메뉴 건너뛰기




Volumn 14, Issue 5, 2012, Pages 454-463

Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model

Author keywords

Blood retinal barrier; Diabetic retinopathy; Dipeptidyl peptidase IV; Endothelial progenitor cells; Sitagliptin; Zucker Diabetic Fatty rat

Indexed keywords

3 NITROTYROSINE; CLAUDIN 5; DNA NUCLEOTIDYLEXOTRANSFERASE; HEMOGLOBIN A1C; INTERLEUKIN 1BETA; OCCLUDIN; PROTEIN BAX; PROTEIN BCL 2; SITAGLIPTIN;

EID: 84859444000     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01548.x     Document Type: Article
Times cited : (79)

References (40)
  • 2
    • 0023601077 scopus 로고
    • The structural basis of the inner blood-retina barrier in the eye of Macaca mulatta.
    • Sagaties MJ, Raviola G, Schaeffer S, Miller C. The structural basis of the inner blood-retina barrier in the eye of Macaca mulatta. Invest Ophthalmol Vis Sci 1987; 28: 2000-2014.
    • (1987) Invest Ophthalmol Vis Sci , vol.28 , pp. 2000-2014
    • Sagaties, M.J.1    Raviola, G.2    Schaeffer, S.3    Miller, C.4
  • 4
    • 0033551811 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors.
    • Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999; 274: 23463-23467.
    • (1999) J Biol Chem , vol.274 , pp. 23463-23467
    • Antonetti, D.A.1    Barber, A.J.2    Hollinger, L.A.3    Wolpert, E.B.4    Gardner, T.W.5
  • 5
    • 0033771018 scopus 로고    scopus 로고
    • Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.
    • Barber AJ, Antonetti DA, Gardner TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci 2000; 41: 3561-3568.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3561-3568
    • Barber, A.J.1    Antonetti, D.A.2    Gardner, T.W.3
  • 6
    • 38449108616 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.
    • Leal EC, Manivannan A, Hosoya K et al. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci 2007; 48: 5257-5265.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 5257-5265
    • Leal, E.C.1    Manivannan, A.2    Hosoya, K.3
  • 7
    • 77957589747 scopus 로고    scopus 로고
    • Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
    • Leal EC, Martins J, Voabil P et al. Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. Diabetes 2010; 59: 2637-2645.
    • (2010) Diabetes , vol.59 , pp. 2637-2645
    • Leal, E.C.1    Martins, J.2    Voabil, P.3
  • 8
    • 33750597534 scopus 로고    scopus 로고
    • Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.
    • Antonetti DA, Barber AJ, Bronson SK et al. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes 2006; 55: 2401-2411.
    • (2006) Diabetes , vol.55 , pp. 2401-2411
    • Antonetti, D.A.1    Barber, A.J.2    Bronson, S.K.3
  • 9
    • 4744347272 scopus 로고    scopus 로고
    • Role of interleukin-1beta in the pathogenesis of diabetic retinopathy.
    • Kowluru RA, Odenbach S. Role of interleukin-1beta in the pathogenesis of diabetic retinopathy. Br J Ophthalmol 2004; 88: 1343-1347.
    • (2004) Br J Ophthalmol , vol.88 , pp. 1343-1347
    • Kowluru, R.A.1    Odenbach, S.2
  • 10
    • 0030923371 scopus 로고    scopus 로고
    • Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid.
    • Lutty GA, Cao J, McLeod DS. Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid. Am J Pathol 1997; 151: 707-714.
    • (1997) Am J Pathol , vol.151 , pp. 707-714
    • Lutty, G.A.1    Cao, J.2    McLeod, D.S.3
  • 12
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression.
    • Joussen AM, Poulaki V, Mitsiades N et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 2002; 16: 438-440.
    • (2002) FASEB J , vol.16 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3
  • 13
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis.
    • Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 14
    • 0037180517 scopus 로고    scopus 로고
    • Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures.
    • Tepper OM, Galiano RD, Capla JM et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002; 106: 2781-2786.
    • (2002) Circulation , vol.106 , pp. 2781-2786
    • Tepper, O.M.1    Galiano, R.D.2    Capla, J.M.3
  • 15
    • 20944436176 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.
