-
1
-
-
84864397125
-
A Placebo-and midazolam-controlled, phase I, single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics
-
Antonik LJ, Goldwater DR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A Placebo-and midazolam-controlled, phase I, single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics. Anesth Analg 2012;115:274-83.
-
(2012)
Anesth Analg
, vol.115
, pp. 274-283
-
-
Antonik, L.J.1
Goldwater, D.R.2
Kilpatrick, G.J.3
Tilbrook, G.S.4
Borkett, K.M.5
-
2
-
-
1642495618
-
Defining the propofol binding site location on the GABAA receptor
-
Bali M, Akabas MH. Defining the propofol binding site location on the GABAA receptor. Mol Pharmacol 2004;65:68-76.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 68-76
-
-
Bali, M.1
Akabas, M.H.2
-
3
-
-
0029001266
-
Postoperative infections traced to contamination of an intravenous anesthetic, propofol
-
Bennett SN, McNeil MM, Bland LA, Arduino MJ, Villarino ME, Perrotta DM, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147-54.
-
(1995)
N Engl J Med
, vol.333
, pp. 147-154
-
-
Bennett, S.N.1
McNeil, M.M.2
Bland, L.A.3
Arduino, M.J.4
Villarino, M.E.5
Perrotta, D.M.6
-
4
-
-
0033966357
-
Soft drug design: General principles and recent applications
-
Bodor N, Buchwald P. Soft drug design: General principles and recent applications. Med Res Rev 2000;20:58-101.
-
(2000)
Med Res Rev
, vol.20
, pp. 58-101
-
-
Bodor, N.1
Buchwald, P.2
-
5
-
-
0031665722
-
Pharmacokinetics of midazolam and its main metabolite 1-hydroxymidazolam in intensive care patients
-
Boulieu R, Lehmann B, Salord F, Fisher C, Morlet D. Pharmacokinetics of midazolam and its main metabolite 1-hydroxymidazolam in intensive care patients. Eur J Drug Metab Pharmacokinet 1998;23:255-8.
-
(1998)
Eur J Drug Metab Pharmacokinet
, vol.23
, pp. 255-258
-
-
Boulieu, R.1
Lehmann, B.2
Salord, F.3
Fisher, C.4
Morlet, D.5
-
6
-
-
66149142795
-
Identification of a fluorescent general anesthetic,1-aminoanthracene
-
Butts C, Xi J, Brannigan G, Klein ML, Saad AA, Venkatachalan SP, et al. Identification of a fluorescent general anesthetic,1-aminoanthracene. Proc Natl Acad Sci U S A 2009;106:6501-6.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6501-6506
-
-
Butts, C.1
Xi, J.2
Brannigan, G.3
Klein, M.L.4
Saad, A.A.5
Venkatachalan, S.P.6
-
7
-
-
34247133872
-
Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model
-
Campagna-Slater V, Weaver DF. Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model. Neurosci Lett 2007;418:28-33.
-
(2007)
Neurosci Lett
, vol.418
, pp. 28-33
-
-
Campagna-Slater, V.1
Weaver, D.F.2
-
8
-
-
61949318570
-
The antinociceptive effects and pharmacological properties of JM-1232(-): A novel isoindoline derivative
-
Chiba S, Nishiyama T, Yamada Y. The antinociceptive effects and pharmacological properties of JM-1232(-): A novel isoindoline derivative. Anesth Analg 2009;108:1008-14.
-
(2009)
Anesth Analg
, vol.108
, pp. 1008-1014
-
-
Chiba, S.1
Nishiyama, T.2
Yamada, Y.3
-
9
-
-
8644281928
-
Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation
-
Choi YF, Wong TW, Lau CC. Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation. Emerg Med J 2004;21:700-2.
-
(2004)
Emerg Med J
, vol.21
, pp. 700-702
-
-
Choi, Y.F.1
Wong, T.W.2
Lau, C.C.3
-
10
-
-
0023869396
-
Haemodynamic changes during anaesthesia induced and maintained with propofol
-
Claeys MA, Gepts E, Camu F. Haemodynamic changes during anaesthesia induced and maintained with propofol. Br J Anaesth 1988;60:3-9.
