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Volumn 4, Issue FEB, 2013, Pages

Genome maintenance and transcription integrity in aging and disease

Author keywords

Cancer; DNA damage; DNA repair; Genetic; Progeria; Transcription

Indexed keywords


EID: 84876190692     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00019     Document Type: Review
Times cited : (55)

References (98)
  • 1
    • 68249113719 scopus 로고    scopus 로고
    • A two-step model for senescence triggered by a single critically short telomere
    • Abdallah, P., Luciano, P., Runge, K. W., Lisby, M., Géli, V., Gilson, E., et al. (2009). A two-step model for senescence triggered by a single critically short telomere. Nat. Cell Biol. 11, 988-993.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 988-993
    • Abdallah, P.1    Luciano, P.2    Runge, K.W.3    Lisby, M.4    Géli, V.5    Gilson, E.6
  • 2
    • 35748950163 scopus 로고    scopus 로고
    • Damage-induced ubiqui-tylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1
    • Anindya, R., Aygun, O., and Svejstrup, J. Q. (2007). Damage-induced ubiqui-tylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol. Cell 28, 386-397.
    • (2007) Mol. Cell , vol.28 , pp. 386-397
    • Anindya, R.1    Aygun, O.2    Svejstrup, J.Q.3
  • 4
    • 0032803070 scopus 로고    scopus 로고
    • The Werner syndrome protein is involved in RNA polymerase II transcription
    • Balajee, A. S., Machwe, A., May, A., Gray, M. D., Oshima, J., Martin, G. M., et al. (1999). The Werner syndrome protein is involved in RNA polymerase II transcription. Mol. Biol. Cell 10, 2655-2668.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2655-2668
    • Balajee, A.S.1    Machwe, A.2    May, A.3    Gray, M.D.4    Oshima, J.5    Martin, G.M.6
  • 5
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoints: from initiation to recovery or adaptation
    • Bartek, J., and Lukas, J. (2007). DNA damage checkpoints: from initiation to recovery or adaptation. Curr. Opin. Cell Biol. 19, 238-245.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 6
    • 66049162098 scopus 로고    scopus 로고
    • The somatotropic axis and aging: mechanisms and persistent questions about practical implications
    • Bartke, A. (2009). The somatotropic axis and aging: mechanisms and persistent questions about practical implications. Exp. Gerontol. 44, 372-374.
    • (2009) Exp. Gerontol. , vol.44 , pp. 372-374
    • Bartke, A.1
  • 7
    • 44949085340 scopus 로고    scopus 로고
    • The role of the DNA damage response in neuronal development, organization and maintenance
    • Barzilai, A., Biton, S., and Shiloh, Y. (2008). The role of the DNA damage response in neuronal development, organization and maintenance. DNA Repair (Amst.) 7, 1010- 1027.
    • (2008) DNA Repair (Amst. ) , vol.7 , pp. 1010-1027
    • Barzilai, A.1    Biton, S.2    Shiloh, Y.3
  • 8
    • 0141480945 scopus 로고    scopus 로고
    • WRN interacts physically and functionally with the recombination mediator protein RAD52
    • Baynton, K., Otterlei, M., Bjørås, M., von Kobbe, C., Bohr, V. A., and Seeberg, E. (2003). WRN interacts physically and functionally with the recombination mediator protein RAD52. J. Biol. Chem. 278, 36476-36486.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36476-36486
    • Baynton, K.1    Otterlei, M.2    Bjørås, M.3    von Kobbe, C.4    Bohr, V.A.5    Seeberg, E.6
  • 9
    • 56449090762 scopus 로고    scopus 로고
    • Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance
    • Bohr, V. A. (2008). Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem. Sci. 33, 609-620.
    • (2008) Trends Biochem. Sci. , vol.33 , pp. 609-620
    • Bohr, V.A.1
  • 10
    • 84871932584 scopus 로고    scopus 로고
    • DNA damage, chromatin, and transcription: the trinity of aging
    • Burgess, R. C., Misteli, T., and Oberdoerffer, P. (2012). DNA damage, chromatin, and transcription: the trinity of aging. Curr. Opin. Cell Biol. 24, 724-730.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 724-730
    • Burgess, R.C.1    Misteli, T.2    Oberdoerffer, P.3
  • 11
    • 0036606952 scopus 로고    scopus 로고
    • A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    • Carter, C. S., Ramsey, M. M., and Sonntag, W. E. (2002). A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 18,295-301.
