An assessment of the developmental, reproductive,and neurotoxicity of endosulfan

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 86, Issue 1, 2009, Pages 1-28

  Silva, Marilyn H ^a   Gammon, Derek ^a  

^a CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BIOGENIC AMINE; CYTOCHROME P450; ENDOSULFAN; IONOPHORE; PESTICIDE; SEROTONIN RECEPTOR;

ACROSOME REACTION; ADIPOSE TISSUE; AGGRESSION; AUTISM; AVOIDANCE BEHAVIOR; BODY WEIGHT; BRAIN; BREAST MILK; CENTRAL NERVOUS SYSTEM; COGNITION; DEVELOPMENT; DIET; DOG; ENDOCRINE SYSTEM; ESTROGEN ACTIVITY; FEEDING; FETUS MALFORMATION; GENOTOXICITY; HISTOPATHOLOGY; HUMAN; LEARNING; MEMORY; NEOPLASM; NEUROTOXICITY; NONHUMAN; PLACENTA; PRACTICE GUIDELINE; PREGNANT WOMAN; PRIORITY JOURNAL; RABBIT; RAT STRAIN; RECEPTOR BINDING; REPRODUCTIVE TOXICITY; REVIEW; RISK ASSESSMENT; SEX DIFFERENCE; SPERM; SPERMATOGENESIS; SPERMATOZOON COUNT; SPRAGUE DAWLEY RAT; STEROIDOGENESIS; SWISS WEBSTER MOUSE; UMBILICAL CORD BLOOD; WISTAR RAT;

ADULT; ANIMALS; AUTISTIC DISORDER; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENDOCRINE DISRUPTORS; ENDOSULFAN; FEMALE; FETAL DEVELOPMENT; HUMANS; INFERTILITY, MALE; INHALATION EXPOSURE; INSECTICIDES; MALE; NERVOUS SYSTEM DISEASES; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PESTICIDE RESIDUES; PREGNANCY; RABBITS; RATS; REPRODUCTION; RISK ASSESSMENT; SPERMATOZOA; TERATOGENS; YOUNG ADULT;

ANIMALIA; MAMMALIA; ORYCTOLAGUS CUNICULUS; RATTUS; RODENTIA;

EID: 64149099090     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20183     Document Type: Review

References (128)

1. Abalis IM, Eldefrawi ME, Eldefrawi AT. 1986. Effects of insecticides on GABA-induced chloride influx into rat brain microsacs. J Toxicol Environ Health 18:3-23.
2. Abraham CC. 2004. Endosulfan's effects: omissions and flawed data. Environ Health Perspect 112:A538.
3. Agrawal AK, Anand M, Zaidi NF, Seth PK. 1983. Involvement of serotonergic receptors in endosulfan neurotoxicity. Biochem Pharmacol 32:3591-3593.
4. Ahmad MM, Maqsood Ahmad M, Sarvat S. 1993. Effects of endosulfan and chlorpyrifos on the reproductive organs and sex hormones of neonatal rats. Pakistan J Zool 25:11-14
5. Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jorgensen EC. 2002. Effects of currently used pesticides in assays for estrogenicity, androgenicity and aromatase activity in vitro. Toxicol Appl Pharm 179:1-12.
6. Barnard AV, Jones DR, Powell LAJ, Heywood R, Street AE, Gibson WA, Gopenath C, Majeed SK, Almond R. 1985. 13-Week toxicity study in rats followed by a 4-week withdrawal period (final report). Huntingdon Research Centre, UK.
7. Barr GA, Sharpless NS, Gibbons JL. 1979. Differences in level of dopamine in the hypothalamus of aggressive and non-aggressive rats. Brain Res 166:211-216.
8. Beauvais S. 2008. Endosulfan Risk Characterization Document, Volume II: Exposure Assessment. Worker Health and Safety Branch, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA. http://www.cdpr.ca.gov/docs/whs/pdf/hs1647.pdf.
9. Bebe FN, Panemangalore M. 2003. Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous antioxidants in tissues of rats. J Environ Sci Hlth B 38:349-363.
10. Birth Defect Prevention Act. 1984. Chapter 2; Article 14, Statutes: 13121-13133 of the California Food and Agriculture Code, Sacramento, CA.
11. Bondy SC. 1982. Mechanisms of action of neurotoxic substances. In: Prasad KN, Vernadakis A, editors. Neurotransmitter binding interaction as a screen for neurotoxicity. New York: Raven Press. p 25-50.