-
(1988)
Br J Anaesth
, vol.60
, pp. 3-9
-
-
Claeys, M.A.1
Gepts, E.2
Camu, F.3
-
11
-
-
77649146802
-
Carboetomidate: A pyrrole analog of etomidate designed not to suppress adrenocortical function
-
Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, et al. Carboetomidate: A pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology 2010;112:637-44.
-
(2010)
Anesthesiology
, vol.112
, pp. 637-644
-
-
Cotten, J.F.1
Forman, S.A.2
Laha, J.K.3
Cuny, G.D.4
Husain, S.S.5
Miller, K.W.6
-
12
-
-
68249158184
-
Methoxycarbonyl-etomidate: A novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression
-
Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, et al. Methoxycarbonyl-etomidate: A novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology 2009;111:240-9.
-
(2009)
Anesthesiology
, vol.111
, pp. 240-249
-
-
Cotten, J.F.1
Husain, S.S.2
Forman, S.A.3
Miller, K.W.4
Kelly, E.W.5
Nguyen, H.H.6
-
13
-
-
80053341746
-
Closed-loop continuous infusions of etomidate and etomidate analogs in rats: A comparative study of dosing and the impact on adrenocortical function
-
Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, et al. Closed-loop continuous infusions of etomidate and etomidate analogs in rats: A comparative study of dosing and the impact on adrenocortical function. Anesthesiology 2011;115:764-73.
-
(2011)
Anesthesiology
, vol.115
, pp. 764-773
-
-
Cotten, J.F.1
Le Ge, R.2
Banacos, N.3
Pejo, E.4
Husain, S.S.5
Williams, J.H.6
-
14
-
-
0021717282
-
Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation
-
de Jong FH, Mallios C, Jansen C, Scheck PA, Lamberts SW. Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation. J Clin Endocrinol Metab 1984;59:1143-7.
-
(1984)
J Clin Endocrinol Metab
, vol.59
, pp. 1143-1147
-
-
De Jong, F.H.1
Mallios, C.2
Jansen, C.3
Scheck, P.A.4
Lamberts, S.W.5
-
15
-
-
38149116854
-
One single dose of etomidate negatively influences adrenocortical performance for at least 24h in children with meningococcal sepsis
-
den Brinker M, Hokken-Koelega AC, Hazelzet JA, de Jong FH, Hop WC, Joosten KF. One single dose of etomidate negatively influences adrenocortical performance for at least 24h in children with meningococcal sepsis. Intensive Care Med 2008;34:163-8.
-
(2008)
Intensive Care Med
, vol.34
, pp. 163-168
-
-
Den Brinker, M.1
Hokken-Koelega, A.C.2
Hazelzet, J.A.3
De Jong, F.H.4
Hop, W.C.5
Joosten, K.F.6
-
16
-
-
0015839271
-
Arterial blood gas analyses following administration of three short-acting i.v. hypnotics (propanidid, etomidate, methohexitone)
-
Doenicke A, Wagner E, Beetz KH. Arterial blood gas analyses following administration of three short-acting i.v. hypnotics (propanidid, etomidate, methohexitone). Anaesthesist 1973;22:353-6.
-
(1973)
Anaesthesist
, vol.22
, pp. 353-356
-
-
Doenicke, A.1
Wagner, E.2
Beetz, K.H.3
-
18
-
-
84861597092
-
AZD-3043, A novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis
-
Egan TD, Obara S, Jenkins TE, Jaw-Tsai SS, Amagasu S, Cook DR, et al. AZD-3043, A novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology 2012;116:1267-77.
-
(2012)
Anesthesiology
, vol.116
, pp. 1267-1277
-
-
Egan, T.D.1
Obara, S.2
Jenkins, T.E.3
Jaw-Tsai, S.S.4
Amagasu, S.5
Cook, D.R.6
-
19
-
-
84861582299
-
A novel fluorescent general anesthetic enables imaging of the in vivo sites of action
-
Emerson D, Liao Z, Eckenhoff RG, Dmochowski IJ. A novel fluorescent general anesthetic enables imaging of the in vivo sites of action. Anesthesiology 2012;116:1363.
