Closed-loop continuous infusions of etomidate and etomidate analogs in rats: A comparative study of dosing and the impact on adrenocortical function

Anesthesiology

Volumn 115, Issue 4, 2011, Pages 764-773

  Cotten, Joseph F ^a,b   Le Ge, Ri ^b   Banacos, Natalie ^b   Pejo, Ervin ^b   Husain, S Shaukat ^a,b   Williams, James H ^a   Raines, Douglas E ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CARBOETOMIDATE; CORTICOSTERONE; ETOMIDATE; ISOFLURANE; METHOXYCARBONYL ETOMIDATE; UNCLASSIFIED DRUG;

ADRENAL CORTEX FUNCTION; ANESTHESIA LEVEL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTINUOUS INFUSION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG INFUSION; ELECTROENCEPHALOGRAPHY; HYPNOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION;

EID: 80053341746     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31821950de     Document Type: Article

References (37)

1. Criado A, Maseda J, Navarro E, Escarpa A, Avello F: Induction of anaesthesia with etomidate: Haemodynamic study of 36 patients. Br J Anaesth 1980; 52:803-6 (Pubitemid 10090449)
2. Gooding JM, Weng JT, Smith RA, Berninger GT, Kirby RR: Cardiovascular and pulmonary responses following etomidate induction of anesthesia in patients with demonstrated cardiac disease. Anesth Analg 1979; 58:40-1 (Pubitemid 9153433)
3. Ebert TJ, Muzi M, Berens R, Goff D, Kampine JP: Sympathetic responses to induction of anesthesia in humans with propofol or etomidate. ANESTHESIOLOGY 1992; 76:725-33
4. Sarkar M, Laussen PC, Zurakowski D, Shukla A, Kussman B, Odegard KC: Hemodynamic responses to etomidate on induction of anesthesia in pediatric patients. Anesth Analg 2005; 101:645-50, table of contents (Pubitemid 41208488)
5. de Jong FH, Mallios C, Jansen C, Scheck PA, Lamberts SW: Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation. J Clin Endocrinol Metab 1984; 59:1143-7 (Pubitemid 15223350)
6. Fragen RJ, Shanks CA, Molteni A, Avram MJ: Effects of etomidate on hormonal responses to surgical stress. ANESTHESIOLOGY 1984; 61:652-6 (Pubitemid 15223412)
7. Wagner RL, White PF: Etomidate inhibits adrenocortical function in surgical patients. ANESTHESIOLOGY 1984; 61: 647-51 (Pubitemid 15223411)
8. Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D: Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984; 310:1415-21 (Pubitemid 14101296)
9. Lamberts SW, Bons EG, Bruining HA, de Jong FH: Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells. J Pharmacol Exp Ther 1987; 240:259-64 (Pubitemid 17235446)
10. Diago MC, Amado JA, Otero M, Lopez-Cordovilla JJ: Antiadrenal action of a subanaesthetic dose of etomidate. Anaesthesia 1988; 43:644-5
11. Allolio B, Schulte HM, Kaulen D, Reincke M, Jaursch-Hancke C, Winkelmann W: Nonhypnotic low-dose etomidate for rapid correction of hypercortisolaemia in Cushing's syndrome. Klin Wochenschr 1988; 66:361-4
12. Schulte HM, Benker G, Reinwein D, Sippell WG, Allolio B: Infusion of low dose etomidate: Correction of hypercortisolemia in patients with Cushing's syndrome and dose-response relationship in normal subjects. J Clin Endocrinol Metab 1990; 70:1426-30
13. Drake WM, Perry LA, Hinds CJ, Lowe DG, Reznek RH, Besser GM: Emergency and prolonged use of intravenous etomidate to control hypercortisolemia in a patient with Cushing's syndrome and peritonitis. J Clin Endocrinol Metab 1998; 83:3542-4 (Pubitemid 28500886)
14. Absalom A, Pledger D, Kong A: Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 1999; 54:861-7 (Pubitemid 29415418)
15. Vinclair M, Broux C, Faure P, Brun J, Genty C, Jacquot C, Chabre O, Payen JF: Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med 2008; 34:714-9 (Pubitemid 351660088)
16. Jackson WL Jr: Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? A critical appraisal. Chest 2005; 127:1031-8 (Pubitemid 40775537)
17. Annane D: ICU physicians should abandon the use of etomidate! Intensive Care Med 2005; 31:325-6
