메뉴 건너뛰기




Volumn 98, Issue 3, 2013, Pages 921-934

Uterine leiomyoma: Available medical treatments and new possible therapeutic options

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANGIOPEPTIN; ASOPRISNIL; CABERGOLINE; CHEMOKINE; CIGLITAZONE; CURCUMIN; CYTOKINE; DANAZOL; EPIGALLOCATECHIN GALLATE; ESTROGEN; GESTRINONE; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GROWTH FACTOR; HALOFUGINONE; HEPARIN; ISOLIQUIRITIGENIN; LEUPRORELIN; LEVONORGESTREL; MIFEPRISTONE; PIRFENIDONE; PLACEBO; PROGESTERONE; RALOXIFENE; ROSIGLITAZONE; TRANILAST; ULIPRISTAL; UNINDEXED DRUG; VITAMIN D;

EID: 84874835388     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3237     Document Type: Review
Times cited : (159)

References (166)
  • 2
    • 0019425414 scopus 로고
    • Uterine leiomyomata: Etiology, symptomatology, and management
    • Buttram VC Jr, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril. 1981;36:433-445. (Pubitemid 11027013)
    • (1981) Fertility and Sterility , vol.36 , Issue.4 , pp. 433-445
    • Buttram Jr., V.C.1    Reiter, R.C.2
  • 3
    • 0035956680 scopus 로고    scopus 로고
    • Uterine fibroids
    • DOI 10.1016/S0140-6736(00)03622-9
    • Stewart EA. Uterine fibroids. Lancet. 2001;357:293-298. (Pubitemid 32120866)
    • (2001) Lancet , vol.357 , Issue.9252 , pp. 293-298
    • Stewart, E.A.1
  • 4
    • 1942501823 scopus 로고    scopus 로고
    • Uterine smooth-muscle tumours: Practical approach to diagnosis
    • DOI 10.1016/S0968-6053(03)00072-3
    • Al-Nafussi A. Uterine smooth-muscle tumours: practical approach to diagnosis. Curr Diagn Pathol. 2004;10:140-156. (Pubitemid 38520433)
    • (2004) Current Diagnostic Pathology , vol.10 , Issue.2 , pp. 140-156
    • Al-Nafussi, A.1
  • 6
    • 34249009878 scopus 로고    scopus 로고
    • Uterine fibroid tumors: Diagnosis and treatment
    • Evans P, Brunsell S. Uterine fibroid tumors: diagnosis and treatment. Am Fam Physician. 2007;75:1503-1508. (Pubitemid 46790333)
    • (2007) American Family Physician , vol.75 , Issue.10 , pp. 1503-1508
    • Evans, P.1    Brunsell, S.2
  • 8
    • 33748779351 scopus 로고    scopus 로고
    • Health care resource use for uterine fibroid tumors in the United States
    • DOI 10.1016/j.ajog.2006.02.020, PII S0002937806002262
    • Flynn M, Jamison M, Datta S, Myers E. Health care resource use for uterine fibroid tumors in the United States. Am J Obstet Gynecol. 2006;195:955-964. (Pubitemid 44415640)
    • (2006) American Journal of Obstetrics and Gynecology , vol.195 , Issue.4 , pp. 955-964
    • Flynn, M.1    Jamison, M.2    Datta, S.3    Myers, E.4
  • 9
    • 0025822362 scopus 로고
    • Treatment of leiomyomata uteri with leuprolide acetate depot: A double-blind, placebo-controlled, multicenter study
    • The Leuprolide Study Group
    • Friedman AJ, Hoffman DI, Comite F, Browneller RW, Miller JD. Treatment of leiomyomata uteri with leuprolide acetate depot: a double-blind, placebo-controlled, multicenter study. The Leuprolide Study Group. Obstet Gynecol. 1991;77:720.