    • (2002) Trends Genet , vol.18 , pp. 295-301
    • Carter, C.S.1    Ramsey, M.M.2    Sonntag, W.E.3
  • 12
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., and Kerber, R. A. (2003). Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361,393-395.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 13
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman, J. R., Taylor, M. R. G., and Boulton, S. J. (2012). Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47, 497-510.
    • (2012) Mol. Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.G.2    Boulton, S.J.3
  • 14
    • 33646937737 scopus 로고    scopus 로고
    • Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links
    • Cheng, W.-H., Kusumoto, R., Opresko, P. L., Sui, X., Huang, S., Nicolette, M. L., et al. (2006). Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res. 34,2751-2760.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2751-2760
    • Cheng, W.-H.1    Kusumoto, R.2    Opresko, P.L.3    Sui, X.4    Huang, S.5    Nicolette, M.L.6
  • 16
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: making it safe to play with knives
    • Ciccia, A., and Elledge, S. J. (2010). The DNA damage response: making it safe to play with knives. Mol. Cell 40, 179-204.
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 17
    • 70350065725 scopus 로고    scopus 로고
    • Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
    • Cleaver, J. E., Lam, E. T., and Revet, I. (2009). Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity. Nat. Rev. Genet. 10, 756-768.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 756-768
    • Cleaver, J.E.1    Lam, E.T.2    Revet, I.3
  • 19
    • 77956875652 scopus 로고    scopus 로고
    • Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts
    • Constantinescu, D., Csoka, A. B., Navara, C. S., and Schatten, G. P. (2010). Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts. Exp. Cell Res. 316,2747-2759.
    • (2010) Exp. Cell Res. , vol.316 , pp. 2747-2759
    • Constantinescu, D.1    Csoka, A.B.2    Navara, C.S.3    Schatten, G.P.4
  • 21
    • 79959635260 scopus 로고    scopus 로고
    • DNA interstrand crosslink repair and cancer
    • Deans, A. J., and West, S. C. (2011). DNA interstrand crosslink repair and cancer. Nat. Rev. Cancer 11,467-480.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 467-480
    • Deans, A.J.1    West, S.C.2
  • 22
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange, T. (2009). How telomeres solve the end-protection problem. Science 326, 948-952.
    • (2009) Science , vol.326 , pp. 948-952
    • de Lange, T.1
  • 23
    • 84857041145 scopus 로고    scopus 로고
    • Shining a light on xeroderma pigmentosum
    • DiGiovanna, J. J., and Kraemer, K. H. (2012). Shining a light on xeroderma pigmentosum. J. Invest. Dermatol. 132,785-796.
    • (2012) J. Invest. Dermatol. , vol.132 , pp. 785-796
    • DiGiovanna, J.J.1    Kraemer, K.H.2
  • 24
    • 79960377780 scopus 로고    scopus 로고
    • A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor
    • Egly, J. M., and Coin, F. (2011). A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst.). 10,714-721.
    • (2011) DNA Repair (Amst. ). , vol.10 , pp. 714-721
    • Egly, J.M.1    Coin, F.2
  • 25
    • 80053538947 scopus 로고    scopus 로고
    • A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells
    • Fong, Y. W., Inouye, C., Yamaguchi, T., Cattoglio, C., Grubisic, I., and Tjian, R. (2011). A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells. Cell 147, 120-131.
    • (2011) Cell , vol.147 , pp. 120-131
    • Fong, Y.W.1    Inouye, C.2    Yamaguchi, T.3    Cattoglio, C.4    Grubisic, I.5    Tjian, R.6
  • 26
    • 70349672704 scopus 로고    scopus 로고
    • Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
    • Freude, S., Hettich, M. M., Schumann, C., Stöhr, O., Koch, L, Kohler, C., et al. (2009). Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEBJ. 23, 3315-3324.
    • (2009) FASEBJ , vol.23 , pp. 3315-3324
    • Freude, S.1    Hettich, M.M.2    Schumann, C.3    Stöhr, O.4    Koch, L.5    Kohler, C.6
  • 27
    • 30344455023 scopus 로고    scopus 로고
    • Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7
    • Friedberg, E. C., and Meira, L. B. (2006). Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7. DNA Repair (Amst.) 5, 189-209.
