메뉴 건너뛰기




Volumn 745, Issue , 2012, Pages 221-253

The use of integrated and intelligent testing strategies in the prediction of toxic hazard and in risk assessment

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BIOLOGICAL PRODUCT; CARCINOGEN; CHLORPHENOTANE; COSMETIC; NANOPARTICLE; PESTICIDE; TGN 1412;

EID: 84859941409     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3055-1_13     Document Type: Article
Times cited : (7)

References (100)
  • 1
    • 84860002016 scopus 로고    scopus 로고
    • ECHA European Chemicals Agency. About the Agency Helsinki: European Chemicals Agency, 2011 Available at:
    • ECHA. European Chemicals Agency. About the Agency. Helsinki: European Chemicals Agency, 2011: Available at: http://echa.europa.eu/home-en.asp.
  • 2
    • 84860002017 scopus 로고    scopus 로고
    • HSE. Registration, Evaluation Authorisation and Restriction of Chemicals (REACH). London: Health and Safety Executive, 2011
    • . HSE. Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). London: Health and Safety Executive, 2011.
  • 3
    • 84926163143 scopus 로고    scopus 로고
    • Washington, DC US Environmental Protection Agency
    • EPA. Summary of the Toxic Substances Control Act. Washington, DC: US Environmental Protection Agency, 2011: Available at: http://www.epa.gov/ regulations/laws/tsca.html.
    • (2011) EPA. Summary of the Toxic Substances Control Act
  • 5
    • 0003531004 scopus 로고    scopus 로고
    • OECD Paris: Organisation for Economic Co-operation and Development
    • OECD. Guidelines for the Testing of Chemicals, Section 4: Health Effects. Paris: Organisation for Economic Co-operation and Development, 2011. Available at: http://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of- chemicals-section-4-health-effects-20745788.
    • (2011) Guidelines for the Testing of Chemicals, Section 4: Health Effects
  • 6
    • 8744282455 scopus 로고    scopus 로고
    • A scientific and animal welfare assessment of the OECD health effects test guidelines for the safety testing of chemicals under the European Union REACH system
    • Combes RD, Gaunt I, Balls M. A scientific and animal welfare assessment of the OECD health effects test guidelines for the safety testing of chemicals under the European Union REACH system. Altern Lab Anim-ATLA 2004; 32(3):163-208.
    • (2004) Altern Lab Anim-ATLA , vol.32 , Issue.3 , pp. 163-208
    • Combes, R.D.1    Gaunt, I.2    Balls, M.3
  • 8
    • 84859958962 scopus 로고    scopus 로고
    • GAO. Comparison of U.S. and recently enacted European Union approaches to protect against the risks of toxic chemicals. GAO- 07-825. Washington, DC: US Government Accountability Office, 2007
    • GAO. Comparison of U.S. and recently enacted European Union approaches to protect against the risks of toxic chemicals. GAO-07-825. Washington, DC: US Government Accountability Office, 2007.
  • 10
    • 33644850151 scopus 로고    scopus 로고
    • Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans
    • Knight A, Bailey J, Balcombe J. Animal carcinogenicity studies: 2. Obstacles to extrapolation of data to humans. Altern Lab Anim-ATLA 2006; 34(1):29-38.
    • (2006) Altern Lab Anim-ATLA , vol.34 , Issue.1 , pp. 29-38
    • Knight, A.1    Bailey, J.2    Balcombe, J.3
  • 11
    • 34249879680 scopus 로고    scopus 로고
    • The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes
    • Bremer S, Pellizzer C, Hoffmann S et al. The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes. Curr Pharm Des 2007; 13(29):3047-3058.
    • (2007) Curr Pharm des , vol.13 , Issue.29 , pp. 3047-3058
    • Bremer, S.1    Pellizzer, C.2    Hoffmann, S.3
  • 12
    • 67650445156 scopus 로고    scopus 로고
    • Toxicology for the twenty-first century
    • Hartung T. Toxicology for the twenty-first century. Nature 2009; 460(7252):208-212.
    • (2009) Nature , vol.460 , Issue.7252 , pp. 208-212
    • Hartung, T.1
  • 13
    • 18844446770 scopus 로고    scopus 로고
    • Toxicity testing-creating a revolution based on new technologies
    • Bhogal N, Grindon C, Combes R et al. Toxicity testing-creating a revolution based on new technologies. Trends Biotechnol 2005; 23(6):299-307.