    • Fadini GP, Miorin M, Facco M et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 2005; 45: 1449-1457.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1449-1457
    • Fadini, G.P.1    Miorin, M.2    Facco, M.3
  • 16
    • 77955835661 scopus 로고    scopus 로고
    • Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.
    • Bento CF, Fernandes R, Matafome P, Sena C, Seica R, Pereira P. Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction. Exp Physiol 2010; 95: 955-970.
    • (2010) Exp Physiol , vol.95 , pp. 955-970
    • Bento, C.F.1    Fernandes, R.2    Matafome, P.3    Sena, C.4    Seica, R.5    Pereira, P.6
  • 17
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha.
    • Fadini GP, Boscaro E, Albiero M et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care 2010; 33: 1607-1609.
    • (2010) Diabetes Care , vol.33 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3
  • 18
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368: 1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 20
    • 77955406467 scopus 로고    scopus 로고
    • Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).
    • Ferreira L, Teixeira-de-Lemos E, Pinto F et al. Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediators Inflamm 2010; 2010: 592760.
    • (2010) Mediators Inflamm , vol.2010 , pp. 592760
    • Ferreira, L.1    Teixeira-de-Lemos, E.2    Pinto, F.3
  • 21
    • 0027233040 scopus 로고
    • Microvascular retinopathy in the Zucker diabetic fatty rat.
    • Danis RP, Yang Y. Microvascular retinopathy in the Zucker diabetic fatty rat. Invest Ophthalmol Vis Sci 1993; 34: 2367-2371.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 2367-2371
    • Danis, R.P.1    Yang, Y.2
  • 22
    • 64649104157 scopus 로고    scopus 로고
    • FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats.
    • Behl Y, Krothapalli P, Desta T, Roy S, Graves DT. FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes 2009; 58: 917-925.
    • (2009) Diabetes , vol.58 , pp. 917-925
    • Behl, Y.1    Krothapalli, P.2    Desta, T.3    Roy, S.4    Graves, D.T.5
  • 23
    • 0029760436 scopus 로고    scopus 로고
    • The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering.
    • Sutherland DR, Anderson L, Keeney M, Nayar R, Chin-Yee I. The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. J Hematother 1996; 5: 213-226.
    • (1996) J Hematother , vol.5 , pp. 213-226
    • Sutherland, D.R.1    Anderson, L.2    Keeney, M.3    Nayar, R.4    Chin-Yee, I.5
  • 24
    • 33846227512 scopus 로고    scopus 로고
    • A new protocol for quantifying CD34(+) cells in peripheral blood of patients with cardiovascular disease.
    • Kikuchi-Taura A, Soma T, Matsuyama T, Stern DM, Taguchi A. A new protocol for quantifying CD34(+) cells in peripheral blood of patients with cardiovascular disease. Tex Heart Inst J 2006; 33: 427-429.
    • (2006) Tex Heart Inst J , vol.33 , pp. 427-429
    • Kikuchi-Taura, A.1    Soma, T.2    Matsuyama, T.3    Stern, D.M.4    Taguchi, A.5
  • 25
    • 37349043715 scopus 로고    scopus 로고
    • Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse.
    • Oltman CL, Davidson EP, Coppey LJ et al. Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse. Diabetes Obes Metab 2008; 10: 64-74.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 64-74
    • Oltman, C.L.1    Davidson, E.P.2    Coppey, L.J.3
  • 26
    • 0029906828 scopus 로고    scopus 로고
    • BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.
    • Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci U S A 1996; 93: 14559-14563.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14559-14563
    • Xiang, J.1    Chao, D.T.2    Korsmeyer, S.J.3
  • 27
    • 0037428288 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3.
    • Kale G, Naren AP, Sheth P, Rao RK. Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem Biophys Res Commun 2003; 302: 324-329.
    • (2003) Biochem Biophys Res Commun , vol.302 , pp. 324-329
    • Kale, G.1    Naren, A.P.2    Sheth, P.3    Rao, R.K.4
  • 28
    • 0036319333 scopus 로고    scopus 로고
    • Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
    • Du Y, Smith MA, Miller CM, Kern TS. Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine. J Neurochem 2002; 80: 771-779.
    • (2002) J Neurochem , vol.80 , pp. 771-779
