. 2188-2197
  • 64
    • 14944340746 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant treatment in diabetes
    • Scott JA, King GL. Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci 2004; 1031: 204-213.
    • (2004) Ann N Y Acad Sci , vol.1031 , pp. 204-213
    • Scott, J.A.1    King, G.L.2
  • 65
    • 70349675632 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets for diabetic endothelial dysfunction
    • Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 2009; 120: 1266-1286.
    • (2009) Circulation , vol.120 , pp. 1266-1286
    • Xu, J.1    Zou, M.H.2
  • 66
    • 34547830983 scopus 로고    scopus 로고
    • Diabetes associated cell stress and dysfunction: Role of mitochondrial and non-mitochondrial ROS production and activity
    • Newsholme P, Haber EP, Hirabara SM, et al. Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 2007;583(Pt 1): 9-24.
    • (2007) J Physiol , vol.583 , Issue.PART 1 , pp. 9-24
    • Newsholme, P.1    Haber, E.P.2    Hirabara, S.M.3
  • 67
    • 0034704167 scopus 로고    scopus 로고
    • High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells
    • Zhang Z, Apse K, Pang J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells. J Biol Chem 2000; 275: 40042-40047.
    • (2000) J Biol Chem , vol.275 , pp. 40042-40047
    • Zhang, Z.1    Apse, K.2    Pang, J.3    Stanton, R.C.4
  • 68
    • 26844519964 scopus 로고    scopus 로고
    • Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex
    • Xu Y, Osborne BW, Stanton RC. Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. Am J Physiol 2005; 289: F1040-F1047.
    • (2005) Am J Physiol , vol.289
    • Xu, Y.1    Osborne, B.W.2    Stanton, R.C.3
  • 69
    • 17744377972 scopus 로고    scopus 로고
    • Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney
    • Lee EA, Seo JY, Jiang Z, et al. Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney. Kidney Int 2005; 67: 1762-1771.
    • (2005) Kidney Int , vol.67 , pp. 1762-1771
    • Lee, E.A.1    Seo, J.Y.2    Jiang, Z.3
  • 70
    • 0034682966 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular complications in diabetes: Isoprostanes as new markers on an old paradigm
    • Mezzetti A, Cipollone F, Cuccurullo F. Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm. Cardiovasc Res 2000; 47: 475-488.
    • (2000) Cardiovasc Res , vol.47 , pp. 475-488
    • Mezzetti, A.1    Cipollone, F.2    Cuccurullo, F.3
  • 71
    • 0343329794 scopus 로고    scopus 로고
    • New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus
    • Leinonen J, Lehtimaki T, Toyokuni S, et al. New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus. FEBS Lett 1997; 417: 150-152.
    • (1997) FEBS Lett , vol.417 , pp. 150-152
    • Leinonen, J.1    Lehtimaki, T.2    Toyokuni, S.3
  • 72
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007; 87: 245-313.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 73
    • 33845875499 scopus 로고    scopus 로고
    • Vascular lipo-toxicity: Endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats
    • Chinen I, Shimabukuro M, Yamakawa K, et al. Vascular lipo-toxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. Endocrinology 2007; 148: 160-165.
    • (2007) Endocrinology , vol.148 , pp. 160-165
    • Chinen, I.1    Shimabukuro, M.2    Yamakawa, K.3
  • 74
    • 10744222995 scopus 로고    scopus 로고
    • Oxidative stress is associated with adiposity and insulin resistance in men
    • Urakawa H, Katsuki A, Sumida Y, et al. Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab 2003; 88: 4673-4676.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4673-4676
    • Urakawa, H.1    Katsuki, A.2    Sumida, Y.3
  • 75
    • 33646021903 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat
    • Diaz-Flores M, Ibanez-Hernandez MA, Galvan RE, et al. Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Life Sci 2006; 78: 2601-2607.
    • (2006) Life Sci , vol.78 , pp. 2601-2607
    • Diaz-Flores, M.1    Ibanez-Hernandez, M.A.2    Galvan, R.E.3
  • 76
    • 0032954074 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant enzyme activities in patients with type 1 diabetes mellitus
    • Ruiz C, Alegria A, Barbera R, Farre R, Lagarda MJ. Lipid peroxidation and antioxidant enzyme activities in patients with type 1 diabetes mellitus. Scand J Clin Lab Invest 1999; 59: 99- 105.
    • (1999) Scand J Clin Lab Invest , vol.59
    • Ruiz, C.1    Alegria, A.2    Barbera, R.3    Farre, R.4    Lagarda, M.J.5
  • 77
    • 0032872586 scopus 로고    scopus 로고
    • Serum vitamin C concentrations and diabetes: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994
    • Will JC, Ford ES, Bowman BA. Serum vitamin C concentrations and diabetes: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 1999; 70: 49-52.
