Gastrointestinal health and function in weaned pigs: A review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds

Journal of Animal Physiology and Animal Nutrition

Volumn 97, Issue 2, 2013, Pages 207-237

  Heo, J M ^a,b   Opapeju, F O ^a   Pluske, J R ^b   Kim, J C ^c   Hampson, D J ^b   Nyachoti, C M ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MURDOCH UNIVERSITY   (Australia)

^c DEPARTMENT OF AGRICULTURE AND FOOD WESTERN AUSTRALIA   (Australia)

Author keywords

Antimicrobial growth promoters; Dietary protein level; Dietary protein source; Organic acids; Pigs; Post weaning diarrhoea; Prebiotics; Probiotics; Trace minerals

Indexed keywords

ANTIINFECTIVE AGENT;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; DIARRHEA; GASTROINTESTINAL TRACT; PHYSIOLOGY; REVIEW; SWINE; SWINE DISEASE;

ANIMAL FEED; ANIMALS; ANTI-BACTERIAL AGENTS; DIARRHEA; GASTROINTESTINAL TRACT; SWINE; SWINE DISEASES;

BACTERIA (MICROORGANISMS); SUIDAE;

EID: 84875528040     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2012.01284.x     Document Type: Review

References (281)

1. Abe, M.; Takase, O.; Shibui, H.; Iriki, T., 1981: Neonatal diarrhoea in calves given milk-substitutes differing in fat source and fed by different procedures. British Journal of Nutrition46, 543-548.
2. Abe, F.; Ishibashi, N.; Shimamura, S., 1995: Effect of administration of bifidobacteria and lactic acid bacteria to newborn calves and piglets. Journal of Dairy Science78, 2838-2846.
3. Adeola, O.; King, D. E., 2006: Developmental changes in morphometry of the small intestine and jejunal sucrase activity during the first nine weeks of postnatal growth in pigs. Journal of Animal Science84, 112-118.
4. Al-Majali, A. M.; Robinson, J. P.; Asem, E. K.; Lamar, C.; Freeman, M. J.; Saeed, A. M., 1999: Age-dependent variation in the density and affinity of Escherichia coli heat-stable enterotoxin receptors in mice. Advances in Experimental Medicine and Biology473, 137-145.
5. Amezcua, R.; Friendship, R. M.; Dewey, C. E.; Gyles, C.; Fairbrother, J. M., 2002: Presentation of postweaning Escherichia coli diarrhea in southern Ontario, prevalence of hemolytic E. coli serogroups involved, and their antimicrobial resistance patterns. Canadian Journal of Veterinary Research66, 73-78.
6. Aumaitre, A.; Peiniau, J.; Madec, F., 1995: Digestive adaptation after weaning and nutritional consequences in the piglet. Pig News and Information16, 73N-79N.
7. Awati, A.; Williams, B. A.; Bosch, M. W.; Gerrits, W. J. J.; Verstegen, M. W. A., 2006: Effect of inclusion of fermentable carbohydrates in the diet on fermentation end-product profile in feces of weanling piglets. Journal of Animal Science84, 2133-2140.
8. Bailey, M.; Clarke, C. J.; Wilson, A. D.; Williams, N. A.; Stokes, C. R., 1992: Depressed potential for interleukin-2 production following early weaning of piglets. Veterinary Immunology and Immunopathology34, 197-207.
9. Bailey, M.; Haverson, K.; Inman, C.; Harris, C.; Jones, P.; Corfield, G.; Miller, B.; Stokes, C., 2005: The development of the mucosal immune system pre- and post-weaning: balancing regulatory and effector function. Proceedings of the Nutrition Society64, 451-457.
10. Ball, R. O.; Aherne, F. X., 1987: Influence of dietary nutrient density, level of feed intake and weaning age on young pigs. 2. Apparent nutrient digestibility and incidence and severity of diarrhea. Canadian Journal of Animal Science67, 1105-1115.
11. Barrow, P. A.; Fuller, R.; Newport, M. J., 1977: Changes in microflora and physiology of anterior intestinal tract of pigs weaned at 2days, with special reference to pathogenesis of diarrhea. Infection and Immunity18, 586-595.
12. Bauer, E.; Williams, B. A.; Voigt, C.; Mosenthin, R.; Verstegen, M. W. A., 2001: Microbial activities of faeces from unweaned and adult pigs, in relation to selected fermentable carbohydrates. Animal Science73, 313-322.
13. van Beers-Schreurs, H. M.; Vellenga, L.; Wensing, T.; Breukink, H. J., 1992: The pathogenesis of the post-weaning syndrome in weaned piglets: a review. Veterinary Quarterly14(2), 9-34.
14. van Beers-Schreurs, H. M.; Nabuurs, M. J.; Vellenga, L.; Kalsbeek-van der Valk, H. J.; Wensing, T.; Breukink, H. J., 1998: Weaning and the weanling diet influence the villous height and crypt depth in the small intestine of pigs and alter the concentrations of short-chain fatty acids in the large intestine and blood. Journal of Nutrition128, 947-953.
15. Benevenga, N. J.; Steinman-Goldsworthy, J. K.; Crenshaw, T. D.; Odle, J., 1989: Utilization of medium-chain triglycerides by neonatal piglets: 1. Effects on milk consumption and body fuel utilization. Journal of Animal Science67, 3331-3339.
16. Bhandari, S. K.; Setia, A.; Krause, D. O.; Nyachoti, C. M., 2007: Response of nursery pigs to a synbiotic based on starch (prebiotic) and an anti-Escherichia coli K88 colicinogenic probiotic. Journal of Animal Science85, 149-150.
17. Bhandari, S. K.; Xu, B.; Nyachoti, C. M.; Giesting, D. W.; Krause, D. O., 2008: Evaluation of alternatives to antibiotics using an Escherichia coli K88(+) model of piglet diarrhea: effects on gut microbial ecology. Journal of Animal Science86, 836-847.
18. Bhandari, S. K.; Nyachoti, C. M.; Krause, D. O., 2009: Raw potato starch in weaned pig diets and its influence on postweaning scours and the molecular microbial ecology of the digestive tract. Journal of Animal Science87, 984-993.
19. Bhandari, S. K.; Opapeju, F. O.; Krause, D. O.; Nyachoti, C. M., 2010: Dietary protein level and probiotic supplementation effects on piglet response to Escherichia coli K88 challenge: performance and gut microbial population. Livestock Science133, 185-188.
20. Bikker, P.; Dirkzwager, A.; Fledderus, J.; Trevisi, P.; le Huerou-Luron, I.; Lalles, J. P.; Awati, A., 2006: The effect of dietary protein and fermentable carbohydrates levels on growth performance and intestinal characteristics in newly weaned piglets. Journal of Animal Science84, 3337-3345.
21. Bikker, P.; Dirkzwager, A.; Fledderus, J.; Trevisi, P.; le Huaerou-Luron, I.; Lalles, J. P.; Awati, A., 2007: Dietary protein and fermentable carbohydrates contents influence growth performance and intestinal characteristics in newly weaned pigs. Livestock Science108, 194-197.
22. Bird, A. R., 1999: Prebiotics: a role for dietary fibre and resistant starch?Asia Pacific Journal of Clinical Nutrition8(Suppl), S32-S36.
23. Blank, R.; Mosenthin, R.; Sauer, W. C.; Huang, S., 1999: Effect of fumaric acid and dietary buffering capacity on ileal and fecal amino acid digestibilities in early-weaned pigs. Journal of Animal Science77, 2974-2984.
24. Blomberg, L.; Henriksson, A.; Conway, P. L., 1993: Inhibition of adhesion of Escherichia coli K88 to piglet ileal mucus by Lactobacillus spp. Applied and Environmental Microbiology59, 34-39.
25. Bolduan, G.; Jung, H.; Schnable, E.; Schneider, R., 1988: Recent advances in the nutrition of weaner piglets. Pig News and Information9, 381-385.
26. Bontempo, V.; Sciannimanico, D.; Pastorelli, G.; Rossi, R.; Rosi, F.; Corino, C., 2004: Dietary conjugated linoleic acid positively affects immunologic variables in lactating sows and piglets. Journal of Nutrition134, 817-824.
27. Bontempo, V.; Di Giancamillo, A.; Savoini, G.; Dell'Orto, V.; Domeneghini, C., 2006: Live yeast dietary supplementation acts upon intestinal morpho-functional aspects and growth in weanling piglets. Animal Feed Science and Technology129, 224-236.
28. Bosi, P.; Casini, L.; Finamore, A.; Cremokolini, C.; Merialdi, G.; Trevisi, P.; Nobili, F.; Mengheri, E., 2004: Spray-dried plasma improves growth performance and reduces inflammatory status of weaned pigs challenged with enterotoxigenic Escherichia coli K88. Journal of Animal Science82, 1764-1772.
29. Boudry, G.; Guerin, S.; Malbert, C. H., 2004a: Effect of an abrupt switch from a milkbased to a fibre-based diet on gastric emptying rates in pigs: difference between origins of fibre. British Journal of Nutrition92, 913-920.
