Human health risk assessment of endosulfan. I: Toxicology and hazard identification

Regulatory Toxicology and Pharmacology

Volumn 56, Issue 1, 2010, Pages 4-17

  Silva, Marilyn H ^a   Beauvais, Sheryl L ^a  

^a CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Critical NOEL NOAEL; Endosulfan; FQPA; Hazard identification; LOEL LOAEL; Risk assessment

Indexed keywords

CHOLINESTERASE; ENDOSULFAN;

ACUTE TOXICITY; ARTICLE; AUTISM; BIOACCUMULATION; BIOTRANSFORMATION; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CHRONIC TOXICITY; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; GENOTOXICITY; HAZARD ASSESSMENT; HEALTH HAZARD; HUMAN; INHALATION; NEUROTOXICOLOGY; NONHUMAN; OCCUPATIONAL EXPOSURE; PESTICIDE SPRAYING; PRENATAL EXPOSURE; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; SEXUAL MATURATION; UNITED STATES; VERTICAL TRANSMISSION;

ANIMALS; CALIFORNIA; ENDOSULFAN; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INSECTICIDES; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RABBITS; RATS; REFERENCE STANDARDS; RISK ASSESSMENT; STATE GOVERNMENT; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 75549086867     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.08.013     Document Type: Article

References (124)

1. Abalis I.M., Eldefrawi M.E., Eldefrawi A.T. Effects of insecticides on GABA-induced chloride influx into rat brain microsacs. J. Toxicol. Environ. Health 1986, 18:13-23.
2. Abraham C.C. Endosulfan's effects: omissions and flawed data. Environ. Health Perspect. 2004, 112(10):A538.
3. ACGIH, 2007. Substances and Physical Agents and Biological Exposure Indices, Cincinnati, OH.
4. Adams J.F. Mutagenicity of some environmental chemicals in Salmonella test systems without microsomal activation. Mutat. Res. 1978, 53(2):142-143.
5. Ansari R.A., Husain K., Gupta P.K. Endosulfan toxicity influence on biogenic amines of rat brain. J. Environ. Biol. 1987, 8(3):229-236.
6. Arnold, D., 1972. Mutagenic Study with Thiodan in Albino Mice. Industrial Bio-Test Laboratories, Inc. Department of Pesticide Regulation Volume/record: 182-042 #047309. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
7. Bajpayee M., Pandey A.K., Zaidi S., Musarat J., Parmar D., Mathur N., Seth P.K., Dhawan A. DNA damage and mutagenicity induced by endosulfan and its metabolites. Environ. Mol. Mutagen. 2006, 47(9):682-692.
8. Barnard, A.V., Jones, D.R. Barnard, A.V., Jones, D.R., Powell, L.A.J., Heywood, R., Street, A.E., Gibson, W.A., Gopenath, C., Majeed, S.K., Almond, R., 1985. 13-Week Toxicity Study in Mice. Huntingdon Research Centre, England. Department of Pesticide Regulation Volume/record: 182-032 #035803. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
9. Beauvais S.L., Silva M.H., Powell S. Human health risk assessment of endosulfan. III: Occupational handler exposure and risk. Regul. Toxicol. Pharmacol. 2009, 56:28-37.
10. Beauvais S.L., Silva M.H., Powell S. Human health risk assessment of endosulfan. IV: Occupational reentry and public non-dietary exposure and risk. Regul. Toxicol. Pharmacol. 2009, 56:38-50.
11. Bebe F.N., Panemangalore M. Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous antioxidants in tissues of rats. J. Environ. Sci. Health B 2003, B38(3):349-363.
12. Birth Defects Prevention Act, 1994. California Senate Bill 950, 1984: Birth Defect Prevention Act (SB950). Article 14, Statutes: 13121-13133 of the California Food and Agriculture Code, Sacramento, CA (Chapter 2).
13. Brunk, R., 1989. Testing for Toxicity by Repeated Oral Administration (1-year Feeding Study) to Beagle Dogs. Hoechst Asktiengesellschaft, Pharma Research, Toxicology and Pathology, Report #: 6230 Frankfurt, Germany. Department of Pesticide Regulation Volume/record: 182-065 #074850. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
14. Bury, D., 1997. Neurotoxicological Screening in the Male and Female Wistar Rat; Acute Oral Toxicity. Hoechst Marion Roussel, Preclinical Development Germany, Drug Safety, FRG. CDPR Department of Pesticide Regulation Volume/record: 182-106 #162457. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
15. Campoy C., Jiménez M., Olea-Serrano M.F., Moreno-Frías M., Cañabate F., Olea N., Bayés R., Molina-Font J.A. Analysis of organochlorine pesticides in human milk: preliminary results. Early Human Dev. 2001, 65(Suppl.):S183-S190.
