Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts

Experimental Cell Research

Volumn 316, Issue 17, 2010, Pages 2747-2759

  Constantinescu, Dan ^b,c   Csoka, Antonei B ^d   Navara, Christopher S ^a,c   Schatten, Gerald P ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Aging; DNA repair; Lamin A; Nuclear lamina; Progeria

Indexed keywords

MRE11 PROTEIN; NIBRIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE;

ARTICLE; CELL STRUCTURE; CORONARY ARTERY; DISULFIDE BOND; DNA REPAIR; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; IONIZING RADIATION; LENTIVIRINAE; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROGERIA; PROTEIN LOCALIZATION; VIRAL GENE DELIVERY SYSTEM; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CELL CULTURE; CELL NUCLEUS; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; PATHOLOGY; SYNDROME;

CASE-CONTROL STUDIES; CELL NUCLEUS; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FIBROBLASTS; HUMANS; PROGERIA; SYNDROME;

EID: 77956875652     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.05.015     Document Type: Article

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