Unique splicing pattern of the TCF7L2 gene in human pancreatic islets

Diabetologia

Volumn 52, Issue 5, 2009, Pages 850-854

  Osmark, P ^a   Hansson, O ^a   Jonsson, A ^a   Ronn T ^a   Groop, L ^a   Renstrom E ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Genetics of type 2 diabetes; Human; Islets; Splicing; TCF7L2; Transcription factors

Indexed keywords

HEMOGLOBIN A1C; MESSENGER RNA; TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; AGED; ARTICLE; EXON; FEMALE; GENE MAPPING; GENETIC VARIABILITY; GENOTYPE; HEMOGLOBIN BLOOD LEVEL; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTRAABDOMINAL FAT; LYMPHOCYTE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PANCREAS ISLET; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; RNA SPLICING; SKELETAL MUSCLE; SUBCUTANEOUS TISSUE; TISSUE SPECIFICITY;

ADIPOSE TISSUE; ADULT; AGED; ALTERNATIVE SPLICING; CADAVER; DIABETES MELLITUS, TYPE 2; EXONS; FEMALE; GENETIC VARIATION; HUMANS; ISLETS OF LANGERHANS; LYMPHOCYTES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TCF TRANSCRIPTION FACTORS; TISSUE DONORS; TRANSCRIPTION, GENETIC;

EID: 64149124055     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1293-z     Document Type: Article

References (14)

1. JC Florez 2007 The new type 2 diabetes gene TCF7L2 Curr Opin Clin Nutr Metab Care 10 391 396
2. HJ Welters RN Kulkarni 2008 Wnt signaling: relevance to beta-cell biology and diabetes Trends Endocrinol Metab 19 349 355
3. A Duval S Rolland E Tubacher H Bui G Thomas R Hamelin 2000 The human T cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines Cancer Res 60 3872 3879
4. H Shiina M Igawa J Breault 2003 The human T cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma Clin Cancer Res 9 2121 2132
5. J Wang J Kuusisto M Vanttinen 2007 Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion Diabetologia 50 1192 1200
6. L Wegner MS Hussain K Pilgaard 2008 Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins J Clin Endocrinol Metab 93 4013 4019
7. M Ahlzen LE Johansson C Cervin H Tornqvist L Groop M Ridderstrale 2008 Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin Biochem Biophys Res Commun 370 49 52
8. P Kovacs J Berndt K Ruschke 2008 TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus Metabolism 57 1227 1231
9. SC Elbein WS Chu SK Das 2007 Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent Diabetologia 50 1621 1630
10. L Shu NS Sauter FT Schulthess AV Matveyenko J Oberholzer K Maedler 2008 Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets Diabetes 57 645 653
11. Z Liu JF Habener 2008 Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation J Biol Chem 283 8723 8735
12. V Lyssenko R Lupi P Marchetti 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes J Clin Invest 117 2155 2163
13. SA Bustin 2000 Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays J Mol Endocrinol 25 169 193
14. T Jin L Liu 2008 The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus Mol Endocrinol 22 2383 2392