메뉴 건너뛰기




Volumn 347, Issue 1, 2012, Pages 103-116

The role of EMT in renal fibrosis

Author keywords

Diabetic nephropathy; EMT; MicroRNA; Renal fibrosis; TGF beta

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CADHERIN; CADHERIN; CALCIUM CHANNEL BLOCKING AGENT; CALVASCULIN; CELL PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRONECTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KALININ; LAMININ 1; MATRIX METALLOPROTEINASE INHIBITOR; MICRORNA; MICRORNA 200; MICRORNA 21; MICRORNA 29; NERVE CELL ADHESION MOLECULE; OB CADHERIN; PARICALCITOL; PYRIDOXAMINE; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA2; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; RUBOXISTAURIN; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; ZEB1 PROTEIN; ZEB2 PROTEIN;

EID: 84858308320     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-011-1227-1     Document Type: Review
Times cited : (257)

References (178)
  • 1
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, De Robertis EM (2002) Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 4:599-604
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 2
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119:1438-1449
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 3
    • 79952350073 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their role in the renal epithelial mesenchymal transition
    • Aresu L, Benali S, Garbisa S, Gallo E, Castagnaro M (2011) Matrix metalloproteinases and their role in the renal epithelial mesenchymal transition. Histol Histopath 26:307-313
    • (2011) Histol Histopath , vol.26 , pp. 307-313
    • Aresu, L.1    Benali, S.2    Garbisa, S.3    Gallo, E.4    Castagnaro, M.5
  • 5
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
    • DOI 10.1074/jbc.M005912200
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275:36803-36810 (Pubitemid 32002090)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 6
    • 23844528776 scopus 로고    scopus 로고
    • The Snail genes as inducers of cell movement and survival: Implications in development and cancer
    • DOI 10.1242/dev.01907
    • Barrallo-Gimeno A, Nieto MA (2005) The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132:3151-3161 (Pubitemid 41167144)
    • (2005) Development , vol.132 , Issue.14 , pp. 3151-3161
    • Barrallo-Gimeno, A.1    Nieto, M.A.2
  • 8
    • 12544252343 scopus 로고    scopus 로고
    • Beta-Catenin: A pivot between cell adhesion and Wnt signalling
    • Bienz M (2005) beta-Catenin: a pivot between cell adhesion and Wnt signalling. Curr Biol 15:R64-67
    • (2005) Curr Biol , vol.15
    • Bienz, M.1
  • 9
    • 0030512150 scopus 로고    scopus 로고
    • Transforming growth factor beta in diabetic nephropathy
    • DOI 10.1002/(SICI)1099-0895(199612)12:4<309::AID-DMR171>3.0.CO;2-A
    • Border WA, Yamamoto T, Noble NA (1996) Transforming growth factor beta in diabetic nephropathy. Diabetes Metab Rev 12:309-339 (Pubitemid 27062225)
    • (1996) Diabetes/Metabolism Reviews , vol.12 , Issue.4 , pp. 309-339
    • Border, W.A.1    Yamamoto, T.2    Noble, N.A.3
  • 10
    • 33751582928 scopus 로고    scopus 로고
    • Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
    • DOI 10.1038/sj.emboj.7601421, PII 7601421
    • Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J, Nieto MA (2006) Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J 25:5603-5613 (Pubitemid 44847200)
    • (2006) EMBO Journal , vol.25 , Issue.23 , pp. 5603-5613
    • Boutet, A.1    De Frutos, C.A.2    Maxwell, P.H.3    Mayol, M.J.4    Romero, J.5    Nieto, M.A.6
  • 11
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 13
    • 33748031093 scopus 로고    scopus 로고
    • Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: Implications for diabetic renal disease
    • DOI 10.1681/ASN.2006050525
    • Burns WC, Twigg SM, Forbes JM, Pete J, Tikellis C, Thallas-Bonke V, Thomas MC, Cooper ME, Kantharidis P (2006) Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. J Am Soc Nephrol 17:2484-2494 (Pubitemid 44300964)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.9 , pp. 2484-2494
