A unitary anesthetic binding site at high resolution

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24176-24184

  Vedula, L Sangeetha ^a   Brannigan, Grace ^a   Economou, Nicoleta J ^b   Xi, Jin ^a   Hall, Michael A ^a   Liu, Renyu ^a   Rossi, Matthew J ^b   Dailey, William P ^a   Grasty, Kimberly C ^b   Klein, Michael L ^a   Eckenhoff, Roderic G ^a   Loll, Patrick J ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOFERRITIN; ATOMIC RESOLUTION; BINDING AFFINITIES; CHANNEL COMPLEX; EQUILIBRIUM POSITIONS; GABAA RECEPTORS; GABAERGIC; HIGH RESOLUTION; HYDROGEN BOND DONORS; HYDROPHOBIC EFFECT; ION CHANNEL; LIGAND-GATED ION CHANNELS; MODEL PROTEINS; MODEL SYSTEM; MOLECULAR DYNAMICS SIMULATIONS; PROPOFOL; PROTEIN TARGETS; STRUCTURAL BIOLOGY; X RAY CRYSTAL STRUCTURES;

BINDING ENERGY; BINDING SITES; BIOLOGY; DYNAMIC RESPONSE; HYDROGEN; HYDROGEN BONDS; HYDROPHOBICITY; LIGANDS; MOLECULAR DYNAMICS; TARGETS; VAN DER WAALS FORCES;

ANESTHETICS;

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; APOFERRITIN; HYDROGEN; LIGAND; PROPOFOL;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG PROTEIN BINDING; HYDROGEN BOND; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; VALIDATION PROCESS;

ANESTHETICS, INTRAVENOUS; APOFERRITINS; BINDING SITES; HUMANS; MODELS, MOLECULAR; PROPOFOL; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GABA-A;

EID: 69949157213     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.017814     Document Type: Article

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