The Werner syndrome protein is involved in RNA polymerase II transcription

Molecular Biology of the Cell

Volumn 10, Issue 8, 1999, Pages 2655-2668

  Balajee, Adayabalam S ^a   Machwe, Amrita ^a   May, Alfred ^a   Gray, Matthew D ^b   Oshima, Junko ^b   Martin, George M ^b   Nehlin, Jan O ^a   Brosh, Robert ^a   Orren, David K ^a   Bohr, Vilhelm A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE; PROTEIN DERIVATIVE; RNA POLYMERASE II;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; GENE CONSTRUCT; GENE DELETION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION; WERNER SYNDROME;

ADENOVIRIDAE;

EID: 0032803070     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.8.2655     Document Type: Article

References (35)

1. Balajee, A.S., May, A., Dianov, G.L., Friedberg, E.C., and Bohr, V.A. (1997). Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells. Proc. Natl. Acad. Sci. USA 94, 4306-4311.
2. Bennett, S.E., Umar, A., Oshima, J., Monnat, R.J.J., and Kunkel, T.A. (1997). Mismatch repair in extracts of Werner syndrome cell lines. Cancer Res. 57, 2956-2960.
3. Biggerstaff, M., Robins, P., Coverly, D., and Wood, R.D. (1991). Effect of exogenous DNA fragments on human cell extract-mediated repair synthesis. Mutat. Res. 254, 217-224.
4. Bootsma, D., and Hoeijmakers, J.H. (1993). DNA repair. Engagement with transcription [news, comment]. Nature 363, 114-115.
5. Breeden, L., and Nasmyth, K. (1985). Regulation of the yeast HO gene. Cold Spring Harbor Symp. Quant. Biol. 50, 643-650.
6. Dianov, G.L., Houle, J.F., Iyer, N., Bohr, V.A., and Friedberg, B.C. (1997). Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells. Nucleic Acids Res. 25, 3636-3642.
7. Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. (1983). Accurate transcription initiation by RNA polymerase II in soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
8. Duguet, M. (1997). When helicase and topoisomerase meet! J Cell Sci. 110, 1345-1350.
9. Fukuchi, K., Martin, G.M., and Monnat, R.J. (1989). Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86, 5893-5897.
10. Gray, M.D., Shen, J.C., Kamath-Loeb, A.S., Blank, A., Sopher, B.L., Martin, G.M., Oshima, J., and Loeb, L.A. (1997). The Werner syndrome protein is a DNA helicase. Nat. Genet. 17, 100-103.
11. Gray, M.D., Wang, L., Youssoufian, H., Martin, G.M., and Oshima, J. (1998). Werner helicase is localized to transcriptionally active nucleoli of cycling cells. Exp. Cell Res. 242, 487-494.
12. Guzder, S.N., Sung, P., Bailly, V., Prakash, L., and Prakash, S. (1994). RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcription. Nature 369, 578-581.
13. Huang, S., Li, B., Gray, M.D., Oshima, J., Mian, I.S., and Campisi, J. (1998). The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nat. Genet. 20, 114-116.
14. Imamura, O., Ichikawa, K., Yamabe, Y., Goto, M., Sugawara, M., and Furuichi, Y. (1997). Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization. Genomics 41, 298-300.
15. Jackson, D.A., Hassan, A.B., and Cook, P.R. (1993). Visualization of focal sites of transcription within human nuclei. EMBO J. 12, 1059-1065.
16. Learned, R.M., Cordes, S., and Tjian, R. (1985). Purification and characterization of a transcription factor that confers promoter specificity to human RNA polymerase I. Mol. Cell. Biol. 5, 1358-1369.
17. Lebel, M., and Leder, P. (1998). A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. USA 95, 13097-13102.
18. Marciniak, R.A., Lombard, D.B., Johnson, F.B., and Guarente, L. (1998). Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. USA 95, 6686-6892.
19. Martin, G.M. (1978). Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig. Artic. Ser. 14, 5-39.
20. Martin, G.M. (1997). The Werner mutation: does it lead to a "public" or "private" mechanism of aging? Mol. Med. 3, 356-358.
21. Millis, A.J., Hoyle, M., McCue, H.M., and Martini, H. (1992). Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp. Cell Res. 201, 373-379.
22. Ramsperger, U., and Stahl, H. (1995). Unwinding of chromatin by the SV40 large T antigen DNA helicase. EMBO J. 14, 3215-3225.
23. Runger, T.M., Bauer, C., Dekant, B., Moller, K., Sobotta, P., Czerny, C., Poot, M., and Martin, G.M. (1994). Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J. Invest. Dermatol. 102, 45-48.
24. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
25. Sawadogo, M., and Roeder, R.G. (1985). Factors involved in specific transcription by RNA polymerase II: analysis by rapid and quantitative in vitro assay. Proc. Natl. Acad. Sci. USA 82, 4394-4398.
26. Schaeffer, L., Roy, R., Humbert, S., Moncollin, V., Vermeulen, W., Hoeijmakers, J.H., Chambon, P., and Egly, J.M. (1993). DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science 260, 58-63.
27. Shiratori, M., et al. (1999). Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their up-regulation by cell transformation and immortalization. J. Cell Biol. 144, 1-9.
28. Sinclair, D.A., Mills, K., and Guarente, L. (1998). Accelerated aging and nudeolar fragmentation in yeast sgs1 mutants. Science 277, 1313-1316.
29. Suzuki, N., Shimamoto, A., Imamura, O., Kuromitsu, J., Kitao, S., Goto, M., and Furuichi, Y. (1997). DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system. Nucleic Acids Res. 25, 2973-2978.
30. Vojtek, A.B., Hollenberg, S.M., and Cooper, J.A. (1993). Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205-214.
31. Webb, D.K., Evans, M.K., and Bohr, V.A. (1996). DNA repair fine structure in Werner's syndrome cell lines. Exp. Cell Res. 224, 272-278.
32. Yan, H., Chen, C-Y., Kobayashi, R., and Newport, J. (1998). Replication focus-forming activity 1 and the Werner syndrome gene product. Nat. Genet. 19, 375-378.
33. Ye, L., Nakura, J., Morishima, A., and Miki, T. (1998). Transcriptional activation by the Werner syndrome gene product in yeast. Exp. Gerontol. 33, 805-812.
34. Yu, C.E., et al. (1996). Positional cloning of the Werner's syndrome gene. Science 272, 258-262.
35. Yu, C.E., et al. (1997). Mutations in the concensus helicase domains of the Werner syndrome gene. Am. J. Hum. Genet. 60, 330-341.