Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies

Acta Diabetologica

Volumn 46, Issue 3, 2009, Pages 217-226

  Ruchat, Stephanie May ^a,b   Elks, Cathy E ^c   Loos, Ruth J F ^c   Vohl, Marie Claude ^b   Weisnagel, S John ^a,b   Rankinen, Tuomo ^d   Bouchard, Claude ^d   Pérusse, Louis ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^d PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Diabetes associated polymorphisms; Glucose tolerance; Insulin secretion; Insulin sensitivity

Indexed keywords

C PEPTIDE; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GLUCOSE; INSULIN; INSULINASE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSCRIPTION FACTOR II;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CANADA; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GLUCOSE TOLERANCE TEST; METABOLISM; MIDDLE AGED; PANCREAS ISLET BETA CELL; RISK FACTOR; SECRETION;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUEBEC; RISK FACTORS;

EID: 69849107894     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-008-0080-5     Document Type: Article

References (50)

1. TM Frayling 2007 Genome-wide association studies provide new insights into type 2 diabetes aetiology Nat Rev Genet 8 657 662 17703236 10.1038/nrg2178 1:CAS:528:DC%2BD2sXptFyrur0%3D (Pubitemid 47281993)
2. J Gudmundsson P Sulem V Steinthorsdottir JT Bergthorsson G Thorleifsson A Manolescu T Rafnar D Gudbjartsson BA Agnarsson A Baker, et al. 2007 Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes Nat Genet 39 977 983 17603485 10.1038/ng2062 1:CAS:528:DC%2BD2sXot1Cms7Y%3D (Pubitemid 47185170)
3. R Saxena BF Voight V Lyssenko NP Burtt PI de Bakker H Chen JJ Roix S Kathiresan JN Hirschhorn MJ Daly, et al. 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 17463246 10.1126/science.1142358 1:CAS:528:DC%2BD2sXmtVyitrk%3D (Pubitemid 46871653)
4. LJ Scott KL Mohlke LL Bonnycastle CJ Willer Y Li WL Duren MR Erdos HM Stringham PS Chines AU Jackson, et al. 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345 17463248 10.1126/science.1142382 1:CAS:528:DC%2BD2sXmtVyitrY%3D (Pubitemid 46871655)
5. R Sladek G Rocheleau J Rung C Dina L Shen D Serre P Boutin D Vincent A Belisle S Hadjadj, et al. 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885 17293876 10.1038/nature05616 1:CAS:528:DC%2BD2sXhvFGiurw%3D (Pubitemid 46309843)
6. V Steinthorsdottir G Thorleifsson I Reynisdottir R Benediktsson T Jonsdottir GB Walters U Styrkarsdottir S Gretarsdottir V Emilsson S Ghosh, et al. 2007 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nat Genet 39 770 775 17460697 10.1038/ng2043 1:CAS:528: DC%2BD2sXlvVSgtL4%3D (Pubitemid 46848592)
7. WTCCC 2007 Genome-wide association study of 14, 000 cases of seven common diseases and 3,000 shared controls Nature 447 661 678 10.1038/nature05911 1:CAS:528:DC%2BD2sXmtFelsb0%3D (Pubitemid 46889737)
8. E Zeggini LJ Scott R Saxena BF Voight JL Marchini T Hu PI de Bakker GR Abecasis P Almgren G Andersen, et al. 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 638 645 18372903 10.1038/ng.120 1:CAS:528:DC%2BD1cXltFylurY%3D (Pubitemid 351601209)
9. E Zeggini MN Weedon CM Lindgren TM Frayling KS Elliott H Lango NJ Timpson JR Perry NW Rayner RM Freathy, et al. 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341 17463249 10.1126/science.1142364 1:CAS:528:DC%2BD2sXmtVymtb0%3D (Pubitemid 46871654)