    • (1999) Am J Clin Nutr , vol.70 , pp. 49-52
    • Will, J.C.1    Ford, E.S.2    Bowman, B.A.3
  • 78
    • 34247501789 scopus 로고    scopus 로고
    • Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice
    • Brezniceanu ML, Liu F, Wei CC, et al. Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice. Kidney Int 2007; 71: 912-923.
    • (2007) Kidney Int , vol.71 , pp. 912-923
    • Brezniceanu, M.L.1    Liu, F.2    Wei, C.C.3
  • 79
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    • El-Osta A, Brasacchio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 2008; 205: 2409-2417.
    • (2008) J Exp Med , vol.205 , pp. 2409-2417
    • El-Osta, A.1    Brasacchio, D.2    Yao, D.3
  • 80
    • 0036834582 scopus 로고    scopus 로고
    • Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the HOPE study and MICRO-HOPE substudy
    • Lonn E, Yusuf S, Hoogwerf B, et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 2002; 25: 1919-1927.
    • (2002) Diabetes Care , vol.25 , pp. 1919-1927
    • Lonn, E.1    Yusuf, S.2    Hoogwerf, B.3
  • 81
    • 0034688195 scopus 로고    scopus 로고
    • Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000; 342: 154-160.
    • (2000) N Engl J Med , vol.342 , pp. 154-160
    • Yusuf, S.1    Dagenais, G.2    Pogue, J.3    Bosch, J.4    Sleight, P.5
  • 82
    • 33746920337 scopus 로고    scopus 로고
    • Advanced glycation end products: Sparking the development of diabetic vascular injury
    • Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 2006; 114: 597-605.
    • (2006) Circulation , vol.114 , pp. 597-605
    • Goldin, A.1    Beckman, J.A.2    Schmidt, A.M.3    Creager, M.A.4
  • 83
    • 21444454887 scopus 로고    scopus 로고
    • Molecular targets of diabetic cardiovascular complications
    • Ahmad FK, He Z, King GL. Molecular targets of diabetic cardiovascular complications. Curr Drug Targets 2005; 6: 487- 494.
    • (2005) Curr Drug Targets , vol.6
    • Ahmad, F.K.1    He, Z.2    King, G.L.3
  • 84
    • 0031008674 scopus 로고    scopus 로고
    • Advanced glycation end products in serum predict changes in the kidney morphology of patients with insulin-dependent diabetes mellitus
    • Berg TJ, Bangstad HJ, Torjesen PA, Osterby R, Bucala R, Hanssen KF. Advanced glycation end products in serum predict changes in the kidney morphology of patients with insulin-dependent diabetes mellitus. Metabolism 1997; 46: 661-665.
    • (1997) Metabolism , vol.46 , pp. 661-665
    • Berg, T.J.1    Bangstad, H.J.2    Torjesen, P.A.3    Osterby, R.4    Bucala, R.5    Hanssen, K.F.6
  • 85
    • 0033055417 scopus 로고    scopus 로고
    • Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions
    • Suzuki D, Miyata T, Saotome N, et al. Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. J Am Soc Nephrol 1999; 10: 822-832.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 822-832
    • Suzuki, D.1    Miyata, T.2    Saotome, N.3
  • 86
    • 0031019612 scopus 로고    scopus 로고
    • Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats
    • Stitt AW, Li YM, Gardiner TA, Bucala R, Archer DB, Vlassara H. Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. Am J Pathol 1997; 150: 523-531.
    • (1997) Am J Pathol , vol.150 , pp. 523-531
    • Stitt, A.W.1    Li, Y.M.2    Gardiner, T.A.3    Bucala, R.4    Archer, D.B.5    Vlassara, H.6
  • 87
    • 0031910005 scopus 로고    scopus 로고
    • The relationship of glycaemic level to advanced glycation end-product (AGE) accumulation and retinal pathology in the spontaneous diabetic hamster
    • Hammes HP, Wellensiek B, Kloting I, Sickel E, Bretzel RG, Brownlee M. The relationship of glycaemic level to advanced glycation end-product (AGE) accumulation and retinal pathology in the spontaneous diabetic hamster. Diabetologia 1998; 41: 165-170.
    • (1998) Diabetologia , vol.41 , pp. 165-170
    • Hammes, H.P.1    Wellensiek, B.2    Kloting, I.3    Sickel, E.4    Bretzel, R.G.5    Brownlee, M.6
  • 88
    • 0028304845 scopus 로고
    • Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes
    • Giardino I, Edelstein D, Brownlee M. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes. J Clin Invest 1994; 94: 110-117.