30. Boudry, G.; Peron, V.; Le Huerou-Luron, I.; Lalles, J. P.; Seve, B., 2004b: Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine. The Journal of Nutrition134, 2256-2262.
31. van den Broeck, W.; Cox, E.; Oudega, B.; Goddeeris, B. M., 2000: The F4 fimbrial antigen of Escherichia coli and its receptors. Veterinary Microbiology71, 223-244.
32. Brooks, P. H.; Moran, C. A.; Beal, J. D.; Demeckova, V.; Campbell., A., 2001: Liquid feeding for the young piglets. In: M. A. Varley, J. R. Wiseman (eds), The Weaner Pig: Nutrition and Management. CAB International, Wallinford, Oxon, pp. 153.
33. Broom, L. J.; Miller, H. M.; Kerr, K. G.; Knapp, J. S., 2006: Effects of zinc oxide and Enterococcus faecium SF68 dietary supplementation on the performance, intestinal microbiota and immune status of weaned piglets. Research in Veterinary Science80, 45-54.
34. Buddle, J. R.; Bolton, J. R., 1992: The pathophysiology of diarrhoea in pigs. Pig News and Information13, 41N-45N.
35. Carlson, D.; Poulsen, H. D.; Vestergaard, M., 2004: Additional dietary zinc for weaning piglets is associated with elevated concentrations of serum IGF-I. Journal of Animal Physiology and Animal Nutrition88, 332-339.
36. Carlson, D.; Sehested, J.; Poulsen, H. D., 2006: Zinc reduces the electrophysiological responses in vitro to basolateral receptor mediated secretagogues in piglet small intestinal epithelium. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology144, 514-519.
37. Case, C. L.; Carlson, M. S., 2002: Effect of feeding organic and inorganic sources of additional zinc on growth performance and zinc balance in nursery pigs. Journal of Animal Science80, 1917-1924.
38. Castillo, M.; Marti{dotless}′n-Oru′e, S. M.; Manzanilla, E. G.; Badiola, I.; Marti{dotless}′n, M.; Gasa, J., 2006: Quantification of total bacteria, enterobacteria and lactobacilli populations in pig digesta by real-time PCR. Veterinary Microbiology114, 165-170.
39. Castillo, M.; Martin-Orue, S. M.; Nofrarias, M.; Manzanilla, E. G.; Gasa, J., 2007: Changes in caecal microbiota and mucosal morphology of weaned pigs. Veterinary Microbiology124, 239-247.
40. Cheng, H.; Leblond, C. P., 1974: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. American Journal of Anatomy141, 461-479.
41. Cherrington, C. A.; Hinton, M.; Mead, G. C.; Chopra, I., 1991: Organic acids -chemistry, antibacterial activity and practical applications. Advances in Microbial Physiology32, 87-108.
42. Chung, T. K.; Baker, D. H., 1992: Ideal amino acid pattern for 10-kilogram pigs. Journal of Animal Science70, 3102-3111.
43. Collington, G. K.; Parker, D. S.; Armstrong, D. G., 1990: The influence of inclusion of either an antibiotic or a probiotic in the diet on the development of digestive enzyme activity in the pig. British Journal of Nutrition64, 59-70.
44. Corino, C.; Bontempo, V.; Sciannimanico, D., 2002: Effects of dietary conjugated linoleic acid on some aspecific immune parameters and acute phase protein in weaned piglets. Canadian Journal of Animal Science82, 115-117.
45. Cranwell, P. D., 1985: The development of acid and pepsin (Ec-3.4.23.1) secretory capacity in the pig - the effects of age and weaning 1. Studies in anesthetized pigs. British Journal of Nutrition54, 305-320.
46. Cranwell, P. D., 1995: Development of the neonatal gut and enzyme systems. In: M. A. Varley (ed.), The Neonatal Pig: Development and Survival. CAB International, Wallingford, pp. 99-154.
47. Cranwell, P. D.; Noakes, D. E.; Hill, K. J., 1976: Gastric secretion and fermentation in suckling pig. British Journal of Nutrition36, 71-86.
48. Cutler, R.; Gardner, I., 1988: A Blue Print for Pig Health Research. Pig Research Council, Canberra, Australia.
49. DANMAP, 2001: Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark. In: F. Bager, H.-D. Emborg, O. E. Heuer (eds), Copenhagen, Denmark, pp. 15.
50. Davis, M. E.; Brown, D. C.; Maxwell, C. V.; Johnson, Z. B.; Kegley, E. B.; Dvorak, R. A., 2004: Effect of phosphorylated mannans and pharmacological additions of zinc oxide on growth and immunocompetence of weanling pigs. Journal of Animal Science82, 581-587.
51. Dibner, J. J.; Richards, J. D., 2005: Antibiotic growth promoters in agriculture: history and mode of action. Poultry Science84, 634-643.
52. van Dijk, A. J.; Everts, H.; Nabuurs, M. J. A.; Margry, R.; Beynen, A. C., 2001: Growth performance of weanling pigs fed spray-dried animal plasma: a review. Livestock Production Science68, 263-274.
53. Edmonds, M. S.; Izquierdo, O. A.; Baker, D. H., 1985: Feed additive studies with newly weaned pigs: efficacy of supplemental copper, antibiotics and organic acids. Journal of Animal Science60, 462-469.
54. Efird, R. C.; Armstrong, W. D.; Herman, D. L., 1982: The development of digestive capacity in young pigs: effects of age and weaning system. Journal of Animal Science55, 1380-1387.
55. Fairbrother, J. M.; Nadeau, E.; Gyles, C. L., 2005: Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Animal Health Research Reviews6, 17-39.
56. Fan, M. Z.; Adeola, O.; Asem, E. K.; King, D., 2002: Postnatal ontogeny of kinetics of porcine jejunal brush border membrane-bound alkaline phosphatase, aminopeptidase N and sucrase activities. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology132, 599-607.
57. Favier, C.; Lalles, J. P.; Seve, B., 2003: Intestinal Variations in the Caecal Microbiota of Piglets at the Time of Weaning, 9th International Symposium on Digestive Physiology in Pigs. Banff, Canada, pp. 102-104.
58. Figueroa, J. L.; Lewis, A. J.; Miller, P. S.; Fischer, R. L.; Gomez, R. S.; Diedrichsen, R. M., 2002: Nitrogen metabolism and growth performance of gilts fed standard corn-soybean meal diets or low-crude protein, amino acid-supplemented diets. Journal of Animal Science80, 2911-2919.
59. Franklin, M. A.; Mathew, A. G.; Vickers, J. R.; Clift, R. A., 2002: Characterization of microbial populations and volatile fatty acid concentrations in the jejunum, ileum, and cecum of pigs weaned at 17 vs 24days of age. Journal of Animal Science80, 2904-2910.
60. Freire, J. B.; Aumaitre, A.; Peiniau, J., 1991: Effects of feeding raw and extruded peas on ileal digestibility, pancreatic enzymes and plasma glucose and insulin in early weaned pigs. Journal of Animal Physiology and Animal Nutrition65, 154-164.
61. Frydendahl, K., 2002: Prevalence of serogroups and virulence genes in Escherichia coli associated with postweaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches. Veterinary Microbiology85, 169-182.
62. Fuller, R., 1977: The importance of lactobacilli in maintaining normal microbial balance in the crop. British Poultry Science18, 85-94.
63. Gaskins, H. R., 2001: Intestinal bacteria and their influence on swine growth. In: A. J. Lewis, L. L. Southern (eds), Swine Nutrition. CRC Press, Boca Raton, Florida, pp. 585-608.
64. Gibson, G. R., 1999: Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin. Journal of Nutrition129, 1438S-1441S.
65. Gibson, G. R.; Wang, X., 1994a: Bifidogenic properties of different types of fructooligosaccharides. Food Microbiology11, 491-498.
66. Gibson, G. R.; Wang, X., 1994b: Regulatory effects of bifidobacteria on the growth of other colonic bacteria. Journal of Applied Microbiology77, 412-420.
67. Gibson, G. R.; Roberfroid, M. B., 1995: Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition125, 1401-1412.
68. Gibson, G. R.; Probert, H. M.; Loo, J. V.; Rastall, R. A.; Roberfroid, M. B., 2004: Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutrition Research Reviews17, 259-275.
69. Giesting, D. W.; Easter, R. A., 1985: Response of starter pigs to supplementation of corn-soybean meal diets with organic acids. Journal of Animal Science60, 1288-1294.
70. Giesting, D. W.; Easter, R. A., 1991: Effect of protein source and fumaric acid supplementation on apparent ileal digestibility of nutrients by young pigs. Journal of Animal Science69, 2497-2503.
71. Hahn, J. D.; Baker, D. H., 1993: Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc. Journal of Animal Science71, 3020-3024.
72. Hahn, T. W.; Lohakare, J. D.; Lee, S. L.; Moon, W. K.; Chae, B. J., 2006: Effects of supplementation of beta-glucans on growth performance, nutrient digestibility, and immunity in weanling pigs. Journal of Animal Science84, 1422-1428.