    • (2005) Trends Biotechnol , vol.23 , Issue.6 , pp. 299-307
    • Bhogal, N.1    Grindon, C.2    Combes, R.3
  • 15
    • 84859982844 scopus 로고    scopus 로고
    • MHRA London: Medicines and Healthcare Products Regulatory Agency
    • MHRA. How we regulate. London: Medicines and Healthcare Products Regulatory Agency, 2011: Available at: http://www.mhra.gov.uk/Howweregulate/ index.htm.
    • (2011) How We Regulate
  • 16
    • 84860011971 scopus 로고    scopus 로고
    • EMA. What we do. London: European Medicines Agency, 2011
    • EMA. What we do. London: European Medicines Agency, 2011: Available at: http://www.ema. europa.eu/ema/index.jsp?curl=pages/about-us/general/general- content-000091.jsp&mid= WC0b01ac0580028a42&jsenabled=true.
  • 20
    • 84860002022 scopus 로고    scopus 로고
    • The value and benefits of ICH to drug regulatory authorities-advancing harmonization for better health
    • ICH Secretariat.
    • ICH Secretariat. The value and benefits of ICH to drug regulatory authorities-advancing harmonization for better health. Geneva: International Conference on Harmonisation, 2010.
    • (2010) Geneva International Conference on Harmonisation
  • 21
    • 74549165352 scopus 로고    scopus 로고
    • An introduction to QT interval prolongation and nonclinical approaches to assessing and reducing risk
    • Pollard CE, Abi-Gerges N, Bridgland-Taylor MH et al. An introduction to QT interval prolongation and nonclinical approaches to assessing and reducing risk. Br J Pharmacol 2010; 159(1):12-21.
    • (2010) Br J Pharmacol , vol.159 , Issue.1 , pp. 12-21
    • Pollard, C.E.1    Abi-Gerges, N.2    Bridgland-Taylor, M.H.3
  • 22
    • 35348840852 scopus 로고    scopus 로고
    • Drug withdrawals in the United States: A systematic review of the evidence and analysis of trends
    • Issa AM, Phillips KA, Van Bebber S et al. Drug withdrawals in the United States: a systematic review of the evidence and analysis of trends. Curr Drug Safety 2007; 2 (3):177-185.
    • (2007) Curr Drug Safety , vol.2 , Issue.3 , pp. 177-185
    • Issa, A.M.1    Phillips, K.A.2    Van Bebber, S.3
  • 25
    • 79251473744 scopus 로고    scopus 로고
    • A FRAME Response to the European Commission Consultation on the Draft Report on Alternative (Nonanimal) Methods for Cosmetics Testing: Current Status and Future Prospects-2010
    • Balls M, Clothier R. A FRAME Response to the European Commission Consultation on the Draft Report on Alternative (Nonanimal) Methods for Cosmetics Testing: Current Status and Future Prospects-2010. Altern Lab Anim-ATLA 2010; 38(5):345-353.
    • (2010) Altern Lab Anim-ATLA , vol.38 , Issue.5 , pp. 345-353
    • Balls, M.1    Clothier, R.2
  • 27
    • 79956348442 scopus 로고    scopus 로고
    • Alternative (non-animal) methods for cosmetics testing: Current status and future prospects-2010
    • Adler S, Basketter D, Creton S et al. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol 2011; 85:367-485.
    • (2011) Arch Toxicol , Issue.85 , pp. 367-485
    • Adler, S.1    Basketter, D.2    Creton, S.3
  • 29
    • 33744922424 scopus 로고    scopus 로고
    • TGN1412: Time to change the paradigm for the testing of new pharmaceuticals
    • Bhogal N, Combes R. TGN1412: time to change the paradigm for the testing of new pharmaceuticals. Altern Lab Anim-ATLA 2006; 34(2):225-239.
    • (2006) Altern Lab Anim-ATLA , vol.34 , Issue.2 , pp. 225-239
    • Bhogal, N.1    Combes, R.2
  • 31
    • 74949096870 scopus 로고    scopus 로고
    • Why animal studies cannot suitably assess nanomedicines
    • Bhogal N, Seabra R. Why animal studies cannot suitably assess nanomedicines. Pharm Technol 2010; 22(1):38-41.
    • (2010) Pharm Technol , vol.22 , Issue.1 , pp. 38-41
    • Bhogal, N.1    Seabra, R.2
  • 32
    • 79960862396 scopus 로고    scopus 로고
    • Toxicity testing of nanomaterials
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Schrand AM, Dai L, Schlager JJ et al. Toxicity testing of nanomaterials. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011: 59-76.