    • Burns, W.C.1    Twigg, S.M.2    Forbes, J.M.3    Pete, J.4    Tikellis, C.5    Thallas-Bonke, V.6    Thomas, M.C.7    Cooper, M.E.8    Kantharidis, P.9
  • 16
    • 0038582623 scopus 로고    scopus 로고
    • Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation
    • Cheng S, Lovett DH (2003) Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 162:1937-1949 (Pubitemid 36613051)
    • (2003) American Journal of Pathology , vol.162 , Issue.6 , pp. 1937-1949
    • Cheng, S.1    Lovett, D.H.2
  • 17
    • 33845787629 scopus 로고    scopus 로고
    • Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway
    • DOI 10.1016/j.bbrc.2006.12.035, PII S0006291X06026611
    • Cho HJ, Baek KE, Saika S, Jeong MJ, Yoo J (2007) Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway. Biochem Biophys Res Commun 353:337-343 (Pubitemid 46014570)
    • (2007) Biochemical and Biophysical Research Communications , vol.353 , Issue.2 , pp. 337-343
    • Cho, H.J.1    Baek, K.E.2    Saika, S.3    Jeong, M.-J.4    Yoo, J.5
  • 18
    • 77955611511 scopus 로고    scopus 로고
    • miR-192 mediates TGF-beta/Smad3-driven renal fibrosis
    • Chung AC, Huang XR, Meng X, Lan HY (2010) miR-192 mediates TGF-beta/Smad3-driven renal fibrosis. J Am Soc Nephrol 21:1317-1325
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1317-1325
    • Chung, A.C.1    Huang, X.R.2    Meng, X.3    Lan, H.Y.4
  • 20
    • 84859439004 scopus 로고    scopus 로고
    • Pathogenesis, prevention, and treatment of diabetic nephropathy
    • Johnson RJ, Feehally J (eds) Mosby, Philadelphia
    • Cooper ME, Gilbert RE (2003) Pathogenesis, prevention, and treatment of diabetic nephropathy. In: Johnson RJ, Feehally J (eds) Comprehensive clinical nephrology. Mosby, Philadelphia, pp 439-451
    • (2003) Comprehensive Clinical Nephrology , pp. 439-451
    • Cooper, M.E.1    Gilbert, R.E.2
  • 21
  • 24
    • 33751161268 scopus 로고    scopus 로고
    • The cellular basis of kidney development
    • Dressler GR (2006) The cellular basis of kidney development. Annu Rev Cell Dev Biol 22:509-529
    • (2006) Annu Rev Cell Dev Biol , vol.22 , pp. 509-529
    • Dressler, G.R.1
  • 25
    • 0032842887 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates tubular epithelial- myofibroblast transdifferentiation in vitro
    • DOI 10.1046/j.1523-1755.1999.00656.x
    • Fan JM, Ng YY, Hill PA, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY (1999) Transforming growth factor-beta regulates tubular epithelial- myofibroblast transdifferentiation in vitro. Kidney Int 56:1455-1467 (Pubitemid 29451252)
    • (1999) Kidney International , vol.56 , Issue.4 , pp. 1455-1467
    • Fan, J.-M.1    Yee-Yung, N.G.2    Hill, P.A.3    Nikolic-Paterson, D.J.4    Mu, W.5    Atkins, R.C.6    Lan, H.Y.7
  • 26
    • 0035061819 scopus 로고    scopus 로고
    • Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro
    • Fan JM, Huang XR, Ng YY, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY (2001) Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro. Am J Kidney Dis 37:820-831 (Pubitemid 32268044)
    • (2001) American Journal of Kidney Diseases , vol.37 , Issue.4 , pp. 820-831
    • Fan, J.-M.1    Huang, X.-R.2    Ng, Y.-Y.3    Nikolic-Paterson, D.J.4    Mu, W.5    Atkins, R.C.6    Lan, H.Y.7
  • 28
    • 30944442610 scopus 로고    scopus 로고
    • Role of anti-TGF-beta antibodies in the treatment of renal injury
    • DOI 10.1016/j.cytogfr.2005.09.005, PII S1359610105001097
    • Gagliardini E, Benigni A (2006) Role of anti-TGF-beta antibodies in the treatment of renal injury. Cytokine Growth Factor Rev 17:89-96 (Pubitemid 43117518)
    • (2006) Cytokine and Growth Factor Reviews , vol.17 , Issue.1-2 , pp. 89-96
    • Gagliardini, E.1    Benigni, A.2
  • 29
    • 79954581525 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition as a biomarker in renal fibrosis: Are we ready for the bedside?
    • Galichon P, Hertig A (2011) Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside? Fibrogenesis Tissue Repair 4:11
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 11
    • Galichon, P.1    Hertig, A.2
  • 30
    • 0032731318 scopus 로고    scopus 로고
    • The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?