12. Brunk R. 1989. Testing for toxicity by repeated oral administration (1-year feeding study) to Beagle dogs. Hoechst Aktiengesellschaft, Pharma Research, Toxicology and Pathology, Report no.: 6230 Frankfurt, Germany. DPR Volume/record: 182-065 no. 074850. http://www.cdpr.ca.gov/docs/risk/toxsums/ pdfs/259.pdf.
13. Bury D, 1997. Neurotoxicological screening in the male and female Wistar rat; acute oral toxicity. Hoechst Marion Roussel, Preclinical Development Germany, Drug Safety, FRG. DPR Volume/record: 182-106 no. 162457. http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
14. Cabaleiro T, Caride A, Romero A, Lafuente A. 2008. Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats. Toxicol Lett 176:58-67.
15. California Assembly Bill 1807. 1983. AB 1807, Tanner. Air pollution: toxic air contaminants. Chapter 1047, p 29-47.
16. California Assembly Bill 2161. 1989. AB 2161. Chapter 2; Article 14, statute nos.: 13134-13135 of the California Food and Agriculture Code, Sacramento, CA.
17. California Food and Agriculture Code: Division 7, Chapter 3, Article 1.5 Pesticides: no. 14021-14027.
18. Campoy C, Jiménez M, Olea-Serrano MF, Moreno-Frías M, Cañabate F, Olea N, Bayés R, Molina-Font JA. 2001. Analysis of organochlorine pesticides in human milk: preliminary results. Early Hum Dev 65:S183-S190.
19. Carrera G, Fernandez P, Grimalt JO, Ventura M, Camarero L, Catalan J, Nickus U, Thies H, Psenner R. 2002. Atmospheric deposition of organochlorine compounds to remote high mountain lakes of Europe. Environ Sci Technol 36:2581-2588.
20. Casabar RCT, Wallace AD, Hodgson E, Rose RL. 2006. Metabolism of endosulfan-α by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug Metab Dispos 34:1179-1785.
21. Casida Je, Lawrence LJ. 1985. Structure-activity correlations for interactions of bicyclophosphorus esters and some polychlorocycloaldane and pyrethroid insecticides with brain-specific t-butylbicyclopho- sphoro-thionate receptor. Environ Health Perspect 61:123-132.
22. Cerrillo I, Granada A, López-Espinosa M, Olmos B, Jiménez M, CañoA, Olea N, Olea-Serrano M. 2005. Endosulfan and its metabolites in fertile women, placenta, cord blood and human milk. Environ Res 98:233-239.
23. 14C-endosulfan in male Sprague-Dawley rats following oral administration of single or repeated doses. New York: Wiley InterScience.
24. Cole LM, Casida JE. 1986. Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore. Life Sci 39:1855-1862.
25. Dalsenter PR, Dallegrave E, Mello JRB, Langeloh A, Oliveira RT, Faqi AS. 1999. Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation. Hum Exp Toxicol 18: 583-589.
26. Dalsenter PR, de Araújo SL, da Silva de Assis HC, Andrade AJM. 2003. Pre- and postnatal exposure to endosulfan in Wistar rats. Hum Exp Toxicol 22:171-175.
27. Den Tonkelaar EM, Van Esch GJ. 1974. No-effect levels of organochlorine pesticides based on induction of microsomal liver enzymes in short- term toxicity experiments. Toxicology 2:371-380.
28. Dikshith TSS, Datta KK. 1977. Environmental pollution and human health. Cytogenetic studies of endosulfan in male rats. Proceedings of the International Symposium on Industrial Toxicology. November 4-7, 1975, p 578-589.
29. Dikshith TSS, Nath G, Datta KK. 1978. Combined cytogenetic effects of endosulfan and metepa in male rats. Indian J Exp Biol 16:1000-1002.
30. Dikshith TSS, Raizada RB, Srivastava MK, Kaphalia BS. 1984. Response of rats to repeated oral administration of endosulfan. Ind Health 22:295-304.
31. Donaubauer HH. 1988. Carcinogenicity study in mice, 24 month feeding study. Environmental Pollution and Human Health. Environmental Pollution and Human Health. DPR Volume/record: 182-064 no. 075035. http://www.cdpr.ca.gov/ docs/risk/toxsums/pdfs/259.pdf.