    • (2006) DNA Repair (Amst. ) , vol.5 , pp. 189-209
    • Friedberg, E.C.1    Meira, L.B.2
  • 28
    • 67349287384 scopus 로고    scopus 로고
    • Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity
    • Garinis, G. A., Uittenboogaard, L. M., Stachelscheid, H., Fousteri, M., van Ijcken, W., Breit, T. M., et al. (2009). Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat. Cell Biol. 11, 604-615.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 604-615
    • Garinis, G.A.1    Uittenboogaard, L.M.2    Stachelscheid, H.3    Fousteri, M.4    van Ijcken, W.5    Breit, T.M.6
  • 29
    • 56749157389 scopus 로고    scopus 로고
    • Transcription-coupled DNA repair: two decades of progress and surprises
    • Hanawalt, P. C., and Spivak, G. (2008). Transcription-coupled DNA repair: two decades of progress and surprises. Nat. Rev. Mol. Cell Biol. 9, 958-970.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 958-970
    • Hanawalt, P.C.1    Spivak, G.2
  • 30
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: ten years after
    • Harper, J. W., and Elledge, S. J. (2007). The DNA damage response: ten years after. Mol. Cell 28, 739-745.
    • (2007) Mol. Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 31
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., et al. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 32
    • 0037364415 scopus 로고    scopus 로고
    • RecQ helicases: caretakers of the genome
    • Hickson, I. D. (2003). RecQ helicases: caretakers of the genome. Nat. Rev. Cancer 3, 169-178.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 169-178
    • Hickson, I.D.1
  • 33
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J. H. (2001). Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 34
    • 0035106336 scopus 로고    scopus 로고
    • Macromolecular dynamics in living cell nuclei revealed by fluorescence redistribution after photo-bleaching
    • Houtsmuller, A. B., and Vermeulen, W. (2001). Macromolecular dynamics in living cell nuclei revealed by fluorescence redistribution after photo-bleaching. Histochem. Cell Biol. 115, 13-21.
    • (2001) Histochem. Cell Biol. , vol.115 , pp. 13-21
    • Houtsmuller, A.B.1    Vermeulen, W.2
  • 35
    • 0036519363 scopus 로고    scopus 로고
    • DNA and its associated processes as targets for cancer therapy
    • Hurley, L. H. (2002). DNA and its associated processes as targets for cancer therapy. Nat. Rev. Cancer 2,188-200.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 188-200
    • Hurley, L.H.1
  • 36
    • 0037013144 scopus 로고    scopus 로고
    • TFIIH plays an essential role in RNA polymerase I transcription
    • Iben, S., Tschochner, H., Bier, M., Hoogstraten, D., Hozák, P., Egly, J. M., et al. (2002). TFIIH plays an essential role in RNA polymerase I transcription. Cell 109, 297-306.
    • (2002) Cell , vol.109 , pp. 297-306
    • Iben, S.1    Tschochner, H.2    Bier, M.3    Hoogstraten, D.4    Hozák, P.5    Egly, J.M.6
  • 37
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S. P., and Bartek, J. (2009). The DNA-damage response in human biology and disease. Nature 461, 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 38
    • 0037027835 scopus 로고    scopus 로고
    • Antitumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways
    • Jaspers, N. G., Raams, A., Kelner, M. J., Ng, J. M., Yamashita, Y. M., Takeda, S., et al. (2002). Antitumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst.) 1, 1027-1038.
    • (2002) DNA Repair (Amst. ) , vol.1 , pp. 1027-1038
    • Jaspers, N.G.1    Raams, A.2    Kelner, M.J.3    Ng, J.M.4    Yamashita, Y.M.5    Takeda, S.6
  • 39
    • 79956205888 scopus 로고    scopus 로고
    • DNA repair deficiency in neurodegeneration
    • Jeppesen, D. K., Bohr, V. A., and Stevnsner, T. (2011). DNA repair deficiency in neurodegeneration. Prog. Neurobiol. 94, 166-200.
    • (2011) Prog. Neurobiol. , vol.94 , pp. 166-200
    • Jeppesen, D.K.1    Bohr, V.A.2    Stevnsner, T.3
  • 40
    • 77956550868 scopus 로고    scopus 로고
    • Human SIRT6 promotes DNA end resection through CtIP deacetylation
    • Kaidi, A., Weinert, B. T., Choudhary, C., and Jackson, S. P. (2010). Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329,1348-1353.
    • (2010) Science , vol.329 , pp. 1348-1353
    • Kaidi, A.1    Weinert, B.T.2    Choudhary, C.3    Jackson, S.P.4
  • 41
    • 84867706701 scopus 로고    scopus 로고
    • Nucleotide excision repair: new tricks with old bricks
    • Kamileri, I., Karakasilioti, I., and Garinis, G. A. (2012a). Nucleotide excision repair: new tricks with old bricks. Trends Genet. 28, 566-573.