10. C Weyer PA Tataranni C Bogardus RE Pratley 2001 Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development Diabetes Care 24 89 94 11194248 10.2337/diacare.24.1.89 1:CAS:528:DC%2BD3MXkvVKlug%3D%3D
11. JC Florez KA Jablonski N Bayley TI Pollin PI de Bakker AR Shuldiner WC Knowler DM Nathan D Altshuler 2006 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 355 241 250 16855264 10.1056/NEJMoa062418 1:CAS:528:DC%2BD28XntVWktrw%3D (Pubitemid 44079339)
12. R Saxena L Gianniny NP Burtt V Lyssenko C Giuducci M Sjogren JC Florez P Almgren B Isomaa M Orho-Melander, et al. 2006 Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals Diabetes 55 2890 2895 17003358 10.2337/db06-0381 1:CAS:528:DC%2BD28XhtVGls77M (Pubitemid 44923692)
13. V Lyssenko R Lupi P Marchetti S Del Guerra M Orho-Melander P Almgren M Sjogren C Ling KF Eriksson AL Lethagen, et al. 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes J Clin Invest 117 2155 2163 17671651 10.1172/JCI30706 1:CAS:528:DC%2BD2sXoslOnsrk%3D (Pubitemid 47219560)
14. M Vaxillaire J Veslot C Dina C Proenca S Cauchi G Charpentier J Tichet F Fumeron M Marre D Meyre, et al. 2008 Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study Diabetes 57 244 254 17977958 10.2337/db07-0615 1:CAS:528:DC%2BD1cXmt1ajsg%3D%3D
15. S Cauchi D Meyre H Choquet C Dina C Born M Marre B Balkau P Froguel 2006 TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the insulin resistance syndrome (DESIR) study Diabetes 55 3189 3192 17065361 10.2337/db06-0692 1:CAS:528:DC%2BD28XhtF2rtrzN (Pubitemid 44923661)
16. C Marzi C Huth M Kolz H Grallert C Meisinger HE Wichmann W Rathmann C Herder T Illig 2007 Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys Horm Metab Res 39 46 52 17226113 10.1055/s-2007-957345 1:CAS:528:DC%2BD2sXis1Wnsbg%3D (Pubitemid 46535156)
17. J Munoz KH Lok BA Gower JR Fernandez GR Hunter C Lara-Castro M De Luca WT Garvey 2006 Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women Diabetes 55 3630 3634 17130514 10.2337/db06-0574 1:CAS:528:DC%2BD28XhtlSmsb3L (Pubitemid 44923627)
18. CM Damcott TI Pollin LJ Reinhart SH Ott H Shen KD Silver BD Mitchell AR Shuldiner 2006 Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance Diabetes 55 2654 2659 16936218 10.2337/db06-0338 1:CAS:528:DC%2BD28XpsVOqs7g%3D (Pubitemid 44871170)
19. ND Palmer AB Lehtinen CD Langefeld JK Campbell SM Haffner JM Norris RN Bergman MO Goodarzi JI Rotter DW Bowden 2008 Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans J Clin Endocrinol Metab 93 304 309 17971425 10.1210/jc.2007-1225 1:CAS:528: DC%2BD1cXnsVygtg%3D%3D
20. GR Chandak CS Janipalli S Bhaskar SR Kulkarni P Mohankrishna AT Hattersley TM Frayling CS Yajnik 2007 Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population Diabetologia 50 63 67 17093941 10.1007/s00125-006-0502-2 1:CAS:528: DC%2BD2sXot1Wh (Pubitemid 46035854)
21. SC Elbein WS Chu SK Das A Yao-Borengasser SJ Hasstedt H Wang N Rasouli PA Kern 2007 Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent Diabetologia 50 1621 1630 17579832 10.1007/s00125-007-0717-x 1:CAS:528:DC%2BD2sXnt1Kisbw%3D (Pubitemid 47036661)
22. T Guo RL Hanson M Traurig YL Muller L Ma J Mack S Kobes WC Knowler C Bogardus LJ Baier 2007 TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3, 501 individuals Diabetes 56 3082 3088 17909099 10.2337/db07-0621 1:CAS:528:DC%2BD2sXhsValurjP (Pubitemid 350223645)