32. Dorough HW, Huhtanen K, Marshall TC, Bryant HE. 1978. Fate of endosulfan in rats and toxicological considerations of apolar metabolites. Pestic Biochem Physiol 8:241-252. Edwards JA, Reid YJ, Offu JM, Almond RH, Gibson WA. 1984. Effect of endosulfan-technical (Code: HOE 02671 0 I AT209) on reproductive function of multiple generations in the rat. DPR Volume/record: 182 022 no. 035789. http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/ 259.pdf Ekwall H, Jansson A, Sjoberg P, Ploen L. 1984. Differentiation of the rat testis between 20 and 120 days of age. Arch Andrology 13:27-36.
33. Erdreich L, Morimoto L. 2007. Endosulfan critical review of epidemio- logical study ''Maternal residence near agricultural pesticide applications and autism sprectum disorders among children in the California Central Valley.'' Makhteshim-Agan of North America Inc., Raleigh, NC 27609. Report ID: AOTO 0807 LEO1; DPR Volume/record: 182-128 no. 235849.
34. Fabacher DL, Kulkarni AP, Hodgson E. 1980. Pesticides as inducers of hepatic drug-metabolizing enzymes-I. Mixed function oxidase activity. Gen Pharmacol 11:429-435.
35. Fan S. 2008. Endosulfan Risk Characterization Document, Volume III: Environmental Fate. Environmental Monitoring Branch, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA, http://www.cdpr.ca.gov/docs/emon/pubs/tac/ finaleval/endosulfan.htm Ffrench-Constant RH. 1993. The molecular and population genetics of cyclodiene insecticide resistance. Insect Biochem Mol Biol 24:335-345.
36. FQPA. 1996. Food Quality Protection Act of 1996. Public Law 104-170. August 3, 1996.
37. Fung W-P. 1981a. Final report. Range-finding study with FMC 5462 in pregnant rabbits. DPR Volume/record: 182-041 no. 045582. http://www.cdpr.ca.gov/ docs/risk/toxsums/pdfs/259.pdf.
38. Fung W-P. 1981b. Range-finding study with FMC 5462 in pregnant rabbits (Supplier: Dutchland Laboratories, Inc.) Raltech study no.: 79032. DPR Volume/record: 182-057 no. 060604. http://www.cdpr.ca.gov/docs/risk/toxsums/ pdfs/259.pdf.
39. Fung W-P. 1980a. Range-finding study with FMC 5462 in pregnant rats. DPR Volume/record: 182-057 no. 060605. http://www.cdpr.ca.gov/ docs/risk/toxsums/ pdfs/259.pdf.
40. Fung W-P. 1980b. Teratology study with FMC rats. DPR Volumes/ records: 182-026 and 057, no. 017686 and 060606. http://www.cdpr.ca.gov/docs/risk/ toxsums/pdfs/259.pdf.
41. Gaines TB. 1969. Acute toxicity of pesticides. Toxicol Appl Pharmacol 14:515-534.
42. Gant DB, Eldefrawi ME, Eldefrawi AT. 1987. Cyclodiene insecticides inhibit GABA receptor-regulated chloride transport. Toxicol Appl Pharmacol 88:313-321.
43. Garg A, Kunwar K, Das N, Gupta PK. 1980. Endosulfan intoxication: blood glucose, electrolytes calcium levels, ascorbic acid and glutathione in rats. Toxicol Lett 5:119.
44. Gilmore RG, Sheets LP, Hoss HE. 2006. A developmental neurotoxicity study with technical grade Endosulfan in Wistar rats. Bayer CropScience LP, Stilwell, KS. DPR Volume/record no.: 182-122 228573. http://www.cdpr.ca.gov/docs/risk/ toxsums/pdfs/259.pdf.
45. Gorbach SG, Christ OE, Kellner H, Kloss G, Borner E. 1968. Metabolism of endosulfan in milk sheep. J Agr Food Chem 16:950-953.
46. Gupta PK, Chandra SV. 1977. Toxicity of endosulfan after repeated oral administration to rats. Bull Environ Contamin Toxicol 18: 378-384.
47. Gupta PK, Gupta RC. 1979. Pharmacology, toxicology and degradation of endosulfan. A review. Toxicology 13:115-130. Hack R, Ebert E, Leist KH. 1995. Chronic toxicity and carcinogenicity studies with the insecticide endosulfan in rats and mice. Food Chem Toxicol 33:941-950.