    • (2012) Trends Genet , vol.28 , pp. 566-573
    • Kamileri, I.1    Karakasilioti, I.2    Garinis, G.A.3
  • 42
    • 84857437037 scopus 로고    scopus 로고
    • Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria
    • Kamileri, I., Karakasilioti, I., Sideri, A., Kosteas, T., Tatarakis, A., Talianidis, I., et al. (2012b). Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc. Natl. Acad. Sci. U.S.A. 109,2995-3000.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 2995-3000
    • Kamileri, I.1    Karakasilioti, I.2    Sideri, A.3    Kosteas, T.4    Tatarakis, A.5    Talianidis, I.6
  • 43
    • 77955889790 scopus 로고    scopus 로고
    • Expanded roles of the Fanconi anemia pathway in preserving genomic stability
    • Kee, Y., and D'Andrea, A. D. (2010). Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 24, 1680-1694.
    • (2010) Genes Dev , vol.24 , pp. 1680-1694
    • Kee, Y.1    D'Andrea, A.D.2
  • 44
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • Kelland, L. (2007). The resurgence of platinum-based cancer chemotherapy. Nat. Rev. Cancer 7, 573-584.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 573-584
    • Kelland, L.1
  • 45
    • 0035917440 scopus 로고    scopus 로고
    • A conserved regulatory system for aging
    • Kenyon, C. (2001). A conserved regulatory system for aging. Cell 105, 165-168.
    • (2001) Cell , vol.105 , pp. 165-168
    • Kenyon, C.1
  • 46
    • 47249106520 scopus 로고    scopus 로고
    • Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing
    • Kusumoto, R., Dawut, L., Marchetti, C., Wan Lee, J., Vindigni, A., Ramsden, D., et al. (2008). Werner protein cooperates with the XRCC4-DNA lig-ase IV complex in end-processing. Biochemistry 47, 7548-7556.
    • (2008) Biochemistry , vol.47 , pp. 7548-7556
    • Kusumoto, R.1    Dawut, L.2    Marchetti, C.3    Wan Lee, J.4    Vindigni, A.5    Ramsden, D.6
  • 47
    • 79955407832 scopus 로고    scopus 로고
    • Real-time observation of transcription initiation and elongation on an endogenous yeast gene
    • Larson, D. R., Zenklusen, D., Wu, B., Chao, J. A., and Singer, R. H. (2011). Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science 332, 475-478.
    • (2011) Science , vol.332 , pp. 475-478
    • Larson, D.R.1    Zenklusen, D.2    Wu, B.3    Chao, J.A.4    Singer, R.H.5
  • 48
    • 75149163382 scopus 로고    scopus 로고
    • Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome
    • Laugel, V., Dalloz, C., Durand, M., Sauvanaud, F., Kristensen, U., Vincent, M. C., et al. (2010). Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. Hum. Mutat. 31, 113-126.
    • (2010) Hum. Mutat. , vol.31 , pp. 113-126
    • Laugel, V.1    Dalloz, C.2    Durand, M.3    Sauvanaud, F.4    Kristensen, U.5    Vincent, M.C.6
  • 49
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    • Lavin, M. F. (2008). Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9, 759-769.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 50
    • 0942268166 scopus 로고    scopus 로고
    • DNA repair-deficient diseases, xeroderma pig-mentosum, Cockayne syndrome and trichothiodystrophy.
    • Lehmann, A. R. (2003). DNA repair-deficient diseases, xeroderma pig-mentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85, 1101-1111.
    • (2003) Biochimie , vol.85 , pp. 1101-1111
    • Lehmann, A.R.1
  • 51
    • 84865377934 scopus 로고    scopus 로고
    • XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes
    • Le May, N., Fradin, D., Iltis, I., Bougnères, P., and Egly, J. M. (2012). XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes. Mol. Cell 47, 622-632.
    • (2012) Mol. Cell , vol.47 , pp. 622-632
    • Le May, N.1    Fradin, D.2    Iltis, I.3    Bougnères, P.4    Egly, J.M.5
  • 52
    • 77950443318 scopus 로고    scopus 로고
    • NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack
    • Le May, N., Mota-Fernandes, D., Velez-Cruz, R., Iltis, I., Biard, D., and Egly, J. M. (2010). NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol. Cell 38, 54-66.
