Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor

Toxicology and Applied Pharmacology

Volumn 245, Issue 3, 2010, Pages 335-343

  Casabar, Richard C T ^a   Das, Parikshit C ^a   DeKrey, Gregory K ^b   Gardiner, Catherine S ^b   Cao, Yan ^a   Rose, Randy L ^a   Wallace, Andrew D ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

CAR; CYP2B6; CYP3A4; Endosulfan; HepG2 cell line; Human hepatocytes; Pesticide; PXR

Indexed keywords

CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; ENDOSULFAN; PREGNANE X RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SLEEP TIME; TOXICOKINETICS; TRANSGENIC MOUSE;

ANESTHETICS; ANIMALS; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOSULFAN; ENZYME INDUCTION; ETHANOL; GENES, REPORTER; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSECTICIDES; LUCIFERASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; SLEEP; TIME FACTORS; TRANSFECTION;

MUS; MUS MUSCULUS; VERTEBRATA;

EID: 77953124821     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.03.017     Document Type: Article

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