    • (1991) Obstet Gynecol. , vol.77 , pp. 720
    • Friedman, A.J.1    Hoffman, D.I.2    Comite, F.3    Browneller, R.W.4    Miller, J.D.5
  • 10
    • 0027510181 scopus 로고
    • The prevention of bone loss in young women treated with GnRH analogues with 'add-back' estrogen therapy
    • Leather AT, Studd JW, Watson NR, Holland EF. The prevention of bone loss in young women treated with GnRH analogues with "add-back" estrogen therapy. Obstet Gynecol. 1993;81:104-107. (Pubitemid 23041712)
    • (1993) Obstetrics and Gynecology , vol.81 , Issue.1 , pp. 104-107
    • Leather, A.T.1    Studd, J.W.W.2    Watson, N.R.3    Holland, E.F.N.4
  • 12
    • 0032752208 scopus 로고    scopus 로고
    • Long-term administration of tibolone plus gonadotropin-releasing hormone agonist for the treatment of uterine leiomyomas: Effectiveness and effects on vasomotor symptoms, bone mass, and lipid profiles
    • DOI 10.1016/S0015-0282(99)00366-0, PII S0015028299003660
    • Palomba S, Affinito P, Di Carlo C, Bifulco G, Nappi C. Long-term administration of tibolone plus gonadotropin-releasing hormone agonist for the treatment of uterine leiomyomas: effectiveness and effects on vasomotor symptoms, bone mass, and lipid profiles. Fertil Steril. 1999;72:889-895. (Pubitemid 29505455)
    • (1999) Fertility and Sterility , vol.72 , Issue.5 , pp. 889-895
    • Palomba, S.1    Affinito, P.2    Di Carlo, C.3    Bifulco, G.4    Nappi, C.5
  • 13
    • 78650735049 scopus 로고    scopus 로고
    • A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia
    • Sayed GH, Zakherah MS, El-Nashar SA, Shaaban MM. A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia. Int J Gynaecol Obstet. 2010;112:126-130.
    • (2010) Int J Gynaecol Obstet. , vol.112 , pp. 126-130
    • Sayed, G.H.1    Zakherah, M.S.2    El-Nashar, S.A.3    Shaaban, M.M.4
  • 14
    • 0037051711 scopus 로고    scopus 로고
    • The effect on menstrual blood loss in women with uterine fibroids of a novel 'frameless' intrauterine levonorgestrel-releasing drug delivery system: A pilot study
    • DOI 10.1016/S0301-2115(01)00555-3, PII S0301211501005553
    • Wildemeersch D, Schacht E. The effect on menstrual blood loss in women with uterine fibroids of a novel "frameless" intrauterine levonorgestrel-releasing drug delivery system: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2002;102:74-79. (Pubitemid 34224081)
    • (2002) European Journal of Obstetrics Gynecology and Reproductive Biology , vol.102 , Issue.1 , pp. 74-79
    • Wildemeersch, D.1    Schacht, E.2
  • 16
    • 20444389034 scopus 로고    scopus 로고
    • Uterine fibroids: The elephant in the room
    • DOI 10.1126/science.1112063
    • Walker CL, Stewart EA. Uterine fibroids: the elephant in the room. Science. 2005;308:1589-1592. (Pubitemid 40807499)
    • (2005) Science , vol.308 , Issue.5728 , pp. 1589-1592
    • Walker, C.L.1    Stewart, E.A.2
  • 17
    • 0037677597 scopus 로고    scopus 로고
    • Etiology and pathogenesis of uterine leiomyomas: A review
    • Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect. 2003;111: 1037-1054. (Pubitemid 36826884)
    • (2003) Environmental Health Perspectives , vol.111 , Issue.8 , pp. 1037-1054
    • Flake, G.P.1    Andersen, J.2    Dixon, D.3
  • 18
    • 44949260958 scopus 로고    scopus 로고
    • Incidence, aetiology and epidemiology of uterine fibroids
    • DOI 10.1016/j.bpobgyn.2008.04.002, PII S152169340800062X
    • Okolo S. Incidence, aetiology and epidemiology of uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2008;22:571-588. (Pubitemid 351804127)
    • (2008) Best Practice and Research: Clinical Obstetrics and Gynaecology , vol.22 , Issue.4 , pp. 571-588
    • Okolo, S.1
  • 19
    • 77951590255 scopus 로고    scopus 로고
    • Proinflammatory and profibrotic mediators: Principal effectors of leiomyoma development as a fibrotic disorder
    • Chegini N. Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder. Semin Reprod Med. 2010;28:180-203.