16. Carrera G.P., Fernandez J.O., Grimalt M., Ventura L., Camarero J., Catalan U., Nikus H., Thies H., Psenner R. Atmospheric deposition of organochlorine compounds to remote high mountain lakes of Europe. Environ. Sci. Technol. 2002, 36(12):2581-2588.
17. Castillo C.G., Montante M., Dufour L., Martinez M.L., Jiménez-Capdeville M.E. Behavioral effects of exposure to endosulfan and methyl parathion in adult rats. Neurotoxicol. Teratol. 2002, 24:797-804.
18. CDPR, 2008. Department of Pesticide Regulation, Medical Toxicology Branch Toxicology Summary for Endosulfan. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
19. Cerrillo I., Granada A., López-Espinosa M., Olmos B., Jiménez M., Caño A., Olea N., Olea-Serrano M. Endosulfan and its metabolites in fertile women, placenta, cord blood and human milk. Environ. Res. 2005, 98:233-239.
20. Chan P.L., Morisawa S., Nakayama A., Kawamoto Y., Sugimoto M., Yoneda M. Toxicokinetics of 14C-endosulfan in male Sprague-Dawley rats following oral administration of single or repeated doses 2005, Wiley Periodicals, Inc., Wiley InterScience, Available from:. doi:10.1002/tox.20142.
21. Chaudhuri K., Selvaraj S., Pal A.K. Studies on the genotoxicity of endosulfan in bacterial systems. Mutat. Res. 1999, 439:63-67.
22. Christensen C. Memorandum: A review of " Maternal Residence near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley" by Roberts et al., 2007. Environ. Health Perspect. 2007, 115(10):1482-1489. Generated by the Office of Prevention, Pesticides and Toxic Substances, USEPA, October 18, 2007 DP Barcode D342660. Available from: .
23. Cifone, M., 1983. Micronucleus Test in Male and Female NMRI Mice Following Oral Administration. Department of Pesticide Regulation Volume/record: 182-025 #035794. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
24. Cifone, M. (Litton Bionetics, Inc.), 1984a. Mutagenicity Evaluation of HOE 002671-substance Technical in the Mouse Lymphoma Forward Mutation Assay. Final report. DPR Volume/record: 182-025 #035792.
25. Cifone, M., 1984b. Evaluation of HOE 002671-substance Technical in the Rat Primary Hepatocyte Unscheduled DNA Synthesis Assay. Final report. Litton Bionetics, Inc. Department of Pesticide Regulation Volume/record: 182-025 #035793. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
26. Cole L.M., Casida J.E. Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore. Life Sci. 1986, 39:1855-1862.
27. Craine, E.M., 1988. A Dermal Absorption Study in Rats with 14C-endosulfan with Extended Test Duration. (Hoechst AG) Department of Pesticide Regulation Volume/record: 182-060 #073679. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
28. Dalsenter P.R., Dallegrave E., Mello J.R.B., Langeloh A., Oliveira R.T., Faqi A.S. Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation. Hum. Exp. Toxicol. 1999, 18:583-589.
29. Dalsenter P.R., de Araújo S.L., de Assis H.C., Andrade A.J.M. Pre and postnatal exposure to endosulfan in Wistar rats. Hum. Exp. Toxicol. 2003, 22:171-175.
30. Daniel C.S., Agarwal S., Agarwal S.S. Human red blood cell membrane damage by endosulfan. Toxicol. Lett. 1986, 32:113-118.
31. Dikshith, T.S.S., Datta, K.K., 1977. Cytogenetic studies of endosulfan in male rats. In: Environmental Pollution and Human Health. Proceedings of the International Symposium on Industrial Toxicology, November 4-7, 1975, pp. 578-589.
32. Dikshith T.S.S., Nath G., Datta K.K. Combined cytogenetic effects of endosulfan and metepa in male rats. Indian J. Exp. Biol. 1978, 16:1000-1002.