-
(2012)
Anesthesiology
, vol.116
, pp. 1363
-
-
Emerson, D.1
Liao, Z.2
Eckenhoff, R.G.3
Dmochowski, I.J.4
-
20
-
-
78149487923
-
Molecular approaches to improving general anesthetics
-
Forman SA. Molecular approaches to improving general anesthetics. Anesthesiol Clin 2010;28:761-71.
-
(2010)
Anesthesiol Clin
, vol.28
, pp. 761-771
-
-
Forman, S.A.1
-
21
-
-
79952043405
-
Clinical and molecular pharmacology of etomidate
-
Forman SA. Clinical and molecular pharmacology of etomidate. Anesthesiology 2011;114:695-707.
-
(2011)
Anesthesiology
, vol.114
, pp. 695-707
-
-
Forman, S.A.1
-
23
-
-
33745902828
-
Propofol infusion syndrome in anaesthesia and intensive care medicine
-
Fudickar A, Bein B, Tonner PH. Propofol infusion syndrome in anaesthesia and intensive care medicine. Curr Opin Anaesthesiol 2006;19:404-10.
-
(2006)
Curr Opin Anaesthesiol
, vol.19
, pp. 404-410
-
-
Fudickar, A.1
Bein, B.2
Tonner, P.H.3
-
24
-
-
84865415180
-
Encephalographic and hypnotic recoveries following brief and prolonged infusions of etomidate and optimized soft etomidate analogs
-
Ge R, Pejo E, Husain SS, Cotten JF, Raines DE. Encephalographic and hypnotic recoveries following brief and prolonged infusions of etomidate and optimized soft etomidate analogs. Anesthesiology 2012;117:1037-43.
-
(2012)
Anesthesiology
, vol.117
, pp. 1037-1043
-
-
Ge, R.1
Pejo, E.2
Husain, S.S.3
Cotten, J.F.4
Raines, D.E.5
-
25
-
-
0001072162
-
Dl-1-(1-Arylalkyl) Imidazole-5-Carboxylate Esters. A novel type of hypnotic agents
-
Godefroi EF, Janssen PA, Vandereycken CA, Vanheertum AH, Niemegeers CJ. Dl-1-(1-Arylalkyl) Imidazole-5-Carboxylate Esters. A novel type of hypnotic agents. J Med Chem 1965;8:220-3.
-
(1965)
J Med Chem
, vol.8
, pp. 220-223
-
-
Godefroi, E.F.1
Janssen, P.A.2
Vandereycken, C.A.3
Vanheertum, A.H.4
Niemegeers, C.J.5
-
26
-
-
84857380650
-
Rational approaches to improving selectivity in drug design
-
Huggins DJ, Sherman W, Tidor B. Rational approaches to improving selectivity in drug design. J Med Chem 2012;55:1424-44.
-
(2012)
J Med Chem
, vol.55
, pp. 1424-1444
-
-
Huggins, D.J.1
Sherman, W.2
Tidor, B.3
-
27
-
-
85027943295
-
Modification of methoxycarbonyl etomidate′s interester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of hypnotic action
-
Husain SS, Pejo E, Ge R, Raines DE. Modification of methoxycarbonyl etomidate′s interester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of hypnotic action. Anesthesiology 2012;117:1027-36.
-
(2012)
Anesthesiology
, vol.117
, pp. 1027-1036
-
-
Husain, S.S.1
Pejo, E.2
Ge, R.3
Raines, D.E.4
-
28
-
-
33746789921
-
Quantitative high throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
-
Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, et al. Quantitative high throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A 2006;103:11473-8.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11473-11478
-
-
Inglese, J.1
Auld, D.S.2
Jadhav, A.3
Johnson, R.L.4
Simeonov, A.5
Yasgar, A.6
-
29
-
-
15844420160
-
Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock?: A critical appraisal
-
Jackson WL Jr. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock?: A critical appraisal. Chest 2005;127:1031-8.
-
(2005)
Chest
, vol.127
, pp. 1031-1038
-
-
Jackson Jr., W.L.1
-
30
-
-
36849081787
-
Novel water-soluble sedative-hypnotic agents: Isoindolin-1-one derivatives
-
Kanamitsu N, Osaki T, Itsuji Y, Yoshimura M, Tsujimoto H, Soga M. Novel water-soluble sedative-hypnotic agents: Isoindolin-1-one derivatives. Chem Pharm Bull (Tokyo) 2007;55:1682-8.