    • (2010) Semin Reprod Med. , vol.28 , pp. 180-203
    • Chegini, N.1
  • 20
    • 33644559047 scopus 로고    scopus 로고
    • Cellular biology of myomas: Interaction of sex steroids with cytokines and growth factors
    • Sozen I, Arici A. Cellular biology of myomas: interaction of sex steroids with cytokines and growth factors. Obstet Gynecol Clin North Am. 2006;33:41-58.
    • (2006) Obstet Gynecol Clin North Am. , vol.33 , pp. 41-58
    • Sozen, I.1    Arici, A.2
  • 21
    • 80054712751 scopus 로고    scopus 로고
    • Growth factors and myometrium: Biological effects in uterine fibroid and possible clinical implications
    • Ciarmela P, Islam MS, Reis FM, et al. Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications. Hum Reprod Update. 2011;17:772-790.
    • (2011) Hum Reprod Update. , vol.17 , pp. 772-790
    • Ciarmela, P.1    Islam, M.S.2    Reis, F.M.3
  • 22
    • 55949108160 scopus 로고    scopus 로고
    • The expression and potential regulatory function of micro RNAs in the pathogenesis of leiomyoma
    • Luo X, Chegini N. The expression and potential regulatory function of micro RNAs in the pathogenesis of leiomyoma. Semin Reprod Med. 2008;26:500-514.
    • (2008) Semin Reprod Med. , vol.26 , pp. 500-514
    • Luo, X.1    Chegini, N.2
  • 23
    • 79955479796 scopus 로고    scopus 로고
    • Agenome-wide association study identifies three loci associated with susceptibility to uterine fibroids
    • Cha PC, Takahashi A, Hosono N, et al. Agenome-wide association study identifies three loci associated with susceptibility to uterine fibroids. Nat Genet. 2011;43:447-450.
    • (2011) Nat Genet. , vol.43 , pp. 447-450
    • Cha, P.C.1    Takahashi, A.2    Hosono, N.3
  • 24
    • 44349113451 scopus 로고    scopus 로고
    • Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium
    • DOI 10.1016/j.fertnstert.2007.05.074, PII S0015028207012204
    • Marsh EE, Lin Z, Yin P, Milad M, Chakravarti D, Bulun SE. Differential expression of micro RNA species in human uterine leiomyoma versus normal myometrium. Fertil Steril. 2008;89:1771-1776. (Pubitemid 351749629)
    • (2008) Fertility and Sterility , vol.89 , Issue.6 , pp. 1771-1776
    • Marsh, E.E.1    Lin, Z.2    Yin, P.3    Milad, M.4    Chakravarti, D.5    Bulun, S.E.6
  • 25
    • 84863281534 scopus 로고    scopus 로고
    • Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma
    • Navarro A, Yin P, Monsivais D, et al. Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma. PloS One. 2012;7:e33284.
    • (2012) PloS One. , vol.7
    • Navarro, A.1    Yin, P.2    Monsivais, D.3
  • 26
    • 0025764950 scopus 로고
    • Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract. Areport of 35 cases
    • Kiechle-Schwarz M, Sreekantaiah C, Berger CS, et al. Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract. Areport of 35 cases. Cancer Genet Cytogenet. 1991;53:125-136.