    • (2011) New Technologies in Toxicity Testing , pp. 59-76
    • Schrand, A.M.1    Dai, L.2    Schlager, J.J.3
  • 34
    • 51349112312 scopus 로고    scopus 로고
    • Translation of new technologies: From basic research to drug discovery and development
    • Bhogal N, Balls M. Translation of new technologies: from basic research to drug discovery and development. Curr Drug Discov Technol 2008; 5(3):250-262.
    • (2008) Curr Drug Discov Technol , vol.5 , Issue.3 , pp. 250-262
    • Bhogal, N.1    Balls, M.2
  • 35
    • 84860002025 scopus 로고    scopus 로고
    • Translation of new technologies in biomedicines: Shaping the road from basic research to drug development and clinical application
    • Kayser O, Warzeka H, eds. Weinheim Wiley-VCG, in press
    • Balls M, Bennett, A, Kendall D. Translation of new technologies in biomedicines: shaping the road from basic research to drug development and clinical application. In: Kayser O, Warzeka H, eds. Pharmaceutical biotechnology-a comprehensive handbook. Weinheim: Wiley-VCG, in press.
    • Pharmaceutical Biotechnology-A Comprehensive Handbook
    • Balls, M.1    Bennett, A.2    Kendall, D.3
  • 36
    • 34548304745 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: Methods for virtual ligand screening and profiling
    • Ekins S, Mestre J, Testa B. In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br J Pharmacol 2007; 152(1):9-20.
    • (2007) Br J Pharmacol , vol.152 , Issue.1 , pp. 9-20
    • Ekins, S.1    Mestre, J.2    Testa, B.3
  • 37
    • 34548319111 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: Applications to targets and beyond
    • Ekins S, Mestre J, Testa B. In silico pharmacology for drug discovery: applications to targets and beyond. Br J Pharmacol 2007; 152(1):21-37.
    • (2007) Br J Pharmacol , vol.152 , Issue.1 , pp. 21-37
    • Ekins, S.1    Mestre, J.2    Testa, B.3
  • 38
    • 79960852057 scopus 로고    scopus 로고
    • In silico methods for toxicity prediction
    • Balls M, Combes R, Bhogal N eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Combes RD. In silico methods for toxicity prediction. In: Balls M, Combes R, Bhogal N eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011: 97-118.
    • (2011) New Technologies in Toxicity Testing , pp. 97-118
    • Combes, R.D.1
  • 40
    • 79958006798 scopus 로고    scopus 로고
    • Trends in cell culture technology
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Marx U. Trends in cell culture technology. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011: 27-47.
    • (2011) New Technologies in Toxicity Testing , pp. 27-47
    • Marx, U.1
  • 41
    • 79958014207 scopus 로고    scopus 로고
    • Engineering Quasi-Vivo® in vitro organ models
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Sceince + Business Media
    • Sbrana T, Ahluwalia A. Engineering Quasi-Vivo® in vitro organ models. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Sceince + Business Media, 2011:139-154.
    • (2011) New Technologies in Toxicity Testing , pp. 139-154
    • Sbrana, T.1    Ahluwalia, A.2
  • 42
    • 79957975059 scopus 로고    scopus 로고
    • Medium to high throughput screening: Microfabrication and chip-based toxicology
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Wen Y, Zhang X, Yang ST. Medium to high throughput screening: microfabrication and chip-based toxicology. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011: 183-212.
    • (2011) New Technologies in Toxicity Testing , pp. 183-212
    • Wen, Y.1    Zhang, X.2    Yang, S.T.3
  • 43
    • 79960887036 scopus 로고    scopus 로고
    • Tissue engineering in the development of replacement technologies
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Shakesheff KM, Rose FRAJ. Tissue engineering in the development of replacement technologies. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011:48-54.
    • (2011) New Technologies in Toxicity Testing , pp. 48-54
    • Shakesheff, K.M.1    Fraj, R.2
  • 44
    • 77749270677 scopus 로고    scopus 로고
    • Ultrahigh-throughput screening in drop-based microfluidics for directed evolution
    • Agresti JJ, Antipov E, Abate AR et al. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc Natl Acad Sci USA 2010; 107(9):4004-4009.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.9 , pp. 4004-4009
    • Agresti, J.J.1    Antipov, E.2    Abate, A.R.3
  • 45
    • 79960874833 scopus 로고    scopus 로고
    • Current developments in cell culture technology
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Stacey G. Current developments in cell culture technology. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011:1-14.
    • (2011) New Technologies in Toxicity Testing , pp. 1-14
    • Stacey, G.1
  • 46
    • 79960877369 scopus 로고    scopus 로고
    • Embryonic stem cells in safety pharmacology and toxicology
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Stummann TC, Bremer S. Embryonic stem cells in safety pharmacology and toxicology. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011: 15-26.