-
(2007)
Chem Pharm Bull (Tokyo)
, vol.55
, pp. 1682-1688
-
-
Kanamitsu, N.1
Osaki, T.2
Itsuji, Y.3
Yoshimura, M.4
Tsujimoto, H.5
Soga, M.6
-
31
-
-
34250792138
-
CNS 7056: A novel ultra-short-acting Benzodiazepine
-
Kilpatrick GJ, McIntyre MS, Cox RF, Stafford JA, Pacofsky GJ, Lovell GG, et al. CNS 7056: A novel ultra-short-acting Benzodiazepine. Anesthesiology 2007;107:60-6.
-
(2007)
Anesthesiology
, vol.107
, pp. 60-66
-
-
Kilpatrick, G.J.1
McIntyre, M.S.2
Cox, R.F.3
Stafford, J.A.4
Pacofsky, G.J.5
Lovell, G.G.6
-
32
-
-
0035079043
-
General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA (A) receptor but not with lipid solubility
-
Krasowski MD, Jenkins A, Flood P, Kung AY, Hopfinger AJ, Harrison NL. General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA (A) receptor but not with lipid solubility. J Pharmacol Exp Ther 2001;297:338-51.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 338-351
-
-
Krasowski, M.D.1
Jenkins, A.2
Flood, P.3
Kung, A.Y.4
Hopfinger, A.J.5
Harrison, N.L.6
-
33
-
-
84856095231
-
Chemical informatics and target identification in a zebrafish phenotypic screen
-
Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, et al. Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol 2011;8:144-6.
-
(2011)
Nat Chem Biol
, vol.8
, pp. 144-146
-
-
Laggner, C.1
Kokel, D.2
Setola, V.3
Tolia, A.4
Lin, H.5
Irwin, J.J.6
-
34
-
-
70349508946
-
A high throughput approach for identification of novel general anesthetics
-
Lea WA, Jadhav A, Xi J, Lu L, Austin CP, Simeonov A, et al. A high throughput approach for identification of novel general anesthetics. PLoS One 2009;4:e7150.
-
(2009)
PLoS One
, vol.4
-
-
Lea, W.A.1
Jadhav, A.2
Xi, J.3
Lu, L.4
Austin, C.P.5
Simeonov, A.6
-
35
-
-
0020574478
-
Influence of sedation on mortality in critically ill multiple trauma patients
-
Ledingham IM, Watt I. Influence of sedation on mortality in critically ill multiple trauma patients. Lancet 1983;1:1270.
-
(1983)
Lancet
, vol.1
, pp. 1270
-
-
Ledingham, I.M.1
Watt, I.2
-
36
-
-
16344374288
-
Structural basis for high affinity volatile anesthetic binding in a natural 4-helix bundle protein
-
Liu R, Loll PJ, Eckenhoff RG. Structural basis for high affinity volatile anesthetic binding in a natural 4-helix bundle protein. FASEB J 2005;19:567-76.
-
(2005)
FASEB J
, vol.19
, pp. 567-576
-
-
Liu, R.1
Loll, P.J.2
Eckenhoff, R.G.3
-
37
-
-
0016760562
-
Etomidate, a new water-soluble non-barbiturate intravenous induction agent
-
Morgan M, Lumley J, Whitwam JG. Etomidate, a new water-soluble non-barbiturate intravenous induction agent. Lancet 1975;1:955-6.
-
(1975)
Lancet
, vol.1
, pp. 955-956
-
-
Morgan, M.1
Lumley, J.2
Whitwam, J.G.3
-
38
-
-
53049087556
-
Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats
-
Nishiyama T, Chiba S, Yamada Y. Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats. Eur J Pharmacol 2008;596:56-61.
-
(2008)
Eur J Pharmacol
, vol.596
, pp. 56-61
-
-
Nishiyama, T.1
Chiba, S.2
Yamada, Y.3
-
39
-
-
0030806927
-
Midazolam: A review of therapeutic uses and toxicity
-
Nordt SP, Clark RF. Midazolam: A review of therapeutic uses and toxicity. J Emerg Med 1997;15:357-65.