    • (1994) J Clin Invest , vol.94 , pp. 110-117
    • Giardino, I.1    Edelstein, D.2    Brownlee, M.3
  • 89
    • 22344442393 scopus 로고    scopus 로고
    • Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation
    • Rosca MG, Mustata TG, Kinter MT, et al. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol 2005; 289: F420-F430.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Rosca, M.G.1    Mustata, T.G.2    Kinter, M.T.3
  • 90
    • 0023705750 scopus 로고
    • Glycation induces expansion of the molecular packing of collagen
    • Tanaka S, Avigad G, Brodsky B, Eikenberry EF. Glycation induces expansion of the molecular packing of collagen. J Mol Biol 1988; 203: 495-505.
    • (1988) J Mol Biol , vol.203 , pp. 495-505
    • Tanaka, S.1    Avigad, G.2    Brodsky, B.3    Eikenberry, E.F.4
  • 91
    • 0026696647 scopus 로고
    • Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen
    • Haitoglou CS, Tsilibary EC, Brownlee M, Charonis AS. Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen. J Biol Chem 1992; 267: 12404-12407.
    • (1992) J Biol Chem , vol.267 , pp. 12404-12407
    • Haitoglou, C.S.1    Tsilibary, E.C.2    Brownlee, M.3    Charonis, A.S.4
  • 92
    • 1842526645 scopus 로고    scopus 로고
    • Microvascular complications of diabetes
    • xi-xii
    • He Z, King GL. Microvascular complications of diabetes. Endocrinol Metab Clin North Am 2004; 33: 215-238, xi-xii.
    • (2004) Endocrinol Metab Clin North Am , vol.33 , pp. 215-238
    • He, Z.1    King, G.L.2
  • 94
    • 0028958852 scopus 로고
    • Identification of the major site of apolipoprotein B modification by advanced glycosylation end products blocking uptake by the low density lipoprotein receptor
    • Bucala R, Mitchell R, Arnold K, Innerarity T, Vlassara H, Cerami A. Identification of the major site of apolipoprotein B modification by advanced glycosylation end products blocking uptake by the low density lipoprotein receptor. J Biol Chem 1995; 270: 10828-10832.
    • (1995) J Biol Chem , vol.270 , pp. 10828-10832
    • Bucala, R.1    Mitchell, R.2    Arnold, K.3    Innerarity, T.4    Vlassara, H.5    Cerami, A.6
  • 95
    • 0033779614 scopus 로고    scopus 로고
    • RAGE: A new target for the prevention and treatment of the vascular and inflammatory complications of diabetes
    • Schmidt AM, Stern DM. RAGE: a new target for the prevention and treatment of the vascular and inflammatory complications of diabetes. Trends Endocrinol Metab 2000; 11: 368-375.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 368-375
    • Schmidt, A.M.1    Stern, D.M.2
  • 96
    • 0033848466 scopus 로고    scopus 로고
    • Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease
    • Tanji N, Markowitz GS, Fu C, et al. Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease. J Am Soc Nephrol 2000; 11: 1656-1666.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1656-1666
    • Tanji, N.1    Markowitz, G.S.2    Fu, C.3
  • 97
    • 0034947508 scopus 로고    scopus 로고
    • Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
    • Yamamoto Y, Kato I, Doi T, et al. Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest 2001; 108: 261-268.
    • (2001) J Clin Invest , vol.108 , pp. 261-268
    • Yamamoto, Y.1    Kato, I.2    Doi, T.3
  • 98
    • 0033538569 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways
    • Huttunen HJ, Fages C, Rauvala H. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 1999; 274: 19919-19924.
    • (1999) J Biol Chem , vol.274 , pp. 19919-19924
    • Huttunen, H.J.1    Fages, C.2    Rauvala, H.3
  • 99
    • 0035656173 scopus 로고    scopus 로고
    • Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB
    • Bierhaus A, Schiekofer S, Schwaninger M, et al. Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 2001; 50: 2792-2808.
    • (2001) Diabetes , vol.50 , pp. 2792-2808
    • Bierhaus, A.1    Schiekofer, S.2    Schwaninger, M.3
  • 100
    • 0028304625 scopus 로고
    • Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
    • Yan SD, Schmidt AM, Anderson GM, et al. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 1994; 269: 9889-9897.
    • (1994) J Biol Chem , vol.269 , pp. 9889-9897
    • Yan, S.D.1    Schmidt, A.M.2    Anderson, G.M.3
  • 101
    • 0037133280 scopus 로고    scopus 로고
    • Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: A mechanism for amplification of inflammatory responses
    • Basta G, Lazzerini G, Massaro M, et al. Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses. Circulation 2002; 105: 816-822.