    • (2011) New Technologies in Toxicity Testing , pp. 15-26
    • Stummann, T.C.1    Bremer, S.2
  • 47
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi T, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131(5):861-872.
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, T.1    Tanabe, K.2    Ohnuki, M.3
  • 48
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu J, Hu K, Smuga-Otto K et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009; 324(5928):797-801.
    • (2009) Science , vol.324 , Issue.5928 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3
  • 49
    • 80052880766 scopus 로고    scopus 로고
    • Industrialised production of human iPSCV-derived cardiomyocytes for use in drug discovery and toxicity testing
    • Anson B, Nuwaysir E, Wang WB et al. Industrialised production of human iPSCV-derived cardiomyocytes for use in drug discovery and toxicity testing. Biopharm Internat 2009; 24(3):58-67.
    • (2009) Biopharm Internat , vol.24 , Issue.3 , pp. 58-67
    • Anson, B.1    Nuwaysir, E.2    Wang, W.B.3
  • 50
    • 73449100456 scopus 로고    scopus 로고
    • Generation of functional human hepatic endoderm from human induced pluripotent stem cells
    • Sullivan GJ, Hay DC, Park IH et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 2010; 51(1):329-335.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 329-335
    • Sullivan, G.J.1    Hay, D.C.2    Park, I.H.3
  • 51
    • 77950654298 scopus 로고    scopus 로고
    • A step closer to complete chemical reprogramming for generating iPS cells
    • Solanki A, Lee KB. A step closer to complete chemical reprogramming for generating iPS cells. Chembiochem 2010; 11(6):755-757.
    • (2010) Chembiochem , vol.11 , Issue.6 , pp. 755-757
    • Solanki, A.1    Lee, K.B.2
  • 52
    • 77949408218 scopus 로고    scopus 로고
    • High-content screening-A decade of evolution
    • Thomas N. High-content screening-a decade of evolution. J Biomol Screen 2010; 15(1), 1-9.
    • (2010) J Biomol Screen , vol.15 , Issue.1 , pp. 1-9
    • Thomas, N.1
  • 53
    • 77956029024 scopus 로고    scopus 로고
    • A personal perspective on high-content screening (HCS): From the beginning
    • Taylor DL. A personal perspective on high-content screening (HCS): from the beginning. J Biomol Screen 2010; 15(7):720-725.
    • (2010) J Biomol Screen , vol.15 , Issue.7 , pp. 720-725
    • Taylor, D.L.1
  • 54
    • 79960860512 scopus 로고    scopus 로고
    • The use of genomics in model in vitro systems
    • Balls M, Combes R, Bhogal N, eds. Austin/New York: Landes Bioscience/Springer Science + Business Media
    • Casciano DA. The use of genomics in model in vitro systems. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin/New York: Landes Bioscience/Springer Science + Business Media, 2011:213-256.
    • (2011) New Technologies in Toxicity Testing , pp. 213-256
    • Casciano, D.A.1
  • 56
    • 77949878275 scopus 로고    scopus 로고
    • Physiologically-based simulation modelling for the reduction of animal use in the discovery of novel pharmaceuticals
    • Thomas S. Physiologically-based simulation modelling for the reduction of animal use in the discovery of novel pharmaceuticals. Altern Lab Anim-ATLA 2009; 37(5):497-511.
    • (2009) Altern Lab Anim-ATLA , vol.37 , Issue.5 , pp. 497-511
    • Thomas, S.1
  • 57
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart-from genes to cells to the whole organ
    • Noble D. Modeling the heart-from genes to cells to the whole organ. Science 2002; 295(5560):1678-1682.
    • (2002) Science , vol.295 , Issue.5560 , pp. 1678-1682
    • Noble, D.1
  • 58
    • 79551693584 scopus 로고    scopus 로고
    • Development and application of human virtual excitable tissues and organs from premature birth to sudden cardiac death
    • Holden AV. Development and application of human virtual excitable tissues and organs from premature birth to sudden cardiac death. Altern Lab Anim-ATLA 2010; 38(suppl. 1):87-99.
    • (2010) Altern Lab Anim-ATLA , vol.38 , Issue.SUPPL. 1 , pp. 87-99
    • Holden, A.V.1
  • 59
    • 72249115598 scopus 로고    scopus 로고
    • Use of virtual patient populations for rescuing discontinued drug candidates and for reducing the number of patients in clinical trials
    • Kleiman M, Sagi Y, Bloch N et al. (2009) Use of virtual patient populations for rescuing discontinued drug candidates and for reducing the number of patients in clinical trials. Altern Lab Anim-ATLA 2009; 37(suppl. 1):39-45.