33. Dikshith T.S.S., Raizada R.B., Srivastava M.K., Kaphalia B.S. Response of rats to repeated oral administration of endosulfan. Indian Health 1984, 22:295-304.
34. Donaubauer, H.H., 1988. Carcinogenicity Study in Mice, 24 Month Feeding Study. Environmental Pollution and Human Health. Environmental Pollution and Human Health. Department of Pesticide Regulation Volume/record: 182-064 #075035. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
35. Dorough H.W., Huhtanen K., Marshall T.C., Bryant H.E. Fate of endosulfan in rats and toxicological considerations of apolar metabolites. Pestic. Biochem. Physiol. 1978, 8:241-252.
36. Dubois M., Pfohl-Leszkowicz A., DeWaziers I., Kremers P. Selective induction of the CYP3a family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells. Environ. Toxicol. Pharmacol. 1996, 1(4):249-256.
37. Dzwonkowska A., Hubner H. Induction of chromosomal aberrations in the Syrian hamster by insecticides tested in vivo. Arch. Toxicol. 1986, 58:152-156.
38. Ebert, E., Leist, K.H., Kramer, A., 1985a. Testing for Subchronic Dermal Toxicity (21 applications over 30 days) in Wistar Rats (Report of 2/22/85). Hoechst AG, Germany. Department of Pesticide Regulation Volume/record: 182-030 #035081. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
39. Ebert, E., Weigand, W., Kramer, A., 1985b. Testing for Subchronic Dermal Toxicity (21 applications over 30 days) in SPF Wistar Rats (Report of 3/11/85). Hoechst AG, Germany. Department of Pesticide Regulation Volume/record: 182-029 #035800. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
40. Edwards, J.A., Reid, Y.J., Offu, J.M., Almond, R.H., Gibson, W.A., 1984. Effect of Endosulfan-technical (Code: HOE 02671 0 I AT209) on Reproductive Function of Multiple Generations in the Rat. Department of Pesticide Regulation Volume/record: 182-022 #035789. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
41. Erdreich, L., Morimoto, L., 2007. Endosulfan Critical Review of Epidemiological Study " Maternal residence near agricultural pesticide applications and autism sprectum disorders among children in the California Central Valley." Makhteshim-Agan of North America Inc., Raleigh, NC 27609. Report ID: AOTO 0807 LEO1; Department of Pesticide Regulation Volume/record: 182-128 #235849. Department of Pesticide Regulation, Sacramento, CA.
42. Fabacher D.L., Kulkarni A.P., Hodgson E. Pesticides as inducers of hepatic drug-metabolizing enzymes - I. Mixed function oxidase activity. Gen. Pharmacol. 1980, 11:429-435.
43. Fahrig, R., 1974. In: Nontesano, R., Tomatis, L. (Eds.), Comparative Mutagenicity Studies with Pesticides. Proceedings of a Workshop on Approaches to Assess the Significance of Experimental Chemical Carcinogenesis Data for Man, Brussels, Belgium, December 10-12, 1973. Lyons, France, International Agency for Research on Cancer (XIV+pp. 230 Illus.), pp. 161-181 (Scientific Publications, No. 10, Chemical Carcinogenesis Essays).
44. Fan, S., 2008. Endosulfan Risk Characterization Document, Volume III: Environmental Fate. Environmental Monitoring Branch, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/emon/pubs/tac/finaleval/endosulfan.htm.
45. Ffrench-Constant R.H. The molecular and population genetics of cyclodiene insecticide resistance. Insect Biochem. Mol. Biol. 1993, 24:335-345.
46. Flodstrom S., Warngard L., Himming H., Fransson R., Ahlborg U.G. Tumour promotion related effects by the cyclodiene insecticide endosulfan studied in vitro and in vivo. Pharmacol. Toxicol. 1988, 62:230-235.
47. Food Quality Protection Act, 1996. Public Law 104-170 (August 3, 1996).
48. Food Safety Act, 1989. California Assembly Bill 2161, 1989: AB2161; Article 14, Statute #: 13134-13135 of the California Food and Agriculture Code, Sacramento, CA (Chapter 2).
49. Fransson-Steen R., Warngard L. Inhibitory effects of endosulfan on gap junctional intercellular communication in WB-F344 rat liver cells and primary rat hepatocytes. Carcinogenesis 1992, 13(4):657-662.