18. Hildreth AN, Mejia VA, Maxwell RA, Smith PW, Dart BW, Barker DE: Adrenal suppression following a single dose of etomidate for rapid sequence induction: A prospective randomized study. J Trauma 2008; 65:573-9
19. Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE: Methoxycarbonyl-etomidate: A novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. ANESTHESIOLOGY 2009; 111:240-9
20. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE: Carboetomidate: A pyrrole analog of etomidate designed not to suppress adrenocortical function. ANESTHESIOLOGY 2010; 112:637-44
21. Vijn PC, Sneyd JR: I.V. anaesthesia and EEG burst suppression in rats: Bolus injections and closed-loop infusions. Br J Anaesth 1998; 81:415-21 (Pubitemid 28416626)
22. Rampil IJ, Laster MJ: No correlation between quantitative electroencephalographic measurements and movement response to noxious stimuli during isoflurane anesthesia in rats. ANESTHESIOLOGY 1992; 77:920-5
23. Tzabazis A, Ihmsen H, Schywalsky M, Schwilden H: EEGcontrolled closed-loop dosing of propofol in rats. Br J Anaesth 2004; 92:564-9 (Pubitemid 38443861)
24. Struys MM, De Smet T, Versichelen LF, Van De Velde S, Van den Broecke R, Mortier EP: Comparison of closed-loop controlled administration of propofol using bispectral index as the controlled variable versus "standard practice" controlled administration. ANESTHESIOLOGY 2001; 95:6-17 (Pubitemid 32622990)
25. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U: General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J 2003; 17:250-2
26. Belelli D, Muntoni AL, Merrywest SD, Gentet LJ, Casula A, Callachan H, Madau P, Gemmell DK, Hamilton NM, Lambert JJ, Sillar KT, Peters JA: The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia. Neuropharmacology 2003; 45:57-71 (Pubitemid 36695011)
27. Zolle IM, Berger ML, Hammerschmidt F, Hahner S, Schirbel A, Peric-Simov B: New selective inhibitors of steroid 11betahydroxylation in the adrenal cortex: Synthesis and structureactivity relationship of potent etomidate analogues. J Med Chem 2008; 51:2244-53 (Pubitemid 351503279)
28. Van Hamme MJ, Ghoneim MM, Ambre JJ: Pharmacokinetics of etomidate, a new intravenous anesthetic. ANESTHESIOLOGY 1978; 49:274-7 (Pubitemid 9032541)
29. Hebron BS, Edbrooke DL, Newby DM, Mather SJ: Pharmacokinetics of etomidate associated with prolonged i.v. infusion. Br J Anaesth 1983; 55:281-7 (Pubitemid 13130254)
30. Lewi PJ, Heykants JJ, Janssen PA: Intravenous pharmacokinetic profile in rats of etomidate, a short-acting hypnotic drug. Arch Int Pharmacodyn Ther 1976; 220:72-85
31. Calvo R, Carlos R, Erill S: Etomidate and plasma esterase activity in man and experimental animals. Pharmacology 1979; 18:294-8 (Pubitemid 10220522)
32. Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ: Design, synthesis, and pharmacological evaluation of ultrashort-to long-acting opioid analgetics. J Med Chem 1991; 34:2202-8
33. Quon CY, Stampfli HF: Biochemical properties of blood esmolol esterase. Drug Metab Dispos 1985; 13:420-4 (Pubitemid 15237523)
34. Haidar SH, Moreton JE, Liang Z, Hoke JF, Muir KT, Eddington ND: The pharmacokinetics and electroencephalogram response of remifentanil alone and in combination with esmolol in the rat. Pharm Res 1997; 14:1817-23 (Pubitemid 28062931)
35. Westmoreland CL, Hoke JF, Sebel PS, Hug CC Jr, Muir KT: Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. ANESTHESIOLOGY 1993; 79:893-903 (Pubitemid 23339046)
36. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D: Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: Remifentanil (GI87084B). Anesth Analg 1993; 77:1031-40 (Pubitemid 23319806)
37. Li B, Berliner M, Buzon R, Chiu CK-F, Colgan ST, Kaneko T, Keene N, Kissel W, Le T, Leeman KR, Marquez B, Morris R, Newell L, Wunderwald S, Witt M, Weaver J, Zhang Z: Aqueous phosphoric acid as a mild reagent for deprotection of tert-butyl carbamates, esters, and ethers. J Org Chem 2006; 71:9045-50 (Pubitemid 44845734)