    • DOI 10.1046/j.1523-1755.1999.00721.x
    • Gilbert RE, Cooper ME (1999) The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 56:1627-1637 (Pubitemid 29518163)
    • (1999) Kidney International , vol.56 , Issue.5 , pp. 1627-1637
    • Gilbert, R.E.1    Cooper, M.E.2
  • 34
    • 0020358296 scopus 로고
    • Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
    • DOI 10.1083/jcb.95.1.333
    • Greenburg G, Hay ED (1982) Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol 95:333-339 (Pubitemid 13197104)
    • (1982) Journal of Cell Biology , vol.95 , Issue.1 , pp. 333-339
    • Greenburg, G.1    Hay, E.D.2
  • 36
    • 54049089608 scopus 로고    scopus 로고
    • MicroRNAs as regulators of epithelial-mesenchymal transition
    • Gregory PA, Bracken CP, Bert AG, Goodall GJ (2008b) MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 7:3112-3118
    • (2008) Cell Cycle , vol.7 , pp. 3112-3118
    • Gregory, P.A.1    Bracken, C.P.2    Bert, A.G.3    Goodall, G.J.4
  • 37
    • 84857115631 scopus 로고    scopus 로고
    • The origin of interstitial myofibroblasts in chronic kidney disease
    • in press
    • Grgic I, Duffield JS, Humphreys BD (2011) The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol (in press)
    • (2011) Pediatr Nephrol
    • Grgic, I.1    Duffield, J.S.2    Humphreys, B.D.3
  • 38
    • 0033802165 scopus 로고    scopus 로고
    • Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
    • Gupta S, Clarkson MR, Duggan J, Brady HR (2000) Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int 58:1389-1399
    • (2000) Kidney Int , vol.58 , pp. 1389-1399
    • Gupta, S.1    Clarkson, M.R.2    Duggan, J.3    Brady, H.R.4
  • 40
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • Hay ED (2005) The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn 233:706-720
    • (2005) Dev Dyn , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 41
    • 0032589970 scopus 로고    scopus 로고
    • TGF-beta1 activates MAP kinase in human mesangial cells: A possible role in collagen expression
    • DOI 10.1046/j.1523-1755.1999.00733.x
    • Hayashida T, Poncelet AC, Hubchak SC, Schnaper HW (1999) TGFbeta1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 56:1710-1720 (Pubitemid 29518171)
    • (1999) Kidney International , vol.56 , Issue.5 , pp. 1710-1720
    • Hayashida, T.1    Poncelet, A.-C.2    Hubchak, S.C.3    Schnaper, H.W.4
  • 42
    • 78651384347 scopus 로고    scopus 로고
    • Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury
    • He W, Kang YS, Dai C, Liu Y (2011) Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22:90-103
    • (2011) J Am Soc Nephrol , vol.22 , pp. 90-103
    • He, W.1    Kang, Y.S.2    Dai, C.3    Liu, Y.4
  • 43
    • 0034465487 scopus 로고    scopus 로고
    • The renal expression of transforming growth factor-beta isoforms and their receptors in acute and chronic experimental diabetes in rats
    • DOI 10.1210/en.141.3.1196
    • Hill C, Flyvbjerg A, Gronbaek H, Petrik J, Hill DJ, Thomas CR, Sheppard MC, Logan A (2000) The renal expression of transforming growth factor-beta isoforms and their receptors in acute and chronic experimental diabetes in rats. Endocrinology 141:1196-1208 (Pubitemid 32260463)
    • (2000) Endocrinology , vol.141 , Issue.3 , pp. 1196-1208
    • Hill, C.1    Flyvbjerg, A.2    Gronbaek, H.3    Petrik, J.4    Hill, D.J.5    Thomas, C.R.6    Sheppard, M.C.7    Logan, A.8
  • 44
    • 0034827951 scopus 로고    scopus 로고
    • Transforming growth factor-beta2 antibody attenuates fibrosis in the experimental diabetic rat kidney
    • DOI 10.1677/joe.0.1700647
    • Hill C, Flyvbjerg A, Rasch R, Bak M, Logan A (2001) Transforming growth factor-beta2 antibody attenuates fibrosis in the experimental diabetic rat kidney. J Endocrinol 170:647-651 (Pubitemid 32834331)
    • (2001) Journal of Endocrinology , vol.170 , Issue.3 , pp. 647-651
    • Hill, C.1    Flyvbjerg, A.2    Rasch, R.3    Bak, M.4    Logan, A.5
  • 45
    • 65549115158 scopus 로고    scopus 로고
    • Cellular and physiological effects of Cpeptide
    • Lond
    • Hills CE, Brunskill NJ (2009) Cellular and physiological effects of Cpeptide. Clin Sci (Lond) 116:565-574
    • (2009) Clin Sci , vol.116 , pp. 565-574
    • Hills, C.E.1    Brunskill, N.J.2
  • 46
    • 57349116972 scopus 로고    scopus 로고
    • Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells
    • Holian J, Qi W, Kelly DJ, Zhang Y, Mreich E, Pollock CA, Chen XM (2008) Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells. Am J Physiol Renal Physiol 295:F1388-1396
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Holian, J.1    Qi, W.2    Kelly, D.J.3    Zhang, Y.4    Mreich, E.5    Pollock, C.A.6    Chen, X.M.7
  • 48
    • 0020413602 scopus 로고
    • Fibronectins: Multifunctional modular glycoproteins
    • DOI 10.1083/jcb.95.2.369
    • Hynes RO, Yamada KM (1982) Fibronectins: multifunctional modular glycoproteins. J Cell Biol 95:369-377 (Pubitemid 13215850)
    • (1982) Journal of Cell Biology , vol.95 , Issue.2 I , pp. 369-377
    • Hynes, R.O.1    Yamada, K.M.2
  • 52
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGF{beta} cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grunert S (2002) Ras and TGF{beta} cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol 156:299-314