    • (2010) Mol. Cell , vol.38 , pp. 54-66
    • Le May, N.1    Mota-Fernandes, D.2    Velez-Cruz, R.3    Iltis, I.4    Biard, D.5    Egly, J.M.6
  • 53
    • 0030983004 scopus 로고    scopus 로고
    • Fludarabine triphosphate inhibits nucleotide excision repair of cisplatin-induced DNA adducts in vitro
    • Li, L., Liu, X., Glassman, A. B., Keating, M. J., Stros, M., Plunkett, W., et al. (1997). Fludarabine triphosphate inhibits nucleotide excision repair of cisplatin-induced DNA adducts in vitro. Cancer Res. 57, 1487-1494.
    • (1997) Cancer Res , vol.57 , pp. 1487-1494
    • Li, L.1    Liu, X.2    Glassman, A.B.3    Keating, M.J.4    Stros, M.5    Plunkett, W.6
  • 54
    • 0015504248 scopus 로고
    • Rate of depurination of native deoxyri-bonucleic acid
    • Lindahl, T., and Nyberg, B. (1972). Rate of depurination of native deoxyri-bonucleic acid. Biochemistry 11, 3610-3618.
    • (1972) Biochemistry , vol.11 , pp. 3610-3618
    • Lindahl, T.1    Nyberg, B.2
  • 55
    • 22544466685 scopus 로고    scopus 로고
    • Genomic instability in laminopathy-based premature aging
    • Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., et al. (2005). Genomic instability in laminopathy-based premature aging. Nat. Med. 11, 780-785.
    • (2005) Nat. Med. , vol.11 , pp. 780-785
    • Liu, B.1    Wang, J.2    Chan, K.M.3    Tjia, W.M.4    Deng, W.5    Guan, X.6
  • 56
    • 0034039040 scopus 로고    scopus 로고
    • Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress
    • Ljungman, M. (2000). Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia 2, 208-225.
    • (2000) Neoplasia , vol.2 , pp. 208-225
    • Ljungman, M.1
  • 57
    • 4544259868 scopus 로고    scopus 로고
    • Transcription - guarding the genome by sensing DNA damage
    • Ljungman, M., and Lane, D. P. (2004). Transcription - guarding the genome by sensing DNA damage. Nat. Rev. Cancer 4, 727-737.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 727-737
    • Ljungman, M.1    Lane, D.P.2
  • 58
    • 52049125943 scopus 로고    scopus 로고
    • Advances in chemical carcinogenesis: a historical review and prospective
    • Loeb, L. A., and Harris, C. C. (2008). Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res. 68, 6863-6872.
    • (2008) Cancer Res , vol.68 , pp. 6863-6872
    • Loeb, L.A.1    Harris, C.C.2
  • 59
    • 0035137181 scopus 로고    scopus 로고
    • Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice
    • Lu, Y., Lian, H., Sharma, P., Schreiber-Agus, N., Russell, R. G., Chin, L., et al. (2001). Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice. Mol. Cell. Biol. 21, 1810-1818.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1810-1818
    • Lu, Y.1    Lian, H.2    Sharma, P.3    Schreiber-Agus, N.4    Russell, R.G.5    Chin, L.6
  • 60
    • 77951819090 scopus 로고    scopus 로고
    • Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair
    • Luijsterburg, M. S., von Bornstaedt, G., Gourdin, A. M., Politi, A. Z., Mone, M. J., Warmerdam, D. O., et al. (2010). Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. J. Cell Biol. 189, 445-463.
    • (2010) J. Cell Biol. , vol.189 , pp. 445-463
    • Luijsterburg, M.S.1    von Bornstaedt, G.2    Gourdin, A.M.3    Politi, A.Z.4    Mone, M.J.5    Warmerdam, D.O.6
  • 61
  • 62
    • 77957981121 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
    • Mariño, G., Ugalde, A. P., Fernández, A. F., Osorio, F. G., Fueyo, A., Freije, J. M. P., et al. (2010). Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc. Natl. Acad. Sci. U.S.A. 107, 16268-16273.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 16268-16273
    • Mariño, G.1    Ugalde, A.P.2    Fernández, A.F.3    Osorio, F.G.4    Fueyo, A.5    Freije, J.M.P.6
  • 63
    • 19444383162 scopus 로고    scopus 로고
    • Dyskeratosis congenita: Telomerase, telomeres and anticipation
    • Marrone, A., Walne, A., and Dokal, I. (2005). Dyskeratosis congenita: Telomerase, telomeres and anticipation. Curr. Opin. Genet. Dev. 15, 249-257.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 249-257
    • Marrone, A.1    Walne, A.2    Dokal, I.3
  • 64
    • 0035068565 scopus 로고    scopus 로고
    • An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele
    • Maser, R. S., Zinkel, R., and Petrini, J. H. (2001). An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Nat. Genet. 27, 417-421.