-
(1997)
J Emerg Med
, vol.15
, pp. 357-365
-
-
Nordt, S.P.1
Clark, R.F.2
-
40
-
-
84857136424
-
Recognition of anesthetic barbituates by a protein binding site: A high resolution structural analysis
-
Oakley S, Vedula S, Xi J, Bu W, Liu R, Eckenhoff RG, et al. Recognition of anesthetic barbituates by a protein binding site: A high resolution structural analysis. PLoS One 2012;7:e32070.
-
(2012)
PLoS One
, vol.7
-
-
Oakley, S.1
Vedula, S.2
Xi, J.3
Bu, W.4
Liu, R.5
Eckenhoff, R.G.6
-
41
-
-
53549094134
-
Update on the propofol infusion syndrome in ICU management of patients with head injury
-
Otterspoor LC, Kalkman CJ, Cremer OL. Update on the propofol infusion syndrome in ICU management of patients with head injury. Curr Opin Anaesthesiol 2008;21:544-51.
-
(2008)
Curr Opin Anaesthesiol
, vol.21
, pp. 544-551
-
-
Otterspoor, L.C.1
Kalkman, C.J.2
Cremer, O.L.3
-
42
-
-
41949110521
-
Mycobacterium tuberculosis CYP130: Crystal structure, biophysical characterization, and interactions with antifungal azole drugs
-
Ouellet H, Podust LM, de Montellano PR. Mycobacterium tuberculosis CYP130: Crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J Biol Chem 2008;283:5069-80.
-
(2008)
J Biol Chem
, vol.283
, pp. 5069-5080
-
-
Ouellet, H.1
Podust, L.M.2
De Montellano, P.R.3
-
43
-
-
84864414890
-
In vivo and in vitro pharmacological studies of methoxycarbonyl- carboetomidate
-
Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, et al. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg 2012;115:297-304.
-
(2012)
Anesth Analg
, vol.115
, pp. 297-304
-
-
Pejo, E.1
Cotten, J.F.2
Kelly, E.W.3
Le Ge, R.4
Cuny, G.D.5
Laha, J.K.6
-
44
-
-
84055195125
-
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia
-
Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE. Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med 2012;40:187-92.
-
(2012)
Crit Care Med
, vol.40
, pp. 187-192
-
-
Pejo, E.1
Feng, Y.2
Chao, W.3
Cotten, J.F.4
Le Ge, R.5
Raines, D.E.6
-
45
-
-
84860737916
-
Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized eomidate analog in rats
-
Pejo E, Ge R, Banacos N, Cotten JF, Husain SS, Raines DE. Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized eomidate analog in rats. Anesthesiology 2012;116:1057-65.
-
(2012)
Anesthesiology
, vol.116
, pp. 1057-1065
-
-
Pejo, E.1
Ge, R.2
Banacos, N.3
Cotten, J.F.4
Husain, S.S.5
Raines, D.E.6
-
46
-
-
34548752270
-
Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics
-
Roumen L, Sanders MP, Pieterse K, Hilbers PA, Plate R, Custers E, et al. Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics. J Comput Aided Mol Des 2007;21:455-71.
-
(2007)
J Comput Aided Mol des
, vol.21
, pp. 455-471
-
-
Roumen, L.1
Sanders, M.P.2
Pieterse, K.3
Hilbers, P.A.4
Plate, R.5
Custers, E.6
-
47
-
-
84655163433
-
An allosteric coagonist model for propofol effects on alpha1beta2 gamma 2L gamma-aminobutyric acid type A receptors
-
Ruesch D, Neumann E, Wulf H, Forman SA. An allosteric coagonist model for propofol effects on alpha1beta2 gamma 2L gamma-aminobutyric acid type A receptors. Anesthesiology 2012;116:47-55.
-
(2012)
Anesthesiology
, vol.116
, pp. 47-55
-
-
Ruesch, D.1
Neumann, E.2
Wulf, H.3
Forman, S.A.4
-
48
-
-
16244396725
-
Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2 gamma 2L gamma-aminobutyric acid type A receptors
-
Rusch D, Forman SA. Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2 gamma 2L gamma-aminobutyric acid type A receptors. Anesthesiology 2005;102:783-92.