73. Halas, D.; Heo, J. M.; Hansen, C. F.; Kim, J. C.; Hampson, D. J.; Mullan, B. P.; Pluske, J. R., 2007: Organic acids, prebiotics and protein level as dietary tools to control the weaning transition and reduce post-weaning diarrhoea in piglets. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources2(No. 079), 13.
74. Hampson, D. J., 1986: Alterations in piglet small intestinal structure at weaning. Research in Veterinary Science40, 32-40.
75. Hampson, D. J.; Kidder, D. E., 1986: Influence of creep feeding and weaning on brush border enzyme activities in the piglet small intestine. Research in Veterinary Science40, 24-31.
76. Hao, W. L.; Lee, Y. K., 2004: Microflora of the gastrointestinal tract: a review. Methods in Molecular Biology268, 491-502.
77. Harel, J.; Lapointe, H.; A., F.; L.A., L.; Bigras-Poulin, M.; Lariviere, S.; Fairbrother, J. M., 1991: Detection of genes for fimbrial antigens and enterotoxins associated with Escherichia coli serogroup isolated from pigs with diarrhea. Journal of Clinical Microbiology29, 745-752.
78. Hartl, D. L.; Dykhuizen, D. E., 1984: The Population Genetics of Escherichia Coli. Annual Review of Genetics18, 31-68.
79. Hayes, D. J.; Jensen, H. H.; Fabiosa., J., 2002: Technology choice and the economic effects of a ban on the use of antimicrobial feed additives in swine rations. Food Control13, 97-101.
80. Hedemann, M. S.; Højsgaard, S.; Jensen, B. B., 2003: Small intestinal morphology and activity of intestinal peptidases in piglets around weaning. Journal of Animal Physiology and Animal Nutrition87, 32-41.
81. Hedemann, M. S.; Jensen, B. B., 2004: Variations in enzyme activity in stomach and pancreatic tissue and digesta in piglets around weaning. Archives of Animal Nutrition58, 47-59.
82. Hedemann, M. S.; Jensen, B. B.; Poulsen, H. D., 2006: Influence of dietary zinc and copper on digestive enzyme activity and intestinal morphology in weaned pigs. Journal of Animal Science84, 3310-3320.
83. Henning, S. J., 1985: Ontogeny of enzymes in the small intestine. Annual Review of Physiology47, 231-245.
84. Heo, J. M., 2010: Reducing the Protein Content in Diets for Weaner Pigs to Control Post-Weaning Diarrhoea: Physiological and Metabolic Responses of the Gastrointestinal Tract, Faculty of Health Sciences, Animal Research Institute, School of Veterinary and Biomedical Sciences. Murdoch University, Perth.
85. Heo, J. M.; Kim, J. C.; Hansen, C. F.; Mullan, B. P.; Hampson, D. J.; Pluske, J. R., 2008: Effects of feeding low protein diets to piglets on plasma urea nitrogen, faecal ammonia nitrogen, the incidence of diarrhoea and performance after weaning. Archives of Animal Nutrition62, 343-358.
86. Heo, J. M.; Kim, J. C.; Hansen, C. F.; Mullan, B. P.; Hampson, D. J.; Pluske, J. R., 2009: Feeding a diet with decreased protein content reduces indices of protein fermentation and the incidence of postweaning diarrhea in weaned pigs challenged with an enterotoxigenic strain of Escherichia coli. Journal of Animal Science87, 2833-2843.
87. van Heugten, E.; Funderburke, D. W.; Dorton, K. L., 2003: Growth performance, nutrient digestibility, and fecal microflora in weanling pigs fed live yeast. Journal of Animal Science81, 1004-1012.
88. Hill, G. M.; Cromwell, G. L.; Crenshaw, T. D.; Dove, C. R.; Ewan, R. C.; Knabe, D. A.; Lewis, A. J.; Libal, G. W.; Mahan, D. C.; Shurson, G. C.; Southern, L. L.; Veum, T. L., 2000: Growth promotion effects and plasma changes from feeding high dietary concentrations of zinc and copper to weanling pigs (regional study). Journal of Animal Science78, 1010-1016.
89. Hill, G. M.; Mahan, D. C.; Carter, S. D.; Cromwell, G. L.; Ewan, R. C.; Harrold, R. L.; Lewis, A. J.; Miller, P. S.; Shurson, G. C.; Veum, T. L., 2001: Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance. Journal of Animal Science79, 934-941.
90. Högberg, A.; Lindberg, J. E., 2004: Influence of cereal non-starch polysaccharides and enzyme supplementation on digestion site and gut environment in weaned piglets. Animal Feed Science and Technology116, 113-128.
91. Hogberg, A.; Lindberg, J. E.; Leser, T.; Wallgren, P., 2004: Influence of cereal non-starch polysaccharides on ileo-caecal and rectal microbial populations in growing pigs. Acta Veterinaria Scandinavica45, 87-98.
92. Højberg, O.; Canibe, N.; Poulsen, H. D.; Hedemann, M. S.; Jensen, B. B., 2005: Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets. Applied and Environmental Microbiology71, 2267-2277.
93. Hopwood, D. E.; Hampson, D. J., 2003: Interactions between the intestinal microflora, diet and diarrhoea, and their influences on piglet health in the immediate post-weaning period. In: J. R. Pluske, J. Le Dividich, M. W. A. Verstegen (eds), Weaning the Pig: Concepts and Consequences. Wageningen Academic Publishers, Wageningen, Netherlands, pp. 199-218.
94. Hou, Y. Q.; Liu, Y. L.; Hu, J.; Shen, W. H., 2006: Effects of lactitol and tributyrin on growth performance, small intestinal morphology and enzyme activity in weaned pigs. Asian-Australasian Journal of Animal Sciences19, 1470-1477.
95. Houdijk, J. G. M.; Hartemink, R.; Verstegen, M. W. A.; Bosch, M., 2002: Effects of dietary non-digestible oligosaccharides on microbial characteristics of ileal chyme and faeces in weaner pigs. Archives of Animal Nutrition56, 297-307.
96. Htoo, J. K.; Araiza, B. A.; Sauer, W. C.; Rademacher, M.; Zhang, Y.; Cervantes, M.; Zijlstra, R. T., 2007: Effect of dietary protein content on ileal amino acid digestibility, growth performance, and formation of microbial metabolites in ileal and cecal digesta of early-weaned pigs. Journal of Animal Science85, 3303-3312.
97. Ilsley, S. E.; Miller, H. M.; Greathead, H. M. R.; Kamel, C., 2003: Plant extracts as supplements for lactating sows: effects on piglet performance, sow food intake and diet digestibility. Animal Science77, 247-254.
98. Jeaurond, E. A.; Rademacher, M.; Pluske, J. R.; Zhu, C. H.; de Lange, C. F. M., 2008: Impact of feeding fermentable proteins and carbohydrates on growth performance, gut health and gastrointestinal function of newly weaned pigs. Canadian Journal of Animal Science88, 271-281.
99. Jensen, B. B., 1998: The impact of feed additives on the microbial ecology of the gut in young pigs. Journal of Animal and Feed Sciences7, 45-64.
100. Jensen, M. S.; Jensen, S. K.; Jakobsen, K., 1997: Development of digestive enzymes in pigs with emphasis on lipolytic activity in the stomach and pancreas. Journal of Animal Science75, 437-445.
101. Jensen, A. R.; Elnif, J.; Burrin, D. G.; Sangild, P. T., 2001: Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent. Journal of Nutrition131, 3259-3265.
102. Jensen, G. M.; Frydendahlb, K.; Svendsen, O.; Jorgensen, C. B.; Cirerac, S.; Fredholm, M.; Nielsen, J. P.; Moller, K., 2006: Experimental infection with Escherichia coli 0149 : F4ac in weaned piglets. Veterinary Microbiology115, 243-249.
103. Jensen-Waern, M.; Melin, L.; Lindberg, R.; Johanisson, A.; Peterson, L.; Wallgren, P., 1998: Dietary zinc oxide in weaned pigs-effects on performance, tissue concentrations, morphology, neutrophil functions and faecal microflora. Research in Veterinary Science64, 225-231.
104. Jiang, R. H.; Chang, X. Y.; Stoll, B.; Ellis, K. J.; Shypailo, R. J.; Weaver, E.; Campbell, J.; Burrin, D. G., 2000: Dietary plasma protein is used more efficiently than extruded soy protein for lean tissue growth in early-weaned pigs. Journal of Nutrition130, 2016-2019.
105. Jin, L. Z.; Marquardt, R. R.; Zhao, X., 2000: A strain of enterococcus faecium (18C23) inhibits adhesion of enterotoxigenic Escherichia coli K88 to porcine small intestine mucus. Applied and Environmental Microbiology66, 4200-4204.
106. Jukes, T. H.; Stokstad, E. L. R.; Taylor, R. R.; Combs, T. J.; Edwards, H. M.; Meadows, G. B., 1950: Growth promoting effects of aureomycin on pigs. Archives of Biochemistry and Biophysics26, 324-330.
107. Juven, B. J.; Meinersmann, R. J.; Stern, N. J., 1991: A review: antagonistic effects of lactobacilli and pediococci to control intestinal colonization by human enteropathogens in live poultry. Journal of Applied Microbiology70, 95-103.
