ReProGlo: A new stem cell-based reporter assay aimed to predict embryotoxic potential of drugs and chemicals

Reproductive Toxicology

Volumn 30, Issue 1, 2010, Pages 103-112

  Uibel, Frederik ^a   Mühleisen, Annette ^a   Köhle, Christoph ^a   Weimer, Marc ^b   Stummann, Tina C ^c   Bremer, Susanne ^c   Schwarz, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Alternative methods; Embryotoxicity; In vitro assay; Mouse embryonic stem cells; Wnt signaling

Indexed keywords

CYCLOPHOSPHAMIDE; LITHIUM CHLORIDE; LUCIFERASE; OCHRATOXIN; RETINOIC ACID; SALICYLIC ACID; THALIDOMIDE; TOXIN; VALPROIC ACID; VALPROIC ACID DERIVATIVE; WNT PROTEIN; BETA CATENIN; FIREFLY LUCIFERASE; TERATOGENIC AGENT;

ARTICLE; CELL ACTIVITY; CELL ASSAY; CELL CLONE; CELL DIFFERENTIATION; CELL VIABILITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; EMBRYO; EMBRYONIC STEM CELL; EMBRYOTOXICITY; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIVER CELL; PREDICTION; REPROGLO ASSAY; TERATOGENESIS; TOXICOKINETICS; ANIMAL; ANIMAL TESTING ALTERNATIVE; CELL LINE; CELL SURVIVAL; CHEMISTRY; COCULTURE; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PROCEDURES; REPORTER GENE; REPRODUCIBILITY; REPRODUCTION; STANDARDS; TOXICITY; TOXICITY TESTING;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BETA CATENIN; CELL LINE; CELL SURVIVAL; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; GENES, REPORTER; HEPATOCYTES; LUCIFERASES, FIREFLY; MICE; REPRODUCIBILITY OF RESULTS; REPRODUCTION; TERATOGENS; TOXICITY TESTS; TRANSFECTION; WNT PROTEINS;

EID: 77954088572     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.12.002     Document Type: Article

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