Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids

Diabetes

Volumn 61, Issue 2, 2012, Pages 292-300

  Gögebakan, Özlem ^a,b   Andres, Janin ^a   Biedasek, Katrin ^a   Mai, Knut ^a   Kühnen, Peter ^c   Krude, Heiko ^c   Isken, Frank ^a,b   Rudovich, Natalia ^b   Osterhoff, Martin A ^a,b   Kintscher, Ulrich ^c   Nauck, Michael ^d   Pfeiffer, Andreas F H ^a,b   Spranger, Joachim ^a  

^a Diabetes and Nutrition ^*  (Germany)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d DIABETESZENTRUM BAD LAUTERBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; FATTY ACID; GASTRIC INHIBITORY POLYPEPTIDE; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REGULATION; ESTERIFICATION; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FATTY ACID TRANSPORT; HORMONE ACTION; HUMAN; HUMAN TISSUE; LIPOLYSIS; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS FAT; TISSUE SPECIFICITY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3-L1 CELLS; ADULT; ANIMALS; CELL DIFFERENTIATION; FATTY ACIDS, NONESTERIFIED; GASTRIC INHIBITORY POLYPEPTIDE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPASE; MALE; MICE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; STEROL ESTERASE;

EID: 84856539533     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0902     Document Type: Article

References (30)

1. Asmar M, Tangaa W, Madsbad S, et al. On the role of glucose-dependent insulintropic polypeptide in postprandial metabolism in humans. Am J Physiol Endocrinol Metab 2010;298:E614-E621
2. Hansotia T, Maida A, Flock G, et al. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J Clin Invest 2007;117:143-152 (Pubitemid 46048461)
3. Yip RG, Wolfe MM. GIP biology and fat metabolism. Life Sci 2000;66:91-103 (Pubitemid 30025456)
4. Miyawaki K, Yamada Y, Ban N, et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 2002;8:738-742 (Pubitemid 34778728)
5. McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR. GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab 2007;293:E1746-E1755 (Pubitemid 350255128)
6. Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology 2007;133:1796-1805 (Pubitemid 350180808)
7. Getty-Kaushik L, Song DH, Boylan MO, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification. Obesity (Silver Spring) 2006;14:1124-1131 (Pubitemid 46219678)
8. Asmar M, Simonsen L, Madsbad S, Stallknecht B, Holst JJ, Bülow J. Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans. Diabetes 2010;59: 2160-2163
9. Yamaoka-Tojo M, Tojo T, Takahira N, et al. Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease. Cardiovasc Diabetol 2010;9:17
10. Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J Biol Chem 2005;280: 22297-22307 (Pubitemid 40827886)
11. Trümper A, Trümper K, Trusheim H, Arnold R, Göke B, Hörsch D. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol Endocrinol 2001;15:1559-1570 (Pubitemid 32826409)
12. Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab 2003;88:2738-2744 (Pubitemid 36724450)
13. Paulsen SK, Pedersen SB, Fisker S, Richelsen B. 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. Obesity (Silver Spring) 2007;15:1954-1960 (Pubitemid 47402227)
14. Purnell JQ, Kahn SE, Samuels MH, Brandon D, Loriaux DL, Brunzell JD. Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss. Am J Physiol Endocrinol Metab 2009;296:E351-E357
15. Morton NM, Paterson JM, Masuzaki H, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004;53:931-938 (Pubitemid 38436604)
16. Alberts P, Engblom L, Edling N, et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 2002;45:1528-1532 (Pubitemid 35352046)
17. Alberts P, Nilsson C, Selen G, et al. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 2003;144:4755-4762 (Pubitemid 37378389)
18. Wan ZK, Chenail E, Xiang J, et al. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J Med Chem 2009;52:5449-5461
19. Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001;294:2166-2170 (Pubitemid 33150673)
20. Andres J, Mai K, Möhlig M, et al. Cell-type specific regulation of the human 11beta-hydroxysteroid dehydrogenase type 1 promoter. Arch Physiol Biochem 2007;113:110-115 (Pubitemid 47547383)
21. Mai K, Andres J, Bobbert T, et al. Rosiglitazone decreases 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue. Clin Endocrinol (Oxf) 2007;67:419-425 (Pubitemid 47283841)
22. Karlsson JO, Ostwald K, Kåbjörn C, Andersson M. A method for protein assay in Laemmli buffer. Anal Biochem 1994;219:144-146 (Pubitemid 24167234)
23. Bobbert T, Rochlitz H, Wegewitz U, et al. Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 2005;54: 2712-2719 (Pubitemid 41233594)
24. Meier JJ, Hücking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes 2001;50:2497-2504 (Pubitemid 33642767)
25. Rudovich N, Kaiser S, Engeli S, et al. GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women. Regul Pept 2007;142:138-145 (Pubitemid 46899243)
26. McIntosh CH, Bremsak I, Lynn FC, et al. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. Endocrinology 1999;140:398-404 (Pubitemid 29011185)
27. Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 2004;279:47066-47075 (Pubitemid 39518362)
28. Rijkelijkhuizen JM, McQuarrie K, Girman CJ, et al. Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses. Metabolism 2010;59:502-511
29. Vollmer K, Holst JJ, Baller B, et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes 2008;57:678-687
30. Isken F, Weickert MO, Tschöp MH, et al. Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice. Diabetologia 2009;52:2159-2168