48. Health Canada, 2007. Preliminary Risk and Value Assessments of Endosulfan. Pest Management Regulatory Agency, Health Canada, Ottawa, Ontario. October 16, 2007. http://www.pmra-arla.gc.ca/ english/pubs/rev-e.html.
49. Hiremath MB, Kaliwal BB. 2002. Effect of endosulfan on ovarian compensatory hypertrophy in hemicastrated albino mice. Reprod Toxicol 16:783-790.
50. Hiremath MB, Kaliwal BB. 2003. Evaluation of estrogenic activity and effect of endosulfan on biochemical constituents in ovariecto- mized (OVX) Swiss albino mice. Bull Environ Contam Toxicol 71:458-464.
51. Hodgson E, Rose RL. 2008. Mini-review. Metabolic interactions of agrochemicals in humans. Society of Chemical Industry. Pest Manage Sci 64:617-621.
52. 50Hoechst AG, Germany. DPR Volume/record: 182-089 no. 128477. http://www.cdpr.ca.gov/docs/ risk/toxsums/pdfs/259.pdf.
53. Hollander H, Weigand W. 1984. Endosulfan, Active ingredient technical: Testing for subchronic inhalation toxicity (21 exposures in 29 days) in SPF Wistar Rats. Hoechst AG, Germany. DPR Volume/record: 182-084 126577. http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
54. Hollander M, Wolfe D. 1973. Non-parametric statistical methods. New York, NY: John Wiley &Sons. Hughes PCR, Tanner JM. 1970a. A longitudinal study of the measurement and rates of growth for skull, limbs, pelvis, nose-rump and tail lengths. J Anat 106:349-370.
55. Hughes PCR, Tanner JM. 1970b. The assessment of skeletal maturity in the growing rat. J Anat 106:371-402.
56. Indulkar AS. 2004. Endosulfan's effects: inaccurate data. Environ Health Perspect 112:A538-A539.
57. IPEN 2008. International Persistent Organic Pesticide Elimination Network: www.ipen.org/ipenweb/poprc/newpops.html Je KH, Kim KN, Nam KW, Cho MH, Mar W. 2005. TERT mRNA expression is up-regulated in MCF-7 cells and a mouse mammary culture (MMOC) system by endosulfan treatment. Arch Pharm Res 28:351-357.
58. Jonsson MC, Toledo MCF. 1993. Bioaccumulation and elimination of endosulfan in the fish yellow tetra (Hyphessobrycon bifasciatus). Bull Environ Contam Toxicol 50:572-577.
59. Kelly BC, Ikonomov MG, Blair JD, Morin AE, Gobas FAPC. 2007. Food web-specific biomagnification of persistent organic pollutants. Science 317:236-239.
60. Khan PK, Sinha SP. 1996. Ameliorating effect of vitamin C on murine sperm toxicity induced by 3 pesticides (endosulfan, phosphamidon and mancozeb). Mutagenesis 11:33-36.
61. Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese Hamster ovary cells. Environ Health Perspect 112:524-531.
62. Korenbrot CC, Huhtaniemi IT, Weiner RI. 1977. Preputial separation as an external sign of pubertal development in the male rat. Bio Reprod 17:298-303.
63. Krinke GJ. 2000. The laboratory rat. Academic Press Publisher, Stein, Switzerland.
64. Lakshmana MK, Raju TR. 1994. Endosulfan induces small but significant changes in the levels of noradrenaline, dopamine and serotonin in the developing rat brain and deficits in the operant learning performance. Toxicol 91:139-150.
65. Lawrence LJ, Casida JE. 1984. Interactions of lindane, toxaphene and cyclodienes with brain specific t-butylcyclophosphorothionate receptor. Life Sci 35:171-178.
66. Lee H-K, Moon J-K, Chang C-H, Choi H, Park H-W, Park B-S, Lee H-S, Hwang E-C, Lee Y-D, Liu K-H, Kim J-H. 2006. Stereoselective metabolism of endosulfan by human liver microsomes and human cytochrome P450 isoforms. Drug Metabol Disp 34:1090-1095.
67. MaierBode H. 1968. Properties, effect, residues and analytics of the insecticide endosulfan. Residue Rev 22:144. Meizel S. 1997. Amino acid neurotransmitter receptor/chloride channels of mammalian sperm and the acrosome reaction. Biol Reprod 56:569-574.
