Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line

Toxicological Sciences

Volumn 48, Issue 1, 1999, Pages 55-66

  Legler, Juliette ^a   Van Den Brink, Christina E ^b   Brouwer, Abraham ^a   Murk, Albertinka J ^a   Van Der Saag, Paul T ^b   Vethaak, A Dick ^c   Van Der Burg, Bart ^b  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b HUBRECHT INSTITUTE   (Netherlands)

^c National Institute for Coastal and Marine Management RIKZ   (Netherlands)

Author keywords

Anti estrogens; In vitro; Luciferase; Reporter gene assay; Stable transfectant; T47D

Indexed keywords

CHLORDANE; CHLORPHENOTANE; DIELDRIN; ENDOSULFAN; ESTROGEN RECEPTOR; LUCIFERASE; METHOXYCHLOR; NONYLPHENOL;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CHEMICAL CARCINOGENESIS; GENE INDUCTION; HUMAN; HUMAN CELL; REPORTER GENE;

BIOLOGICAL ASSAY; BREAST NEOPLASMS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; GENES, REPORTER; HUMANS; LIVER NEOPLASMS; LUCIFERASES; RECEPTORS, ESTROGEN; TRANSFECTION; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0033054361     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/48.1.55     Document Type: Article

References (58)

1. Aarts, J. M. M. J. G., Denison, M. S., Cox, M. A., Schalk, A. C., Garrison, P. A., Tullis, K., de Haan, L. H. J., and Brouwer, A. (1995). Species-specific antagonism of Ah receptor action by 2,2′,5,5′-tetrachloro- and 2,2′3,3′,4,4′-hexachlorobiphenyl. Eur. J. Pharmacol. Environ. Tox. 293, 463-474.
2. Arnold, S. F., Robinson, M. K., Notides, A. C., Guillette, L. J., Jr., and McClachlan, J. A. (1996). A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. Environ. Health Perspect. 104, 544-548.
3. Balaguer, P., Joyeux, A., Denison, M. S., Vincent, R., Gillesby, B. E., and Zacharewski, T. (1996). Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays. Can. J. Physiol. Pharmacol. 74, 216-222.
4. Berthois, Y., Katzenellenbogen, J. A., and Katzenellenbogen, B. S. (1986). Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc. Natl. Acad. Sci. U S A 83, 2496-2500.
5. Bitman, J., Cecil, H. C., Harris, S. J., and Fries, G. F. (1969). Estrogenic activity of o,p'DDT in the mammalian uterus and avian oviduct. Science 162, 371-372.
6. Bondy, K. L., and Zacharewski, T. R. (1993). ICI 164,384 - a control for investigating estrogen-responsive genes. Nuc. Acids Res. 21, 5277-5278.
7. Cavailles, V., Augereau, P, Garcia, M., and Rochefort, H. (1988). Estrogens and growth factors induce the messenger RNA of the 52k-procathepsin-D secreted by breast cancer cells. Nucleic Acids Res. 16, 1903-1919.
8. Cavailles, V., Garcia, M., and Rochefort, H. (1989). Regulation of cathepsin-D and pS2 gene expression by growth factors in MCF7 human breast cancer cells. Mol. Endocrin. 3, 552-558.
9. Colborn, T., vom Saal, F. S., and Soto, A. M. (1993). Developmental effects of endocrine-disrupting chemicals in wildlife and human. Environ. Health. Perpect. 101, 378-384.
10. Cranmer, J., Cranmer, M., and Goad, P. (1984). Prenatal chlordane exposure: Effects on plasma corticosterone concentrations over the lifespan of mice. Environ. Res. 35, 204-210.
11. Dickson, R. B., and Lippman, M. E. 1995. Growth factors in breast cancer. Endocr. Rev. 16, 559-589.
12. Dotzlaw, H., Leygue, E., Watson, Peter, H., and Murphy, L. (1996). Expression of estroen receptor-beta in human breast tumors. J. of Clin. Endocrinol. Metab. 82, 2371-2374.
13. Evans, R. (1988). The steroid and thyroid hormone receptor superfamily. Science 240, 889-895.
14. Fry, D. M., and Toone, C. K. (1981). DDT-induced feminization of gull embryos. Science 231, 922-924.
15. Gaido, K. W., McDonnell, D. P., Korach, K. S., and Safe, S. H. (1997). Estrogenic activity of chemical mixtures: Is there synergism? CIIT Activities 17, 1-7.
16. Garrison, P. M., Tullis, K., Aarts, J. M. M. J. G., Brouwer, A., and Giesy, J. (1996). Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachloro-dipenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30, 194-203.
17. Gray, L. E, Ostby, J., Ferrell, J., Rehnberg, G., Linder, R., Cooper, R., Goldman, J., Slott, V. and Laskey, J. (1989). A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12, 92-108.