23. J Wang J Kuusisto M Vanttinen T Kuulasmaa J Lindstrom J Tuomilehto M Uusitupa M Laakso 2007 Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion Diabetologia 50 1192 1200 17437080 10.1007/s00125-007-0656-6 1:CAS:528:DC%2BD2sXkvFKisr8%3D (Pubitemid 46701561)
24. K Kirchhoff F Machicao A Haupt SA Schafer O Tschritter H Staiger N Stefan HU Haring A Fritsche 2008 Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion Diabetologia 51 597 601 18264689 10.1007/s00125-008-0926-y 1:CAS:528:DC%2BD1cXjsFGiu7o%3D
25. RJ Loos PW Franks RW Francis I Barroso FM Gribble DB Savage KK Ong S O'Rahilly NJ Wareham 2007 TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population Diabetes 56 1943 1947 17416797 10.2337/db07-0055 1:CAS:528:DC%2BD2sXnvVWisrc%3D (Pubitemid 47025464)
26. A Dahlgren B Zethelius K Jensevik AC Syvanen C Berne 2007 Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men Diabetologia 50 1852 1857 17618413 10.1007/s00125-007-0746-5 1:CAS:528:DC%2BD2sXos1CjtL0%3D (Pubitemid 47222863)
27. S Cauchi C Proenca H Choquet S Gaget F De Graeve M Marre B Balkau J Tichet D Meyre M Vaxillaire, et al. 2008 Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study J Mol Med 86 341 348 18210030 10.1007/s00109-007-0295-x 1:CAS:528:DC%2BD1cXitlGnuro%3D
28. M Horikoshi K Hara C Ito N Shojima R Nagai K Ueki P Froguel T Kadowaki 2007 Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population Diabetologia 50 2461 2466 17928989 10.1007/s00125-007-0827-5 1:CAS:528:DC%2BD2sXht1Kku7nN (Pubitemid 350060646)
29. ND Palmer MO Goodarzi CD Langefeld J Ziegler JM Norris SM Haffner M Bryer-Ash RN Bergman LE Wagenknecht KD Taylor, et al. 2008 Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the insulin resistance atherosclerosis family study Diabetes 57 1093 1100 18252897 10.2337/db07-1169 1:CAS:528:DC%2BD1cXksVGrsr8%3D
30. L Pascoe A Tura SK Patel IM Ibrahim E Ferrannini E Zeggini MN Weedon A Mari AT Hattersley MI McCarthy, et al. 2007 Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function Diabetes 56 3101 3104 17804762 10.2337/db07-0634 1:CAS:528:DC%2BD2sXhsValurjK (Pubitemid 350223648)
31. A Stancakova J Pihlajamaki J Kuusisto N Stefan A Fritsche H Haring F Andreozzi E Succurro G Sesti TW Boesgaard, et al. 2008 Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance J Clin Endocrinol Metab 93 1924 1930 18285412 10.1210/jc.2007-2218 1:CAS:528:DC%2BD1cXlvFWgtrs%3D (Pubitemid 351656539)
32. N Grarup CS Rose EA Andersson G Andersen AL Nielsen A Albrechtsen JO Clausen SS Rasmussen T Jorgensen A Sandbaek, et al. 2007 Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies Diabetes 56 3105 3111 17827400 10.2337/db07-0856 1:CAS:528:DC%2BD2sXhsValurjL (Pubitemid 350223649)
33. H Staiger F Machicao N Stefan O Tschritter C Thamer K Kantartzis SA Schafer K Kirchhoff A Fritsche HU Haring 2007 Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function PLoS ONE 2 e832 17786204 10.1371/journal.pone.0000832 1:CAS:528:DC%2BD2sXhtFGnurjF
34. H Staiger A Stancakova J Zilinskaite M Vanttinen T Hansen MA Marini A Hammarstedt PA Jansson G Sesti U Smith, et al. 2008 A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study Diabetes 57 514 517 18039816 10.2337/db07-1254 1:CAS:528:DC%2BD1cXhvVOktLc%3D
35. TW Boesgaard J Zilinskaite M Vanttinen M Laakso PA Jansson A Hammarstedt U Smith N Stefan A Fritsche H Haring, et al. 2008 The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients-the EUGENE2 study Diabetologia 51 816 820 18324385 10.1007/s00125-008-0955-6 1:CAS:528: DC%2BD1cXkt1yjs78%3D
