Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys

American Journal of Physiology - Renal Physiology

Volumn 292, Issue 1, 2007, Pages

  Li, Ningjun ^a   Yi, Fan ^a   Sundy, Christina M ^a   Chen, Li ^a   Hilliker, Molly L ^a   Donley, Dustin K ^a   Muldoon, Daniel B ^a   Li, Pin Lan ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anoxia; Fluid homeostasis; Gene transcription; Natriuretic factor; Renal hemodynamics; Renal tubules

Indexed keywords

FUROSEMIDE; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; MIMOSINE; OLIGODEOXYNUCLEOTIDE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIURETIC ACTIVITY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; KIDNEY MEDULLA; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM EXCRETION; UPREGULATION; WESTERN BLOTTING;

EID: 33846220305     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00457.2005     Document Type: Article

References (54)

1. Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279: 38458-38465, 2004.
2. Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. J Cell Biochem 92: 491-501, 2004.
3. Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J 22: 4082-4090, 2003.
4. Boddy JL, Fox SB, Han C, Campo L, Turley H, Kanga S, Malone PR, Harris AL. The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1α, HIF-2α, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res 11: 7658-7663, 2005.
5. Brezis M, Agmon Y, Epstein FH. Determinants of intrarenal oxygenation. I. Effects of diuretics. Am J Physiol Renal Fluid Electrolyte Physiol 267: F1059-F1062, 1994.
6. Brezis M, Heyman SN, Dinour D, Epstein FH, Rosen S. Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys. J Clin Invest 88: 390-395, 1991.
7. Bruick RK, McKnight SL. A conserved family of prolyl-4- hydroxylases that modify HIF. Science 294: 1337-1340, 2001.
8. Callapina M, Zhou J, Schnitzer S, Metzen E, Lohr C, Deitmer JW, Brune B. Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation - implications for prolyl hydroxylase activity and iron. Exp Cell Res 306: 274-284, 2005.
9. Cioffi CL, Qin Liu X, Kosinski PA, Garay M, Bowen BR. Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem Biophys Res Commun 303: 947-953, 2003.
10. Cowley AW Jr. Long-term control of arterial blood pressure. Physiol Rev 72: 231-300, 1992.
11. D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem 278: 38183-38187, 2003.
12. Del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem 278: 48690-48695, 2003.
13. Dos Santos EA, Dahly-Vernon AJ, Hoagland KM, Roman RJ. Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis. Am J Physiol Regul Integr Comp Physiol 287: R58-R68, 2004.
14. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54, 2001.
15. Epstein FH. Oxygen and renal metabolism. Kidney Int 51: 381-385, 1997.
16. Franchini KG, Cowley AW Jr. Renal cortical and medullary blood flow responses during water restriction: role of vasopressin. Am J Physiol Regul Integr Comp Physiol 270: R1257-R1264, 1996.
17. Franchini KG, Mattson DL, Cowley AW Jr. Vasopressin modulation of medullary blood flow and pressure-natriuresis-diuresis in the decerebrated rat. Am J Physiol Regul Integr Comp Physiol 272: R1472-R1479, 1997.
18. Gross JM, Dwyer JE, Knox FG. Natriuretic response to increased pressure is preserved with COX-2 inhibitors. Hypertension 34: 1163-1167, 1999.
19. Guyton AC. Renal function curves and control of body fluids and arterial pressure. Acta Physiol Scand Suppl 591: 107-113, 1990.
20. Hall JE. The kidney, hypertension, and obesity. Hypertension 41: 625-633, 2003.
21. Hierholzer C, Harbrecht BG, Billiar TR, Tweardy DJ. Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock. Arch Orthop Trauma Surg 121: 219-222, 2001.
22. Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278: 30772-30780, 2003.
23. 2 sensing. Science 292: 464-468, 2001.
24. 2-regulated prolyl hydroxylation. Science 292: 468-472, 2001.
25. Jung F, Palmer LA, Zhou N, Johns RA. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res 86: 319-325, 2000.
26. Komatsu DE, Hadjiargyrou M. Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone 34: 680-688, 2004.
27. Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 65: 9047-9055, 2005.
28. Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14: 1535-1548, 2003.
29. Lieb ME, Menzies K, Moschella MC, Ni R, Taubman MB. Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem Cell Biol 80: 421-426, 2002.
30. Lorenz JN, Gruenstein E. A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin. Am J Physiol Renal Physiol 276: F172-F177, 1999.
31. Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem 280: 41928-41939, 2005.
32. Lukiw WJ, Ottlecz A, Lambrou G, Grueninger M, Finley J, Thompson HW, Bazan NG. Coordinate activation of HIF-1 and NF-κB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Invest Ophthalmol Vis Sci 44: 4163-4170, 2003.
33. Majid DS, Navar LG. Nitric oxide in the control of renal hemodynamics and excretory function. Am J Hypertens 14: 74S-82S, 2001.
34. Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases. Biochem J 381: 761-767, 2004.
35. McCaffrey TA, Pomerantz KB, Sanborn TA, Spokojny AM, Du B, Park MH, Folk JE, Lamberg A, Kivirikko KI, Falcone DJ, Mehta SB, Hanauske-Abeil HM. Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries. J Clin Invest 95: 446-455, 1995.
36. Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, Fandrey J. Intracellular localisation of human HIF-1α hydroxylases: implications for oxygen sensing. J Cell Sci 116: 1319-1326, 2003.
37. Ockaili R, Natarajan R, Salloum F, Fisher BJ, Jones D, Fowler AA III, Kukreja RC. HIF-1 activation attenuates post-ischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ Physiol 289: H542-H548, 2005.
38. Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol Lung Cell Mol Physiol 274: L212-L219, 1998.
39. Prasad PV, Edelman RR, Epstein FH. Noninvasive evaluation of intrarenal oxygenation with BOLD MRI. Circulation 94: 3271-3275, 1996.
40. 2 during water diuresis as evaluated by blood oxygenation level-dependent magnetic resonance imaging: effects of aging and cyclooxygenase inhibition. Kidney Int 55: 294-298, 1999.
41. Rodriguez F, Kemp R, Balazy M, Nasjletti A. Effects of exogenous heme on renal function: role of heme oxygenase and cyclooxygenase. Hypertension 42: 680-684, 2003.
42. Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Horstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU. Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 13: 1721-1732, 2002.
43. Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem 279: 40337-40344, 2004.
44. Santos BC, Chevaile A, Hebert MJ, Zagajeski J, Gullans SR. A combination of NaCl and urea enhances survival of IMCD cells to hyperosmolality. Am J Physiol Renal Physiol 274: F1167-F1173, 1998.
45. 2 homeostasis. Curr Opin Genet Dev 8: 588-594, 1998.
46. Wang G, Semenza G. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268: 21513-21518, 1993.
47. Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, Schrier R. Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice. J Am Soc Nephrol 15: 645-649, 2004.
48. Warnecke C, Griethe W, Weidemann A, Jurgensen JS, Willam C, Bachmann S, Ivashchenko Y, Wagner I, Frei U, Wiesener M, Eckardt KU. Activation of the hypoxia-inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J 17: 1186-1188, 2003.
49. Wright G, Higgin JJ, Raines RT, Steenbergen C, Murphy E. Activation of the prolyl hydroxylase oxygen sensor results in induction of GLUT1, heme oxygenase-1, and nitric oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. J Biol Chem 278: 20235-20239, 2003.
50. Yang ZZ, Zou AP. Transcriptional regulation of heme oxygenases by HIF-1α in renal medullary interstitial cells. Am J Physiol Renal Physiol 281: F900-F908, 2001.
51. Zhang AY, Chen YF, Zhang DX, Yi FX, Qi J, Andrade-Gordon P, de Garavilla L, Li PL, Zou AP. Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney. Am J Physiol Renal Physiol 285: F792-F798, 2003.
52. Zou AP, Billington H, Su N, Cowley AW Jr. Expression and actions of heme oxygenase in the renal medulla of rats. Hypertension 35: 342-347, 2000.
53. Zou AP, Cowley AW. Reactive oxygen species and molecular regulation of renal oxygenation. Acta Physiol Scand 179: 233-241, 2003.
54. Zou AP, Yang ZZ, Li PL, Cowley AW Jr. Oxygen-dependent expression of hypoxia-inducible factor-1α in renal medullary cells of rats. Physiol Genomics 6: 159-168, 2001.