18. Green, S., Issemann, I., and Sheer, E. (1988). A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nuc. Acids Res. 16, 369.
19. Haake, J., Kelley, M., Keys, B., and Safe, S. T. (1987). The effects of organochlorine pesticides as inducers of testosterone and benzo(a)pyrene hydroxylases. Gen. Pharmacol. 18, 165-169.
20. Hess, R. A., Bunick, D., Lee, K. H., Bahr, J., Taylor, J. A., Korach, K. S., and Lubahn, D. B. ( 1997). A role for oestrogens in the male reproductive system. Nature 390, 509-512.
21. Hoglund, M., Siden, T., and Rohme, D. (1992). Different pathways for chromosomal integration of transfected circular pSVneo plasmids in normal and established rodent cells. Gene 116, 215-222.
22. Horwitz, K. B., and McGuire, W. L. (1978). Estrogen control of progesterone receptor in human breast cancer: Correlation with nuclear processing of estrogen receptor. J. Biol. Chem. 253, 2222-2228.
23. Ing, N. H., and O'Malley, B. W. (1995). The steroid hormone receptor superfamily: Molecular mechanisms of action. In Molecular Endocrinology: Basic Concepts and Clinical Correlations. (Weintraub, B. D., Ed.), pp. 195-215. Raven Press, New York.
24. Jausons-Loffreda, N., Balaguer, P., Roux, S., Fuentes, M., Pons, M., Nicolas, J. C., Gelmini, S., and Pazzagli, M. (1994). Chimeric receptors as a tool for luminescent measurement of biological activities of steroid hormones. J. Biolumin. Chemilumin. 9, 217-221.
25. Jobling, S., Reynolds, T., White, R., Parker, M. G., and Sumpter, J. P. (1995). A variety of environmental persistent chemicals, including some phthalate plasticizers are weakly estrogenic. Environ. Health Perspect. 103, 582-587.
26. Jobling, S., and Sumpter, J. P. (1993). Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 27, 361-372.
27. Klotz, D. M., Beckman, B. S., Hill, S. M., McLachlan, J. A., Walters, M. R., and Arnold, S.F. (1996). Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays. Environ. Health Perspect. 104, 1084-1089.
28. Kohno, H., Gandini, O., Curtis, S. W., and Korach, K. S. (1994). Anti-estrogen activity in the yeast transcription system: Estrogen receptor mediated agonist response. Steroids 59, 572-578.
29. Korach, K. S., Metzler, M., and McLachlan, J.A. (1978). Estrogen activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs. Proc. Natl. Acad. Sci. U S A 75, 468-471.
30. Kramer, V. J., Helferich, W. G., Bergman, A., Klasson-Wehler, E., and Giesy, J. P. (1997). Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF-7) cell line. Tax. Aplp. Pharmacol. 144, 363-376.
31. Kuil, C. W., Brouwer, A., van der Saag, P. T., and van der Burg, B. (1998). Interference between progesterone and dioxin signal transduction pathways: Different mechanisms are involved in repression by the progesterone receptor A and B isoforms. J.. Biol. Chem. 273, 8829-8834.
32. Kuiper, G. J. M., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and Gustaffson, J.A. (1997). Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138, 863-870.
33. Kuiper, G. J. M., Enmark, E., Peto-Huikko, M., Nilsson, S., and Gustafsson, J. A. (1996). Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U S A 93, 5925-5930.
34. Kuiper, G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., Van der Saag, P. T., Van der Burg, B., and Gustafsson, J. A. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139, 4252-4263.
35. Lyttle, C. R., Damian-Matsumura, P., Juul, H., and Butt, T. R. (1992). Human estrogen receptor regulation in a yeast model system and studies on receptor agonists and antagonists. J. Steroid Biochem. Mol. Biol. 42, 677-685.
36. Mayr, U., Butsch, A., and Schneider, S. (1992). Validation of two in vitro test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts. Toxicology 74,135.
37. Migliaccio, S., Davis, V. L., Gibson, M. K., Gray, T. K., and Korach, K. S. (1992). Estrogens modulate the responsiveness of osteoblast-like cells stably transfected with estrogen receptor. Endocrinology 130,2617-2624.
38. Mosselman, S., Polman, J., and Dijkema, R. (1996). ERβ: Identification and characterization of a novel human estrogen receptor. FEBS Lett.. 392, 49-53.