    • (2009) Altern Lab Anim-ATLA , vol.37 , Issue.SUPPL. 1 , pp. 39-45
    • Kleiman, M.1    Sagi, Y.2    Bloch, N.3
  • 60
    • 33745004785 scopus 로고    scopus 로고
    • Biomarkers of cardiovascular disease-molecular basis and practical considerations
    • Vasan RS. Biomarkers of cardiovascular disease-molecular basis and practical considerations. Circulation 2006; 113(19):2335-2362.
    • (2006) Circulation , vol.113 , Issue.19 , pp. 2335-2362
    • Vasan, R.S.1
  • 61
    • 77953806557 scopus 로고    scopus 로고
    • Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: From experiments to computer simulations
    • Corrias A, Jie X, Romero L et al. Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations. Phil Trans Roy Soc A 2010; 368(1921):3001-3025.
    • (2010) Phil Trans Roy Soc A , vol.368 , Issue.1921 , pp. 3001-3025
    • Corrias, A.1    Jie, X.2    Romero, L.3
  • 62
    • 77952138048 scopus 로고    scopus 로고
    • Renal biomarker qualification submission: A dialog between the FDA-EMEA and Predictive Safety Testing Consortium
    • Dieterle F, Sistare F, Goodsaid F et al. Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium. Nat Biotechnol 2010; 28(5):455-462.
    • (2010) Nat Biotechnol , vol.28 , Issue.5 , pp. 455-462
    • Dieterle, F.1    Sistare, F.2    Goodsaid, F.3
  • 63
    • 84859983766 scopus 로고    scopus 로고
    • New developments in clinical imaging
    • Anon
    • Anon. New developments in clinical imaging. NGP Magazine, 2008:13. Available at: http://www.ngpharma. com/article/New-Developments-in-Clinical- Imaging.
    • (2008) NGP Magazine , vol.13
  • 64
    • 10044291608 scopus 로고    scopus 로고
    • Bioinformatics
    • Cronin B, ed. Medford: Information Today for ASIST
    • Benoit G. Bioinformatics. In: Cronin B, ed. Annual Review of Information Science and Technology. Medford: Information Today for ASIST 2005; 39:179-218.
    • (2005) Annual Review of Information Science and Technology , vol.39 , pp. 179-218
    • Benoit, G.1
  • 65
  • 66
    • 33748801463 scopus 로고    scopus 로고
    • Toward an evidence-based toxicology
    • Hoffmann S, Hartung T. Toward an evidence-based toxicology. Hum Exp Toxicol 2006; 25(9):497-513.
    • (2006) Hum Exp Toxicol , vol.25 , Issue.9 , pp. 497-513
    • Hoffmann, S.1    Hartung, T.2
  • 67
    • 84897514972 scopus 로고    scopus 로고
    • Integrated testing strategies and the prediction of toxic hazard
    • Cronin MTD, Madden JC, eds Cambridge Royal Society of Chemistry
    • Balls M. Integrated testing strategies and the prediction of toxic hazard. In: Cronin MTD, Madden JC, eds. In Silico Toxicology: Principles and Applications. Cambridge: Royal Society of Chemistry, 2010; 584-605.
    • (2010) Silico Toxicology: Principles and Applications , pp. 584-605
    • Balls, M.1
  • 68
    • 79960868438 scopus 로고    scopus 로고
    • Integrated testing strategies for toxicity employing new and existing technologies
    • Combes RD, Balls M. Integrated testing strategies for toxicity employing new and existing technologies. Altern Lab Anim-ATLA 2011; 39(3):213-225.
    • (2011) Altern Lab Anim-ATLA , vol.39 , Issue.3 , pp. 213-225
    • Combes, R.D.1    Balls, M.2
  • 69
    • 33748577206 scopus 로고    scopus 로고
    • Integrated testing strategies for use in the EU REACH system
    • Grindon C, Combes R, Cronin MTD et al. Integrated testing strategies for use in the EU REACH system. Altern Lab Anim-ATLA 2006; 34(4):407-427.