    • (2002) J Cell Biol , vol.156 , pp. 299-314
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6    Beug, H.7    Grunert, S.8
  • 53
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • DOI 10.1172/JCI200320530
    • Kalluri R, Neilson EG (2003) Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776-1784 (Pubitemid 38063698)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 54
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420-1428
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 56
    • 77958583070 scopus 로고    scopus 로고
    • Post-transcriptional upregulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells
    • Kato M, Wang L, Putta S, Wang M, Yuan H, Sun G, Lanting L, Todorov I, Rossi JJ, Natarajan R. Post-transcriptional upregulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. J Biol Chem 285:34004-34015
    • J Biol Chem , vol.285 , pp. 34004-34015
    • Kato, M.1    Wang, L.2    Putta, S.3    Wang, M.4    Yuan, H.5    Sun, G.6    Lanting, L.7    Todorov, I.8    Rossi, J.J.9    Natarajan, R.10
  • 59
    • 49949114895 scopus 로고    scopus 로고
    • Protein kinase B/Akt activity is involved in renal TGF{beta}-1 driven epithelial-mesenchymal transition in vitro and in vivo
    • Kattla JJ, Carew RM, Heljic M, Godson C, Brazil DP (2008) Protein kinase B/Akt activity is involved in renal TGF{beta}-1 driven epithelial-mesenchymal transition in vitro and in vivo. Am J Physiol Renal Physiol 295:F215-F225
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Kattla, J.J.1    Carew, R.M.2    Heljic, M.3    Godson, C.4    Brazil, D.P.5
  • 60
    • 0037743636 scopus 로고    scopus 로고
    • Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
    • DOI 10.1038/ng1178
    • Khokha MK, Hsu D, Brunet LJ, Dionne MS, Harland RM (2003) Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet 34:303-307 (Pubitemid 36792863)
    • (2003) Nature Genetics , vol.34 , Issue.3 , pp. 303-307
    • Khokha, M.K.1    Hsu, D.2    Brunet, L.J.3    Dionne, M.S.4    Harland, R.M.5
  • 61
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • DOI 10.1006/cbir.2002.0901
    • Kim K, Lu Z, Hay ED (2002a) Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 26:463-476 (Pubitemid 34762099)
    • (2002) Cell Biology International , vol.26 , Issue.5 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 62
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • DOI 10.1006/cbir.2002.0901
    • Kim K, Lu Z, Hay ED (2002b) Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 26:463-476 (Pubitemid 34762099)
    • (2002) Cell Biology International , vol.26 , Issue.5 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 64
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283:14910-14914
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 69
    • 79952695743 scopus 로고    scopus 로고
    • Targeting the jagged/notch pathway: A new treatment for fibrosis?
    • Leask A (2010) Targeting the jagged/notch pathway: a new treatment for fibrosis? J Cell Commun Signal 4:197-198
    • (2010) J Cell Commun Signal , vol.4 , pp. 197-198
    • Leask, A.1
  • 70
    • 0033667322 scopus 로고    scopus 로고
    • Renal fibrosis in mice treated with human recombinant transforming growth factor-beta2
    • Ledbetter S, Kurtzberg L, Doyle S, Pratt BM (2000) Renal fibrosis in mice treated with human recombinant transforming growth factor-beta2. Kidney Int 58:2367-2376
    • (2000) Kidney Int , vol.58 , pp. 2367-2376
    • Ledbetter, S.1    Kurtzberg, L.2    Doyle, S.3    Pratt, B.M.4
  • 71
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R, Thompson EW (2006) The epithelial- mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172:973-981
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 72
    • 34248209601 scopus 로고    scopus 로고
    • Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis
    • DOI 10.1091/mbc.E06-09-0823
    • Leroy P, Mostov KE (2007) Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis. Mol Biol Cell 18:1943-1952 (Pubitemid 46717573)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.5 , pp. 1943-1952
    • Leroy, P.1    Mostov, K.E.2
  • 74
    • 0141720342 scopus 로고    scopus 로고
    • Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
    • DOI 10.1172/JCI200317913
    • Li Y, Yang J, Dai C, Wu C, Liu Y (2003) Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Investig 112:503-516 (Pubitemid 38056335)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.4 , pp. 503-516
    • Li, Y.1    Yang, J.2    Dai, C.3    Wu, C.4    Liu, Y.5
  • 75
    • 39549098861 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria
    • DOI 10.2353/ajpath.2008.070057
    • Li Y, Kang YS, Dai C, Kiss LP, Wen X, Liu Y (2008) Epithelial-to- mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. Am J Pathol 172:299-308 (Pubitemid 351282018)
    • (2008) American Journal of Pathology , vol.172 , Issue.2 , pp. 299-308
    • Li, Y.1    Kang, Y.S.2    Dai, C.3    Kiss, L.P.4    Wen, X.5    Liu, Y.6
  • 76
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention
    • Liu Y (2004) Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15:1-12
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 77
    • 77950500403 scopus 로고    scopus 로고
    • Renal medullary microRNAs in Dahl saltsensitive rats: MiR-29b regulates several collagens and related genes