    • Du, Y.1    Smith, M.A.2    Miller, C.M.3    Kern, T.S.4
  • 29
    • 77953959949 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.
    • Oeseburg H, de Boer RA, Buikema H, van der Harst P, van Gilst WH, Sillje HH. Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A. Arterioscler Thromb Vasc Biol 2010; 30: 1407-1414.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1407-1414
    • Oeseburg, H.1    de Boer, R.A.2    Buikema, H.3    van der Harst, P.4    van Gilst, W.H.5    Sillje, H.H.6
  • 30
    • 0034531053 scopus 로고    scopus 로고
    • Effect of cyclosporin-A on the blood-retinal barrier permeability in streptozotocin-induced diabetes.
    • Carmo A, Cunha-Vaz JG, Carvalho AP, Lopes MC. Effect of cyclosporin-A on the blood-retinal barrier permeability in streptozotocin-induced diabetes. Mediators Inflamm 2000; 9: 243-248.
    • (2000) Mediators Inflamm , vol.9 , pp. 243-248
    • Carmo, A.1    Cunha-Vaz, J.G.2    Carvalho, A.P.3    Lopes, M.C.4
  • 31
    • 79251541159 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice.
    • Dobrian AD, Ma Q, Lindsay JW et al. Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice. Am J Physiol Endocrinol Metab 2011; 300: E410-421.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Dobrian, A.D.1    Ma, Q.2    Lindsay, J.W.3
  • 32
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy.
    • Kowluru RA, Chan PS. Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007; 2007: 43603.
    • (2007) Exp Diabetes Res , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 33
    • 20444491588 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression.
    • Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J Biol Chem 2005; 280: 22297-22307.
    • (2005) J Biol Chem , vol.280 , pp. 22297-22307
    • Kim, S.J.1    Winter, K.2    Nian, C.3    Tsuneoka, M.4    Koda, Y.5    McIntosh, C.H.6
  • 34
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice.
    • Wang Q, Brubaker PL. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 2002; 45: 1263-1273.
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2
  • 36
    • 58249083287 scopus 로고    scopus 로고
    • Correlation of different circulating endothelial progenitor cells to stages of diabetic retinopathy: first in vivo data.
    • Brunner S, Schernthaner GH, Satler M et al. Correlation of different circulating endothelial progenitor cells to stages of diabetic retinopathy: first in vivo data. Invest Ophthalmol Vis Sci 2009; 50: 392-398.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 392-398
    • Brunner, S.1    Schernthaner, G.H.2    Satler, M.3
  • 37
    • 33748364339 scopus 로고    scopus 로고
    • Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population.
    • Fadini GP, Coracina A, Baesso I et al. Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population. Stroke 2006; 37: 2277-2282.
    • (2006) Stroke , vol.37 , pp. 2277-2282
    • Fadini, G.P.1    Coracina, A.2    Baesso, I.3
  • 38
    • 24344442873 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells and cardiovascular outcomes.
    • Werner N, Kosiol S, Schiegl T et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353: 999-1007.
    • (2005) N Engl J Med , vol.353 , pp. 999-1007
    • Werner, N.1    Kosiol, S.2    Schiegl, T.3
  • 39
    • 0035874498 scopus 로고    scopus 로고
    • Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner.
    • Majka M, Janowska-Wieczorek A, Ratajczak J et al. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood 2001; 97: 3075-3085.
    • (2001) Blood , vol.97 , pp. 3075-3085
    • Majka, M.1    Janowska-Wieczorek, A.2    Ratajczak, J.3
  • 40
    • 79953806049 scopus 로고    scopus 로고
    • Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in mice.
    • Albiero M, Menegazzo L, Boscaro E, Agostini C, Avogaro A, Fadini GP. Defective recruitment, survival and proliferation of bone marrow-derived progenitor cells at sites of delayed diabetic wound healing in mice. Diabetologia 2011; 54: 945-953.
    • (2011) Diabetologia , vol.54 , pp. 945-953
    • Albiero, M.1    Menegazzo, L.2    Boscaro, E.3    Agostini, C.4    Avogaro, A.5    Fadini, G.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.