A placebo-and midazolam-controlled phase i single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. safety, efficacy, and basic pharmacokinetics

Anesthesia and Analgesia

Volumn 115, Issue 2, 2012, Pages 274-283

  Antonik, Laurie J ^a   Goldwater, D Ronald ^b   Kilpatrick, Gavin J ^c   Tilbrook, Gary S ^c   Borkett, Keith M ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARBOR HOSPITAL   (United States)

^c PAION UK Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; MIDAZOLAM; PLACEBO; REMIMAZOLAM;

ADULT; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; BREATHING RATE; COHORT ANALYSIS; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEART RATE; HUMAN; HYPOXIA; INJECTION SITE PAIN; MALE; NAUSEA; NORMAL HUMAN; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; VITAL SIGN;

ADULT; BENZODIAZEPINES; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; LINEAR MODELS; MALE; MARYLAND; METABOLIC CLEARANCE RATE; MIDAZOLAM; MIDDLE AGED; MODELS, BIOLOGICAL; PLACEBOS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84864397125     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31823f0c28     Document Type: Article

References (11)

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