    • Liu Y, Taylor NE, Lu L, Usa K, Cowley AW, Jr, Ferreri NR, Yeo NC, Liang M (2010) Renal medullary microRNAs in Dahl saltsensitive rats: miR-29b regulates several collagens and related genes. Hypertension 55:974-982
    • (2010) Hypertension , vol.55 , pp. 974-982
    • Liu, Y.1    Taylor, N.E.2    Lu, L.3    Usa, K.4    Cowley Jr., A.W.5    Ferreri, N.R.6    Yeo, N.C.7    Liang, M.8
  • 79
    • 0037407520 scopus 로고    scopus 로고
    • Extracellular matrix metabolism in diabetic nephropathy
    • DOI 10.1097/01.ASN.0000065640.77499.D7
    • Mason RM, Wahab NA (2003) Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol 14:1358-1373 (Pubitemid 36519197)
    • (2003) Journal of the American Society of Nephrology , vol.14 , Issue.5 , pp. 1358-1373
    • Mason, R.M.1    Wahab, N.A.2
  • 81
    • 0034616419 scopus 로고    scopus 로고
    • IHG-2, a mesangial cell gene induced by high glucose, is human gremlin: Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1
    • DOI 10.1074/jbc.275.14.9901
    • McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C, Martin F, Brady HR (2000) IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. J Biol Chem 275:9901-9904 (Pubitemid 30202033)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.14 , pp. 9901-9904
    • McMahon, R.1    Murphy, M.2    Clarkson, M.3    Taal, M.4    Mackenzie, H.S.5    Godson, C.6    Martin, F.7    Brady, H.R.8
  • 82
    • 42549116610 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 (BMP7) in chronic kidney disease
    • DOI 10.2741/3035
    • Mitu G, Hirschberg R (2008) Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci 13:4726-4739 (Pubitemid 351589193)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.12 , pp. 4726-4739
    • Mitu, G.1    Hirschberg, R.2
  • 84
    • 0033605162 scopus 로고    scopus 로고
    • Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells
    • DOI 10.1074/jbc.274.9.5830
    • Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, Brady HR (1999) Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 274:5830-5834 (Pubitemid 29109239)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.9 , pp. 5830-5834
    • Murphy, M.1    Godson, C.2    Cannon, S.3    Kato, S.4    Mackenzie, H.S.5    Martin, F.6    Brady, H.R.7
  • 85
    • 0026769228 scopus 로고
    • Tubulointerstitial changes as a major determinant in the progression of renal damage
    • Nath KA (1992) Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20:1-17
    • (1992) Am J Kidney Dis , vol.20 , pp. 1-17
    • Nath, K.A.1
  • 86
    • 33644830593 scopus 로고    scopus 로고
    • Mechanisms of disease: Fibroblasts-a new look at an old problem
    • Neilson EG (2006) Mechanisms of disease: Fibroblasts-a new look at an old problem. Nat Clin Pract Nephrol 2:101-108
    • (2006) Nat Clin Pract Nephrol , vol.2 , pp. 101-108
    • Neilson, E.G.1
  • 87
    • 34447264295 scopus 로고    scopus 로고
    • Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia
    • Neilson EG (2007) Plasticity, nuclear diapause, and a requiem for the terminal differentiation of epithelia. J Am Soc Nephrol 18:1995-1998
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1995-1998
    • Neilson, E.G.1
  • 88
    • 79952029824 scopus 로고    scopus 로고
    • The origin of fibroblasts and the terminality of epithelial differentiation
    • The Jeremiah Metzger lecture. The Jeremiah Metzger lecture
    • Neilson EG (2010) The Jeremiah Metzger lecture. The origin of fibroblasts and the terminality of epithelial differentiation. Trans Am Clin Climatol Assoc 121:240-250, The Jeremiah Metzger lecture
    • (2010) Trans Am Clin Climatol Assoc , vol.121 , pp. 240-250
    • Neilson, E.G.1
  • 89
    • 0031682715 scopus 로고    scopus 로고
    • Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats
    • DOI 10.1046/j.1523-1755.1998.00076.x
    • Ng YY, Huang TP, Yang WC, Chen ZP, Yang AH, Mu W, Nikolic-Paterson DJ, Atkins RC, Lan HY (1998) Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54:864-876 (Pubitemid 28397404)
    • (1998) Kidney International , vol.54 , Issue.3 , pp. 864-876
    • Ng, Y.-Y.1    Huang, T.-P.2    Yang, W.-C.3    Chen, Z.-P.4    Yang, A.-H.5    Mu, W.6    Nikolic-, P.D.J.7    Atkins, R.C.8    Lan, H.Y.9
  • 90
    • 0033857531 scopus 로고    scopus 로고
    • The missing link: A single unifying mechanism for diabetic complications
    • Nishikawa T, Edelstein D, Brownlee M (2000) The missing link: a single unifying mechanism for diabetic complications. Kidney Int Suppl 77:S26-30
    • (2000) Kidney Int Suppl , vol.77
    • Nishikawa, T.1    Edelstein, D.2    Brownlee, M.3
  • 92
  • 93
    • 0033865917 scopus 로고    scopus 로고
    • Progressive renal fibrosis in routine polycystic kidney disease: An immunohistochemical observation
    • DOI 10.1046/j.1523-1755.2000.00205.x
    • Okada H, Ban S, Nagao S, Takahashi H, Suzuki H, Neilson EG (2000a) Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int 58:587-597 (Pubitemid 30620008)
    • (2000) Kidney International , vol.58 , Issue.2 , pp. 587-597
    • Okada, H.1    Ban, S.2    Nagao, S.3    Takahashi, H.4    Suzuki, H.5    Neilson, E.G.6
  • 94
    • 0033661430 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transformation of renal tubular epithelial cells in vitro and in vivo