68. -channel in the zona pellucida-initiated acrosome reaction. Biol Reprod 53:676-683.
69. - channel in porcine sperm. Biochem Biophys Res Commun 223:675-678.
70. Murono EP, Derk RC, de Leon JH. 2001. Differential effects of octylphenol, 17β -estradiol, endosulfan, or bisphenol A on the steroidogenic competence of cultured adult rat Leydig cells. Repro Toxicol 15:551-560.
71. Naqvi SM, Vaishnavi C. 1993. Mini review. Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp Biochem Physiol C 105:347-361. Narayan S, Dani HM, Misra UK. 1984. Effect of intratracheally administered DDT and endosulfan on pulmonary and hepatic respiratory cytochromes. Bull Environ Contam Toxicol 33: 193-199.
72. Narayan S, Dani HM, Misra UK. 1990a. Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT of endosulfan. B25:243-257.
73. Narayan S, Dani HM, Misra UK. 1990b. Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally. B25:259-272.
74. NRCC. 1975. Endosulfan: its effects on environmental quality. Ottawa, Ontario: National Research Council Canada, Environmental Secretariat, Publication #: NRCC 14098.
75. Nye D. 1981. Teratology study with FMC 5462 in rabbits. DPR Volume/ record: 027 & 057, no. 035798 & 060607. http://www.cdpr.ca.gov/ docs/risk/toxsums/pdfs/259.pdf.
76. Olea N, Barba A, Lardelli P, Rivas A, Olea-Serrano MF. 1999. Inadvertent exposure to xenoestrogens in children. Toxicol Indust Health 15:151-158.
77. Ozoe Y, Matsumura F. 1986. Structural requirements for bridged bicyclic compounds acting on picrotoxinin receptor. J Ag Food Chem 34:126 134.
78. PANNA. 2008. Endosulfan Monograph. http://www.panna.org/files/ PAN%20Int%20Endosulfan%20Monograph.pdf.
79. Paul V, Balasubramaniam E, Kazi M. 1994. The neuro-behavioral toxicity of endosulfan in rats: a serotonergic involvement in learning impairment. Eur J Pharmacol Environ Toxicol Pharmacol 270.
80. Plimmer JR, Gammon DW. 2003. Encyclopedia of agrochemicals. In: Plimmer JR, Gammon DW, Ragsdale NN, editors. Insecticides, organochlorines. New York, NY: John Wiley & Sons, Inc. p 1-31.
81. Robb CW, Amann RP, Killian GJ. 1978. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 54:103-107.
82. Robacker KM, Kulkarni AP, Hodgson E. 1981. Pesticide induced changes in the mouse hepatic microsomal cytochrome P-450-dependent monooxygenase system and other systems. J. Environ Sci Health B16:529-545.
83. Roberts EM, English PB, Grether JK, Windham GC, Somberg L, Wolff C. 2007. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley. Environ Health Perspect 115:1482-1489.
84. Ruckman SA, Waterson LA, Crook D, Gopinath C, Majeed SK, Anderson A, Chanter DO 1989. Combined chronic toxicity/carcinogenicity study 104 week feeding in rats. DPR Vol. 182066 #074851. http://www.cdpr.ca.gov/docs/risk/ toxsums/pdfs/259.pdf.
85. Saiyed H, Dewan A, Bhatnagar V, Shenoy U, Shenoy R, Rajmohan H, Patel K, Kashyap R, Kulkarni P, Rajan B, Lakkad B. 2003. Effect of endosulfan on male reproductive development. Environ Health Perspect 111:1958-1962
86. Scholz J, Weigand W (Hoechst AG). 1971a. Acute oral toxicity to the male Sherman rat. DPR Volume/record: 182-086 no. 128472. http://www.cdpr.ca.gov/docs/ risk/toxsums/pdfs/259.pdf.
87. Scholz J, Weigand W (Hoechst AG). 1971b. Acute oral toxicity to the female Sherman rat. DPR Vol 182-086 no. 128473.
88. Seth PK, Saidi NF, Agrawal, AK, Anand M. 1986. Neurotoxicity of endosulfan in young and adult rats. Neurotoxicology 7:623-635.