    • (2001) Nat. Genet. , vol.27 , pp. 417-421
    • Maser, R.S.1    Zinkel, R.2    Petrini, J.H.3
  • 65
    • 84869005179 scopus 로고    scopus 로고
    • DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy
    • McNeil, E. M., and Melton, D. W. (2012). DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy. Nucleic Acids Res. 40,9990-10004.
    • (2012) Nucleic Acids Res , vol.40 , pp. 9990-10004
    • McNeil, E.M.1    Melton, D.W.2
  • 66
    • 0034981048 scopus 로고    scopus 로고
    • Homologous recombination: from model organisms to human disease
    • reviews 1014.1-1014.5
    • Modesti, M., and Kanaar, R. (2001). Homologous recombination: from model organisms to human disease. Genome Biol. 2, reviews 1014.1-1014.5.
    • (2001) Genome Biol , vol.2
    • Modesti, M.1    Kanaar, R.2
  • 67
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., et al. (2006). Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329.
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1    Chua, K.F.2    Lombard, D.B.3    Pang, W.W.4    Fischer, M.R.5    Gellon, L.6
  • 68
    • 0033213392 scopus 로고    scopus 로고
    • Brca1 controls homology-directed DNA repair
    • Moynahan, M. E., Chiu, J. W., Koller, B. H., and Jasin, M. (1999). Brca1 controls homology-directed DNA repair. Mol. Cell 4, 511-518.
    • (1999) Mol. Cell , vol.4 , pp. 511-518
    • Moynahan, M.E.1    Chiu, J.W.2    Koller, B.H.3    Jasin, M.4
  • 69
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan, M. E., Pierce, A. J., and Jasin, M. (2001). BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263-272.
    • (2001) Mol. Cell , vol.7 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 70
    • 84860330507 scopus 로고    scopus 로고
    • Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair
    • Nakazawa, Y., Sasaki, K., Mitsutake, N., Matsuse, M., Shimada, M., Nardo, T., et al. (2012). Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nat. Genet. 44, 586-592.
    • (2012) Nat. Genet. , vol.44 , pp. 586-592
    • Nakazawa, Y.1    Sasaki, K.2    Mitsutake, N.3    Matsuse, M.4    Shimada, M.5    Nardo, T.6
  • 71
    • 33845914051 scopus 로고    scopus 로고
    • A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
    • Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., et al. (2006). A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444, 1038-1043.
    • (2006) Nature , vol.444 , pp. 1038-1043
    • Niedernhofer, L.J.1    Garinis, G.A.2    Raams, A.3    Lalai, A.S.4    Robinson, A.R.5    Appeldoorn, E.6
  • 72
    • 18244362081 scopus 로고    scopus 로고
    • DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
    • O'Driscoll, M., Cerosaletti, K. M., Girard, P. M., Dai, Y., Stumm, M., Kysela, B., et al. (2001). DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell 8, 1175-1185.
    • (2001) Mol. Cell , vol.8 , pp. 1175-1185
    • O'Driscoll, M.1    Cerosaletti, K.M.2    Girard, P.M.3    Dai, Y.4    Stumm, M.5    Kysela, B.6
  • 73
    • 33846141125 scopus 로고    scopus 로고
    • Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATRin response to ICL-induced replication arrest.
    • Otterlei, M., Bruheim, P., Ahn, B., Bussen, W., Karmakar, P., Baynton, K., et al. (2006). Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATRin response to ICL-induced replication arrest.J. CellSci. 119,5137-5146.
    • (2006) J. CellSci. , vol.119 , pp. 5137-5146
    • Otterlei, M.1    Bruheim, P.2    Ahn, B.3    Bussen, W.4    Karmakar, P.5    Baynton, K.6
  • 74
    • 33751088563 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors
    • Paci, A., Rezai, K., Deroussent, A., De Valeriola, D., Re, M., Weill, S., et al. (2006). Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors. Drug Metab. Dispos. 34,1918-1926.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1918-1926
    • Paci, A.1    Rezai, K.2    Deroussent, A.3    De Valeriola, D.4    Re, M.5    Weill, S.6
  • 75
    • 79952257414 scopus 로고    scopus 로고
    • Transcription and replication: breaking the rules of the road causes genomic instability
    • Poveda, A. M., Le Clech, M., and Pasero, P. (2011). Transcription and replication: breaking the rules of the road causes genomic instability. Transcription 1, 99-102.