    • Okada H, Inoue T, Suzuki H, Strutz F, Neilson EG (2000b) Epithelial-mesenchymal transformation of renal tubular epithelial cells in vitro and in vivo. Nephrol Dial Transplant 15(Suppl 6):44-46
    • (2000) Nephrol Dial Transplant , vol.15 , Issue.SUPPL. 6 , pp. 44-46
    • Okada, H.1    Inoue, T.2    Suzuki, H.3    Strutz, F.4    Neilson, E.G.5
  • 96
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • DOI 10.1101/gad.1640608
    • Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894-907 (Pubitemid 351482843)
    • (2008) Genes and Development , vol.22 , Issue.7 , pp. 894-907
    • Park, S.-M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 97
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 induces Snail transcription factor in epithelial cell lines. Mechanisms for epithelial mesenchymal transitions
    • DOI 10.1074/jbc.M211304200
    • Peinado H, Quintanilla M, Cano A (2003) Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113-21123 (Pubitemid 36806424)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.23 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 98
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415-428 (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 99
    • 30744478450 scopus 로고    scopus 로고
    • The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells
    • DOI 10.1042/BJ20051106
    • Phanish MK, Wahab NA, Colville-Nash P, Hendry BM, Dockrell ME (2006) The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells. Biochem J 393:601-607 (Pubitemid 43099100)
    • (2006) Biochemical Journal , vol.393 , Issue.2 , pp. 601-607
    • Phanish, M.K.1    Wahab, N.A.2    Colville-Nash, P.3    Hendry, B.M.4    Dockrell, M.E.C.5
  • 100
    • 55249126800 scopus 로고    scopus 로고
    • The role of endothelial-to-mesenchymal transition in cancer progression
    • Potenta S, Zeisberg E, Kalluri R (2008) The role of endothelial-to- mesenchymal transition in cancer progression. Br J Cancer 99:1375-1379
    • (2008) Br J Cancer , vol.99 , pp. 1375-1379
    • Potenta, S.1    Zeisberg, E.2    Kalluri, R.3
  • 104
    • 33644849416 scopus 로고    scopus 로고
    • Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells
    • DOI 10.1038/sj.ki.5000189, PII 5000189
    • Qi W, Chen X, Twigg S, Polhill TS, Gilbert RE, Pollock CA (2006b) Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells. Kidney Int 69:989-995 (Pubitemid 43372173)
    • (2006) Kidney International , vol.69 , Issue.6 , pp. 989-995
    • Qi, W.1    Chen, X.2    Twigg, S.3    Polhill, T.S.4    Gilbert, R.E.5    Pollock, C.A.6
  • 105
  • 110
  • 111
    • 0031933224 scopus 로고    scopus 로고
    • Molecular and cell biology of TGF-beta
    • Roberts AB (1998) Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 24:111-119
    • (1998) Miner Electrolyte Metab , vol.24 , pp. 111-119
    • Roberts, A.B.1
  • 112
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta)
    • Roberts AB, Sporn MB (1993) Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 8:1-9 (Pubitemid 23093206)
    • (1993) Growth Factors , vol.8 , Issue.1 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 114
    • 24044486529 scopus 로고    scopus 로고
    • 4 modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells
    • Rodgers K, McMahon B, Mitchell D, Sadlier D, Godson C (2005) Lipoxin A4 modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells. Am J Pathol 167:683-694 (Pubitemid 41216354)
    • (2005) American Journal of Pathology , vol.167 , Issue.3 , pp. 683-694
    • Rodgers, K.1    McMahon, B.2    Mitchell, D.3    Sadlier, D.4    Godson, C.5
  • 115
    • 1642535424 scopus 로고    scopus 로고
    • The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-beta1
    • DOI 10.1074/jbc.M310412200
    • Runyan CE, Schnaper HW, Poncelet AC (2004) The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1. J Biol Chem 279:2632-2639 (Pubitemid 38114250)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.4 , pp. 2632-2639
    • Runyan, C.E.1    Schnaper, H.W.2    Poncelet, A.-C.3
  • 116
    • 77953541796 scopus 로고    scopus 로고
    • Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor
    • Saad S, Stanners SR, Yong R, Tang O, Pollock CA (2010) Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int J Biochem Cell Biol 42:1115-1122
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1115-1122
    • Saad, S.1    Stanners, S.R.2    Yong, R.3    Tang, O.4    Pollock, C.A.5
  • 117
  • 121
    • 0029076281 scopus 로고
    • Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator
    • Sharma K, Ziyadeh FN (1995) Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 44:1139-1146
    • (1995) Diabetes , vol.44 , pp. 1139-1146
    • Sharma, K.1    Ziyadeh, F.N.2
  • 122
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGFbeta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN (1996) Neutralization of TGFbeta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45:522-530
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 124
    • 0242413065 scopus 로고    scopus 로고
    • Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development
    • DOI 10.1016/j.mod.2003.06.005
    • Shook D, Keller R (2003) Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 120:1351-1383 (Pubitemid 37421168)
    • (2003) Mechanisms of Development , vol.120 , Issue.11 , pp. 1351-1383
