Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles

Toxicology and Applied Pharmacology

Volumn 253, Issue 2, 2011, Pages 103-111

  de Jong, Esther ^a,b   Barenys, Marta ^c   Hermsen, Sanne A B ^a,b,d   Verhoef, Aart ^b   Ossendorp, Bernadette C ^b   Bessems, Jos G M ^b   Piersma, Aldert H ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UNIVERSITY OF BARCELONA   (Spain)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Alternative testing method; Embryonic stem cell test; Rat postimplantation whole embryo culture; Triazoles; Zebrafish embryotoxicity test

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; CYPROCONAZOLE; FLUSILAZOLE; HEXACONAZOLE; MYCLOBUTANIL; TRIADIMEFON; TRITICONAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; COMPARATIVE STUDY; CRANIOFACIAL MALFORMATION; DRUG POTENCY; EMBRYO; EMBRYO CULTURE; EMBRYONIC STEM CELL; EMBRYOTOXICITY; FEMALE; HEART MUSCLE CELL; MOUSE; NONHUMAN; RAT; TERATOGENICITY; TOXICITY TESTING; ZEBRA FISH;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; FEMALE; MICE; NITRILES; RATS; TRIAZOLES; ZEBRAFISH;

ANIMALIA; DANIO RERIO; RATTUS; RODENTIA;

EID: 79955604503     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.03.014     Document Type: Article

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