50. Fransson-Steen R., Flodstrom S., Warngard L. The insecticide endosulfan and its two stereoisomers promote the growth of altered hepatic foci in rats. Carcinogenesis 1992, 13(12):2299-2303.
51. Fung, W.-P., 1981a. Final Report. Range-finding Study with FMC 5462 in Pregnant Rabbits. Department of Pesticide Regulation Volume/record: 182-041 #045582. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
52. Fung, W.-P., 1981b. Range-finding Study with FMC 5462 in Pregnant Rabbits (Supplier: Dutchland Laboratories, Inc.) Raltech Study #: 79032. Department of Pesticide Regulation Volume/record: 182-057 #060604. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
53. Fung, W.-P., 1980a. Range-finding Study with FMC 5462 in Pregnant Rats. Department of Pesticide Regulation Volume/record: 182-057 #060605. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
54. Fung, W-P., 1980b. Teratology study with FMC rats. Department of Pesticide Regulation Volume/record: 182-026 and 057, #017686 and 060606. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
55. Gant D.B., Eldefrawi M.E., Eldefrawi A.T. Cyclodiene insecticides inhibit GABA receptor-regulated chloride transport. Toxicol. Appl. Pharmacol. 1987, 88:313-321.
56. Gilmore, R.G., Sheets, L.P., Hoss, H.E., 2006. A Developmental Neurotoxicity Study with Technical Grade Endosulfan in Wistar Rats. Bayer CropScience LP, KS. Department of Pesticide Regulation Volume/record: 182-122 #228573. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
57. Gorbach S.G., Christ O.E., Kellner H., Kloss G., Borner E. Metabolism of endosulfan in milk sheep. J. Agric. Food Chem. 1968, 16:950-953.
58. Health Canada, 2007. Preliminary Risk and Value Assessments of Endosulfan. Pest Management Regulatory Agency, Health Canada, Ottawa, Ont., October 16, 2007. Available from: . http://www.pmra-arla.gc.ca/english/pubs/rev-e.html.
59. Hollander, H., Weigand, W., 1983. Testing for Acute Aerosol Inhalation Toxicity in Male and Female SPF Wistar Rats. 4 hours - LC50. Hoechst AG, Germany. Department of Pesticide Regulation Volume/record: 182-089 #128477. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
60. Hollander, H., Weigand, W., Kramer, P., 1984. Endosulfan, Active Ingredient Technical: Testing for Subchronic Inhalation Toxicity (21 exposures in 29 days) in SPF Wistar Rats. Hoechst AG, Germany. Department of Pesticide Regulation Volume/record: 182-084 #126577. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
61. Indulkar A.S. Endosulfan's effects: inaccurate data. Environ. Health Perspect. 2004, 112(10):A538-A539.
62. IPEN, 2008. International Persistent Organic Pesticide Elimination Network. Available from: . http://www.ipen.org/ipenweb/poprc/newpops.html.
63. Kurinnyi A.I., Pilinskaya M.A., German I.V., L'vova T.S. Implementation of a program of cytogenetic study of pesticides. Tsitol. Genet. 1982, 16(1):45-49.
64. Kushwah H.S., Dikshith T.S.S. In vivo and in vitro response to endosulphan vis-a-vis cholinergic phenomenon. Indisan J. Biochem. Biophys. 1981, 18(Suppl.):152.
65. Lawrence L.J., Casida J.E. Interactions of lindane, toxaphene and cyclodienes with brain specific t-butylcyclophosphorothionate receptor. Life Sci. 1984, 35:171-178.
66. Lee H.-K., Moon J.-K., Chang C.-H., Choi H., Park H.-W., Park B.-S., Lee H.-S., Hwang E.-C., Lee Y.-D., Liu K.-H., Kim J.-H. Stereoselective metabolism of endosulfan by human liver microsomes and human cytochrome P450 isoforms. Drug Metabol. Dispos. 2006, 34(7):1090-1095.
67. Lu Y., Morimoto K., Takeshita T., Takeuchi T., Saito T. Genotoxic effects of α-endosulfan and β-endosulfan on human HeoG2 cells. Environ. Health Perspect. 2000, 108(6):559-561.
68. L'vova T.S. Study of the mutagenic effect of five promising pesticides on mouse bone marrow, cultured human peripheral blood lymphocytes, and saccharomycetes. Tsitol. Genet. 1984, 18(6):455-457.
