A placebo-and midazolam-controlled phase i single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. population pharmacokinetic and pharmacodynamic modeling and simulation

Anesthesia and Analgesia

Volumn 115, Issue 2, 2012, Pages 284-296

  Wiltshire, Hugh R ^a   Kilpatrick, Gavin J ^b   Tilbrook, Gary S ^b   Borkett, Keith M ^b  

^a Independent Consultant   (United Kingdom)

^b PAION UK Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MIDAZOLAM; PLACEBO; REMIMAZOLAM;

AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG HALF LIFE; DRUG SAFETY; HEART OUTPUT; HUMAN; IC 50; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; STEADY STATE;

ADULT; BENZODIAZEPINES; COMPUTER SIMULATION; CONSCIOUSNESS; CONSCIOUSNESS MONITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; MALE; MARYLAND; METABOLIC CLEARANCE RATE; MIDAZOLAM; MIDDLE AGED; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PLACEBOS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84864413541     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e318241f68a     Document Type: Article

References (7)

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