    • Shook, D.1    Keller, R.2
  • 125
    • 25144460253 scopus 로고    scopus 로고
    • Cyclosporine A - induced renal fibrosis: A role for epithelial- mesenchymal transition
    • Slattery C, Campbell E, McMorrow T, Ryan MP (2005) Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition. Am J Pathol 167:395-407 (Pubitemid 43026096)
    • (2005) American Journal of Pathology , vol.167 , Issue.2 , pp. 395-407
    • Slattery, C.1    Campbell, E.2    McMorrow, T.3    Ryan, M.P.4
  • 126
    • 0034703087 scopus 로고    scopus 로고
    • Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7: The TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation
    • DOI 10.1074/jbc.M003282200
    • Stopa M, Anhuf D, Terstegen L, Gatsios P, Gressner AM, Dooley S (2000) Participation of Smad2, Smad3, and Smad4 in transforming growth factor beta (TGF-beta)-induced activation of Smad7. The TGF-beta response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J Biol Chem 275:29308-29317 (Pubitemid 32043801)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.38 , pp. 29308-29317
    • Stopa, M.1    Anhuf, D.2    Terstegen, L.3    Gatsios, P.4    Gressner, A.M.5    Dooley, S.6
  • 129
    • 34347375050 scopus 로고    scopus 로고
    • Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    • DOI 10.2337/db06-1226
    • Sugimoto H, Grahovac G, Zeisberg M, Kalluri R (2007) Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 56:1825-1833 (Pubitemid 47025452)
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1825-1833
    • Sugimoto, H.1    Grahovac, G.2    Zeisberg, M.3    Kalluri, R.4
  • 130
    • 0043063969 scopus 로고    scopus 로고
    • Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells
    • DOI 10.1111/j.1349-7006.2003.tb01488.x
    • Taki M, Kamata N, Yokoyama K, Fujimoto R, Tsutsumi S, Nagayama M (2003) Down-regulation of Wnt-4 and up-regulation of Wnt- 5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 94:593-597 (Pubitemid 36975013)
    • (2003) Cancer Science , vol.94 , Issue.7 , pp. 593-597
    • Taki, M.1    Kamata, N.2    Yokoyama, K.3    Fujimoto, R.4    Tsutsumi, S.5    Nagayama, M.6
  • 132
    • 16344378397 scopus 로고    scopus 로고
    • TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • DOI 10.1091/mbc.E04-08-0658
    • Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A (2005) TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 16:1987-2002 (Pubitemid 40471965)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.4 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.-H.4    Moustakas, A.5
  • 134
    • 0031309902 scopus 로고    scopus 로고
    • The discoidin domain receptor tyrosine kinases are activated by collagen
    • Vogel W, Gish GD, Alves F, Pawson T (1997) The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1:13-23 (Pubitemid 127376389)
    • (1997) Molecular Cell , vol.1 , Issue.1 , pp. 13-23
    • Vogel, W.1    Gish, G.D.2    Alves, F.3    Pawson, T.4
  • 135
    • 20544462075 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis
    • DOI 10.1111/j.1600-6143.2005.00843.x
    • Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF (2005) Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 5:1367-1374 (Pubitemid 40839427)
    • (2005) American Journal of Transplantation , vol.5 , Issue.6 , pp. 1367-1374
    • Vongwiwatana, A.1    Tasanarong, A.2    Rayner, D.C.3    Melk, A.4    Halloran, P.F.5
  • 138
    • 0034951422 scopus 로고    scopus 로고
    • Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy
    • DOI 10.1046/j.1523-1755.2001.00776.x
    • Wang S, Denichilo M, Brubaker C, Hirschberg R (2001) Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy. Kidney Int 60:96-105 (Pubitemid 32587544)
    • (2001) Kidney International , vol.60 , Issue.1 , pp. 96-105
    • Wang, S.1    DeNichilo, M.2    Brubaker, C.3    Hirschberg, R.4
  • 139
    • 34547620873 scopus 로고    scopus 로고
    • Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion
    • DOI 10.1158/0008-5472.CAN-06-4729
    • Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (2007) Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res 67:7184-7193 (Pubitemid 47206546)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7184-7193
    • Wang, X.1    Zheng, M.2    Liu, G.3    Xia, W.4    McKeown-Longo, P.J.5    Hung, M.-C.6    Zhao, J.7
  • 140
    • 57349186092 scopus 로고    scopus 로고
    • MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
    • Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X, Quigg RJ (2008) MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J 22:4126-4135
    • (2008) FASEB J , vol.22 , pp. 4126-4135
    • Wang, Q.1    Wang, Y.2    Minto, A.W.3    Wang, J.4    Shi, Q.5    Li, X.6    Quigg, R.J.7
  • 146
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue C, Plieth D, Venkov C, Xu C, Neilson EG (2003) The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 63:3386-3394 (Pubitemid 36735899)
    • (2003) Cancer Research , vol.63 , Issue.12 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 150
    • 0034785496 scopus 로고    scopus 로고
    • Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    • Yang J, Liu Y (2001) Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159:1465-1475 (Pubitemid 32947976)
    • (2001) American Journal of Pathology , vol.159 , Issue.4 , pp. 1465-1475