    • (2006) Altern Lab Anim-ATLA , vol.34 , Issue.4 , pp. 407-427
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 70
    • 41149150770 scopus 로고    scopus 로고
    • Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation
    • Combes R, Grindon C, Cronin MTD et al. Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation. Altern Lab Anim-ATLA 2008; 36(1):45-63.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.1 , pp. 45-63
    • Combes, R.1    Grindon, C.2    Mtd, C.3
  • 71
    • 34250000327 scopus 로고    scopus 로고
    • Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH legislation
    • Combes R, Grindon C, Cronin MTD et al. Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH legislation. Altern Lab Anim-ATLA 2007; 35(2):267-287.
    • (2007) Altern Lab Anim-ATLA , vol.35 , Issue.2 , pp. 267-287
    • Combes, R.1    Grindon, C.2    Mtd, C.3
  • 72
    • 57349096415 scopus 로고    scopus 로고
    • Integrated decision-tree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation
    • Grindon C, Combes R, Cronin MTD et al. Integrated decision-tree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation. Altern Lab Anim-ATLA 2008; 36(1):65-80.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.1 , pp. 65-80
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 73
    • 41149150239 scopus 로고    scopus 로고
    • An integrated decision-tree testing strategy for eye irritation with respect to the requirements of the EU REACH legislation
    • Grindon C, Combes R, Cronin MTD et al. An integrated decision-tree testing strategy for eye irritation with respect to the requirements of the EU REACH legislation. Altern Lab Anim-ATLA 2008; 36(1):81-92.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.1 , pp. 81-92
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 74
    • 41149121608 scopus 로고    scopus 로고
    • An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation
    • Grindon C, Combes R, Cronin MTD et al. An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation. Altern Lab Anim-ATLA 2008; 36(1):93-101.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.1 , pp. 93-101
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 75
    • 38649114341 scopus 로고    scopus 로고
    • Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation
    • Grindon C, Combes R, Cronin MTD et al. Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation. Altern Lab Anim-ATLA 2007; 35(6):673-682.
    • (2007) Altern Lab Anim-ATLA , vol.35 , Issue.6 , pp. 673-682
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 76
    • 38649099696 scopus 로고    scopus 로고
    • An integrated decision-tree testing strategy for skin sensitisation with respect to the requirements of the EU REACH legislation
    • Grindon C, Combes R, Cronin MTD et al. An integrated decision-tree testing strategy for skin sensitisation with respect to the requirements of the EU REACH legislation.Altern Lab Anim-ATLA 2007; 35(6):683-697.
    • (2007) Altern Lab Anim-ATLA , vol.35 , Issue.6 , pp. 683-697
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 77
    • 57349096415 scopus 로고    scopus 로고
    • Integrated decision-tree testing strategies for environmental toxicity with respect to the requirements of the EU REACH legislation
    • Grindon C, Combes R, Cronin MTD et al. Integrated decision-tree testing strategies for environmental toxicity with respect to the requirements of the EU REACH legislation. Altern Lab Anim-ATLA 2008; 36(suppl. 1):29-42.
    • (2008) Altern Lab Anim-ATLA , vol.36 , Issue.SUPPL. 1 , pp. 29-42
    • Grindon, C.1    Combes, R.2    Cronin, M.T.D.3
  • 78
    • 73949115799 scopus 로고    scopus 로고
    • Relevance of in vitro neurotoxicity testing for regulatory requirements: Challenges to be considered
    • Bal-Price AK, Hogberg HT, Buzanska L et al. Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered. Neurotoxicol Teratol 2010; 32(1):36-41.
    • (2010) Neurotoxicol Teratol , vol.32 , Issue.1 , pp. 36-41
    • Bal-Price, A.K.1    Hogberg, H.T.2    Buzanska, L.3
  • 79
    • 31544482732 scopus 로고    scopus 로고
    • The value of alternative testing for neurotoxicity in the context of regulatory needs
    • Coecke S, Eskes C, Gartlon J et al. The value of alternative testing for neurotoxicity in the context of regulatory needs. Environ Toxicol Pharmacol 2006; 21(2):153-167.
    • (2006) Environ Toxicol Pharmacol , vol.21 , Issue.2 , pp. 153-167
    • Coecke, S.1    Eskes, C.2    Gartlon, J.3
  • 80
    • 0037406978 scopus 로고    scopus 로고
    • Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing
    • Combes RD, Berridge T, Connelly J et al. Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing. Eur J Pharm Sci 2003; 19(1):1-11.
    • (2003) Eur J Pharm Sci , vol.19 , Issue.1 , pp. 1-11
    • Combes, R.D.1    Berridge, T.2    Connelly, J.3
  • 81
    • 79960857778 scopus 로고    scopus 로고
    • Luminescent quantum dots for molecular toxicology
    • Balls M, Combes R, Bhogal N, eds. Austin, TX, USA: Landes Bioscience
    • Dave SR, White CC, Kavanagh TJ et al. Luminescent quantum dots for molecular toxicology. In: Balls M, Combes R, Bhogal N, eds. New Technologies in Toxicity Testing. Austin, TX, USA: Landes Bioscience 2011: 118-138.