69. Maier-Bode H. Properties, effect, residues and analytics of the insecticide endosulfan. Residue Rev. 1968, 22:1-44.
70. McGregor D.B., Brown A., Cattanach P., Edwards I., McBride D., Riach C., Caspary W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: 72 coded chemicals. Environ. Mol. Mutagen. 1988, 12:85-154.
71. Mellano, D. (Instituto di Richerche Biomediche), 1984. Study of the Mutagenic Activity " In Vitro" of the Compound Endosulfan B Technical. Department of Pesticide Regulation Volume/record: 182-025 #035796. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
72. Milone, M.F., Hirsch, I.E. (Instituto di Ricerche Biomediche), 1986. Endosulfan (technical): Chromosome Aberration in Human Lymphocytes Cultured " In Vitro." Department of Pesticide Regulation Volume/record: 182-042 #048638. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.dpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
73. Moriya M., Ohta T., Watanabe K., Miyazawa T., Kato K., Shirasu Y. Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutat. Res. 1983, 116:185-216.
74. Naqvi S.M., Vaishnavi C. Mini review. Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals. Comp. Biochem. Physiol. C 1993, 105(3):347-361.
75. NRC (National Research Council) Risk Assessment in the Federal Government: Managing the Process. Committee on the Institutional Means for Assessment of Risks to Public Health, Commission of Life Sciences, NRC 1983, National Academy Press, Washington, DC.
76. NRCC, 1975. Endosulfan: Its Effects on Environmental Quality. National Research Council Canada, Environmental Secretariat, Ottawa, Ont., Publication #: NRCC 14098.
77. NTP (National Toxicology Program), 2007. Bioassay of Endosulfan for Possible Carcinogenicity. Available from: . http://www.ntp.niehs.hih.gov.
78. Nye, D., 1981. Teratology Study with FMC 5462 in Rabbits. Department of Pesticide Regulation Volume/record: 182-027 and 057, #035798 and 060607. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
79. Olea N., Barba A., Lardelli P., Rivas A., Olea-Serrano M.F. Inadvertent exposure to xenoestrogens in children. Toxicol. Ind. Health 1999, 15:151-158.
80. Ozoe Y., Matsumura F. Structural requirements for bridged bicyclic compounds acting on picrotoxinin receptor. J. Agric. Food Chem. 1986, 34:126-134.
81. PANNA, 2008. Endosulfan Monograph. Available from: . http://www.panna.org/files/PAN%20Int%20Endosulfan%20Monograph.pdf.
82. Pednekar M.D., Gandhi S.R., Netrawali M.S. Evaluation of mutagenic activities of endosulfan, phosalone, malathion and permethrin, before and after metabolic activation in the Ames Salmonella test. Bull. Environ. Contam. Toxicol. 1987, 38:925-933.
83. Quinto I., Martire G., Vricella G., Riccardi F., Perfumo A., Giulivo R., De Lorenzo F. Screening of 24 pesticides by Salmonella/microsome assay: mutagenicity of benazolin, metoxuron and paraoxon. Mutat. Res. 1981, 85:265.
84. Roberts E.M., English P.B., Grether J.K., Windham G.C., Somberg L., Wolff C. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley. Environ. Health Perspect. 2007, 115(10):1482-1489.
85. Ruch R.J., Fransson R., Flodstrom S., Warngard L., Klaunig J.E. Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chordane and heptachlor. Carcinogenesis 1990, 11(7):1097-1101.
86. Ruckman, S.A., Waterson, L.A., Crook, D., Gopinath, C., Majeed, S.K. Anderson, A., Chanter, D.O., 1989. Combined Chronic Toxicity/carcinogenicity Study 104-week Feeding in Rats. Department of Pesticide Regulation Volume/record: 182-066 #074851. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
87. Saiyed H., Dewan A., Bhatnagar V., Shenoy U., Shenoy R., Rajmohan H., Patel K., Kashyap R., Kulkarni P., Rajan B., Lakkad B. Effect of endosulfan on male reproductive development. Environ. Health Perspect. 2003, 111(16):1958-1962.
88. Seth P.K., Saidi N.F., Agrawal A.K., Anand M. Neurotoxicity of endosulfan in young and adult rats. Neurotoxicology 1986, 7(2):623-635.