108. Katouli, M.; Melin, L.; Jensen-Waern, M.; Wallgren, P.; Möllby, R., 1999: The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. Journal of Applied Microbiology87, 564-573.
109. Kaunitz, J. D.; Barrett, K. E.; McRoberts, J. A., 1995: Electrolyte secretion and absorption: small intestine and colon. In: T. Yamada, J. B. Lippincott (eds), Gastroenterology, Blackwell Publishing Ltd., Oxford, pp. 326.
110. Kelly, D.; King, T. P.; Mcfadyen, M.; Travis, A. J., 1991a: Effect of lactation on the decline of brush-border lactase activity in neonatal pigs. Gut32, 386-392.
111. Kelly, D.; Smyth, J. A.; McCracken, K. J., 1991b: Digestive development of the early-weaned pig. II, Effect of level of food intake on digestive enzyme activity during the immediate post-weaning period. British Journal of Nutrition65, 181-188.
112. Khan, A. R.; Khazanovich-Bernstein, N.; Bergmann, E. M.; James, M. N. G., 1999: Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors. Proceedings of The National Academy of Sciences of The United States of America96, 10968-10975.
113. Kiarie, E. G.; Slominski, B. A.; Krause, D. O.; Nyachoti, C. M., 2008a: Acute phase responses in piglets fed diets containing non-starch polysaccharide (NSP) hydrolysis products and egg yolk antibodies upon Escherichia coli K88 oral challenge. Journal of Animal Science86(E-Supplementary 3), 68.
114. Kiarie, E. G.; Slominski, B. A.; Krause, D. O.; Nyachoti, C. M., 2008b: Non-starch polysaccharide hydrolysis products of soybean and canola meal protect against enterotoxigenic Escherichia coli in piglets. Journal of Nutrition138, 502-508.
115. Kim, J. C.; Simmins, P. H.; Mullan, B. P.; Pluske, J. R., 2005: The effect of wheat phosphorus content and supplemental enzymes on digestibility and growth performance of weaner pigs. Animal Feed Science and Technology118, 139-152.
116. Kim, J. C.; Mullan, B. P.; Hampson, D. J.; Pluske, J. R., 2008: Addition of oat hulls to an extruded rice-based diet for weaner pigs ameliorates the incidence of diarrhoea and reduces indices of protein fermentation in the gastrointestinal tract. British Journal of Nutrition99, 1217-1225.
117. Kim, Y. G.; Lohakare, J. D.; Chae, B. J., 2006: Growth performance, nutrient digestibility and intestinal morphology in weaned piglets fed fungal and bacterial fermented soya proteins. Journal of Animal and Feed Sciences15, 213-224.
118. Kim, Y. S.; McCarthy, D. M.; Lane, W.; Fong, W., 1973: Alterations in the levels of peptide hydrolases and other enzymes in brush-border and soluble fractions of rat small intestinal mucosa during starvation and refeeding. Biochimica et Biophysica Acta (BBA) - Enzymology321, 262-273.
119. Knarreborg, A.; Miquel, N.; Granli, T.; Jensen, B. B., 2002: Establishment and application of an in vitro methodology to study the effects of organic acids on coliform and lactic acid bacteria in the proximal part of the gastrointestinal tract of piglets. Animal Feed Science and Technology99, 131-140.
120. Kogan, G.; Kocher, A., 2007: Role of yeast cell wall polysaccharides in pig nutrition and health protection. Livestock Science109, 161-165.
121. Konstantinov, S. R.; Zhu, Y. H.; Williams, B. A.; Tamminga, S.; de Vos, W. M.; Akkermans, A. D. L., 2003: Effect of fermentable carbohydrates on piglet faecal bacterial communities as revealed by denaturing gradient gel electrophoresis analysis of 16S ribosomal DNA. FEMS Microbiology Ecology43, 225-235.
122. Konstantinov, S. R.; Awati, A.; Smidt, H.; Williams, B. A.; Akkermans, A. D. L.; de Vos, W. M., 2004: Specific response of a novel and abundant Lactobacillus amylovorus-like phylotype to dietary prebiotics in the guts of weaning piglets. Applied and Environmental Microbiology70, 3821-3830.
123. Konstantinov, S. R.; Awati, A.; Williams, B. A.; Miller, B. G.; Jones, P.; Stokes, C. R., 2006: Post-natal development of the porcine microbiota composition and activities. Environmental Microbiology8, 1191-1199.
124. Kornegay, E. T.; Rhein-Welker, D.; Lindemann, M. D.; Wood, C. M., 1995: Performance and nutrient digestibility in weanling pigs as influenced by yeast culture additions to starter diets containing dried whey or one of two fiber sources. Journal of Animal Science73, 1381-1389.
125. Krause, D. O.; Bhandari, S. K.; House, J. D.; Nyachoti, C. M., 2010: Response of nursery pigs to a synbiotic preparation of starch and an anti-Escherichia coli K88 probiotic. Applied and Environmental Microbiology73, 1381-1389. AEM.01427-01410..
126. Kyriakis, S. C.; Tsiloyiannis, V. K.; Vlemmas, J.; Sarris, K.; Tsinas, A. C.; Alexopoulos, C.; Jansegers, L., 1999: The effect of probiotic LSP 122 on the control of post-weaning diarrhoea syndrome of piglets. Research in Veterinary Science67, 223-228.
127. Lai, C. H.; Yin, J. D.; Li, D. F.; Zhao, L. D.; Chen, X. J., 2005: Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs. Archives of Animal Nutrition59, 41-51.
128. Lalles, J. P.; Boudry, G.; Favier, C.; Le Floc'h, N.; Lurona, I.; Montagne, L.; Oswald, I. P.; Pie, S.; Piel, C.; Seve, B., 2004: Gut function and dysfunction in young pigs: physiology. Animal Research53, 301-316.
129. Lalles, J. P.; Bosi, P.; Smidt, H.; Stokes, C. R., 2007: Weaning - A challenge to gut physiologists. Livestock Science108, 82-93.
130. Lane, M. C.; Mobley, H. L. T., 2007: Role of P-fimbrial-mediated adherence in pyelonephritis and persistence of uropathogenic Escherichia coli (UPEC) in the mammalian kidney. Kidney International72, 19-25.
131. Le Bouguénec, C., 2005: Adhesins and invasins of pathogenic Escherichia coli. International Journal of Medical Microbiology295, 471-478.
132. Lee, H. F.; Chiang, S. H., 1994: Energy value of medium-chain triglycerides and their efficacy in improving survival of neonatal pigs. Journal of Animal Science72, 133-138.
133. Leser, T. D.; Amenuvor, J. Z.; Jensen, T. K.; Lindecrona, R. H.; Boye, M.; Moller, K., 2002: Culture-independent analysis of gut bacteria: the pig gastrointestinal tract microbiota revisited. Applied and Environmental Microbiology68, 673-690.
134. Lessard, M.; Brisson, G. J., 1987: Effect of a Lactobacillus fermentation product on growth, immune response and fecal enzyme activity in weaned pigs. Canadian Journal of Animal Science67, 509-516.
135. Li, D. F.; Nelssen, J. L.; Reddy, P. G.; Blecha, F.; Hancock, J. D.; Allee, G. L.; Goodband, R. D.; Klemm, R. D., 1990: Transient hypersensitivity to soybean meal in the early-weaned pig. Journal of Animal Science68, 1790-1799.
136. Li, D. F.; Nelssen, J. L.; Reddy, P. G.; Blecha, F.; Klemm, R. D.; Giesting, D. W.; Hancock, J. D.; Allee, G. L.; Goodband, R. D., 1991: Measuring suitability of soybean products for early-weaned pigs with immunological criteria. Journal of Animal Science69, 3299-3307.
137. Li, D. F.; Jiang, J. Y.; Ma, Y. X., 2003: Early weaning diets and feed additives. In: R. J. Xu, P. D. Cranwell (eds), The Neonatal Pig: Gastrointestinal Physiology and Nutrition. Nottingham University Press, Thrumptom, Nottingham, UK, pp. 247.
138. Li, X. L.; Yin, J. D.; Li, D. F.; Chen, X. J.; Zang, J. J.; Zhou, X., 2006: Dietary supplementation with zinc oxide increases IGF-I and IGF-I receptor gene expression in the small intestine of weanling piglets. Journal of Nutrition136, 1786-1791.
139. Li, Z. J.; Yi, G. F.; Yin, J. D.; Sun, P.; Li, D.; Knight, C., 2008: Effects of organic acids on growth performance, gastrointestinal pH, intestinal microbial populations and immune responses of weaned pigs. Asian-Australasian Journal of Animal Sciences21, 252-261.
140. Liu, P.; Piao, X. S.; Kim, S. W.; Wang, L.; Shen, Y. B.; Lee, H. S.; Li, S. Y., 2008: Effects of chito-oligosaccharide supplementation on the growth performance, nutrient digestibility, intestinal morphology, and fecal shedding of Escherichia coli and lactobacillus in weaning pigs. Journal of Animal Science86, 2609-2618.