    • (2002) Circulation , vol.105 , pp. 816-822
    • Basta, G.1    Lazzerini, G.2    Massaro, M.3
  • 102
    • 0029088742 scopus 로고
    • Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes
    • Schmidt AM, Hori O, Chen JX, et al. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 1995; 96: 1395-1403.
    • (1995) J Clin Invest , vol.96 , pp. 1395-1403
    • Schmidt, A.M.1    Hori, O.2    Chen, J.X.3
  • 104
    • 0029366113 scopus 로고
    • Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): A new member of the AGE-receptor complex
    • Vlassara H, Li YM, Imani F, et al. Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex. Mol Med 1995; 1: 634-646.
    • (1995) Mol Med , vol.1 , pp. 634-646
    • Vlassara, H.1    Li, Y.M.2    Imani, F.3
  • 105
    • 0028364606 scopus 로고
    • Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors
    • el Khoury J, Thomas CA, Loike JD, Hickman SE, Cao L, Silver-stein SC. Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. J Biol Chem 1994; 269: 10197-10200.
    • (1994) J Biol Chem , vol.269 , pp. 10197-10200
    • el Khoury, J.1    Thomas, C.A.2    Loike, J.D.3    Hickman, S.E.4    Cao, L.5    Silver-stein, S.C.6
  • 106
    • 0026063185 scopus 로고
    • Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat
    • Soulis-Liparota T, Cooper M, Papazoglou D, Clarke B, Jerums G. Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat. Diabetes 1991; 40: 1328-1334.
    • (1991) Diabetes , vol.40 , pp. 1328-1334
    • Soulis-Liparota, T.1    Cooper, M.2    Papazoglou, D.3    Clarke, B.4    Jerums, G.5
  • 107
    • 0026323337 scopus 로고
    • Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
    • Hammes HP, Martin S, Federlin K, Geisen K, Brownlee M. Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc Natl Acad Sci U S A 1991; 88: 11555-11558.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 11555-11558
    • Hammes, H.P.1    Martin, S.2    Federlin, K.3    Geisen, K.4    Brownlee, M.5
  • 108
    • 10644246127 scopus 로고    scopus 로고
    • Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process
    • Bakris GL, Bank AJ, Kass DA, Neutel JM, Preston RA, Oparil S. Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. Am J Hypertens 2004; 17(12 Pt 2): 23S-30S.
    • (2004) Am J Hypertens , vol.17 , Issue.12 PART 2
    • Bakris, G.L.1    Bank, A.J.2    Kass, D.A.3    Neutel, J.M.4    Preston, R.A.5    Oparil, S.6
  • 109
    • 0037453647 scopus 로고    scopus 로고
    • A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes
    • Candido R, Forbes JM, Thomas MC, et al. A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes. Circ Res 2003; 92: 785-792.
    • (2003) Circ Res , vol.92 , pp. 785-792
    • Candido, R.1    Forbes, J.M.2    Thomas, M.C.3
  • 110
    • 3042704196 scopus 로고    scopus 로고
    • Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis
    • Forbes JM, Yee LT, Thallas V, et al. Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis. Diabetes 2004; 53: 1813-1823.
    • (2004) Diabetes , vol.53 , pp. 1813-1823
    • Forbes, J.M.1    Yee, L.T.2    Thallas, V.3
  • 111
    • 0141483457 scopus 로고    scopus 로고
    • The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes
    • Forbes JM, Thallas V, Thomas MC, et al. The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. FASEB J 2003; 17: 1762-1764.
    • (2003) FASEB J , vol.17 , pp. 1762-1764
    • Forbes, J.M.1    Thallas, V.2    Thomas, M.C.3
  • 112
    • 3543148984 scopus 로고    scopus 로고
    • Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: Role of advanced glycation end products
    • Lassila M, Seah KK, Allen TJ, et al. Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products. J Am Soc Nephrol 2004; 15: 2125-2138.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2125-2138
    • Lassila, M.1    Seah, K.K.2    Allen, T.J.3
  • 113
    • 0037180531 scopus 로고    scopus 로고
    • RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice
    • Bucciarelli LG, Wendt T, Qu W, et al. RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice. Circulation 2002; 106: 2827-2835.
    • (2002) Circulation , vol.106 , pp. 2827-2835
    • Bucciarelli, L.G.1    Wendt, T.2    Qu, W.3
  • 114
    • 0037380608 scopus 로고    scopus 로고
    • Central role of RAGE-dependent neointimal expansion in arterial restenosis
    • Sakaguchi T, Yan SF, Yan SD, et al. Central role of RAGE-dependent neointimal expansion in arterial restenosis. J Clin Invest 2003; 111: 959-972.