39. Murk, A. J., Legler, J., Denison, M. S., Giesy, J. P., Van de Guchte, C., and Brouwer, A. (1996). Chemical-activated luciferase gene expression (CALUX): A novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam. Appl. Tox. 33, 149-160.
40. Piao, Y.-S., Pelttoketo, H., Jouppila, A., and Vihko, R. (1997). Retinoic acidsincrease 17β-hydroxysteroid dehydrogenase type 1 expression in JEG-3 and T47D cells, but the stimulation is potentiated by epidermal growth factor, 12-O-tetradecanoylphorbol-13-acetate and cychlic adenosine 3′,5′-monophosphate only in JEG-3 cells. Endocrinology 138, 898-904.
41. Pons, M., Gagne, D., Nicolas, J. C., and Mehtali, M. (1990) A new cellular model of response to estrogens: A bioluminescent test to characterize (anti)estrogen molecules. Biotechniques 9, 450-459.
42. Routledge, E. J., and Sumpter, J. P. (1996). Estrogenic activity of surfactants and some of their degradation productes assessed using a recombinant yeast screen. Environ. Tox. Chem. 15, 241-248.
43. Safe, S. (1995). Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol. Ther. 67, 247-281.
44. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. (Irwin, N., Ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
45. Schlenk, D., Stresser, D. M., McCants, J. C., Nimrod, A. C., and Benson, W. H. (1997). Influence of b-naphtoflavone and methoxychlor pretreatment on the biotransformation and estrogenic activity of methoxychlor in channel catfish (Ictalurus panctatus). Toxicol. Appl. Pharmacol. 145, 349-356.
46. Shelby, M. D., Newbold, R. R., Tully, D. B., Chae, K, and Davis, V. L. (1996) Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ. Health. Perspect. 104,1296-1300.
47. Sherf, B. A., and Wood, K. V. (1994). Firefly luciferase engineerd for improved genetic reporting. Promega Notes 49,14-21.
48. Soto, A. M., Chung, K. L., and Sonnenschein, C. (1994) The pesticides endosulfan, toxaphene and dieldrin have estrogenic effects on human estrogen sensitive cells. Environ. Health Perspect. 102, 380-383.
49. Soto, A. M., Jusiticia, H., Wray, J. W., and Sonnenschein, C. (1991). P-Nonylphenol: An estrogenic xenobiotic released from "modified" polystyrene. Environ. Health Perspect. 92, 167-173.
50. Soto, A. M., Lin, T. M., Justicia, H., Silvia, R. M., and Sonnenschein, C. (1992) An "in culture" bioassay to assess the estrogenicity of xenobiotics. In Chemically Induced Alterations in Sexual Development: The Wildlife/Human Connection. (Colborn, T., and Clement, C., Eds.), pp. 295-309. Princeton Scientific, Princeton, NJ.
51. Soto, A. M., Sonnenschein, C., Chung, L. K., Fernandez, M. F., Olea, N., and Olea Serrano, F. (1995). The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Env. Health Persp. 103(suppl. 7), 113-122.
52. Spink, D. C., Spink, B. C., Cao, J. Q, Depasquale, J. A., Pentecost, B. T., Fasco, M. J., Li, Y., and Sutter, T. R. (1998). Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis 19, 291-298.
53. te Riele, H., Maandag, E. R., Clarke, A., Hooper, M., and Berns, A. (1990). Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells. Nature 348, 649-651.
54. van der Burg, B., Rutteman, G. R., Blankestein, M. A., de Laat, S. W., and van Zoelen, E. J. J. (1988). Mitogenic stimulation of human breast cancer cells in a growth factor-defined medium: synergistic action of insulin and estrogen. J. Cell Physiol. 134, 101-108.
55. Watanabe, T. Junzheng, W., Morikawa, K., Fuchigami, M., Kuranami, M., Adachi, I, Yamaguchi, K., and Abe, K. (1990). In vitro sensitivity test of breast cancer cells to hormonal agents in a radionucleotide-incorporation assay. Jpn. J. Cancer Res. 81, 536-543.
56. White, R., Jobling, S., Hoare, S. A., Sumpter, J. P., and Parker, M. G. (1994). Environmentally persitstent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.
57. Zacharewski, T. R. (1997) In vitro bioassays for assessing estrogenic substances. Environ. Sci. Technol. 31, 613-623.
58. Zacharewski, T. R., Berhane, K., Gillesby, B. E., and Burnison, B. K. (1995). Detection of estrogen- and dioxin-like activity in pulp and paper mill black liquor and effluent using in vitro recombinant receptor/reporter gene assays. Environ. Sci. Technol. 29, 2140-2146.