141. Llyod, D. A. J.; Gabe, S. M., 2008: Intestinal morphology, intestinal regeneration and the promise of tissue engineering. In: A. N. Langnas, O. Goulet, E. M. M. Quigley, K. A. Tappenden (eds), Intestinal Failure: Diagnosis, Management and Transplantation. Wiley-Blackwell, Maiden, MA, USA, pp. 13.
142. Lodemann, U.; Hubener, K.; Jansen, N.; Martens, H., 2006: Effects of enterococcus faecium NCIMB 10415 as probiotic supplement on intestinal transport and barrier function of piglets. Archives of Animal Nutrition60, 35-48.
143. Lopes, E. L.; Junqueira, O. M.; Araujo, L. F.; Nunes, R. D.; Duarte., K. F., 2004: Protein sources and levels in the initial diets for piglets weaned at 21days of age. Brazilian Journal of Animal Science33, 2292-2299.
144. Lordelo, M. M.; Gaspar, A. M.; Le Bellego, L.; Freire, J. P. B., 2008: Isoleucine and valine supplementation of a low-protein corn-wheat-soybean meal-based diet for piglets: growth performance and nitrogen balance. Journal of Animal Science86, 2936-2941.
145. Lusk, J.; L., F. B. N.; Pruitt, J. R., 2006: Consumer demand for a ban on antibiotic drug use in pork production. American Journal of Agricultural Economics88, 1015-1033.
146. Macfarlane, S. M. G. T., 1995: Proteolysis and amino acid fermentation. In: G. R. Gibson, G. T. Macfarlane (eds), Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology. CRC Press, Boca Raton, FL, pp. 75.
147. Madec, F.; Bridoux, N.; Bounaix, S.; Cariolet, R.; Duval-Iflah, Y.; Hampson, D. J.; Jestin, A., 2000: Experimental models of porcine post-weaning colibacillosis and their relationship to post-weaning diarrhoea and digestive disorders as encountered in the field. Veterinary Microbiology72, 295-310.
148. Makkink, C. A.; Berntsen, P. J.; op den Kamp, B. M.; Kemp, B.; Verstegen, M. W., 1994: Gastric protein breakdown and pancreatic enzyme activities in response to two different dietary protein sources in newly weaned pigs. Journal of Animal Science72, 2843-2850.
149. Manners, M. J., 1976: The development of digestive function in the pig. Proceedings of the Nutrition Society35, 49-55.
150. Manzanilla, E. G.; Perez, J. F.; Martin, M.; Kamel, C.; Baucells, F.; Gasa, J., 2004: Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs. Journal of Animal Science82, 3210-3218.
151. Marion, J.; Petersen, Y. M.; Romé, V.; Thomas, F.; Sangild, P. T.; Dividich, J. L.; Huërou-Luron, I. L., 2005: Early weaning stimulates intestinal brush border enzyme activities in piglets, mainly at the posttranscriptional level. Journal of Pediatric Gastroenterology and Nutrition41, 401-410.
152. Martinez, V.; Wang, L.; Million, M.; Rivier, J.; Taché, Y., 2004: Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides25, 1733-1744.
153. Mathew, A. G.; Chattin, S. E.; Robbins, C. M.; Golden, D. A., 1998: Effects of a direct-fed yeast culture on enteric microbial populations, fermentation acids, and performance of weanling pigs. Journal of Animal Science76, 2138-2145.
154. McCracken, B. A.; Spurlock, M. E.; Roos, M. A.; Zuckermann, F. A.; Gaskins, H. R., 1999: Weaning anorexia may contribute to local inflammation in the piglet small intestine. Journal of Nutrition129, 613-619.
155. Melin, L.; Katouli, M.; Lindberg, A.; Fossum, C.; Wallgren, P., 2000: Weaning of piglets. Effects of an exposure to a pathogenic strain of Escherichia coli. Journal of Veterinary Medicine Series B-Infectious Diseases and Veterinary Public Health47, 663-675.
156. Metzler, B. U.; Vahjen, W.; Baumgärtel, T.; Rodehutscord, M.; Mosenthin, R., 2009: Changes in bacterial populations in the ileum of pigs fed low-phosphorus diets supplemented with different sources of fermentable carbohydrates. Animal Feed Science and Technology148, 69-89.
157. Miguel, J. C.; Rodriguez-Zas, S. L.; Pettigrew, J. E., 2004: Efficacy of a mannan oligosaccharide (Bio-Mos®) for improving nursery pig performance. Journal of Swine Health and Production12, 296-307.
158. Mikkelsen, L. L.; Jensen, B. B., 2004: Effect of fructo-oligosaccharides and transgalacto-oligosaccharides on microbial populations and microbial activity in the gastrointestinal tract of piglets post-weaning. Animal Feed Science and Technology117, 107-119.
159. Mikkelsen, L. L.; Bendixen, C.; Jakobsen, M.; Jense, B. B., 2003a: Enumeration of bifidobacteria in gastrointestinal samples from piglets. Applied and Environmental Microbiology69, 654-658.
160. Mikkelsen, L. L.; Jacobsen, M.; Jensen, B. B., 2003b: Effects of dietary oligosaccharides on microbial diversity and fructo-oligosaccharide degrading bacteria in faeces of piglets post-weaning. Animal Feed Science and Technology109, 133-150.
161. Miller, B. G.; Skadhauge, E., 1997: Effect of weaning in the pig on ileal Ion transport measured in vitro. Journal of Veterinary Medicine Series A44, 289-299.
162. Miller, B. G.; James, P. S.; Smith, M. W.; Bourne, F. J., 1986: Effect of weaning on the capacity of pig intestinal villi to digest and absorb nutrients. The Journal of Agricultural Science107, 579-590.
163. Modesto, M.; Stefanini, I.; D'Aimmo, M. R.; Mazzoni, M.; Trevisi, P.; Tittarelli, C.; Bosi, P.; Biavati, B., 2007: Effect of probiotic inocula on the population density of lactic acid bacteria and enteric pathogens in the intestine of weaning piglets. In 3rd International Congress of the European Integrated Project Quality Low Input Food (QLIF), Germany.
164. Modler, H. W.; Mckellar, R. C.; Yaguchi, M., 1990: Bifidobacteria and bifidogenic factors. Canadian Institute of Food Science and Technology Journal23, 29-41.
165. Moeser, A. J.; Klok, C. V.; Ryan, K. A.; Wooten, J. G.; Little, D.; Cook, V. L.; Blikslager, A. T., 2007: Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. American Journal of Physiology-Gastrointestinal and Liver Physiology292, G173-G181.
166. Montgomery, R. K.; Sybicki, M. A.; Grand, R. J., 1981: Autonomous biochemical and morphological differentiation in fetal rat intestine transplanted at 17 and 20days of gestation. Developmental Biology87, 76-84.
167. Moore, P. R.; Evenson, A.; Luckey, T. D.; McCoy, E.; Elvehjem, C. A.; Hart, E. B., 1946: Use of sulfasuxidine, streptothricin, and streptomycin in nutritional studies with the chick. Journal of Biological Chemistry165, 437-441.
168. Motohashi, Y.; Fukushima, A.; Kondo, T.; Sakuma, K., 1997: Lactase decline in weaning rats is regulated at the transcriptional level and not caused by termination of milk ingestion. Journal of Nutrition127, 1737-1743.
169. Nabuurs, M. J. A., 1998: Weaning Piglets as a Model for Studying Pathophysiology of Diarrhea, Conference Proceedings, Gastro-Intestinal Disorders in Juveniles, Lelystad, Netherlands, 16-17 September, 1997, pp. S42-S45.
170. Nabuurs, M. J.; Hoogendoorn, A.; van Zijderveld, F. G., 1994: Effects of weaning and enterotoxigenic Escherichia coli on net absorption in the small intestine of pigs. Research in Veterinary Science56, 379-385.
171. Nagy, B.; Fekete, P. Z., 1999: Enterotoxigenic E. coli (ETEC) in farm animals. Veterinary Research30, 259-284.
172. Nagy, B.; Fekete, P. Z., 2005: Enterotoxigenic Escherichia coli in veterinary medicine. International Journal of Medical Microbiology295, 443-454.
173. Nagy, B.; Casey, T. A.; Moon, H. W., 1990: Phenotype and genotype of Escherichia coli isolated from pigs with postweaning diarrhea in Hungary. Journal of Clinical Microbiology28, 651-653.
174. van Nevel, C. J.; Decuypere, J. A.; Dierick, N.; Molly, K., 2003: The influence of Lentinus edodes (Shiitake mushroom) preparations on bacteriological and morphological aspects of the small intestine in piglets. Archives of Animal Nutrition57, 399-412.
175. Niewold, T. A.; van Dijk, A. J.; Geenen, P. L.; Roodink, H.; Margry, R.; van der Meulen, J., 2007: Dietary specific antibodies in spray-dried immune plasma prevent enterotoxigenic Escherichia coli F4 (ETEC) post weaning diarrhoea in piglets. Veterinary Microbiology124, 362-369.
176. +Escherichia coli by non-immune plasma powder. Veterinary Microbiology65, 37-45.