    • (2003) J Clin Invest , vol.111 , pp. 959-972
    • Sakaguchi, T.1    Yan, S.F.2    Yan, S.D.3
  • 115
    • 0037696629 scopus 로고    scopus 로고
    • Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury
    • Zhou Z, Wang K, Penn MS, et al. Receptor for AGE (RAGE) mediates neointimal formation in response to arterial injury. Circulation 2003; 107: 2238-2243.
    • (2003) Circulation , vol.107 , pp. 2238-2243
    • Zhou, Z.1    Wang, K.2    Penn, M.S.3
  • 116
    • 0037377697 scopus 로고    scopus 로고
    • RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
    • Wendt TM, Tanji N, Guo J, et al. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol 2003; 162: 1123-1137.
    • (2003) Am J Pathol , vol.162 , pp. 1123-1137
    • Wendt, T.M.1    Tanji, N.2    Guo, J.3
  • 117
    • 33644873810 scopus 로고    scopus 로고
    • Hexosamines, insulin resistance, and the complications of diabetes: Current status
    • Buse MG. Hexosamines, insulin resistance, and the complications of diabetes: current status. Am J Physiol Endocrinol Metab 2006; 290: E1-E8.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Buse, M.G.1
  • 118
    • 0030907389 scopus 로고    scopus 로고
    • Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
    • Han I, Kudlow JE. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility. Mol Cell Biol 1997; 17: 2550-2558.
    • (1997) Mol Cell Biol , vol.17 , pp. 2550-2558
    • Han, I.1    Kudlow, J.E.2
  • 119
    • 0030772457 scopus 로고    scopus 로고
    • O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions
    • Roos MD, Su K, Baker JR, Kudlow JE. O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions. Mol Cell Biol 1997; 17: 6472-6480.
    • (1997) Mol Cell Biol , vol.17 , pp. 6472-6480
    • Roos, M.D.1    Su, K.2    Baker, J.R.3    Kudlow, J.E.4
  • 120
    • 0035811072 scopus 로고    scopus 로고
    • O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability
    • Yang X, Su K, Roos MD, Chang Q, Paterson AJ, Kudlow JE. O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability. Proc Natl Acad Sci U S A 2001; 98: 6611-6616.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6611-6616
    • Yang, X.1    Su, K.2    Roos, M.D.3    Chang, Q.4    Paterson, A.J.5    Kudlow, J.E.6
  • 121
    • 0032478827 scopus 로고    scopus 로고
    • Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells
    • Chen YQ, Su M, Walia RR, Hao Q, Covington JW, Vaughan DE. Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells. J Biol Chem 1998; 273: 8225-8231.
    • (1998) J Biol Chem , vol.273 , pp. 8225-8231
    • Chen, Y.Q.1    Su, M.2    Walia, R.R.3    Hao, Q.4    Covington, J.W.5    Vaughan, D.E.6
  • 122
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • Du XL, Edelstein D, Rossetti L, et al. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci U S A 2000; 97: 12222-12226.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12222-12226
    • Du, X.L.1    Edelstein, D.2    Rossetti, L.3
  • 124
    • 1942469517 scopus 로고    scopus 로고
    • Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: Up-regulation of USF activity by the hexosamine biosynthetic pathway
    • Weigert C, Brodbeck K, Sawadogo M, Haring HU, Schleicher ED. Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathway. J Biol Chem 2004; 279: 15908-15915.
    • (2004) J Biol Chem , vol.279 , pp. 15908-15915
    • Weigert, C.1    Brodbeck, K.2    Sawadogo, M.3    Haring, H.U.4    Schleicher, E.D.5
  • 125
    • 0035180299 scopus 로고    scopus 로고
    • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    • Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 2001; 108: 1341-1348.
    • (2001) J Clin Invest , vol.108 , pp. 1341-1348
    • Du, X.L.1    Edelstein, D.2    Dimmeler, S.3    Ju, Q.4    Sui, C.5    Brownlee, M.6
  • 127
    • 33845742185 scopus 로고    scopus 로고
    • Mechanisms of Disease: Endothelial dysfunction in insulin resistance and diabetes
    • Rask-Madsen C, King GL. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab 2007; 3: 46-56.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 46-56
    • Rask-Madsen, C.1    King, G.L.2
  • 128
    • 0028867689 scopus 로고
    • Prevention of diabetic renal disease with special reference to microalbuminuria
    • Mogensen CE, Keane WF, Bennett PH, et al. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet 1995; 346: 1080-1084.
    • (1995) Lancet , vol.346 , pp. 1080-1084
    • Mogensen, C.E.1    Keane, W.F.2    Bennett, P.H.3
  • 129
    • 0035839532 scopus 로고    scopus 로고
    • Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179)
    • Montagnani M, Chen H, Barr VA, Quon MJ. Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem 2001; 276: 30392-30398.
