The rat as a model in developmental immunotoxicology

Human and Experimental Toxicology

Volumn 21, Issue 9-10, 2002, Pages 513-519

  Smialowicz, R J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

2,3, 7,8 tetrachlor odibenzo p dioxin; Developmental immunotox icology; Organotins; Pesti cides; Rat

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; BIS(TRIBUTYLTIN) OXIDE; CHLORINE DERIVATIVE; ENVIRONMENTAL CHEMICAL; HALOGENATED HYDROCARBON; HEPTACHLOR; METHOXYCHLOR; ORGANOCHLORINE PESTICIDE; ORGANOTIN COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FETOTOXICITY; FETUS; GESTATION PERIOD; IMMUNE DEFICIENCY; IMMUNE FUNCTION TEST; IMMUNE SYSTEM; IMMUNOTOXICITY; LACTATION; MALE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; EMBRYONIC AND FETAL DEVELOPMENT; ENVIRONMENTAL POLLUTANTS; IMMUNE SYSTEM; INSECTICIDES; ORGANOTIN COMPOUNDS; RATS; RISK ASSESSMENT; TETRACHLORODIBENZODIOXIN; TOXICOLOGY;

ANIMALIA; RODENTIA;

EID: 0036759958     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327102ht290oa     Document Type: Article

References (38)