177. Nørgaard, J.; Fernández, J., 2009: Isoleucine and valine supplementation of crude protein-reduced diets for pigs aged 5-8weeks. Animal Feed Science and Technology154, 248-253.
178. NRC, 1998: Nutrient Requirements of Swine. 10th rev. edn. National Academy Press, Washington, DC.
179. Nyachoti, C. M.; Omogbenigun, F. O.; Rademacher, M.; Blank, G., 2006: Performance responses and indicators of gastrointestinal health in early-weaned pigs fed low-protein amino acid-supplemented diets. Journal of Animal Science84, 125-134.
180. Odle, J.; Benevenga, N. J.; Crenshaw, T. D., 1989: Utilization of medium-chain triglycerides by neonatal piglets: 2. Effects of even- and odd-chain triglyceride consumption over the first 2days of life on blood metabolites and urinary nitrogen excretion. Journal of Animal Science67, 3340-3351.
181. Opapeju, F. O.; Rademacher, M.; Blank, G.; Nyachoti, C. M., 2008: Effect of low-protein amino acid-supplemented diets on the growth performance, gut morphology, organ weights and digesta characteristics of weaned pigs. Animal2, 1457-1464.
182. Opapeju, F. O.; Krause, D. O.; Payne, R. L.; Rademacher, M.; Nyachoti, C. M., 2009: Effect of dietary protein level on growth performance, indicators of enteric health, and gastrointestinal microbial ecology of weaned pigs induced with postweaning colibacillosis. Journal of Animal Science87, 2635-2643.
183. Opapeju, F. O.; Rademacher, M.; Payne, R. L.; Krause, D. O.; Nyachoti, C. M., 2010: Inflammation-associated responses in piglets induced with post-weaning colibacillosis are influenced by dietary protein level. Livestock Science131, 58-64.
184. Osek, J., 1999: Prevalence of virulence factors of Escherichia coli strains isolated from diarrheic and healthy piglets after weaning. Veterinary Microbiology68, 209-217.
185. O'Sulllivan, G. C.; Kelly, P.; O'Halloran, S.; Collins, C.; Collins, J. K.; Dunne, C.; Shanahan, F., 2005: Probiotics: an emerging therapy. Current Pharmaceutical Design11, 3-10.
186. Owusu-Asiedu, A.; Baidoo, S. K.; Nyachoti, C. M., 2002a: Effect of heat processing on nutrient digestibility in pea and supplementing amylase and xylanase to raw, extruded or micronized pea-based diets on performance of early-weaned pigs. Canadian Journal of Animal Science82, 367-374.
187. Owusu-Asiedu, A.; Baidoo, S. K.; Nyachoti, C. M.; Marquardt, R. R., 2002b: Response of early-weaned pigs to spray-dried porcine or animal plasma-based diets supplemented with egg-yolk antibodies against enterotoxigenic Escherichia coli. Journal of Animal Science80, 2895-2903.
188. Owusu-Asiedu, A.; Nyachoti, C. M.; Baidoo, S. K.; Marquardt, R. R.; Yang, X., 2003a: Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody. Journal of Animal Science81, 1781-1789.
189. Owusu-Asiedu, A.; Nyachoti, C. M.; Marquardt, R. R., 2003b: Response of early-weaned pigs to an enterotoxigenic Escherichia coli (K88) challenge when fed diets containing spray-dried porcine plasma or pea protein isolate plus egg yolk antibody, zinc oxide, fumaric acid, or antibiotic. Journal of Animal Science81, 1790-1798.
190. Pácha, J., 2000: Development of intestinal transport function in mammals. Physiological Reviews80, 1633-1667.
191. Partanen, K. H.; Mroz, Z., 1999: Organic acids for performance enhancement in pig diets. Nutrition Research Reviews12, 117-145.
192. Partridge, G. G.; Tucker, L., 2000: A healthy role for enzymes. Pig International30, 28-31.
193. Patience, J. F.; Austic, R. E.; Boyd, R. D., 1987: Effect of dietary electrolyte balance on growth and acid-base status in swine. Journal of Animal Science64, 457-466.
194. Patterson, R.; Connor, M. L.; Krause, D. O.; Nyachoti, C. M., 2008: Response of piglets weaned from sows fed diets supplemented with conjugated linoleic acid (CLA) to an Escherichia coli K88(+) oral challenge. Animal2, 1303-1311.
195. van der Peet-Schwering, C. M. C.; Jansman, A. J. M.; Smidt, H.; Yoon, I., 2007: Effects of yeast culture on performance, gut integrity, and blood cell composition of weanling pigs. Journal of Animal Science85, 3099-3109.
196. Pettigrew, J. E., 2006: Reduced use of antibiotic growth promoters in diets fed to weanling pigs: dietary tools, part 1. Animal Biotechnology17, 207-215.
197. Pié, S.; Lallès, J. P.; Blazy, F.; Laffitte, J.; Sève, B.; Oswald, I. P., 2004: Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. The Journal of Nutrition134, 641-647.
198. Pieper, R.; Janczyk, P.; Urubschurov, V.; Hou, Z.; Korn, U.; Pieper, B.; Souffrant, W. B., 2010: Effect of Lactobacillus plantarum on intestinal microbial community composition and response to enterotoxigenic Escherichia coli challenge in weaning piglets. Livestock Science133, 98-100.
199. Pierce, K. M.; Callan, J. J.; McCarthy, P.; O'Doherty, J. V., 2005: Performance of weanling pigs offered low or high lactose diets supplemented with avilamycin or inulin. Animal Science80, 313-318.
200. Pierce, K. M.; Sweeney, T.; Brophy, P. O.; Callan, J. J.; Fitzpatrick, E.; McCarthy, P.; O'Doherty, J. V., 2006: The effect of lactose and inulin on intestinal morphology, selected microbial populations and volatile fatty acid concentrations in the gastro-intestinal tract of the weanling pig. Animal Science82, 311-318.
201. Piva, A.; Panciroli, A.; Meola., E.; Formigoni, A., 1996: Lactitol enhances short-chain fatty acid and gas production by swine cecal microflora to a great extent when fermenting low rather than high fibre diets. Journal of Nutrition126, 280-289.
202. Piva, A.; Prandini, A.; Fiorentini, L.; Morlacchini, M.; Galvano, F.; Luchansky, J. B., 2002: Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs. Journal of Animal Science80, 670-680.
203. Piva, A.; Grilli, E.; Fabbri, L.; Pizzamiglio, V.; Gatta, P. P.; Galvano, F.; Bognanno, M.; Fiorentini, L.; Wolinski, J.; Zabielski, R.; Patterson, J. A., 2008: Intestinal metabolism of weaned piglets fed a typical United States or European diet with or without supplementation of tributyrin and lactitol. Journal of Animal Science86, 2952-2961.
204. Pluske, J. R.; Hampson, D. J., 2005: Rice-based diets in pigs-for protection against intestinal bacterial infections. In: RIRDC (ed.), A report for the Rural Industries Research and Development Corporation. Rural Industries Research and Development Corporation, Australia.
205. Pluske, J. R.; Hampson, D. J.; Williams, I. H., 1997: Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livestock Production Science51, 215-236.
206. Pluske, J. R.; Siba, P. M.; Pethick, D. W.; Durmic, Z.; Mullan, B. P.; Hampson, D. J., 1996a: The incidence of swine dysentery in pigs can be reduced by feeding diets that limit the amount of fermentable substrate entering the large intestine. Journal of Nutrition126, 2920-2933.
207. Pluske, J. R.; Williams, I. H.; Aherne, F. X., 1996b: Villous height and crypt depth in piglets in response to increases in the intake of cows' milk after weaning. Animal Science62, 145-158.
208. Pluske, J. R.; Pethick, D. W.; Hopwood, D. E.; Hampson, D. J., 2002: Nutritional influences on some major enteric bacterial diseases of pigs. Nutrition Research Reviews15, 333-371.
209. Pluske, J. R.; Kerton, D. J.; Cranwell, P. D.; Campbell, R. G.; Mullan, B. P.; King, R. H.; Power, G. N.; Pierzynowski, S. G.; Westrom, B.; Rippe, C.; Peulen, O.; Dunshea, F. R., 2003: Age, sex, and weight at weaning influence organ weight and gastrointestinal development of weanling pigs. Australian Journal of Agricultural Research54, 515-527.
210. Pluske, J. R.; Hansen, C. F.; Payne, H. G.; Mullan, B. P.; Kim, J. C.; Hampson, D. J., 2007: Gut health in the pig. In: J. E. Patterson, J. E. Barker (eds), Manipulating Pig Production XI. Australasian Pig Science Association, Werribee, Victoria, Australia, pp. 147-158.
211. Poulsen, H. D., 1995: Zinc oxide for weanling piglets. Acta Agriculturae Scandinavica, Section A - Animal Science45, 159-167.
212. Pouteaux, V. A.; Christison, G. I.; Rhodes, C. S., 1982: The involvement of dietary protein source and chilling in the etiology of diarrhea in newly weaned pigs. Canadian Journal of Animal Science62, 1199-1209.
