The somatotropic axis and aging: Mechanisms and persistent questions about practical implications

Experimental Gerontology

Volumn 44, Issue 6-7, 2009, Pages 372-374

  Bartke, Andrzej ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Frailty; GH; IGF 1; Mutants

Indexed keywords

GHRELIN; GROWTH HORMONE; SOMATOMEDIN C; HUMAN GROWTH HORMONE;

AGING; BODY COMPOSITION; CANCER PREVENTION; ENDOCRINE FUNCTION; FRAIL ELDERLY; GROWTH HORMONE RELEASE; HUMAN; INSULIN RESISTANCE; LONGEVITY; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; SARCOPENIA;

MUS;

AGING; ANIMALS; GROWTH HORMONE; HUMAN GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MICE; SARCOPENIA;

EID: 66049162098     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.04.001     Document Type: Review

References (56)

1. Bartke A. Is growth hormone deficiency a beneficial adaptation to aging? Evidence from experimental animals. Trends Endocrinol. Metabol. 14 (2003) 340-344
2. Bartke A., Peluso M.R., Moretz N., Wright C., Bonkowski M., Winters T.A., Shanahan M.F., Kopchick J.J., and Banz W.J. Effects of soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long-lived and short-lived mice. Horm. Metab. Res. 36 (2004) 550-558
3. Besson A., Salemi S., Gallati S., Jenal A., Horn R., Mullis P.S., and Mullis P.E. Reduced longevity in untreated patients with isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 88 (2003) 3664-3667
4. Blackman M.R., Sorkin J.D., Munzer T., Bel'lantoni M.F., Busby-Whitehead J., Stevens T.E., Jayme J., O'Connor K.G., Christmas C., Tobin J.D., Stewart K.J., Cottrell E., St. Clair C., Pabst K.M., and Harman S.M. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 288 (2002) 2282-2292
5. Bonkowski M.S., Rocha J.S., Masternak M.M., Al-Regaiey K.A., and Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. USA 103 (2006) 7901-7905
6. Brosnahan M.M., and Paradis M.R. Demographic and clinical characteristics of geriatric horses: 467 cases (1989-1999). J. Am. Vet. Med. Assoc. 223 (2003) 93-98
7. Brown-Borg H.M., Borg K.E., Meliska C.J., and Bartke A. Dwarf mice and the ageing process. Nature 384 (1996) 33
8. Conover C.A., and Bale L.K. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell 6 (2007) 727-729
9. Coschigano K.T., Holland A.N., Riders M.E., List E.O., Flyvbjerg A., and Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144 (2003) 3799-3810
10. Crew M.D., Spindler S.R., Walford R.L., and Koizumi A. Age-related decrease of growth hormone and prolactin gene expression in the mouse pituitary. Endocrinology 121 (1987) 1251-1255
11. Flurkey K., Papaconstantinou J., Miller R.A., and Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98 (2001) 6736-6741
12. Fontana L., Weiss E.P., Villareal D.T., Klein S., and Holloszy J.O. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 7 (2008) 681-687
13. Giovannini S., Marzetti E., Borst S.E., and Leuwenburgh C. Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults. Mech. Ageing Dev. 129 (2008) 593-601
14. Greer K.A., Canterberry S.C., and Murphy K.E. Statistical analysis regarding the effects of height and weight on life span of the domestic dog. Res. Vet. Sci. 82 (2007) 208-214
15. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Evens P., Cervera P., and LeBouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421 (2003) 182-187
16. Ikeno Y., Bronson R.T., Hubbard G.B., Lee S., and Bartke A. Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 58A (2003) 291-296
17. Kappeler L., De Magalhaes Filho C.M., Dupont J., Leneuve P., Cervera P., Perin L., Loudes C., Blaise A., Klein R., Epelbaum J., Le Bouc Y., and Holzenberger M. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol. 6 (2008) e254
18. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 120 (2005) 449-460
19. Khan A.S., Lynch C.D., Sane D.C., Willingham M.C., and Sonntag W.E. Growth hormone increases regional coronary blood flow and capillary density in aged rats. J. Gerontol. A Biol. Sci. Med. Sci. 56 (2001) B364-B371
20. Kimura K.D., Tissenbaum H.A., Liu Y., and Ruvkun G. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277 (1997) 942-946
21. Kinney B.A., Coschigano K.T., Kopchick J.J., and Bartke A. Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol. Behav. 72 (2001) 653-660
22. Kinney B.A., Meliska C.J., Steger R.W., and Bartke A. Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 39 (2001) 277-284
23. Krzisnik C., Kolacio Z., Battelino T., Brown M., Parks J.S., and Laron Z. The "Little People" of the island of Krk - revisited. Etiology of hypopituitarism revealed. J. Endocr. Genet. 1 (1999) 9-19
24. Laron Z. Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?. Mech. Ageing Dev. 126 (2005) 305-307
25. Le Corvoisier P., Hittinger L., Chanson P., Montagne O., Macquin-Mavier I., and Maison P. Cardiac effects of growth hormone treatment in chronic heart failure: a meta-analysis. J. Clin. Endocrinol. Metab. 92 (2007) 180-185
26. LeRoith D. Clinical relevance of systemic and local IGF-I: lessons from animal models. Pediatr. Endocrinol. Rev. 5 Suppl. 2 (2008) 739-743
27. Liu H., Bravata D.M., Olkin I., Nayak S., Roberts B., Garber A.M., and Hoffman A.R. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann. Intern. Med. 146 (2007) 104-115