    • (2001) J Biol Chem , vol.276 , pp. 30392-30398
    • Montagnani, M.1    Chen, H.2    Barr, V.A.3    Quon, M.J.4
  • 130
    • 0034651949 scopus 로고    scopus 로고
    • Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: A specific vascular action of insulin
    • Kuboki K, Jiang ZY, Takahara N, et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 2000; 101: 676-681.
    • (2000) Circulation , vol.101 , pp. 676-681
    • Kuboki, K.1    Jiang, Z.Y.2    Takahara, N.3
  • 131
    • 0032719024 scopus 로고    scopus 로고
    • Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
    • Jiang ZY, Lin YW, Clemont A, et al. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 1999; 104: 447-457.
    • (1999) J Clin Invest , vol.104 , pp. 447-457
    • Jiang, Z.Y.1    Lin, Y.W.2    Clemont, A.3
  • 132
    • 0033968126 scopus 로고    scopus 로고
    • Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
    • Cusi K, Maezono K, Osman A, et al. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 2000; 105: 311-320.
    • (2000) J Clin Invest , vol.105 , pp. 311-320
    • Cusi, K.1    Maezono, K.2    Osman, A.3
  • 133
    • 33646711638 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia
    • He Z, Opland DM, Way KJ, et al. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol 2006; 26: 787-793.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 787-793
    • He, Z.1    Opland, D.M.2    Way, K.J.3
  • 134
    • 33644781862 scopus 로고    scopus 로고
    • Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
    • Naruse K, Rask-Madsen C, Takahara N, et al. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes 2006; 55: 691-698.
    • (2006) Diabetes , vol.55 , pp. 691-698
    • Naruse, K.1    Rask-Madsen, C.2    Takahara, N.3
  • 135
    • 0038665339 scopus 로고    scopus 로고
    • The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
    • Vicent D, Ilany J, Kondo T, et al. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest 2003; 111: 1373-1380.
    • (2003) J Clin Invest , vol.111 , pp. 1373-1380
    • Vicent, D.1    Ilany, J.2    Kondo, T.3
  • 136
    • 57749105450 scopus 로고    scopus 로고
    • Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway
    • Geraldes P, Yagi K, Ohshiro Y, et al. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem 2008; 283: 34327-34336.
    • (2008) J Biol Chem , vol.283 , pp. 34327-34336
    • Geraldes, P.1    Yagi, K.2    Ohshiro, Y.3
  • 137
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22: 1276-1312.
    • (2008) Genes Dev , vol.22 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 138
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997; 277: 242-245.
    • (1997) Science , vol.277 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 139
    • 18544366585 scopus 로고    scopus 로고
    • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    • Enge M, Bjarnegard M, Gerhardt H, et al. Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J 2002; 21: 4307-4316.
    • (2002) EMBO J , vol.21 , pp. 4307-4316
    • Enge, M.1    Bjarnegard, M.2    Gerhardt, H.3
  • 140
    • 33750809382 scopus 로고
    • Retinal vascular patterns. IV. Diabetic retinopathy
    • Cogan DG, Toussaint D, Kuwabara T. Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol 1961; 66: 366-378.
    • (1961) Arch Ophthalmol , vol.66 , pp. 366-378
    • Cogan, D.G.1    Toussaint, D.2    Kuwabara, T.3
  • 141
    • 0013824090 scopus 로고
    • Retinal vascular patterns. VII. Acellular change
    • Kuwabara T, Cogan DG. Retinal vascular patterns. VII. Acellular change. Invest Ophthalmol 1965; 4: 1049-1064.
    • (1965) Invest Ophthalmol , vol.4 , pp. 1049-1064
    • Kuwabara, T.1    Cogan, D.G.2
  • 142
    • 0017638265 scopus 로고
    • Clinicopathologic correlations in diabetic retinopathy. II. Clinical and histologic appearances of retinal capillary microaneurysms
    • Bresnick GH, Davis MD, Myers FL, de Venecia G. Clinicopathologic correlations in diabetic retinopathy. II. Clinical and histologic appearances of retinal capillary microaneurysms. Arch Ophthalmol 1977; 95: 1215-1220.
    • (1977) Arch Ophthalmol , vol.95 , pp. 1215-1220
    • Bresnick, G.H.1    Davis, M.D.2    Myers, F.L.3    de Venecia, G.4
  • 143
    • 70449108112 scopus 로고    scopus 로고
    • Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
    • Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med 2009; 15: 1298-1306.