213. Prasad, A. S.; Oberleas, D., 1971: Changes in activities of zinc-dependent enzymes in zinc-deficient tissues of rats. Journal of Applied Physiology31, 842-846.
214. Prasad, A. S.; Oberleas, D.; Wolf, P.; Horwitz, J. P.; Miller, E. R.; Luecke, R. W., 1969: Changes in trace elements and enzyme activities in tissues of zinc-deficient pigs. American Journal of Clinical Nutrition22, 628-637.
215. Prohászka, L.; Baron, F., 1980: The predisposing role of high dietary protein supplies in enteropathogenic E. coli infections of weaned pigs. Zentralblatt für Veterinärmedizin Reihe B27, 222-232.
216. Que, J. U.; Casey, S. W.; Hentges, D. J., 1986: Factors responsible for increased susceptibility of mice to intestinal colonization after treatment with streptomycin. Infection and Immunity53, 116-123.
217. Ravindran, V.; Kornegay, E. T., 1993: Acidification of weaner pig diets: a review. Journal of the Science of Food and Agriculture62, 313-322.
218. Reid, C.-A.; Hillman, K., 1999: The effects of retrogradation and amylose/amylopectin ratio of starches on carbohydrate fermentation and microbial populations in the porcine colon. Animal Science68, 503-510.
219. Reilly, P.; O'Doherty, J. V.; Pierce, K. M.; Callan, J. J.; O'Sullivan, J. T.; Sweeney, T., 2008: The effects of seaweed extract inclusion on gut morphology, selected intestinal microbiota, nutrient digestibility, volatile fatty acid concentrations and the immune status of the weaned pig. Animal2, 1465-1473.
220. Rettedal, E.; Vilain, S.; Lindblom, S.; Lehnert, K.; Scofield, C.; George, S.; Clay, S.; Kaushik, R. S.; Rosa, A. J. M.; Francis, D.; Brozel, V. S., 2009: Alteration of the ileal microbiota of weanling piglets by the growth-promoting antibiotic chlortetracycline. Applied and Environmental Microbiology75, 5489-5495.
221. Risley, C. R.; Kornegay, E. T.; Lindemann, M. D.; Wood, C. M.; Eigel, W. N., 1992: Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs. Journal of Animal Science70, 196-206.
222. Roberfroid, M., 2007: Prebiotics: the concept revisited. Journal of Nutrition137, 830S-837S.
223. Roselli, M.; Finamore, A.; Britti, M. S.; Bosi, P.; Oswald, I.; Mengheri, E., 2005: Alternatives to in-feed antibiotics in pigs: evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. Animal Research54, 203-218.
224. Roselli, M.; Finamore, A.; Britti, M. S.; Mengheri, E., 2006: Probiotic bacteria bifidobacterium animalis MB5 and lactobacillus rhamnosus GG protect intestinal Caco-2 cells from the inflammation -associated response induced by enterotoxigenic Escherichia coli K88. British Journal of Nutrition95, 1177-1184.
225. Roselli, M.; Finamore, A.; Britti, M. S.; Konstantinov, S. R.; Smidt, H.; de Vos, W. M.; Mengheri, E., 2007: The novel porcine lactobacillus sobrius strain protects intestinal cells from enterotoxigenic Escherichia coli K88 infection and prevents membrane barrier damage. Journal of Nutrition137, 2709-2716.
226. Rydning, A.; Berstad, A.; Berstad, T.; Hertzenberg, L., 1985: The effect of guar gum and fiber-enriched wheat bran on gastric emptying of a semisolid meal in healthy subjects. Scandinavian Journal of Gastroenterology20, 330-334.
227. Sakata, T.; Kojima, T.; Fujieda, M.; Takahashi, M.; Michibata, T., 2003: Influences of probiotic bacteria on organic acid production by pig caecal bacteria in vitro. Proceedings of the Nutrition Society62, 73-80.
228. Salajka, E.; Salajkova, Z.; Alexa, P.; Hornich, M., 1992: Colonization factor different from K88, K99, F41 and 987P in enterotoxigenic Escherichia coli strains isolated from postweaning diarrhoea in pigs. Veterinary Microbiology132, 163-175.
229. Salgado, P.; Freire, J. P. B.; Mourato, M.; Cabral, F.; Toullec, R.; Lallès, J. P., 2002: Comparative effects of different legume protein sources in weaned piglets: nutrient digestibility, intestinal morphology and digestive enzymes. Livestock Production Science74, 191-202.
230. Sauerwein, H.; Schmitz, S.; Hiss, S., 2007: Effects of a dietary application of a yeast cell wall extract on innate and acquired immunity, on oxidative status and growth performance in weanling piglets and on the ileal epithelium in fattened pigs. Journal of Animal Physiology and Animal Nutrition91, 369-380.
231. Schierack, P.; Steinruck, H.; Kleta, S.; Vahjen, W., 2006: Virulence factor gene profiles of Escherichia coli Isolates from clinically healthy pigs. Applied and Environmental Microbiology72, 6680-6686.
232. Schrezenmeir, J.; de Vrese, M., 2001: Probiotics, prebiotics, and synbiotics--approaching a definition. American Journal of Clinical Nutrition73, 361S-364S.
233. Setia, A.; Bhandari, S. K.; House, J. D.; Nyachoti, M. C.; Krause, D. O., 2009: Development and in vitro evaluation of an Escherichia coli probiotic able to inhibit the growth of pathogenic E. coli K88. Journal of Animal Science87, 2005-2012.
234. Shi, G.; Leray, V.; Scarpignato, C.; Bentouimou, N.; Varannes, S. B.d.; Cherbut, C.; Galmiche, J. P., 1997: Specific adaptation of gastric emptying to diets with differing protein content in the rat: is endogenous cholecystokinin implicated?Gut41, 612-618.
235. Shim, S. B.; Williams, B. A.; Verstegen, M. W. A., 2005: Effects of dietary fructose-oligosaccharide on villous height and disaccharidase activity of the small intestine, pH, VFA and ammonia concentrations in the large intestine of weaned pigs. Acta Agriculturae Scandinavica, Section A - Animal Science55, 91-97.
236. Shimizu, M.; Terashima., T., 1982: Appearance of enterotoxigenic Escherichia coli in piglets with diarrhea in connection with feed changes. Current Topics in Microbiology and Immunology26, 467-477.
237. Shu, Q.; Qu, F.; Gill, H. S., 2001: Probiotic treatment using bifidobacterium lactis HN019 reduces weanling diarrhea associated with rotavirus and Escherichia coli infection in a piglet model. Journal of Pediatric Gastroenterology and Nutrition33, 171-177.
238. Smith, H. W.; Jones, J. E. T., 1963: Observations on the alimentary tract and its bacterial flora in healthy and diseased pigs. Journal of Pathology and Bacteriology86, 387-412.
239. Snoeck, V.; Huyghebaert, N.; Cox, E.; Vermeire, A.; Saunders, J.; Remon, J. P.; Verschooten, F.; Goddeeris, B. M., 2004: Gastrointestinal transit time of non-disintegrating radio-opaque pellets in suckling and recently weaned piglets. Journal of Controlled Release94, 143-153.
240. Stein, H. H., 2002: Experience of feeding pigs without antibiotics: a European perspective. Animal Biotechnology13, 85-95.
241. Stein, H. H.; Kil, D. Y., 2006: Reduced use of antibiotic growth promoters in diets fed to weanling pigs: dietary tools, part 2. Animal Biotechnology17, 217-231.
242. Stokes, C. R.; Bailey, M.; Haverson, K.; Harris, C.; Jones, P.; Inman, C.; Pie, S.; Oswald, I. P.; Williams, B. A.; Akkermans, A. D. L.; Sowa, E.; Rothkotter, H. J.; Miller, B. G., 2004: Postnatal development of intestinal immune system in piglets: implications for the process of weaning. Animal Research53, 325-334.
243. Tang, M.; Laarveld, B.; Van Kessel, A. G.; Hamilton, D. L.; Estrada, A.; Patience, J. F., 1999: Effect of segregated early weaning on post-weaning small intestinal development in pigs. Journal of Animal Science77, 3191-3200.
244. Taras, D.; Vahjen, W.; Macha, M.; Simon, O., 2006: Performance, diarrhea incidence, and occurrence of Escherichia coli virulence genes during long-term administration of a probiotic enterococcus faecium strain to sows and piglets. Journal of Animal Science84, 608-617.
245. Taube, V. A.; Neu, M. E.; Hassan, Y.; Verspohl, J.; Beyerbach, M.; Kamphues, J., 2009: Effects of dietary additives (potassium diformate/organic acids) as well as influences of grinding intensity (coarse/fine) of diets for weaned piglets experimentally infected with Salmonella Derby or Escherichia coli. Journal of Animal Physiology and Animal Nutrition93, 350-358.
246. Thomlinson, J. R.; Lawrence, T. L., 1981: Dietary manipulation of gastric pH in the prophylaxis of enteric disease in weaned pigs: some field observations. Veterinary Record109, 120-122.