-
(2005)
Anesthesiology
, vol.102
, pp. 783-792
-
-
Rusch, D.1
Forman, S.A.2
-
49
-
-
79952015165
-
Enhancement of GABAergic activity: Neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology
-
Saari TI, Uusi-Oukari M, Ahonen J, Olkkola KT. Enhancement of GABAergic activity: Neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology. Pharmacol Rev 2011;63:243-67.
-
(2011)
Pharmacol Rev
, vol.63
, pp. 243-267
-
-
Saari, T.I.1
Uusi-Oukari, M.2
Ahonen, J.3
Olkkola, K.T.4
-
50
-
-
3042553224
-
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl) imidazole at 1.9-A resolution: Insight into the range of P450 conformations and the coordination of redox partner binding
-
Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl) imidazole at 1.9-A resolution: Insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem 2004;279:27294-301.
-
(2004)
J Biol Chem
, vol.279
, pp. 27294-27301
-
-
Scott, E.E.1
White, M.A.2
He, Y.A.3
Johnson, E.F.4
Stout, C.D.5
Halpert, J.R.6
-
51
-
-
33846015513
-
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode
-
Seward HE, Roujeinikova A, McLean KJ, Munro AW, Leys D. Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode. J Biol Chem 2006;281:39437-43.
-
(2006)
J Biol Chem
, vol.281
, pp. 39437-39443
-
-
Seward, H.E.1
Roujeinikova, A.2
McLean, K.J.3
Munro, A.W.4
Leys, D.5
-
52
-
-
77956042313
-
PF0713 produced rapid induction of general anesthesia without injection pain in a phase 1 study
-
Siegel LC, Konstantatos A. PF0713 produced rapid induction of general anesthesia without injection pain in a phase 1 study. Anesthesiology 2009;A463. Available from: http://www.asaabstracts.com/strands/asaabstracts/abstract. htm;jsessionid=DA93833E41FF06A7178351B6D992EC52?year=2008&index= 2&absnum=1096.
-
(2009)
Anesthesiology
-
-
Siegel, L.C.1
Konstantatos, A.2
-
53
-
-
84877988329
-
Dose response of PF0713, a novel investigational intravenous anesthetic agent
-
Siegel LC, Pelc LR, Shaff K. Dose response of PF0713, a novel investigational intravenous anesthetic agent. Anesthesiology 2008;A463. Available from: http://www.asaabstracts.com/strands/asaabstracts/abstract. htm;jsessionid=DA93833E41FF06A7178351B6D992EC52?year=2008&index= 2&absnum=1096.
-
(2008)
Anesthesiology
-
-
Siegel, L.C.1
Pelc, L.R.2
Shaff, K.3
-
54
-
-
0036676629
-
Mapping of the benzodiazepine recognition site on GABA (A) receptors
-
Sigel E. Mapping of the benzodiazepine recognition site on GABA (A) receptors. Curr Top Med Chem 2002;2:833-9.
-
(2002)
Curr Top Med Chem
, vol.2
, pp. 833-839
-
-
Sigel, E.1
-
56
-
-
77956025805
-
New drugs and technologies, intravenous anaesthesia is on the move (again)
-
Sneyd JR, Rigby-Jones AE. New drugs and technologies, intravenous anaesthesia is on the move (again). Br J Anaesth 2010;105:246-54.
-
(2010)
Br J Anaesth
, vol.105
, pp. 246-254
-
-
Sneyd, J.R.1
Rigby-Jones, A.E.2
-
57
-
-
84856447491
-
First human administration of MR04A3: A novel water-soluble nonbenzodiazepine sedative
-
Sneyd JR, Rigby-Jones AE, Cross M, Tominaga H, Shimizu S, Ohkura T, et al. First human administration of MR04A3: A novel water-soluble nonbenzodiazepine sedative. Anesthesiology 2012;116:385-95.
