Developmental toxic effects of antifungal flusilazole administered by gavage to mice

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 80, Issue 1, 2007, Pages 12-17

  Farag, Amina Tolba ^a,b   Ibrahim, Hala H ^a  

^a Alexandria University   (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Developmental toxicity; Flusilazole; Mice; Skeletal malformations; Teratogenic effects

Indexed keywords

FLUSILAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHEMICAL TERATOGENESIS; DEVELOPMENTAL DISORDER; FEMALE; FETUS; FETUS GROWTH; FETUS MALFORMATION; FETUS WEIGHT; GROWTH RETARDATION; INCIDENCE; MALE; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; SKELETON MALFORMATION; TOXICITY TESTING; WEIGHT GAIN; WEIGHT REDUCTION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTIFUNGAL AGENTS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETUS; MALE; MICE; MICE, INBRED ICR; ORGAN SIZE; PREGNANCY; SILANES; TRIAZOLES;

MUS; ZEA MAYS;

EID: 33847206773     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20098     Document Type: Article

References (36)

1. Aliverti V, Bonanomi L, Giavini E, Leone VG, Mariani L. 1979. The extent of fetal ossification as an index of delayed development in teratogenic studies on the rat. Teratology 20:237-242.
2. 14C-DPX-H6573 in rats. Wilmington, DE: DuPont de Nemours and Co., Inc.
3. Ariyuki F, Higaki K, Yasuda M. 1980. A study of fetal growth retardation in teratological tests: an examination of the relationship between body weight and ossification of coccygeal vertebrae in mouse and rat fetuses. Teratology 22:43-49.
4. Ariyuki F, Ishihara H, Higaki K, Yasuda M. 1982. A study of fetal growth retardation in teratological tests: An examination of the relationship between body weight and ossification of the skeleton in rat fetuses. Teratology 26:263-267.
5. Brent RL. 2004. Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents). Pediatrics 113:984-995.
6. Buchenauer H. 1987. Mechanism of action of triazole fungicides and related compounds. In: Lyr H, editor. New York: Wiley. p 205-231.
7. Chahoud L, Paumgartten FJR. 2005. Relationships between fetal body weight of Wistar rats at term and the extent of skeletal ossification. Braz J Med Biol Res 38:565-575.
8. 14C] DPX-H6573. Wilmington, DE: Haskell Laboratory for Toxicology and Industrial Medicine.
9. Committee on Developmental Toxicology. 2000. Board on environmental studies and toxicology. Washington, DC: National Academy Press. p 58-84.
10. Food and Agriculture Organization. 1981. FAO plant and protection papers. 42. Pesticide residues in food-Evaluations, p 521-523.
11. Food and Agriculture Organization. 1983. FAP plant and protection papers. 61. Pesticide residues in food-Evaluations, p 447-450.
12. Food and Agriculture Organization. 1989. Plant and protection papers. 100/2 Pesticide residues in food -Evaluations. Part II: Toxicology. p 117-139.
13. Hayes WJ. 1994. Pesticides studies in man. Baltimore: Williams and Wilkins.
14. Hollingsworth J. 1995. Fungicide studies offer little comfort. A Medical Mystery. Tampa, FL: Tampa Tribune Press, p 4.
15. Lamontia CL, Staples RE, Alvarez L. 1984. Embryo-fetal toxicity and teratogenicity study of INH-6573-39 by gavage in the rat. Wilmington, DE: Haskell Laboratory for Toxicology and Industrial Medicine.
16. Lehmann EL. 1975. Nonparametrics: statistical methods based on ranks. San Francisco: Holden-Day
17. Machemer L. 1976. Evaluation of embryotoxic and teratogenic effects on rats following oral administration. Wuppertal-Elberfeld, Germany: Bayer AG.
18. Machera K. 1995. Developmental toxicity of cyproconazole, an inhibitor of fungal ergosterol biosynthesis, in the rat. Bull Environ Contam Toxicol 54:363-369.
19. Menegola E, Broccia ML, Di Renzo F, Giavini E. 2001. Antifungal triazoles induce malformations in vitro. Reprod Toxicol 15:421-427.
20. Menegola E, Broccia ML, Di Renzo F, Massa V, Giavini E. 2005. Study on the common teratogenic pathway elicited by the fungicides triazole-derivatives. Toxicol In Vitro 19:737-748.
21. Norusis M. 1994. Statistical package for social sciences, Version 6 SPSS. New York: McGraw-Hill.
22. Peters PWJ. 1965. Double staining of fetal skeletons for cartilage and bone. In: Wilson JG, Wurkany J, editors. Chicago: University of Chicago Press. 153p.
23. Salewski E. 1964. Staining method tor a macroscopic test for implantation points in the uterus of the rat. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 247:367.
24. Simes RJ. 1986. An improved Bonferroni procedure for multiple tests of significance. Biometrika 73:751-754.
25. Solomon HM, Alvarez L, Staples RE, Hamill JC. 1984. Developmental toxicity study in rabbits given INH-6573 by gavage on days 7-19 of gestation. Wilmington, DE: Haskell Laboratory for Toxicology and Industrial Medicine.
26. Trösken ER, Main FA. 2005. Toxicological evaluation of azole fungicides in agriculture and food chemistry. Dissertation zur Erlangung des naturwissenschaftlichen Doktorgrades der Bayerischen Julius-Maximilians- Universität Würzburg.
27. Vanden Bossche H, Lauvers W, Willemsens G, Marichal P, Cools W. 1984. The molecular basis for the antifungal activities of N-substituted azole derivatives. In: Trinci A, Ryles J, editors. British Mycological Society Press, p 321-341.
28. Vergieva T 1990. Triazoles teratogenicity in rats. Teratology 42:27A-28A.
29. Walpole RE, Meyers RH. 1978. Probability and statistics for engineers and scientists. New York: McMillan.
30. Waterman MR, Lepesheva GI. 2005. Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase. Biochem Biophys Res Commun 338:418-422.
31. Wilson JG, Warkany J. 1965. Teratology: principles and techniques. Chicago: University of Chicago Press.
32. Winer BJ. 1971. Statistical principles in experimental design. New York: McGraw-Hill.
33. Wylie CN, Redgate D, Warheit DB, Chromey NC. 1985. Approximate lethal dose (ALD) of INH-6573-66 in male and female mice.
34. Wilmington, DE: Haskell Laboratory for Toxicology and Industrial Medicine.
35. Yoshida Y. 1988. Cytochrome P450 of fungi: primary target for azole antifungal agents. Curr Top Med Mycol 2:388-418.
36. Zarn JA, Bruschweiler BJ, Schlatter JR. 2003. Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase. Environ Health Perspect 111:255-262.