Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters

Toxicological Sciences

Volumn 117, Issue 2, 2010, Pages 325-335

  Tonk, Elisa C M ^a,b,c   de Groot, Didima M G ^c   Penninks, André H ^c   Waalkens Berendsen, Ine D H ^c   Wolterbeek, André P M ^c   Slob, Wout ^b,d   Piersma, Aldert H ^b,d   van Loveren, Henk ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c TNO   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Benchmark dose; Developmental immunotoxicity; Developmental toxicity; Dose response modeling; Methylmercury; Perinatal exposure; Rat

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; KEYHOLE LIMPET HEMOCYANIN; METHYLMERCURY; T LYMPHOCYTE ANTIBODY;

ADHERENT CELL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BASOPHIL; BODY WEIGHT; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD8+ T LYMPHOCYTE; CLINICAL EVALUATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DEVELOPMENTAL SCREENING; DIAGNOSTIC VALUE; ENVIRONMENTAL EXPOSURE; EPIDIDYMIS; ERYTHROCYTE; FEMALE; GESTATIONAL AGE; IMMUNOLOGICAL PARAMETERS; IMMUNOTOXICITY; KIDNEY MASS; LEUKOCYTE COUNT; LITTER SIZE; LIVER WEIGHT; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NEWBORN MORTALITY; NONHUMAN; RAT; RETICULOCYTE COUNT; SENSITIVITY AND SPECIFICITY; SPLEEN CELL; SPLEEN WEIGHT; STILLBIRTH; TESTIS WEIGHT; THROMBOCYTE COUNT; THYMUS; WEIGHT REDUCTION;

ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEATH; IMMUNE SYSTEM; LACTATION; LITTER SIZE; LONGEVITY; MALE; MATERNAL EXPOSURE; METHYLMERCURY COMPOUNDS; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SPLEEN; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL;

RATTUS; RATTUS NORVEGICUS;

EID: 77956915860     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq223     Document Type: Article

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