89. Sharma A.K., Gautam D.C. Chromosomal aberrations induced by phosphamidon and endosulfan in the bone marrow cells of mice in vivo. Cytologia 1991, 56:71-78.
90. Sheets, L.P., Gilmore, R.G., Fickbohm, B.L., 2004. A Subchronic Neurotoxicity Screening Study with Technical Grade Endosulfan in Wistar Rats, Bayer CropScience LP, Toxicology, Stilwell, KS; Lab ID#: 02-N72MJ; Report #: 201069; Report ID#: B004881. Department of Pesticide Regulation Volume/record: 182-127 #234702. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
91. Shirasu, Y., Moriya, M., Ohta, T. (Hoechst Japan Limited--Institute of Environmental Toxicology, Japan), 1978. Microbial Mutagenicity Testing on Endosulfan. Department of Pesticide Regulation Volume/record: 182-042 #047306. Department of Pesticide Regulation, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/risk/toxsums/pdfs/259.pdf.
92. Shirasu Y., Moriya M., Tzuka H., Teramoto S., Ohta T., Inoue T. Mutagenicity screening studies on pesticides. Environmental Mutagens and Carcinogens 1982, 331-335. A.R. Liss, New York. T. Sugimura, S. Kondo, H. Takebe (Eds.).
93. Siddiqui M.K.J., Anjum F., Qadri S.S.H. Some metabolic changes induced by endosulfan in hepatic and extra hepatic tissues of rat. J. Environ. Sci. Health 1987, B22:553-564.
94. Silva, M.H., 2008. Endosulfan: Risk Characterization Document. Medical Toxicology and Worker Health and Safety Branches, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA. Available from: . http://www.cdpr.ca.gov/docs/emon/pubs/tac/finaleval/endosulfan.htm.
95. Silva M.H., Carr W.C. Human health risk assessment of endosulfan. II: Dietary exposure assessment. Regul. Toxicol. Pharmacol. 2009, 56:18-27.
96. Silva M.H., Gammon D. An assessment of developmental, reproductive and neurobehavioral toxicology of endosulfan. Birth Defects Res. B 2009, 86(1):1-28.
97. Singh S.K., Pandey R.S. Differential effects of chronic endosulfan exposure to male rats in relation to hepatic drug metabolism and androgen formation. Indian J. Exp. Biol. 1989, 26:262-267.
98. Singh S.K., Pandey R.S. Toxicity of endosulfan on kidney of male rats in relation to drug metabolizing enzymes and microsomal lipid peroxidation. Indian J. Exp. Biol. 1989, 27:725-728.
99. Singh S.K., Pandey R.S. Ethanol potentiates in vivo hepatoxicity of endosulfan in adult male rats. Indian J. Exp. Biol. 1991, 29:1035-1038.
100. Sinha N., Narayan R., Shanker R., Saxena D.K. Endosulfan-induced biochemical changes in the testis of rats. Vet. Hum. Toxicol. 1995, 37(6):547-549.
101. Sinha N., Narayan R., Saxena D.K. Effect of endosulfan on the testis of growing rats. Bull. Environ. Contam. Toxicol. 1997, 58(1):79-86.
102. Sinha N., Adhikari N., Saxena D.K. Effect of endosulfan during fetal gonadal differentiation on spermatogenesis in rats. Environ. Toxicol. Pharmacol. 2001, 10:29-32.
103. Sobti R.C., Krishan A., Davies J. Cytokinetic and cytogenetic effect of agricultural chemicals on human lymphoid cells in vitro. Arch. Toxicol. 1983, 52:221-231.
104. Suntio L.R., Shiu W.Y., Glotfelty D., MacKay D., Seiber J.N. Critical review of Henry's Law constants for pesticides. Rev. Environ. Contam. Toxicol. 1988, 103:1-59.
105. Toledo M.C.F., Jonsson C.M. Bioaccumulation and elimination of endosulfan in zebra fish (Brachydanio rerio). Pesticide Sci. 1992, 36:207-211.
106. Toxic Air Contaminants Act, 1983. California Assembly Bill 1807, 1983: AB 1807. Air pollution: Toxic Air Contaminants, pp. 29-47 (Chapter 1047).
107. Tyagi S.R., Singh Y., Srivastave P.K., Misra U.K. Induction of hepatic mixed function oxidase system by endosulfan in rats. Bull. Environ. Contam. Toxicol. 1984, 32:550-556.
