Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

Molecular Systems Biology

Volumn 6, Issue , 2010, Pages

  Fendt, Sarah Maria ^a,b,c   Buescher, Joerg Martin ^a,b   Rudroff, Florian ^a   Picotti, Paola ^a   Zamboni, Nicola ^a,c   Sauer, Uwe ^a,c  

^a ETH ZURICH   (Switzerland)

^b Life Science Zurich   (Switzerland)

^c Competence Center for Systems Physiology and Metabolic Diseases ^*  (Switzerland)

Author keywords

Design principle; Metabolic network; Metabolomics; Proteomics; Transcriptome

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GCR2; UNCLASSIFIED DRUG; ENZYME; GCR2 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); DATA ANALYSIS; DELETION MUTANT; ENZYME ACTIVITY; ENZYME CAPACITY; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME SUBSTRATE; GENE DELETION; HOMEOSTASIS; HYPOTHESIS; METABOLIC BALANCE; METABOLIC RATE; METABOLISM; METABOLITE; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN EXPRESSION; PROTEIN FOLDING; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; VALIDATION STUDY; BIOLOGICAL MODEL; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METHODOLOGY; REPRODUCIBILITY; SYSTEMS BIOLOGY;

SACCHAROMYCES CEREVISIAE;

DOWN-REGULATION; ENZYMES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; HOMEOSTASIS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SYSTEMS BIOLOGY; TRANSCRIPTION FACTORS;

EID: 77951125481     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2010.11     Document Type: Article

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