Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia

Critical Care Medicine

Volumn 40, Issue 1, 2012, Pages 187-192

  Pejo, Ervin ^a   Feng, Yan ^a   Chao, Wei ^a   Cotten, Joseph F ^a   Le Ge, Ri ^a   Raines, Douglas E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CARBOETOMIDATE; CORTICOSTERONE; CORTICOTROPIN; DIMETHYL SULFOXIDE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; ETOMIDATE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; PYRROLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADRENAL CORTEX FUNCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; CYTOKINE RESPONSE; DOSE RESPONSE; DRUG EFFECT; ENDOTOXEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SINGLE DRUG DOSE; TREATMENT RESPONSE;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CORTICOSTERONE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; ETOMIDATE; HYPNOTICS AND SEDATIVES; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84055195125     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31822d7924     Document Type: Article

References (54)

1. Coates DP, Monk CR, Prys-Roberts C, et al: Hemodynamic effects of infusions of the emulsion formulation of propofol during nitrous oxide anesthesia in humans. Anesth Analg 1987; 66:64-70
2. Illievich UM, Petricek W, Schramm W, et al: Electroencephalographic burst suppression by propofol infusion in humans: Hemodynamic consequences. Anesth Analg 1993; 77: 155-160
3. McKinney MS, Fee JP: Cardiovascular effects of 50% nitrous oxide in older adult patients anaesthetized with isoflurane or halothane. Br J Anaesth 1998; 80:169-173
4. Kikura M, Ikeda K: Comparison of effects of sevoflurane/nitrous oxide and enflurane/nitrous oxide on myocardial contractility in humans. Load-independent and noninvasive assessment with transesophageal echocardiography. Anesthesiology 1993; 79:235-243
5. Benson M, Junger A, Fuchs C, et al: Use of an anesthesia information management system (AIMS) to evaluate the physiologic effects of hypnotic agents used to induce anesthesia. J Clin Monit Comput 2000; 16:183-190
6. Reich DL, Hossain S, Krol M, et al: Predictors of hypotension after induction of general anesthesia. Anesth Analg 2005; 101:622-628
7. Janssen PA, Niemegeers CJ, Schellekens KH, et al: Etomidate, R-(+)-ethyl-1-(-methylbenzyl) imidazole-5-carboxylate (R 16659), a potent, short-acting and relatively atoxic intravenous hypnotic agent in rats. Arzneimittelforschung 1971; 21:1234-1243
8. Gooding JM, Weng JT, Smith RA, et al: Cardiovascular and pulmonary responses following etomidate induction of anesthesia in patients with demonstrated cardiac disease. Anesth Analg 1979; 58:40-41
9. Gillies GW, Lees NW: The effects of speed of injection on induction with propofol. A comparison with etomidate. Anaesthesia 1989; 44:386-388
10. Boisson-Bertrand D, Taron F, Laxenaire MC: Etomidate vs. propofol to carry out suspension laryngoscopies. Eur J Anaesthesiol 1991; 8:141-144
11. Sokolove PE, Price DD, Okada P: The safety of etomidate for emergency rapid sequence intubation of pediatric patients. Pediatr Emerg Care 2000; 16:18-21
12. Vinson DR, Bradbury DR: Etomidate for procedural sedation in emergency medicine. Ann Emerg Med 2002; 39:592-598
13. Guldner G, Schultz J, Sexton P, et al: Etomidate for rapid-sequence intubation in young children: hemodynamic effects and adverse events. Acad Emerg Med 2003; 10: 134-139
14. Choi YF, Wong TW, Lau CC: Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation. Emerg Med J 2004; 21: 700-702
15. Zed PJ, Abu-Laban RB, Harrison DW: Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: An observational cohort study. Acad Emerg Med 2006; 13: 378-383
16. Dhawan N, Chauhan S, Kothari SS, et al: Hemodynamic responses to etomidate in pediatric patients with congenital cardiac shunt lesions. J Cardiothorac Vasc Anesth 2010; 24:802-807
17. Siedy J, Knapik P, Saucha W, et al: Comparison of propofol and etomidate anaesthesia for elective electrical cardioversion. Kardiol Pol 2010; 68:1249-1255
18. de Jong FH, Mallios C, Jansen C, et al: Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation. J Clin Endocrinol Metab 1984; 59:1143-1147
19. Wagner RL, White PF, Kan PB, et al: Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984; 310: 1415-1421
20. Duthie DJ, Fraser R, Nimmo WS: Effect of induction of anaesthesia with etomidate on corticosteroid synthesis in man. Br J Anaesth 1985; 57:156-159
21. Bloomfield R, Noble DW: Etomidate, pharmacological adrenalectomy and the critically ill: A matter of vital importance. Crit Care 2006; 10:161
22. Jackson WL Jr: Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? A critical appraisal. Chest 2005; 127:1031-1038