    • (2011) Transcription , vol.1 , pp. 99-102
    • Poveda, A.M.1    Le Clech, M.2    Pasero, P.3
  • 76
    • 33646589650 scopus 로고    scopus 로고
    • Cockayne syndrome B protein regulates the transcriptional program after UV irradiation
    • Proietti-De-Santis, L., Drane, P., and Egly, J. M. (2006). Cockayne syndrome B protein regulates the transcriptional program after UV irradiation. EMBO J. 25,1915-1923.
    • (2006) EMBO J , vol.25 , pp. 1915-1923
    • Proietti-De-Santis, L.1    Drane, P.2    Egly, J.M.3
  • 77
    • 33846484332 scopus 로고    scopus 로고
    • Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions
    • Ramirez, C. L., Cadinanos, J., Varela, I., Freije, J. M., and Lopez-Otin, C. (2007). Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell. Mol. Life Sci. 64, 155-170.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 155-170
    • Ramirez, C.L.1    Cadinanos, J.2    Varela, I.3    Freije, J.M.4    Lopez-Otin, C.5
  • 78
    • 84857443702 scopus 로고    scopus 로고
    • The p53 network: cellular and systemic DNA damage responses in aging and cancer
    • Reinhardt, H. C., and Schumacher, B. (2012). The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet. 28, 128-136.
    • (2012) Trends Genet , vol.28 , pp. 128-136
    • Reinhardt, H.C.1    Schumacher, B.2
  • 79
    • 0026587204 scopus 로고
    • The wee1 protein kinase is required for radiation-induced mitotic delay
    • Rowley, R., Hudson, J., and Young, P. G. (1992). The wee1 protein kinase is required for radiation-induced mitotic delay. Nature 356, 353-355.
    • (1992) Nature , vol.356 , pp. 353-355
    • Rowley, R.1    Hudson, J.2    Young, P.G.3
  • 80
    • 34848881418 scopus 로고    scopus 로고
    • Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors
    • Saydam, N., Kanagaraj, R., Dietschy T., Garcia, P. L., Peña-Diaz, J., Shevelev, I., et al. (2007). Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35,5706-5716.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5706-5716
    • Saydam, N.1    Kanagaraj, R.2    Dietschy, T.3    Garcia, P.L.4    Peña-Diaz, J.5    Shevelev, I.6
  • 81
    • 73149120015 scopus 로고    scopus 로고
    • Transcription-blocking DNA damage in aging: a mechanism for hormesis
    • Schumacher, B. (2009). Transcription-blocking DNA damage in aging: a mechanism for hormesis. Bioessays 31,1347-1356.
    • (2009) Bioessays , vol.31 , pp. 1347-1356
    • Schumacher, B.1
  • 83
    • 84860330462 scopus 로고    scopus 로고
    • UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair
    • Schwertman, P., Lagarou, A., Dekkers, D. H. W., Raams, A., van der Hoek, A. C., Laffeber, C., et al. (2012). UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nat. Genet. 44, 598-602.
    • (2012) Nat. Genet. , vol.44 , pp. 598-602
    • Schwertman, P.1    Lagarou, A.2    Dekkers, D.H.W.3    Raams, A.4    van der Hoek, A.C.5    Laffeber, C.6
  • 84
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: safeguarding genome integrity
    • Shiloh, Y. (2003). ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 85
    • 0037128211 scopus 로고    scopus 로고
    • Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
    • Spann, T. P., Goldman, A. E., Wang, C., Huang, S., and Goldman, R. D. (2002). Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J. Cell Biol. 156, 603-608.
    • (2002) J. Cell Biol. , vol.156 , pp. 603-608
    • Spann, T.P.1    Goldman, A.E.2    Wang, C.3    Huang, S.4    Goldman, R.D.5
  • 86
    • 17944374027 scopus 로고    scopus 로고
    • Antipro-liferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
    • Takebayashi, Y., Pourquier, P., Zimonjic, D. B., Nakayama, K., Emmert, S., Ueda, T., et al. (2001). Antipro-liferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat. Med. 7, 961-966.
    • (2001) Nat. Med. , vol.7 , pp. 961-966
    • Takebayashi, Y.1    Pourquier, P.2    Zimonjic, D.B.3    Nakayama, K.4    Emmert, S.5    Ueda, T.6
  • 87
    • 0036785375 scopus 로고    scopus 로고
    • S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
    • Taniguchi, T., Garcia-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M., and D'Andrea, A. D. (2002). S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 100, 2414-2420.