    • (2009) Nat Med , vol.15 , pp. 1298-1306
    • Geraldes, P.1    Hiraoka-Yamamoto, J.2    Matsumoto, M.3
  • 144
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 145
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-1487.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 146
    • 0031939649 scopus 로고    scopus 로고
    • Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat
    • Hammes HP, Lin J, Bretzel RG, Brownlee M, Breier G. Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. Diabetes 1998; 47: 401-406.
    • (1998) Diabetes , vol.47 , pp. 401-406
    • Hammes, H.P.1    Lin, J.2    Bretzel, R.G.3    Brownlee, M.4    Breier, G.5
  • 148
    • 49349103253 scopus 로고    scopus 로고
    • Intravitreous anti-VEGF for diabetic retinopathy: Hopes and fears for a new therapeutic strategy
    • Simo R, Hernandez C. Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy. Diabetologia 2008; 51: 1574-1580.
    • (2008) Diabetologia , vol.51 , pp. 1574-1580
    • Simo, R.1    Hernandez, C.2
  • 149
    • 0032712434 scopus 로고    scopus 로고
    • Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
    • Cooper ME, Vranes D, Youssef S, et al. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes 1999; 48: 2229-2239.
    • (1999) Diabetes , vol.48 , pp. 2229-2239
    • Cooper, M.E.1    Vranes, D.2    Youssef, S.3
  • 150
    • 0035850826 scopus 로고    scopus 로고
    • The regulation of the induction of vascular endothelial growth factor at the onset of diabetes in spontaneously diabetic rats
    • Braun L, Kardon T, Reisz-Porszasz ZS, Banhegyi G, Mandl J. The regulation of the induction of vascular endothelial growth factor at the onset of diabetes in spontaneously diabetic rats. Life Sci 2001; 69: 2533-2542.
    • (2001) Life Sci , vol.69 , pp. 2533-2542
    • Braun, L.1    Kardon, T.2    Reisz-Porszasz, Z.S.3    Banhegyi, G.4    Mandl, J.5
  • 151
    • 0035034655 scopus 로고    scopus 로고
    • Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes
    • de Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH. Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol 2001; 12: 993-1000.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 993-1000
    • de Vriese, A.S.1    Tilton, R.G.2    Elger, M.3    Stephan, C.C.4    Kriz, W.5    Lameire, N.H.6
  • 152
    • 0036789207 scopus 로고    scopus 로고
    • Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody
    • Flyvbjerg A, Dagnaes-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R. Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 2002; 51: 3090-3094.
    • (2002) Diabetes , vol.51 , pp. 3090-3094
    • Flyvbjerg, A.1    Dagnaes-Hansen, F.2    De Vriese, A.S.3    Schrijvers, B.F.4    Tilton, R.G.5    Rasch, R.6
  • 153
    • 13944274471 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes
    • Schrijvers BF, De Vriese AS, Tilton RG, et al. Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes. Horm Metab Res 2005; 37: 21-25.
    • (2005) Horm Metab Res , vol.37 , pp. 21-25
    • Schrijvers, B.F.1    De Vriese, A.S.2    Tilton, R.G.3
  • 154
    • 33646501496 scopus 로고    scopus 로고
    • Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man
    • Hohenstein B, Hausknecht B, Boehmer K, Riess R, Brekken RA, Hugo CP. Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man. Kidney Int 2006; 69: 1654-1661.
    • (2006) Kidney Int , vol.69 , pp. 1654-1661
    • Hohenstein, B.1    Hausknecht, B.2    Boehmer, K.3    Riess, R.4    Brekken, R.A.5    Hugo, C.P.6
  • 155
    • 15944376565 scopus 로고    scopus 로고
    • Vascular endothelial growth factor gene expression is correlated with glomerular neovascularization in human diabetic nephropathy
    • Kanesaki Y, Suzuki D, Uehara G, et al. Vascular endothelial growth factor gene expression is correlated with glomerular neovascularization in human diabetic nephropathy. Am J Kidney Dis 2005; 45: 288-294.
    • (2005) Am J Kidney Dis , vol.45 , pp. 288-294
    • Kanesaki, Y.1    Suzuki, D.2    Uehara, G.3
  • 156
    • 33846669530 scopus 로고    scopus 로고
    • Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss
    • Baelde HJ, Eikmans M, Lappin DW, et al. Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss. Kidney Int 2007; 71: 637-645.
    • (2007) Kidney Int , vol.71 , pp. 637-645
    • Baelde, H.J.1    Eikmans, M.2    Lappin, D.W.3
  • 157
    • 0030357278 scopus 로고    scopus 로고
    • Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases
    • Shulman K, Rosen S, Tognazzi K, Manseau EJ, Brown LF. Expression of vascular permeability factor (VPF/VEGF) is altered in many glomerular diseases. J Am Soc Nephrol 1996; 7: 661-666.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 661-666
    • Shulman, K.1    Rosen, S.2    Tognazzi, K.3    Manseau, E.J.4    Brown, L.F.5
  • 159
    • 3242659972 scopus 로고    scopus 로고
    • Quantitave and qualitative changes in vascular endothelial growth factor gene expression in glomeruli of patients with type 2 diabetes
    • Bortoloso E, Del Prete D, Dalla Vestra M, et al. Quantitave and qualitative changes in vascular endothelial growth factor gene expression in glomeruli of patients with type 2 diabetes. Eur J Endocrinol 2004; 150: 799-807.