    • (2011) New Technologies in Toxicity Testing , pp. 118-138
    • Dave, S.R.1    White, C.C.2    Kavanagh, T.J.3
  • 82
    • 64849086385 scopus 로고    scopus 로고
    • In vitro models of inhalation toxicity and disease. The report of a frame workshop
    • BéruBé K, Aufderheide M, Breheny D et al. In vitro models of inhalation toxicity and disease. The Report of a FRAME Workshop. Altern Lab Anim-ATLA 2009; 37(1):89-141.
    • (2009) Altern Lab Anim-ATLA , vol.37 , Issue.1 , pp. 89-141
    • Bérubé, K.1    Aufderheide, M.2    Breheny, D.3
  • 83
    • 21844460852 scopus 로고    scopus 로고
    • Intelligent testing strategies for chemicals testing-A case of more haste, less speed?
    • Combes R, Balls M. Intelligent testing strategies for chemicals testing-A case of more haste, less speed? Altern Lab Anim-ATLA 2005; 33(3):289-297.
    • (2005) Altern Lab Anim-ATLA , vol.33 , Issue.3 , pp. 289-297
    • Combes, R.1    Balls, M.2
  • 84
    • 70449637644 scopus 로고    scopus 로고
    • Overcoming barriers to validation of non-animal partial replacement methods/integrated testing strategies: The Report of an EPAA-ECVAM Workshop
    • Kinsner-Ovaskainen A, Akkan Z, Casati S et al. Overcoming barriers to validation of non-animal partial replacement methods/integrated testing strategies: The Report of an EPAA-ECVAM Workshop. Altern Lab Anim-ATLA 2009; 37(4):437-444.
    • (2009) Altern Lab Anim-ATLA , vol.37 , Issue.4 , pp. 437-444
    • Kinsner-Ovaskainen, A.1    Akkan, Z.2    Casati, S.3
  • 85
    • 33748540237 scopus 로고    scopus 로고
    • Use of literature and surrogate safety data for notifications, HPV chemicals and biocides
    • Knight DJ, Poncipe C. Use of literature and surrogate safety data for notifications, HPV chemicals and biocides. Spec Chem Mag 2002; 22(10):28-29.
    • (2002) Spec Chem Mag , vol.22 , Issue.10 , pp. 28-29
    • Knight, D.J.1    Poncipe, C.2
  • 86
    • 79958018127 scopus 로고    scopus 로고
    • Alternatives for lung research: Stuck between a rat and a hard place
    • BéruBé K. Alternatives for lung research: stuck between a rat and a hard place. Altern Lab Anim- ATLA 2011; 39(2):121-130.
    • (2011) Altern Lab Anim- ATLA , vol.39 , Issue.2 , pp. 121-130
    • Bérubé, K.1
  • 87
    • 70349406480 scopus 로고    scopus 로고
    • Current concepts of mechanisms in drug-induced hepatotoxicity
    • Russmann S, Kullak-Ublick GA, Grattagliano I. Current concepts of mechanisms in drug-induced hepatotoxicity. Curr Med Chem 2009; 16:3041-3053.
    • (2009) Curr Med Chem , vol.16 , pp. 3041-3053
    • Russmann, S.1    Kullak-Ublick, G.A.2    Grattagliano, I.3
  • 88
    • 79551696589 scopus 로고    scopus 로고
    • Mind the gap
    • Aithal GP. Mind the gap. Altern Lab Anim-ATLA 2010; 38(suppl. 1):1-4.
    • (2010) Altern Lab Anim-ATLA , vol.38 , Issue.SUPPL. 1 , pp. 1-4
    • Aithal, G.P.1
  • 89
    • 72249109867 scopus 로고    scopus 로고
    • The use and value of in vitro technologies in metabolism studies
    • Doehmer J. The use and value of in vitro technologies in metabolism studies. Altern Lab Anim-ATLA 2009; 37(suppl. 1):29-32.
    • (2009) Altern Lab Anim-ATLA , vol.37 , Issue.SUPPL. 1 , pp. 29-32
    • Doehmer, J.1
  • 90
    • 13444273562 scopus 로고    scopus 로고
    • Recognising drug induced liver injury: Current problems, possible solutions
    • Lee WM, Senior JR. Recognising drug induced liver injury: current problems, possible solutions. Toxicol Pathol 2005; 33:155-164.