36. Bouchard C (1994) Genetic epidemiology, association and sib-pair linkage: results from the Quebec Family Study. In: Bray G, Ryan D (eds) Molecular and genetic aspects of obesity. Louisiana State University Press, Baton Rouge, pp 470-481
37. T Rice A Nadeau L Perusse C Bouchard DC Rao 1996 Familial correlations in the Quebec family study: cross-trait familial resemblance for body fat with plasma glucose and insulin Diabetologia 39 1357 1364 8933005 10.1007/s001250050583 1:CAS:528:DyaK28XmvFCjtrc%3D (Pubitemid 26356067)
38. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419 3899825 10.1007/BF00280883 1:CAS:528:DyaL2MXlslKnu7k%3D (Pubitemid 15018832)
39. J Cederholm L Wibell 1990 Insulin release and peripheral sensitivity at the oral glucose tolerance test Diabetes Res Clin Pract 10 167 175 2261853 10.1016/0168-8227(90)90040-Z 1:STN:280:DyaK3M%2FosFelsw%3D%3D (Pubitemid 20350538)
40. RW Bergstrom PW Wahl DL Leonetti WY Fujimoto 1990 Association of fasting glucose levels with a delayed secretion of insulin after oral glucose in subjects with glucose intolerance J Clin Endocrinol Metab 71 1447 1453 2229300 10.1210/jcem-71-6-1447 1:STN:280:DyaK3M%2FjsFylsA%3D%3D
41. HS Seltzer EW Allen AL Herron Jr MT Brennan 1967 Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus J Clin Invest 46 323 335 6023769 10.1172/JCI105534 1:CAS:528:DyaF2sXptlalsA%3D%3D
42. RN Bergman M Ader K Huecking G Van Citters 2002 Accurate assessment of beta-cell function: the hyperbolic correction Diabetes 51 suppl 1 S212 S220 11815482 10.2337/diabetes.51.2007.S212 1:CAS:528:DC%2BD38XhtVaqsbs%3D
43. RL Hanson RE Pratley C Bogardus KM Narayan JM Roumain G Imperatore A Fagot-Campagna DJ Pettitt PH Bennett WC Knowler 2000 Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies Am J Epidemiol 151 190 198 10645822 1:STN:280:DC%2BD3c7gvVChsg%3D%3D
44. M Stumvoll A Mitrakou W Pimenta T Jenssen H Yki-Jarvinen T Van Haeften W Renn J Gerich 2000 Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity Diabetes Care 23 295 301 10868854 10.2337/diacare.23.3.295 1:CAS:528:DC%2BD3cXjt1Ckuro%3D (Pubitemid 30131733)
45. KJ Livak 1999 Allelic discrimination using fluorogenic probes and the 5' nuclease assay Genet Anal 14 143 149 10084106 1:CAS:528:DyaK1MXhvVylsbo%3D
46. B Devlin N Risch 1995 A comparison of linkage disequilibrium measures for fine-scale mapping Genomics 29 311 322 8666377 10.1006/geno.1995.9003 1:CAS:528:DyaK2MXovVSls7s%3D
47. TM Frayling 2007 A new era in finding Type 2 diabetes genes-the unusual suspects Diabet Med 24 696 701 17561964 10.1111/j.1464-5491.2007.02172.x 1:STN:280:DC%2BD2sznvFGmtA%3D%3D (Pubitemid 47012137)
48. SA Schafer O Tschritter F Machicao C Thamer N Stefan B Gallwitz JJ Holst JM Dekker LM t'Hart G Nijpels, et al. 2007 Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms Diabetologia 50 2443 2450 17661009 10.1007/s00125-007-0753-6 1:CAS:528:DC%2BD2sXht1Kku7vI (Pubitemid 350060632)
49. JC Florez 2008 Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 51 1100 1110 18504548 10.1007/s00125-008-1025-9 1:CAS:528:DC%2BD1cXmslWgs7w%3D
50. KE Lohmueller CL Pearce M Pike ES Lander JN Hirschhorn 2003 Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease Nat Genet 33 177 182 12524541 10.1038/ng1071 1:CAS:528:DC%2BD3sXnsFSltQ%3D%3D (Pubitemid 36177070)