23. Lipiner-Friedman D, Sprung CL, Laterre PF, et al: Adrenal function in sepsis: The retrospective Corticus cohort study. Crit Care Med 2007; 35:1012-1018
24. Cotton BA, Guillamondegui OD, Fleming SB, et al: Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients. Arch Surg 2008; 143:62-67; discussion 67
25. Fengler BT: Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients? Am J Emerg Med 2008; 26:229-232
26. Hildreth AN, Mejia VA, Maxwell RA, et al: Adrenal suppression following a single dose of etomidate for rapid sequence induction: A prospective randomized study. J Trauma 2008; 65:573-579
27. Cuthbertson BH, Sprung CL, Annane D, et al: The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009; 35: 1868-1876
28. Edwin SB, Walker PL: Controversies surrounding the use of etomidate for rapid sequence intubation in patients with suspected sepsis. Ann Pharmacother 2010; 44: 1307-1313
29. Kulstad EB, Kalimullah EA, Tekwani KL, et al: Etomidate as an induction agent in septic patients: Red flags or false alarms? West J Emerg Med 2010; 11:161-172
30. Cotten JF, Forman SA, Laha JK, et al: Carboetomidate: A pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology 2010; 112: 637-644
31. Roumen L, Sanders MP, Pieterse K, et al: Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics. J Comput Aided Mol Des 2007; 21:455-471
32. Goujon E, Parnet P, Laye S, et al: Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain Res Mol Brain Res 1996; 36:53-62
33. Keh D, Boehnke T, Weber-Cartens S, et al: Immunologic and hemodynamic effects of 'low-dose' hydrocortisone in septic shock: A double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 2003; 167:512-520
34. Oppert M, Schindler R, Husung C, et al: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005; 33:2457-2464
35. Webster JI, Sternberg EM: Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products. J Endocrinol 2004; 181:207-221
36. Cotten JF, Husain SS, Forman SA, et al: Methoxycarbonyl-etomidate: A novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology 2009; 111:240-249
37. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock-A review of laboratory models and a proposal. J Surg Res 1980; 29:189-201
38. Deitch EA: Animal models of sepsis and shock: A review and lessons learned. Shock 1998; 9:1-11
39. Dyson A, Singer M: Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting? Crit Care Med 2009; 37(Suppl):S30-S37
40. Schultz MJ, van der Poll T: Animal and human models for sepsis. Ann Med 2002; 34: 573-581
41. Rittirsch D, Huber-Lang MS, Flierl MA, et al: Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009; 4:31-36
42. Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:885-891
43. Uehara A, Gottschall PE, Dahl RR, et al: Stimulation of ACTH release by human interleukin-1 beta, but not by interleukin-1 alpha, in conscious, freely-moving rats. Biochem Biophys Res Commun 1987; 146: 1286-1290
44. Morrow LE, McClellan JL, Conn CA, et al: Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol 1993; 264: R1010-1016
45. Cavaillon JM: Pathophysiological role of proand anti-inflammatory cytokines in sepsis. Sepsis 1998; 2:127-140
46. Haddad JJ, Saade NE, Safieh-Garabedian B: Cytokines and neuro-immune-endocrine interactions: A role for the hypothalamicpituitary- adrenal revolving axis. J Neuroimmunol 2002; 133:1-19
47. Allolio B, Stuttmann R, Leonhard U, et al: Adrenocortical suppression by a single induction dose of etomidate. Klin Wochenschr 1984; 62:1014-1017
48. Fragen RJ, Shanks CA, Molteni A, et al: Effects of etomidate on hormonal responses to surgical stress. Anesthesiology 1984; 61: 652-656
49. Calvo R, Carlos R, Erill S: Etomidate and plasma esterase activity in man and experimental animals. Pharmacology 1979; 18: 294-298
50. Fry DE, Griffiths H: The inhibition by etomidate of the 11 beta-hydroxylation of cortisol. Clin Endocrinol (Oxf) 1984; 20:625-629
51. Staruch MJ, Wood DD: Reduction of serum interleukin-1-like activity after treatment with dexamethasone. J Leukoc Biol 1985; 37:193-207
52. Jameson P, Desborough JP, Bryant AE, et al: The effect of cortisol suppression on interleukin-6 and white blood cell responses to surgery. Acta Anaesthesiol Scand 1997; 41: 304-308
53. den Brinker M, Joosten KF, Liem O, et al: Adrenal insufficiency in meningococcal sepsis: Bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. J Clin Endocrinol Metab 2005; 90:5110-5117
54. Yeager MP, Rassias AJ, Fillinger MP, et al: Cortisol antiinflammatory effects are maximal at postoperative plasma concentrations. Crit Care Med 2005; 33:1507-1512