Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

Diabetes Research and Clinical Practice

Volumn 98, Issue 3, 2012, Pages

  Nemr, Rita ^a   Turki, Amira ^b   Echtay, Akram ^c   Al Zaben, Ghadeer S ^d   Daher, Hoda S ^d   Irani Hakime, Noha A ^e   Keleshian, Sose H ^e   Almawi, Wassim Y ^d  

^a RIZK HOSPITAL   (Lebanon)

^b UNIVERSITY OF MONASTIR   (Tunisia)

^c RAFIC HARIRI UNIVERSITY HOSPITAL   (Lebanon)

^d ARABIAN GULF UNIVERSITY   (Bahrain)

^e St Georges University Hospital   (Lebanon)

Author keywords

Diabetes; Genome wide association; Replication; TCF7L2

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; ARTICLE; CAUCASIAN; CELL FUNCTION; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; ETHNIC GROUP; FEMALE; GENE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LEBANESE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PILOT STUDY; POPULATION RESEARCH; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; TCF7L2 GENE;

ADULT; AGED; ALLELES; ARABS; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; LEBANON; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84870677267     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.09.044     Document Type: Article

References (20)

1. Gupta V., Vinay D.G., Rafiq S., Kranthikumar M.V., Janipalli C.S., Giambartolomei C., et al. Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs. Diabetologia 2012, 55:349-357.
2. Nemr R., Echtay A., Dashti E.A., Almawi A.W., Al-Busaidi A.S., Keleshian S.H., et al. Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs. Diabetes Res Clin Pract 2012, 10.1016/j.diabres.2011.12.026.
3. Ezzidi I., Mtiraoui N., Cauchi S., Vaillant E., Dechaume A., Chaieb M., et al. Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC Med Genet 2009, 10:33.
4. Cauchi S., El Achhab Y., Choquet H., Dina C., Krempler F., Weitgasser R., et al. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 2007, 85:777-782.
5. Grant S.F., Thorleifsson G., Reynisdottir I., Benediktsson R., Manolescu A., Sainz J., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006, 38:320-323.
6. Horikoshi M., Hara K., Ito C., Nagai R., Froguel P., Kadowaki T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia 2007, 50:747-751.
7. Saxena R., Hivert M.F., Langenberg C., Tanaka T., Pankow J.S., Vollenweider P., et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010, 42:142-148.
8. Helgason A., Palsson S., Thorleifsson G., Grant S.F., Emilsson V., Gunnarsdottir S., et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 2007, 39:218-225.
9. Saxena R., Gianniny L., Burtt N.P., Lyssenko V., Giuducci C., Sjögren M., et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 2006, 55:2890-2895.
10. Ng M.C., Tam C.H., Lam V.K., So W.Y., Ma R.C., Chan J.C. Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese. J Clin Endocrinol Metab 2007, 92:3733-3737.
11. Humphries S.E., Gable D., Cooper J.A., Ireland H., Stephens J.W., Hurel S.J., et al. Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med 2006, 84:1005-1014.
12. van Vliet-Ostaptchouk J.V., Shiri-Sverdlov R., Zhernakova A., Strengman E., van Haeften T.W., Hofker M.H., et al. Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort. Diabetologia 2007, 50:59-62.
13. Bodhini D., Radha V., Dhar M., Narayani N., Mohan V. The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians. Metabolism 2007, 56:1174-1178.
14. Chandak G.R., Janipalli C.S., Bhaskar S., Kulkarni S.R., Mohankrishna P., Hattersley A.T., et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 2007, 50:63-67.
15. Hayashi T., Iwamoto Y., Kaku K., Hirose H., Maeda S. Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia 2007, 50:980-984.
16. Ereqat S., Nasereddin A., Cauchi S., Azmi K., Abdeen Z., Amin R. Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population. Acta Diabetol 2010, 47(Suppl 1):S195-S198.
17. Amoli M., Amiri P., Tavakkoly-Bazzaz J., Charmchi E., Hafeziyeh J., Keramatipour M., et al. Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population. Genet Mol Biol 2010, 33:449-451.
18. Saadi H., Nagelkerke N., Carruthers S.G., Benedict S., Abdulkhalek S., Reed R., et al. Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects. Diabetes Res Clin Pract 2008, 80:392-398.
19. Alsmadi O., Al-Rubeaan K., Mohamed G., Alkayal F., Al-Saud H., Al-Saud N.A., et al. Weak or no association of TCF7L2 variants with type 2 diabetes risk in an Arab population. BMC Med Genet 2008, 9:72.
20. Nemr R., Almawi A.W., Echtay A., Sater M.S., Daher H.S., Almawi W.Y. Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population. Diabetes Res Clin Pract 2012, 95:e37-e40.