1. National Research Council (NRC). Pesticides in the diets of infants and children. Washington, DC: National Academy Press, 1993.
2. International Life Sciences Institute. Research needs on age-related differences in susceptibility to chemical toxicants. Report of an ILSI Risk Science Institute Working Group. Washington, DC: ILSI Risk Science Institute, 1996.
3. Rosen FS, Cooper MD, Wedgwood RJP. The primary immunodeficiencies. N Engl J Med 1995; 333: 431-40.
4. Holladay SD, Smialowicz RJ. Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure. Environ Health Perspect 2000; 108(Suppl 3): 463-74.
5. Smialowicz RJ, Riddle MM, Rogers RR, et al. Immunologic effects of perinatal exposure of rats to dioctyltin dichloride. J Toxicol Environ Health 1988; 25: 403-22.
6. Smialowicz RJ, Riddle MM, Rogers RR, Luebke RW, Copeland CB. Immunotoxicity of tributyltin oxide in rats exposed as adults or pre-weanlings. Toxicology 1989; 57: 97-111.
7. Gehrs BC, Smialowicz RJ. Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: I. Effects on the fetus and the neonate. Toxicology 1997; 122: 219-28.
8. Gehrs BC, Riddle MM, Williams WC, Smialowicz RJ. Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin II. Effects on the pup and the adult. Toxicology 1997; 122: 229-40.
9. Gehrs BC, Smialowicz RJ. Persistent suppression of delayed-type hypersensitivity in adult F344 rats after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 1999; 134: 79-88.
10. Chapin RE, Harris MW, Davis BJ, et al. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune and reproductive system function. Fundam Appl Toxicol 1997; 40: 138-57.
11. Smialowicz RJ, Williams WC, Copeland CB, et al. Effect of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats. Toxicol Sci 2001; 61: 164-75.
12. Piver WT. Organotin compounds: industrial applications and biological investigations. Environ Health Perspect 1973; 4: 61-79.
13. Pennicks AH, Pieters RHH. Immunotoxicity of organotins. In Smialowicz RJ, Holsapple MP eds. Exp immunotoxicol. Boca Raton: CRC Press, 1995: 229-43.
14. Poland A, Knutson JC. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 1982; 22: 517-54.
15. Holsapple MP. Immunotoxicity of halogenated aromatic hydrocarbons. In Smialowicz RJ, Holsapple MP eds. Exp immunotoxicol. Boca Raton: CRC Press, 1995: 265-305.
16. Couture LA, Abbott BD, Birnbaum LS. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. Teratology 1990; 42: 619-27.
17. Murray FJ, Smith FA, Nitschke KD, Humiston CG, Kociba RJ, Schwetz BA. Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin in the diet. Toxicol Appl Pharmacol 1979; 50: 241-52.
18. Mably TA, Bjerke DL, Moore RW, Gendron-Fitzpatrick, A, Peterson RE. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin 3. Effects on spermatogenesis and reproductive capability. Toxicol Appl Pharmacol 1992; 114: 118-26.
19. Gray LE, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. Exposure to TCDD during development permanently alters reproductive function in male Long-Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol Appl Pharmacol 1995; 131: 108-18.
20. Thiel R, Koch E, Ulbrich B, Chahoud I. Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: effects on physiological development, reflexes, locomotor activity and learning behavior in Wistar rats. Arch Toxicol 1994; 69: 79-86.
21. Vos JG, Moore JA. Suppression of cellular immunity in rats and mice by maternal treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Int Arch Allergy 1974; 47: 777-94.
22. Schecter A, Startin J, Wright C, et al. Congener-specific levels of dioxins and dibenzofurans in US food and estimated daily dioxin toxic equivalent intake. Environ Health Perspect 1994; 102: 962-66.
23. Beck H, Eckart K, Mathar W, Wittkowski R. PCDD and PCDF body burden from food intake in the Federal Republic of Germany. Chemosphere 1989; 18: 417-24.
24. Fürst P, Fürst C, Groebel W. Levels of PCDDs and PCDFs in food-stuffs from the Federal Republic of Germany. Chemosphere 1990; 20: 787-92.
25. Theelen RMC, Liem AKD, Slob W, van Wijnen JH. Intake of 2,3,7,8 chlorine substituted dioxins, furans, and planar PCBs from food in the Netherlands: median and distribution. Chemosphere 1993; 27: 1625-35.
26. McLachlan MS. Digestive tract absorption of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in a nursing infant. Toxicol Appl Pharmacol 1993; 123: 68-72.
27. Korte M, Stahlmann R, Neubert D. Induction of hepatic monooxygenases in female rats and offspring in correlation with TCDD concentrations after single treatment during pregnancy. Chemosphere 1990; 20: 1193-98.
28. Li X, Weber LWD, Rozman KK. Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats including placental and lactational transfer to fetuses and neonates. Fundam Appl Toxicol 1995; 27: 70-76.
29. Faith RE, Moore JA. Impairment of thymus-dependent immune functions by exposure of the developing immune system to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). J Toxicol Environ Health 1977; 3: 451-64.
30. Holladay SD, Lindstrom P, Blaylock BL, et al. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 1991; 44: 385-93.
31. Fine JS, Gasiewicz TA, Silverstone AE. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 1989; 35: 18-25.
32. Kampinga J, Aspinall R. Thymocyte differentiation and thymic microenvironment development in the fetal rat thymus: an immunohistological approach. In Kendall MD, Ritter MA eds. Thymus update, Volume 3. London: Harwood Academic Publishers, 1990: 149-86.
33. Blaylock BL, Holladay SD, Comment CE, Heindel JJ, Luster MI. Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol Appl Pharmacol 1992; 112: 207-13.
34. Fan F, Wierda D, Rozman KK. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats. Toxicology 1996; 106: 221-28.
35. Fendick EA, Mather-Mihaich E, Houck KA, et al. Ecological toxicology and human health effects of heptachlor. In Ware GW ed. Reviews of environmental contamination and toxicology, Volume 111. New York: Springer-Verlag, 1990: 61-142.
36. Baker DB, Loo S, Barker J. Evaluation of human exposure to the heptachlor epoxide contamination of milk in Hawaii. Hawaii Med J 1991; 50: 108-18.
37. Smith RJ. Hawaiian milk contamination creates alarm. Science 1982; 217: 137-40.
38. Siegel BZ. Heptachlor epoxide in mothers' milk in Hawaii 1981-1984 and its relationship to the recall of contaminated dairy products on Oahu in 1982. Completion Report. Honolulu Pesticide Hazard Assessment Project. Pacific Biomedical Center, University of Hawaii, Honolulu, HI, June 1988.