    • (2002) Blood , vol.100 , pp. 2414-2420
    • Taniguchi, T.1    Garcia-Higuera, I.2    Andreassen, P.R.3    Gregory, R.C.4    Grompe, M.5    D'Andrea, A.D.6
  • 88
    • 3242889151 scopus 로고    scopus 로고
    • Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
    • Taylor, A. M. R., Groom, A., and Byrd, P. J. (2004). Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair (Amst.) 3, 1219- 1225.
    • (2004) DNA Repair (Amst. ) , vol.3 , pp. 1219-1225
    • Taylor, A.M.R.1    Groom, A.2    Byrd, P.J.3
  • 89
    • 33846030099 scopus 로고    scopus 로고
    • Impaired genome maintenance suppresses the growth hormone - insulin-like growth factor 1 axis in mice with Cockayne syndrome
    • doi: 10.1371/journal.pbio.0050002
    • van der Pluijm, I., Garinis, G. A., Brandt, R. M., Gorgels, T. G., Wijnhoven, S. W., Diderich, K. E., et al. (2006). Impaired genome maintenance suppresses the growth hormone - insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 5:e2. doi: 10.1371/journal.pbio.0050002
    • (2006) PLoS Biol , vol.5
    • van der Pluijm, I.1    Garinis, G.A.2    Brandt, R.M.3    Gorgels, T.G.4    Wijnhoven, S.W.5    Diderich, K.E.6
  • 90
    • 25644440744 scopus 로고    scopus 로고
    • Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
    • Varela, I., Cadinanos, J., Pendas, A. M., Gutierrez-Fernandez, A., Folgueras, A. R., Sanchez, L. M., et al. (2005). Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437, 564-568.
    • (2005) Nature , vol.437 , pp. 564-568
    • Varela, I.1    Cadinanos, J.2    Pendas, A.M.3    Gutierrez-Fernandez, A.4    Folgueras, A.R.5    Sanchez, L.M.6
  • 91
    • 78650733298 scopus 로고    scopus 로고
    • Cdc48/p97 mediates UV-dependent turnover of RNA Pol II
    • Verma, R., Oania, R., Fang, R., Smith, G. T., and Deshaies, R. J. (2011). Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol. Cell 41, 82-92.
    • (2011) Mol. Cell , vol.41 , pp. 82-92
    • Verma, R.1    Oania, R.2    Fang, R.3    Smith, G.T.4    Deshaies, R.J.5
  • 92
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B., Lane, D., and Levine, A. J. (2000). Surfing the p53 network. Nature 408, 307-310.
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 93
    • 0242721664 scopus 로고    scopus 로고
    • Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage
    • von Kobbe, C., Harrigan, J. A., May, A., Opresko, P. L., Dawut, L., Cheng, W.-H., et al. (2003). Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol. Cell. Biol. 23,8601-8613.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8601-8613
    • von Kobbe, C.1    Harrigan, J.A.2    May, A.3    Opresko, P.L.4    Dawut, L.5    Cheng, W.-H.6
  • 94
    • 77956775152 scopus 로고    scopus 로고
    • The Fanconi anemia pathway and ICL repair: implications for cancer therapy
    • Wang, L. C., and Gautier, J. (2010). The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit. Rev. Biochem. Mol. Biol. 45, 424-439.
    • (2010) Crit. Rev. Biochem. Mol. Biol. , vol.45 , pp. 424-439
    • Wang, L.C.1    Gautier, J.2
  • 95
    • 0024782856 scopus 로고
    • Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae
    • Weinert, T., and Hartwell, L. (1989). Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae. J. Cell Sci. Suppl. 12,145-148.
    • (1989) J. Cell Sci. Suppl. , vol.12 , pp. 145-148
    • Weinert, T.1    Hartwell, L.2
  • 97
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • Xiao, Y., and Weaver, D. T. (1997). Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25, 2985-2991.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 98
    • 84860336243 scopus 로고    scopus 로고
    • Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair
    • Zhang, X., Horibata, K., Saijo, M., Ishigami, C., Ukai, A., Kanno, S.-I., et al. (2012). Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nat. Genet. 44, 593-597.
    • (2012) Nat. Genet. , vol.44 , pp. 593-597
    • Zhang, X.1    Horibata, K.2    Saijo, M.3    Ishigami, C.4    Ukai, A.5    Kanno, S.-I.6


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