247. Topping, D. L.; Fukushima, M.; Bird, A. R., 2003: Resistant Starch as a Prebiotic and Synbiotic: State of the Art, Proceedings of the Nutrition Society. CABI Publishing, Royal College of Physicians, Edinburgh, UK, pp. 171-176.
248. Trevisi, P.; Filippi, S.D.; Minieri, L.; Mazzoni, M.; Modesto, M.; Biavati, B.; Bosi, P., 2008: Effect of fructo-oligosaccharides and different doses of Bifidobacterium animalis in a weaning diet on bacterial translocation and Toll-like receptor gene expression in pigs. Nutrition Abstracts and Reviews24, 1023-1029.
249. Tsiloyiannis, V. K.; Kyriakis, S. C.; Vlemmas, J.; Sarris, K., 2001: The effect of organic acids on the control of porcine post-weaning diarrhoea. Research in Veterinary Science70, 287-293.
250. Valencia, D. G.; Serrano, M. P.; Centeno, C.; Lazaro, R.; Mateos, G. G., 2008: Pea protein as a substitute of soya bean protein in diets for young pigs: effects on productivity and digestive traits. Livestock Science118, 1-10.
251. Vega-López, M. A.; Bailey, M.; Telemo, E.; Stokes, C. R., 1995: Effect of early weaning on the development of immune cells in the pig small intestine. Veterinary Immunology and Immunopathology44, 319-327.
252. Vente-Spreeuwenberg, M. A. M.; Verdonk, J.; Bakker, G. C. M.; Beynen, A. C.; Verstegen, M. W. A., 2004: Effect of dietary protein source on feed intake and small intestinal morphology in newly weaned piglets. Livestock Production Science86, 169-177.
253. Verdonk, J. M. A. J.; Bruininx, E. M. A. M.; Meulen, J.v.d.; Verstegen, M. W. A., 2007: Post-weaning feed intake level modulates gut morphology but not gut permeability in weaned piglets. Livestock Science108, 146-149.
254. Verstegen, M. W. A.; Williams, B. A., 2002: Alternatives to the use of antibiotics as growth promoters for monogastric animals. Animal Biotechnology13, 113-127.
255. Vu-Khac, H.; Holoda, E.; Pilipcinec, E.; Blanco, M.; Blanco, J. E.; Dahbi, G.; Mora, A.; Lopez, C.; Gonzalez, E. A.; Blanco, J., 2007: Serotypes, virulence genes, intimin types and PFGE profiles of Escherichia coli isolated from piglets with diarrhoea in Slovakia. Veterinary Journal174, 176-187.
256. Walsh, M. C.; Saddoris, K. L.; Sholly, D. M.; Hinson, R. B.; Sutton, A. L.; Applegate, T. J.; Richert, B. T.; Radcliffe, J. S., 2007: The effects of direct fed microbials delivered through the feed and/or in a bolus at weaning on growth performance and gut health. Livestock Science108, 254-257.
257. Wang, Y. Z.; Xu, Z. R.; Lin, W. X.; Huang, H. Q.; Wang, Z. Q., 2004: Developmental gene expression of antimicrobial peptide PR-39 and effect of zinc oxide on gene regulation of PR-39 in piglets. Asian-Australasian Journal of Animal Sciences17, 1635-1640.
258. Wang, N. F.; Chen, Q.; Le, G. W.; Shi, Y. H.; Sun, J., 2007: Effect of lactic acid fermented soyabean meal on the growth performance, intestinal microflora and morphology of weaned piglets. Journal of Animal and Feed Sciences16, 75-85.
259. Wapnir, R. A.; Teichberg, S., 2002: Regulation mechanisms of intestinal secretion: implications in nutrient absorption. The Journal of Nutritional Biochemistry13, 190-199.
260. Warnecke, T.; Gill, R., 2005: Organic acid toxicity, tolerance, and production in Escherichia coli biorefining applications. Microbial Cell Factories4, 25.
261. Weijers, H. A.; van de Kamer, J. H., 1965: Alteration of intestinal bacterial flora as a cause of diarrhoea. Nutrition Abstracts and Reviews35, 591-604.
262. Wellock, I. J.; Fortomaris, P. D.; Houdijk, J. G. M.; Kyriazakis, I., 2006a: The effect of dietary protein supply on the performance and risk of post-weaning enteric disorders in newly weaned pigs. Animal Science82, 327-335.
263. Wellock, I. J.; Houdijk, J. G. M.; Fortomaris, P. D.; Edwards, S. A.; Kyriazakis., I., 2006b: Too much of a good thing - protein, gut health and performance. The Pig Journal57, 158-172.
264. Wellock, I. J.; Fortomaris, P. D.; Houdijk, J. G. M.; Kyriazakis, I., 2008a: Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: health. Animal2, 834-842.
265. Wellock, I. J.; Fortomaris, P. D.; Houdijk, J. G. M.; Kyriazakis, I., 2008b: Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: performance. Animal2, 825-833.
266. White, F.; Wenham, G.; Sharman, G. A.; Jones, A. S.; Rattray, E. A.; McDonald, I., 1969: Stomach function in relation to a scour syndrome in the piglet. British Journal of Nutrition23, 847-858.
267. Wierup, M., 2001: The Swedish experience of the 1986 year ban of antimicrobial growth promoters, with special reference to animal health, disease prevention, productivity, and usage of antimicrobials. Microbial Drug Resistance7, 183-190.
268. Williams, I. H., 2003: Growth of the weaned pig. In: J. R. Pluske, J. V. Le Dividich, M. W. A. Verstegen (eds), Weaning the Pig: Concepts and Consequences, Wageningen Academic Publishers, Wageningen, Netherlands, pp. 17-36.
269. Williams, B. A.; Verstegen, M. W. A.; Tamminga, S., 2001: Fermentation in the large intestine of single-stomached animals and its relationship to animal health. Nutrition Research Reviews14, 207-227.
270. Wilson, R. H.; Leibholz, J., 1981: Digestion in the pig between 7d and 35d of age. II. The digestion of dry matter and the pH of digesta in pigs given milk and soybean proteins. British Journal of Nutrition45, 321-336.
271. Xu, R. J., 2003: Gastrointestinal secretory function. In: R. J. Xu, P. D. Cranwell (eds), The Neonatal Pig: Gastrointestinal Physiology and Nutrition. Nottingham University Press, Thrumpton, Nottinghamn, pp. 117.
272. Yen, J., 2000: Anatomy of the digestive system and nutritional physiology. In: A. J. Lewis, L. L. Southern (eds), Swine Nutrition. CRC Press, Florida, USA, pp. 32.
273. Yen, J. T.; Pond, W. G.; Prior, R. L., 1981: Calcium chloride as a regulator of feed intake and weight gain in pigs. Journal of Animal Science52, 778-782.
274. Yin, Q.; Zheng, Q., 2005: Isolation and identification of the dominant lactobacillus in gut and faeces of pigs using carbohydrate fermentation and 16S rDNA analysis. Journal of Bioscience and Bioengineering99, 68-71.
275. Yin, Y. L.; Tang, Z. R.; Sun, Z. H.; Liu, Z. Q.; Li, T. J.; Huang, R. L.; Ruan, Z.; Deng, Z. Y.; Gao, B.; Chen, L. X.; Wu, C. Y.; Kim, S. W., 2008: Effect of galacto-mannan-oligosaccharides or chitosan supplementation on cytoimmunity and humoral immunity in early-weaned piglets. Asian-Australasian Journal of Animal Sciences21, 723-731.
276. Yu, B.; Lee, T. T. T.; Chiou, P. W. S., 2002: Effects of sources of protein and enzyme supplementation on protein digestibility and chyme characteristics in broilers. British Poultry Science43, 424-431.
277. Yue, L. Y.; Qiao, S. Y., 2008: Effects of low-protein diets supplemented with crystalline amino acids on performance and intestinal development in piglets over the first 2weeks after weaning. Livestock Science115, 144-152.
278. Yun, J. H.; Kwon, I. K.; Lohakare, J. D.; Choi, J. Y.; Yong, J. S.; Zheng, J.; Cho, W. T.; Chae, B. J., 2005: Comparative efficacy of plant and animal protein sources on the growth performance, nutrient digestibility, morphology and caecal microbiology of early-weaned pigs. Asian-Australasian Journal of Animal Sciences18, 1285-1293.
279. Zani, J. L.; Weykamp da Cruz, F.; Freitas dos Santos, A.; Gil-Turnes, C., 1998: Effect of probiotic CenBiot on the control of diarrhoea and feed efficiency in pigs. Journal of Applied Microbiology84, 68-71.
280. Zhang, Y.; Xu, R. J., 2003: Anatomy and histology of the gastrointestinal tract. In: R. J. Xu, P. D. Cranwell (eds), The Neonatal Pig: Gastrointestinal Physiology and Nutrition. Nottingham University Press, Thrumpton, Nottingham, UK, pp. 1.
281. Zhang, W. P.; Zhao, M. J.; Ruesch, L.; Omot, A.; Francis, D., 2007: Prevalence of virulence genes in Escherichia coli strains recently isolated from young pigs with diarrhea in the US. Veterinary Microbiology123, 145-152.