A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems

British Journal of Pharmacology

Volumn 155, Issue 1, 2008, Pages 52-61

  Upton, R N ^a   Martinez, A M ^a   Grant, C ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Cardiovascular effects; CNS 7056; Respiratory effects; Sedation; Sheep

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; CNS 7054; CNS 7056; DRUG METABOLITE; HEMOGLOBIN; MIDAZOLAM; PROPOFOL; UNCLASSIFIED DRUG; XYLAZINE;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BINDING AFFINITY; BREATHING RATE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG INFUSION; DRUG METABOLISM; DRUG RECEPTOR BINDING; ELECTROENCEPHALOGRAM; FEMALE; HEART OUTPUT; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SEDATION; SHEEP; SINGLE DRUG DOSE;

ANIMALS; BENZODIAZEPINES; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOVASCULAR SYSTEM; CEREBROVASCULAR CIRCULATION; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; FEMALE; HEART RATE; HYPNOTICS AND SEDATIVES; PULMONARY GAS EXCHANGE; RESPIRATORY MECHANICS; RESPIRATORY SYSTEM; SHEEP; TIME FACTORS;

EID: 50249099702     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.228     Document Type: Article

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