Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning

Toxicological Sciences

Volumn 68, Issue 1, 2002, Pages 147-163

  Odum, J ^a   Lefevre, P A ^a   Tinwell, H ^a   Van Miller, J P ^b   Joiner, R L ^c   Chapin, R E ^d   Wallis, N T ^a   Ashby, J ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b Toxicology/Regulatory Services Inc   (United States)

^c GENERAL ELECTRIC COMPANY   (United States)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

Diethylstilbestrol; In utero; Lactational exposure; Neonatal period; Rat; Reproductive toxicity

Indexed keywords

DIETHYLSTILBESTROL; DRINKING WATER; ESTROGEN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BREEDING; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DOSE RESPONSE; ENDOCRINE DISEASE; FERTILITY; HISTOPATHOLOGY; LACTATION; LITTER SIZE; NONHUMAN; ORGAN WEIGHT; PRENATAL EXPOSURE; PREPUCE; RAT; REPRODUCTIVE TOXICITY; SENSITIVITY ANALYSIS; SEXUAL DEVELOPMENT; SPERMATOZOON COUNT; TESTIS DESCENT; WEANING; ANIMAL; COMPARATIVE STUDY; CONGENITAL MALFORMATION; DRINKING; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; FEMALE; MALE; NEWBORN; ORAL DRUG ADMINISTRATION; PATHOLOGY; PREGNANCY; REPRODUCTION; SUBCUTANEOUS DRUG ADMINISTRATION; SUCKLING; TIME; UTERUS; WISTAR RAT;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMAL; ANIMALS, NEWBORN; ANIMALS, SUCKLING; COMPARATIVE STUDY; DIETHYLSTILBESTROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; ESTROGENS, NON-STEROIDAL; FEMALE; INJECTIONS, SUBCUTANEOUS; LACTATION; MALE; MATERNAL EXPOSURE; PREGNANCY; RATS; RATS, WISTAR; REPRODUCTION; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; UTERUS; WEANING; ANIMALS;

ANIMALIA;

EID: 0035996072     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/68.1.147     Document Type: Article

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