89. Sheets LP, Gilmore RG, Fickbohm BL. 2004. A subchronic neurotoxicity screening study with technical grade endosulfan in Wistar rats, Bayer CropScience LP, Toxicology, Stilwell, KS; Lab ID no.: 02-N72MJ; Report no.: 201069; Report ID no.: B004881. DPR Volume/record #:182-0127/234702. Shelby MD, Newbold RR, Tully DB, Chae K, Davis V. 1996. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect 104:1296 1300.
90. A-like receptor is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa. Biol Reprod 52:373-381.
91. Siddiqui MKJ, Anjum F, Qadri SSH. 1987. Some metabolic changes induced by endosulfan in hepatic and extra hepatic tissues of rat. J Environ Sci Health B22:553-564.
92. Silva MH. 2008. Endosulfan: Risk Characterization Document. Medical Toxicology and Worker Health and Safety Branches, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA. http://www.cdpr.ca.gov/docs/emon/pubs/tac/ finaleval/endosulfan.htm.
93. Singh SK, Pandey RS. 1989a. Gonadal toxicity of short term chronic endosulfan exposure to male rats. Ind J Exp Biol 27:341-346.
94. Singh SK, Pandey RS. 1989b. Toxicity of endosulfan on kidney of male rats in relation to drug metabolizing enzymes and microsomal lipid peroxidation. Ind J Exp Biol 27:725-728.
95. Singh SK, Pandey RS. 1990. Effect of sub-chronic endosulfan exposures on plasma gonadotrophins, testosterone, testicular testosterone and enzymes of androgen biosynthesis in rat. Ind J Exp Biol 28:953-956.
96. Sinha N, Narayan R, Shanker R, Saxena DK. 1995. Endosulfan-induced biochemical changes in the testis of rats. Vet Hum Toxicol 37: 547-549.
97. Sinha N, Narayan R, Saxena DK. 1997. Effect of endosulfan on the testis of growing rats. Bull Environ Contam Toxicol 58:79-86.
98. Sinha N, Adhikari N, Saxena DK. 2001a. Effect of endosulfan during fetal gonadal differentiation on spermatogenesis in rats. Environ Toxicol Pharmacol 10:29-32. Sinha N, Adhikari N, Saxena DK. 2001b. Effect of endosulfan on the enzymes of polyol pathway in rat Sertoli-germ cell coculture. Bull
99. Environ Contam Toxicol 67:821-827. Soto AM, Chung KL, Sonnenschein C. 1994. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 102:380-383.
100. Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. 1995. The E-Screen assay as a tool to identify estrogens: an update on estrogen environmental pollutants. Environ Health Perspect 103:113-122.
101. Srivastava AK, Gupta BN, Mathur AK, Mathur N, Mahendra PN, Bharti RS. 1991. The clinical and biochemical study of pesticide sprayers. Hum Exp Toxicol 10:279-283.
102. Suntio LR, Shiu WY, MacKay D, et al. 1988. Critical review of Henry's Law constants for pesticides. Rev Environ Contam Tox 103:159.
103. Toledo MCF, Jonsson CM. 1992. Bioacumulation and elimination of endosulfan in zebra fish (Brachydanio rerio). Pestic Sci 36:207-211.
104. Turner KO, Syvanen M, Meizel S. 1997. The human acrosome reaction is highly sensitive to inhibition by cyclodiene insecticides. J Androl 18:571-575.
105. Tyagi SR, Singh Y, Srivastave PK, Misra UK. 1984. Induction of hepatic mixed function oxidase system by endosulfan in rats. Bull Environ Contam Toxicol 32:550-556.
106. USEPA. 1997a. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and Federal Food, Drug, and Cosmetic Act (FFDCA) as Amended by the Food Quality Protection Act (FQPA) of August 3, 1996. Document no. 730L97001, March 1997. Office of Pesticide
107. Programs, U.S. Environmental Protection Agency, Washington, DC. http://www.epa.gov/opptsfrs/home/testmeth.htm.
108. USEPA. 1997b. 1996 Food Quality Protection Act Implementation Plan. March, 1997. Office of Prevention, Pesticides and Toxic Substances (7506C), U.S. Environmental Protection Agency, Washington, DC. http://www.epa.gov/fedrgstr/.
109. USEPA. 1998. Health Effects Test Guidelines, OPPTS 870.1000. EPA 712-C-98-189, Prevention, Pesticides and Toxic Substances (7101), United States Environmental Protection Agency.
