Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.

Anesthesiology

Volumn 117, Issue 5, 2012, Pages 1027-1036

  Husain, S Shaukat ^a   Pejo, Ervin ^b   Ge, Rile ^b   Raines, Douglas E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; ESTER; ETOMIDATE; HYPNOTIC SEDATIVE AGENT; METHOXYCARBONYLETOMIDATE;

ANIMAL; ARTICLE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; HALF LIFE TIME; MALE; METABOLISM; PHYSIOLOGY; RAT; RIGHTING REFLEX; SPRAGUE DAWLEY RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTERS; ETOMIDATE; HALF-LIFE; HYPNOTICS AND SEDATIVES; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFLEX, RIGHTING;

MLCS; MLOWN;

EID: 85027943295     PISSN: None     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/aln.0b013e31826d3bef     Document Type: Article

References (0)