108. USEPA, 1997. The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and Federal Food, Drug, and Cosmetic Act (FFDCA) as Amended by the Food Quality Protection Act (FQPA) of August 3, 1996. Document No. 730L97001, March 1997. Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC. Available from: . http://www.epa.gov/opptsfrs/home/testmeth.htm.
109. USEPA, 1998. Health Effects Test Guidelines, OPPTS 870.1000. EPA 712-C-98-189, Prevention, Pesticides and Toxic Substances (7101), United States Environmental Protection Agency.
110. USEPA, 2000. Toxicological Profile for Endosulfan. U.S. Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry. Available from: . http://www.atsdr.cdc.gov/toxprofiles/tp41.html.
111. USEPA, 2002. Reregistration Eligibility Decision for Endosulfan. Case 0014. Office of Prevention, Pesticides and Toxic Substances, U.S. Environmental Protection Agency, Washington, DC. Available from: . http://www.epa.gov/oppsrrd1/REDs/endosulfan_red.pdf.
112. USEPA, 2004. An Examination of EPA Risk Assessment Principles and Practices: Staff Paper Prepared for the U.S. Environmental Protection Agency by Members of the Risk Assessment Task Force. Office of the Science Advisor, USEPA, Washington, DC.
113. USEPA, 2007a. OPPTS Harmonized Test Guidelines Series 870 Health Effects Test Guidelines Final Guidelines. June 21, 2007. Available from: . http://www.epa.gov/opptsfrs/publications/OPPTS_Harmonized/870_Health_Effects_Test_Guidelines/Series/.
114. USEPA, 2007b. Endosulfan. Hazard Characterization and Endpoint Selection Reflecting Receipt of a Developmental Neurotoxicity Study and Subchronic Neurotoxicity Study. PC Code: 079401. DP Barcode D338576. Reaves, E., Washington, DC: Office of Prevention, Pesticides a Toxic Substances, U.S. Environmental Protection Agency. April 7, 2007. Available from: . http://www.epa.gov/pesticides/reregistration/endosulfan/.
115. USEPA, 2009. Overview of Risk Assessment in the Pesticide Program. U.S. Environmental Protection Agency. Updated January 29, 2009. Available from: . http://www.epa.gov/pesticides/about/overview_risk_assess.htm.
116. Usha, S., Harikrishnan, V.R., 2005. IPEN Pesticide Working Group Project 2004. Endosulfan - Fact Sheet and Answers to Common Questions. IPEN Pesticide Working Group Secretariat, Kerala, India. Available from: . http://www.thanal.org.
117. Usha Rani M.V., Reddy P.P. Cytogenetic effects of aldrin and endosulfan in mice. IRSC Med. Sci. 1986, 14:1125-1126.
118. Usha Rani M.V., Reddi O.S., Reddy P.P. Mutagenicity studies involving aldrin, endosulfan, dimethoate, phosphamidon, carbaryl and ceresan. Bull. Environ. Contam. Toxicol. 1980, 25:277-282.
119. Velazquez A., Creus A., Xamena N., Marcos R. Mutagenicity of the insecticide endosulfan in Drosophila Melanogaster. Mutat. Res. 1984, 136:115-118.
120. Ware, G.W., 1994. Insecticides. In: The Pesticide Book. Thomson Publications, Fresno, CA, pp. 44-46 (Chapter 4).
121. WHO, 1998. Endosulfan. International Programme on Chemical Safety. Health and Safety Guide #17, Geneva, Switzerland: World Health Organization. Available from: . http://www.wpro.who.int/NR/rdonlyres/A68749B9-8F06-4361-BCDC-E74FAAF12912/0/Endosulfan_HSG1_1998.pdf.
122. WHO, 2006. Endosulfan. Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade Chemical Review Committee; Second Meeting, Geneva, 13-17 February 2006.
123. Yadav A.S., Vashishat R.K., Kakar S.N. Testing of endosulfan and fenitrothion for genotoxicity in Saccharomyces cerevisiae. Mutat. Res. 1982, 105:403-407.
124. Zhu X.-Q., Zheng Y.-F., Zhu H.-H., Ni Z.-M., Chang Y., Huang Y.-S. Effects of endosulfan on reproductive system of male pups after gestational and lactational exposure. Chin. J. Pharmacol. Toxicol. 2000, 14(10):352-356.