-
(2012)
Anesthesiology
, vol.116
, pp. 385-395
-
-
Sneyd, J.R.1
Rigby-Jones, A.E.2
Cross, M.3
Tominaga, H.4
Shimizu, S.5
Ohkura, T.6
-
58
-
-
80055097094
-
The effect of a new water-soluble sedative-hypnotic drug, JM-1232(-), on long-term potentiation in the CA1 region of the mouse hippocampus
-
Takamatsu I, Sekiguchi M, Yonamine R, Wada K, Kazama T. The effect of a new water-soluble sedative-hypnotic drug, JM-1232(-), on long-term potentiation in the CA1 region of the mouse hippocampus. Anesth Analg 2011;113:1043-9.
-
(2011)
Anesth Analg
, vol.113
, pp. 1043-1049
-
-
Takamatsu, I.1
Sekiguchi, M.2
Yonamine, R.3
Wada, K.4
Kazama, T.5
-
59
-
-
84857441425
-
Actions of a novel water-soluble benzodiazepine-receptor agonist JM-1232(-) on synaptic transmission in adult rat spinal substantia gelatinosa neurons
-
Uemura S, Fujita T, Sakaguchi Y, Kumamoto E. Actions of a novel water-soluble benzodiazepine-receptor agonist JM-1232(-) on synaptic transmission in adult rat spinal substantia gelatinosa neurons. Biochem Biophys Res Commun 2012;418:695-700.
-
(2012)
Biochem Biophys Res Commun
, vol.418
, pp. 695-700
-
-
Uemura, S.1
Fujita, T.2
Sakaguchi, Y.3
Kumamoto, E.4
-
60
-
-
50249099702
-
A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems
-
Upton R, Martinez A, Grant C. A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems. Br J Pharmacol 2008 155:52-61.
-
(2008)
Br J Pharmacol
, vol.155
, pp. 52-61
-
-
Upton, R.1
Martinez, A.2
Grant, C.3
-
61
-
-
71749095346
-
Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep
-
Upton RN, Martinez AM, Grant C. Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep. Br J Anaesth 2009;103:848-57.
-
(2009)
Br J Anaesth
, vol.103
, pp. 848-857
-
-
Upton, R.N.1
Martinez, A.M.2
Grant, C.3
-
62
-
-
69949157213
-
A unitary anesthetic protein binding site at high resolution
-
Vedula S, Brannigan G, Economou NJ, Xi J, Hall MA, Dailey WP, et al. A unitary anesthetic protein binding site at high resolution. J Biol Chem 2009;284:24176-84.
-
(2009)
J Biol Chem
, vol.284
, pp. 24176-24184
-
-
Vedula, S.1
Brannigan, G.2
Economou, N.J.3
Xi, J.4
Hall, M.A.5
Dailey, W.P.6
-
63
-
-
43349098272
-
Duration of adrenal inhibition following a single dose of etomidate in critically ill patients
-
Vinclair M, Broux C, Faure P, Brun J, Genty C, Jacquot C, et al. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med 2008;34:714-9.
-
(2008)
Intensive Care Med
, vol.34
, pp. 714-719
-
-
Vinclair, M.1
Broux, C.2
Faure, P.3
Brun, J.4
Genty, C.5
Jacquot, C.6
-
64
-
-
0021253073
-
Inhibition of adrenal steroidogenesis by the anesthetic etomidate
-
Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984;310:1415-21.
-
(1984)
N Engl J Med
, vol.310
, pp. 1415-1421
-
-
Wagner, R.L.1
White, P.F.2
Kan, P.B.3
Rosenthal, M.H.4
Feldman, D.5
-
65
-
-
0021604882
-
Mortality amongst multiple trauma patients admitted to an intensive therapy unit
-
Watt I, Ledingham IM. Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia 1984;39:973-81.
-
(1984)
Anaesthesia
, vol.39
, pp. 973-981
-
-
Watt, I.1
Ledingham, I.M.2
-
66
-
-
84864413541
-
A Placebo and Midazolam-Controlled Phase i Single Ascending Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056). Part II: Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation
-
Wiltshire HR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A Placebo and Midazolam-Controlled Phase I Single Ascending Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056). Part II: Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation. Anesth Analg 2012;115:284-96.
-
(2012)
Anesth Analg
, vol.115
, pp. 284-296
-
-
Wiltshire, H.R.1
Kilpatrick, G.J.2
Tilbrook, G.S.3
Borkett, K.M.4
|