    • (2004) Eur J Endocrinol , vol.150 , pp. 799-807
    • Bortoloso, E.1    Del Prete, D.2    Dalla Vestra, M.3
  • 160
    • 33846638744 scopus 로고    scopus 로고
    • Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis
    • Zhu X, Wu S, Dahut WL, Parikh CR. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 2007; 49: 186-193.
    • (2007) Am J Kidney Dis , vol.49 , pp. 186-193
    • Zhu, X.1    Wu, S.2    Dahut, W.L.3    Parikh, C.R.4
  • 161
    • 0037373006 scopus 로고    scopus 로고
    • Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    • Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658.
    • (2003) J Clin Invest , vol.111 , pp. 649-658
    • Maynard, S.E.1    Min, J.Y.2    Merchan, J.3
  • 162
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111: 707-716.
    • (2003) J Clin Invest , vol.111 , pp. 707-716
    • Eremina, V.1    Sood, M.2    Haigh, J.3
  • 163
    • 34250374471 scopus 로고    scopus 로고
    • Role of the VEGF - a signaling pathway in the glomerulus: Evidence for crosstalk between components of the glomerular filtration barrier
    • Eremina V, Baelde HJ, Quaggin SE. Role of the VEGF - a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol 2007; 106: p32-p37.
    • (2007) Nephron Physiol , vol.106
    • Eremina, V.1    Baelde, H.J.2    Quaggin, S.E.3
  • 164
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 358: 1129-1136.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 165
    • 0034917262 scopus 로고    scopus 로고
    • Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
    • Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ. Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001; 12: 1448-1457.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1448-1457
    • Kang, D.H.1    Hughes, J.2    Mazzali, M.3    Schreiner, G.F.4    Johnson, R.J.5
  • 166
    • 14344270356 scopus 로고    scopus 로고
    • Post-cyclosporine-medi-ated hypertension and nephropathy: Amelioration by vascular endothelial growth factor
    • Kang DH, Kim YG, Andoh TF, et al. Post-cyclosporine-medi-ated hypertension and nephropathy: amelioration by vascular endothelial growth factor. Am J Physiol Renal Physiol 2001; 280: F727-F736.
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Kang, D.H.1    Kim, Y.G.2    Andoh, T.F.3
  • 167
    • 0034889558 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulo-nephritis
    • Masuda Y, Shimizu A, Mori T, et al. Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulo-nephritis. Am J Pathol 2001; 159: 599-608.
    • (2001) Am J Pathol , vol.159 , pp. 599-608
    • Masuda, Y.1    Shimizu, A.2    Mori, T.3
  • 168
    • 0032589378 scopus 로고    scopus 로고
    • VEGF(165) mediates glomerular endothelial repair
    • Ostendorf T, Kunter U, Eitner F, et al. VEGF(165) mediates glomerular endothelial repair. J Clin Invest 1999; 104: 913- 923.
    • (1999) J Clin Invest , vol.104
    • Ostendorf, T.1    Kunter, U.2    Eitner, F.3
  • 169
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood 2007; 109: 3161-3172.
    • (2007) Blood , vol.109 , pp. 3161-3172
    • Mosnier, L.O.1    Zlokovic, B.V.2    Griffin, J.H.3
  • 170
    • 0031886870 scopus 로고    scopus 로고
    • Mechanisms of elevation of serum and urinary concentrations of soluble thrombomod-ulin in diabetic patients: Possible application as a marker for vascular endothelial injury
    • Aso Y, Inukai T, Takemura Y. Mechanisms of elevation of serum and urinary concentrations of soluble thrombomod-ulin in diabetic patients: possible application as a marker for vascular endothelial injury. Metabolism 1998; 47: 362-365.
    • (1998) Metabolism , vol.47 , pp. 362-365
    • Aso, Y.1    Inukai, T.2    Takemura, Y.3
  • 172
    • 35948934636 scopus 로고    scopus 로고
    • Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    • Isermann B, Vinnikov IA, Madhusudhan T, et al. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 2007; 13: 1349-1358.
    • (2007) Nat Med , vol.13 , pp. 1349-1358
    • Isermann, B.1    Vinnikov, I.A.2    Madhusudhan, T.3


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