28. Liu J.-P., Baker J., Perkins A.S., Robertson E.J., and Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor 1 (Igf1) and type 1 IGF receptor (Igf2r). Cell 75 (1993) 59-72
29. Mekala K.C., and Tritos N.A. Effects of recombinant human growth hormone therapy in obesity in adults: a metaanalysis. J. Clin. Endocrinol. Metab. 94 (2009) 130-137
30. Miller R.A., Harper J.M., Dysko R.C., Durkee S.J., and Austad S.N. Longer life spans and delayed maturation in wild-derived mice. Exp. Biol. Med. (Maywood) 227 (2002) 500-508
31. Miller R.A., Harper J.M., Galecki A., and Burke D.T. Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice. Aging Cell 1 (2002) 22-29
32. Müller, E.E., Cella, S.G., De Gennaro Colonna, V., Parenti, M., Cocchi, D., Locatelli, V., 1993. Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals. In: Falvo, R., Bartke, A., Giacobini, E., Thorne, A. (Eds.), Neurobiology and Neuroendocrinology of Ageing. J. Reprod. Fert. Suppl. 46, 99-114.
33. Nass, R., Johannsson, G., Christiansen, J.S., Kopchick, J.J., Thorner, M.O., 2008. The aging population - Is there a role for endocrine interventions? Growth Horm. IGF Res. (Epub ahead of print).
34. Thorner, M.O. et al., in press. Statement by the Growth Hormone Research Society on GH/IGF-1 Axis in Extending Healthspan (Epub ahead of print).
35. Oliveira J.L., Aguiar-Oliveira M.H., D'Oliveira Jr. A., Pereira R.M., Oliveira C.R., Farias C.T., Barreto-Filho J.A., Anjos-Andrade F.D., Marques-Santos C., Nascimento-Junior A.C., Alves E.O., Oliveira F.T., Campos V.C., Ximenes R., Blackford A., Parmigiani G., and Salvatori R. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults. J. Clin. Endocrinol. Metab. 92 (2007) 4664-4670
36. Papadakis M.A., Grady D., Black D., Tierney M.J., Gooding G.A., Schambelan M., and Grunfeld C. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann. Intern. Med. 124 (1996) 708-716
37. Patronek G.J., Waters D.J., and Glickman L.T. Comparative longevity of pet dogs and humans: implications for gerontology research. J. Gerontol. A Biol. Sci. Med. Sci. 52A (1997) B171-B178
38. Piper M.D.W., Selman C., McElwee J.J., and Partridge L. Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?. J. Intern. Med. 263 (2008) 179-191
39. Redman L.M., Martin C.K., Williamson D.A., and Ravussin E. Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes. Physiol. Behav. 94 (2008) 643-648
40. Richardson, A., Personal comment.
41. Rollo C.D. Growth negatively impacts the life span of mammals. Evol. Dev. 4 (2002) 55-61
42. Rudman D., Feller A.G., Nagraj H.S., Gergans G.A., Lalitha P.Y., Goldberg A.F., Schlenker R.A., Cohn L., Rudman I.W., and Mattson D.E. Effects of human growth hormone in men over 60 years old. N. Engl. J. Med. 323 (1990) 1-6
43. Samaras T.T. Human Body Size and The Laws of Scaling: Physiological, Performance, Growth, Longevity and Ecological Ramifications (2007), Nova Science Publishers, Inc., New York
44. Schumacher B., van der Pluijm I., Moorhouse M.J., Kosteas T., Robinson A.R., Suh Y., Breit T.M., van Steeg H., Niedernhofer L.J., van Ijcken W., Bartke A., Spindler S.R., Hoeijmakers J.H.J., van der Horst G.T.J., and Garinis G.A. Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet. 4 (2008) e1000161
45. Shechter M., Ginsberg S., Scheinowitz M., Feinberg MS., and Laron Z. Obese adults with primary growth hormone resistance (Laron syndrome) have normal endothelial function. Growth Horm. IGF Res. 17 2 (2007) 165-170
46. Sell, C., Lorenzini, S., 2007. Aging in IGF-1 hypomorphic mice, The American Aging Association 36th Annual Meeting. American Aging Association, San Antonio, TX.
47. Silberberg R. Articular aging and osteoarthrosis in dwarf mice. Pathol. Microbiol. (Basel) 38 (1972) 417-430
48. Smith R.G., Sun Y., Jiang H., Albarran-Zeckler R., and Timchenko N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann. NY Acad. Sci. 1119 (2007) 147-164
49. Sonntag E.W., Steger R.W., Forman J.L., and Meites J. Decreased pulsatile release of growth hormone in old male rats. Endocrinology 107 (1980) 1875-1879
50. Sonntag W.E., Ramsey M., and Carter C.S. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res. Rev. 4 (2005) 195-212
51. Taguchi A., Wartschow L.M., and White M.F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317 (2007) 369-372
52. Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
53. Veldhuis J., Iranmanesh A., and Weltman A. Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans. Endocrine 7 (1997) 41-48
54. Vergara M., Smith-Wheelock M., Harper J.M., Sigler R., and Miller R.A. Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J. Gerontol. A Biol. Sci. Med. Sci. 59 (2004) 1244-1250
55. Welle S., Thornton C., Statt M., and McHenry B. Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. J. Clin. Endocrinol. Metab. 81 (1996) 3239-3243
56. White, H.K., Petrie, C.D., Landschulz, W., Maclean, D., Taylor, A., Lyles, K., Wei, J.Y., Hoffman, A.R., Salvatori, R., Ettinger, M.P., Morey, M.C., Blackman, M.R., Merriam, G.R., in press. Effects of an oral growth hormone secretagogue in older adults. J. Clin. Endocrinol. Metab.