    • Yang, J.1    Liu, Y.2
  • 151
    • 0036138824 scopus 로고    scopus 로고
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
    • Yang J, Liu Y (2002) Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 13:96-107 (Pubitemid 34042016)
    • (2002) Journal of the American Society of Nephrology , vol.13 , Issue.1 , pp. 96-107
    • Yang, J.1    Liu, Y.2
  • 152
    • 0034782480 scopus 로고    scopus 로고
    • Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice
    • DOI 10.1038/sj.gt.3301545
    • Yang J, Dai C, Liu Y (2001) Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Gene Ther 8:1470-1479 (Pubitemid 32994658)
    • (2001) Gene Therapy , vol.8 , Issue.19 , pp. 1470-1479
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 153
    • 0036785218 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice
    • Yang J, Dai C, Liu Y (2002a) Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J Am Soc Nephrol 13:2464-2477
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2464-2477
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 154
    • 0036854980 scopus 로고    scopus 로고
    • Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
    • DOI 10.1172/JCI200216219
    • Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, Nejak K, Liu Y (2002b) Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 110:1525-1538 (Pubitemid 35396923)
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.10 , pp. 1525-1538
    • Yang, J.1    Shultz, R.W.2    Mars, W.M.3    Wegner, R.E.4    Li, Y.5    Dai, C.6    Nejak, K.7    Liu, Y.8
  • 160
    • 54549086654 scopus 로고    scopus 로고
    • The role of twist during palate development
    • Yu W, Kamara H, Svoboda KK (2008) The role of twist during palate development. Dev Dyn 237:2716-2725
    • (2008) Dev Dyn , vol.237 , pp. 2716-2725
    • Yu, W.1    Kamara, H.2    Svoboda, K.K.3
  • 161
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP (2005) TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24:5764-5774
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 162
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    • DOI 10.1038/sj.emboj.7600069
    • Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP (2004) Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J 23:1155-1165 (Pubitemid 38436879)
    • (2004) EMBO Journal , vol.23 , Issue.5 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 163
    • 34250770436 scopus 로고    scopus 로고
    • Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity
    • DOI 10.1159/000101316
    • Zavadil J, Narasimhan M, Blumenberg M, Schneider RJ (2007) Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity. Cells Tissues Organs 185:157-161 (Pubitemid 46956856)
    • (2007) Cells Tissues Organs , vol.185 , Issue.1-3 , pp. 157-161
    • Zavadil, J.1    Narasimhan, M.2    Blumenberg, M.3    Schneider, R.J.4
  • 164
    • 77955602944 scopus 로고    scopus 로고
    • Resolved: EMT produces fibroblasts in the kidney
    • Zeisberg M, Duffield JS (2010) Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 21:1247-1253
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1247-1253
    • Zeisberg, M.1    Duffield, J.S.2
  • 165
    • 1642379154 scopus 로고    scopus 로고
    • The role of epithelial-to-mesenchymal transition in renal fibrosis
    • DOI 10.1007/s00109-003-0517-9
    • Zeisberg M, Kalluri R (2004) The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 82:175-181 (Pubitemid 38392167)
    • (2004) Journal of Molecular Medicine , vol.82 , Issue.3 , pp. 175-181
    • Zeisberg, M.1    Kalluri, R.2
  • 166
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119:1429-1437
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 169
    • 0036088906 scopus 로고    scopus 로고
    • Renal fibrosis: Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells
    • Zeisberg M, Maeshima Y, Mosterman B, Kalluri R (2002) Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am J Pathol 160:2001-2008 (Pubitemid 34663393)
    • (2002) American Journal of Pathology , vol.160 , Issue.6 , pp. 2001-2008
    • Zeisberg, M.1    Maeshima, Y.2    Mosterman, B.3    Kalluri, R.4
  • 171
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • DOI 10.1038/nm888
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R (2003b) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nature Med 9:964-968 (Pubitemid 36889942)
    • (2003) Nature Medicine , vol.9 , Issue.7 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.-I.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6    Kalluri, R.7
  • 175
    • 57349185929 scopus 로고    scopus 로고
    • Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase
    • Zhang Z, Zhang Y, Ning G, Deb DK, Kong J, Li YC (2008) Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase. Proc Natl Acad Sci USA 105:15896-15901
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15896-15901
    • Zhang, Z.1    Zhang, Y.2    Ning, G.3    Deb, D.K.4    Kong, J.5    Li, Y.C.6
  • 177
    • 0347511753 scopus 로고    scopus 로고
    • Mediators of diabetic renal disease: The case for tgf-Beta as the major mediator
    • Ziyadeh FN (2004) Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator. J Am Soc Nephrol 15(Suppl 1):S55-57
    • (2004) J Am Soc Nephrol , vol.15 , Issue.SUPPL. 1
    • Ziyadeh, F.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.