The mechanism of action of cyclosporin A and FK506

Clinical Immunology and Immunopathology

Volumn 80, Issue 3 II, 1996, Pages

  Ho, Steffan ^a   Clipstone, Neil ^a   Timmermann, Luika ^a   Northrop, Jeffrey ^a   Graef, Isabella ^a   Fiorentino, David ^a   Nourse, Jamie ^a   Crabtree, Gerald R ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; NUCLEAR FACTOR; RAPAMYCIN; TACROLIMUS;

CONFERENCE PAPER; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029797189     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0140     Document Type: Conference Paper

References (31)

1. Crabtree, G. R., Contingent genetic regulatory events in T-lymphocyte activation. Science 243, 355-361, 1989.
2. Verweij, C. L., Guidos, C., and Crabtree, G. R., Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. J. Biol. Chem. 265, 15788-15795, 1990.
3. Schall, T. J., Bacon, K., Toy, K. J., and Goeddel, D. V., Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347, 669-671, 1990.
4. Jung, T. M., Gallatin, W. M., Weissman, I. L., and Dailey, M. O., Down-regulation of homing receptors after T-cell activation. J. Immunol. 141, 4110-4117, 1988.
5. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., and Nagata, S., Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317, 1992.
6. Itoh, N., Tsujimoto, Y., and Nagata, S., Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151, 621-627, 1993.
7. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S., Lethal effect of the anti-Fas antibody in mice. Nature 364, 806-809, 1993.
8. Lowenthal, J. W., Tougne, C., MacDonald, R., Smith, K. A., and Nabholz, M., Antigen stimulation regulates the expression of IL-2 receptors in a cytolytic T-lymphocyte clone. J. Immunol. 134, 931-939, 1985.
9. Weiss, A., and Littman, D. R., Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274, 1994.
10. Crabtree, G. R., and Clipstone, N. A., Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63, 1045-1083, 1994.
11. Durand, D. B., Bush, M. R., Morgan, J. G., Weiss, A., and Crabtree, G. R., A 275 bp fragment at the 5′ end of the IL-2 gene enhances expression from a heterologous promoter in response to signals from the T-cell antigen receptor. J. Exp. Med. 165, 395-407, 1987.
12. Shaw, J. P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., and Crabtree, G. R., Identification of a putative regulator of early T-cell activation genes. Science 241, 202-205, 1988.
13. ras upon T-cell activation. Nature 346, 719-723, 1990.
14. Gulbins, E., Coggeshall, K. M., Baier, G., Katzav, S., Burn, P., and Altman, A., Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T-cell activation. Science 260, 822-825, 1993.
15. Ravichandran, K. S., Lee, K. K., Songyang, Z., Cantley, L. C., Burn, P., and Burakoff, S. J., Interaction of She with the zeta chain of the T-cell receptor upon T-cell activation. Science 262, 902-905, 1993.
16. Sieh, M., Batzer, A., Schlessinger, J., and Weiss, A., GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol. Cell. Biol. 14, 4435-4442, 1994.
17. Buday, L., Egan, S. E., Rodriguez, V. P., Cantrell, D. A., and Downward, J., A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J. Biol. Chem. 269, 9019-9023, 1994.
18. McCormick, F., How receptors turn Ras on. Nature 363, 15-16, 1993.
19. Clapham, D. E., Calcium signaling. Cell 80, 259-268, 1995.
20. Bram, R. J., and Crabtree, G. R., Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. Nature 371, 355-358, 1994.
21. Hubbard, M. J., and Klee, C. B., Functional domain structure of calcineurin A: Mapping by limited proteolysis. Biochemistry 28, 1868-1874, 1989.
22. Fruman, D. A., Klee, C. B., Bierer, B. E., and Burakoff, S. J., Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc. Natl. Acad. Sci. USA 89, 3686-3690, 1992.
23. Cohen, P., The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58, 453-508, 1989.
24. Clipstone, N. A., and Crabtree, G. R., Identification of calcineurin as a key signalling enzyme in T-cell activation. Nature 357, 695-697, 1992.
25. Flanagan, W. F., Corthesy, B., Bram, R. J., and Crabtree, G. R., Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 352, 803-807, 1991.
26. Northrop, J. P., Crabtree, G. R., and Mattila, P. S., Negative regulation of interleukin-2 transcription by glucocorticoid receptors. J. Exp. Med. 175, 1235-1245, 1992.
27. Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., and Schreiber, S. L., Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815, 1991.
28. O'Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., and O'Neill, E. A., FK506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357, 692-694, 1992.
29. Yang, D., Rosen, M. K., and Schreiber, S. L., A composite FKBP12-FK506 surface that contacts calcineurin. J. Am. Chem. Soc. 115, 819-820, 1993.
30. Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E., and Crabtree, G. R., Cyclosporin A specifically inhibits function of nuclear proteins involved in T-cell activation. Science 246, 1617-1620, 1989.
31. Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., Massague, J., Crabtree, G. R., and Roberts, J. M., Rapamycin prevents interleukin 2-mediated elimination of the cyclin-dependent kinase inhibitor, p27Kip1. Nature 372, 570-573, 1994.