    • (2005) Toxicol Pathol , vol.33 , pp. 155-164
    • Lee, W.M.1    Senior, J.R.2
  • 91
    • 72449143623 scopus 로고    scopus 로고
    • An expert system approach to the assessment of hepatotoxic potential
    • Marchant CA, Fisk L, Note RR et al. An expert system approach to the assessment of hepatotoxic potential. Chem Biodivers 2009; 6:2107-2114.
    • (2009) Chem Biodivers , vol.6 , pp. 2107-2114
    • Marchant, C.A.1    Fisk, L.2    Note, R.R.3
  • 92
    • 79958019157 scopus 로고    scopus 로고
    • Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines-A report on the Vitrocellomics EU-project
    • Mandenius CF, Andersson TB, Alves PM et al. Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines-a report on the Vitrocellomics EU-project. Altern Lab Anim-ATLA 2011; 39:147-171.
    • Altern Lab Anim-ATLA , vol.2011 , Issue.39 , pp. 147-171
    • Mandenius, C.F.1    Andersson, T.B.2    Alves, P.M.3
  • 93
    • 79958007055 scopus 로고    scopus 로고
    • Anon Research Triangle Park: Hamner-UNC Institute for Drug Safety Sciences
    • Anon. The DILI-sim initiative. Research Triangle Park: Hamner-UNC Institute for Drug Safety Sciences, 2011: Available at: http://www.thehamner. org/content/DILI-sim-WebEx-4-7-2011.pdf.
    • (2011) The DILI-sim Initiative
  • 94
    • 79957984018 scopus 로고    scopus 로고
    • Anon Liverpool: MRC Centre for Drug Safety Studies
    • Anon. Drug-induced liver injury. Liverpool: MRC Centre for Drug Safety Studies, 2011: Available at: http://www.liv.ac.uk/drug-safety/research/ researchareas/liver-injury.htm.
    • (2011) Drug-induced Liver Injury
  • 95
    • 67649859295 scopus 로고    scopus 로고
    • HLA-B*5701 genotype is a majordeterminant of drug-induced liver injury due to flucloxacillin
    • Daly AK, Donaldson PT, Bhatnagar P et al. HLA-B*5701 genotype is a majordeterminant of drug-induced liver injury due to flucloxacillin. Nat Genet 2009; 41:816-819.
    • (2009) Nat Genet , vol.41 , pp. 816-819
    • Daly, A.K.1    Donaldson, P.T.2    Bhatnagar, P.3
  • 96
    • 77952697081 scopus 로고    scopus 로고
    • Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci
    • Gamazon ER, Huang RS, Cox NJ et al. Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. Proc Natl Acad Sci USA 2010; 107:9287-9292.
    • Proc Natl Acad Sci USA , vol.2010 , Issue.107 , pp. 9287-9292
    • Gamazon, E.R.1    Huang, R.S.2    Cox, N.J.3
  • 97
    • 77957232748 scopus 로고    scopus 로고
    • Genevar: A database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies
    • Yang TP, Beazley C, Montgomery SB et al. Genevar: A database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics 2010; 26:2474-2476.
    • (2010) Bioinformatics , vol.26 , pp. 2474-2476
    • Yang, T.P.1    Beazley, C.2    Montgomery, S.B.3
  • 98
    • 79957988797 scopus 로고    scopus 로고
    • Modern alternative approaches to the problem of drug-induced liver injury
    • Balls M. Modern alternative approaches to the problem of drug-induced liver injury. Altern Lab Anim- ATLA 2011; 39:103-107.
    • (2011) Altern Lab Anim- ATLA , vol.39 , pp. 103-107
    • Balls, M.1
  • 99
    • 77955919042 scopus 로고    scopus 로고
    • The application of metabonomics to predict drug-induced liver injury
    • OConnell TM, Watkins PB. The application of metabonomics to predict drug-induced liver injury. Clin Pharmacol Ther 2010; 88:394-399.
    • (2010) Clin Pharmacol Ther , Issue.88 , pp. 394-399
    • Oconnell, T.M.1    Watkins, P.B.2
  • 100
    • 80051665573 scopus 로고    scopus 로고
    • FDA-approved drug labeling for the study of drug-induced liver injury
    • in press
    • Chen M, Vijay V, Shi Q et al. FDA-approved drug labeling for the study of drug-induced liver injury. Drug Discov Today 2011; in press.
    • (2011) Drug Discov Today
    • Chen, M.1    Vijay, V.2    Shi, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.