110. USEPA. 2000. Toxicological Profile for Endosulfan. U.S. Department of Health and Human Services, Public Health Service Agency for Toxic
111. Substances and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/ tp41.html USEPA. 2001. Endosulfan: HED risk assessment for the endosulfan re-registration eligibility decision (RED) document. Memo from D. Locke to R. Dumas dated January 31, 2001. U.S. Environmental Protection Agency, Washington, D.C.
112. USEPA. 2002. Reregistration Eligibility Decision for Endosulfan. Case 0014. Washington, DC: Office of Prevention, Pesticides and Toxic Substances, U.S. Environmental Protection Agency. http://www.epa.gov/ oppsrrd1/REDs/ endosulfan-red.pdf.
113. USEPA. 2004. An examination of EPA risk assessment principles and practices: staff paper prepared for the U.S. Environmental Protection Agency by members of the Risk Assessment Task force. Office of the Science Advisor, USEPA, Washington, DC. USEPA. 2007. Endosulfan. Hazard Characterization and Endpoint Selection Reflecting Receipt of a Developmental Neurotoxicity Study andSubchronic Neurotoxicity Study. PC Code: 079401. DP Barcode D338576. Reaves, E., Washington, DC: Office of Prevention, Pesticidesand Toxic Substances, U.S. Environmental Protection Agency.April 7, 2007. http://www.epa.gov/pesticides/ reregistration/ endosulfan/.
114. Usha S, Harikrishnan VR. 2005. IPEN Pesticide Working Group Project 2004. Endosulfan: fact sheet and answers to common questions. IPEN Pesticide Working Group Secretariat, Kerala, India. www.thanal.org.
115. Usha Rani MV, Reddy PP. 1986. Cytogenetic effects of aldrin and endosulfan in mice. IRSC Med Sci 14:1125-1126.
116. Vanparys C, Maras M, Lenjou M, Robbens J, Van Bockstaele D, Blust R, De Coen W. 2006. Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells. Toxicol In Vitro 20:1238-1248.
117. Varayoud J, Monje L, Bernhardt T, Munoz-de-Toro M, Luque EH, Ramos JG. 2008. Endosulfan modulates estrogen-dependent genes like a non-uterotrophic dose of 17β-estradiol. Reprod Toxicol 26:138-145.
118. Wade GM, Desaulniers D, Leingartner K, Foster WG. 1997. Interactions between endosulfan and dieldrin on estrogen-mediated processes in vitro and in vivo. Reprod Toxicol 11:791-798.
119. Ware GW. 1994. Insecticides. In: The Pesticide book (Chapter 4, pp. 4446), Thomson Publications, Fresno, CA.
120. WHO. 1984. Endosulfan. International Programme on Chemical Safety. Environmental Health Criteria 40. Geneva, Switzerland: World Health Organization. p 1-62.
121. WHO. 1998. Endosulfan. International Programme on Chemical Safety. Health and Safety Guide no.17, Geneva, Switzerland: World Health Organization http://www.wpro.who.int/NR/rdonlyres/A68749B9- 8F06-4361-BCDC-E74FAAF12912/0/ Endosulfan-HSG1-1998.pdf.
122. WHO. 2006. Endosulfan. Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade Chemical Review Committee; Second meeting; Geneva, 13-17 February 2006.
123. Wilson VS, LeBlanc GA. 1998. Endosulfan elevates testosterone biotrans- formation and clearance in CD-1 mice. Toxicol Appl Pharmacol 148:158-168.
124. -hannel complex in the progesterone-initiated acrosome reaction. Dev Biol 159:679-690.
125. Zaidi NF, Agrawal AK, Anand M, Seth PK. 1985. Neonatal endosulfan neurotoxicity: Behavioral and biochemical changes in rat pups. Neurobehav Toxicol Teratol 7:439-442.
126. Zemunik T, Peruzovic M, Capkun V, Zekan L, Tomic S, Milkovic K. 2003. Reproductive ability of pubertal male and female rats. Braz J Med Biol Res 36:871-877.
127. Zhu X-Q, Zheng Y-F, Zhu H-H, Ni Z-M, Chang Y, Huang Y-S. 2000. Effects of endosulfan on reproductive system of male pups after gestational and lactational exposure. Chinese J Pharmacol Toxicol 14:352-356.
128. Zhu X-Q, Zheng Y-F, Zhang Q-W, Jiang H, Huang X-S. 2002. Effects of endosulfan on spermatogenesis and oxidative damage in rats. Chinese J Pharmacol Toxicol 16:391-395.