    • (1991) Cancer Genet Cytogenet. , vol.53 , pp. 125-136
    • Kiechle-Schwarz, M.1    Sreekantaiah, C.2    Berger, C.S.3
  • 30
    • 34247099301 scopus 로고    scopus 로고
    • Physical mapping of distinct 7q22 deletions in uterine leiomyoma and analysis of a recently annotated 7q22 candidate gene
    • DOI 10.1016/j.cancergencyto.2006.11.018, PII S0165460806007928
    • Ptacek T, Song C, Walker CL, Sell SM. Physical mapping of distinct 7q22 deletions in uterine leiomyoma and analysis of a recently annotated 7q22 candidate gene. Cancer Genet Cytogenet. 2007;174:116-120. (Pubitemid 46602533)
    • (2007) Cancer Genetics and Cytogenetics , vol.174 , Issue.2 , pp. 116-120
    • Ptacek, T.1    Song, C.2    Walker, C.L.3    Sell, S.M.4
  • 32
    • 80054097980 scopus 로고    scopus 로고
    • MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas
    • Mäkinen N, Mehine M, Tolvanen J, et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science. 2011;334:252-255.
    • (2011) Science. , vol.334 , pp. 252-255
    • Mäkinen, N.1    Mehine, M.2    Tolvanen, J.3
  • 33
    • 78650002248 scopus 로고    scopus 로고
    • 6p21 rearrangements in uterine leiomyomas targeting HMGA1
    • Nezhad MH, Drieschner N, Helms S, et al. 6p21 rearrangements in uterine leiomyomas targeting HMGA1. Cancer Genet Cytogenet. 2010;203:247-252.
    • (2010) Cancer Genet Cytogenet. , vol.203 , pp. 247-252
    • Nezhad, M.H.1    Drieschner, N.2    Helms, S.3
  • 34
    • 14844356480 scopus 로고    scopus 로고
    • Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Leiomyoma
    • DOI 10.1016/j.cancergencyto.2004.08.025
    • Sandberg AA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer Genet Cytogenet. 2005;158:1-26. (Pubitemid 40354320)
    • (2005) Cancer Genetics and Cytogenetics , vol.158 , Issue.1 , pp. 1-26
    • Sandberg, A.A.1
  • 35
    • 76349099117 scopus 로고    scopus 로고
    • Cytogenetic aberrations and the development of uterine leiomyomata
    • El-Gharib MN, Elsobky ES. Cytogenetic aberrations and the development of uterine leiomyomata. J Obstet Gynaecol Res. 2010;36:101-107.
    • (2010) J Obstet Gynaecol Res. , vol.36 , pp. 101-107
    • El-Gharib, M.N.1    Elsobky, E.S.2
  • 38
    • 41149175606 scopus 로고    scopus 로고
    • Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids: In Focus
    • DOI 10.1111/j.1582-4934.2007.00207.x
    • Pan Q, Luo X, Chegini N. Differential expression of micro RNAs in myometrium and leiomyomas and regulation by ovarian steroids. J Cell Mol Med. 2008;12:227-240. (Pubitemid 351430465)
    • (2007) Journal of Cellular and Molecular Medicine , vol.12 , Issue.1 , pp. 227-240
    • Pan, Q.1    Luo, X.2    Chegini, N.3
  • 39
    • 34447093669 scopus 로고    scopus 로고
    • Concentration-dependent effects of a selective estrogen receptor modulator raloxifene on proliferation and apoptosis in human uterine leiomyoma cells cultured in vitro
    • DOI 10.1093/humrep/del515
    • Liu J, Matsuo H, Xu Q, Chen W, Wang J, Maruo T. Concentration-dependent effects of a selective estrogen receptor modulator raloxifene on proliferation and apoptosis in human uterine leiomyoma cells cultured in vitro. Hum Reprod. 2007;22:1253-1259. (Pubitemid 47062792)
    • (2007) Human Reproduction , vol.22 , Issue.5 , pp. 1253-1259
    • Liu, J.1    Hiroya, M.2    Xu, Q.3    Chen, W.4    Wang, J.5    Maruo, T.6
  • 41
    • 84864404690 scopus 로고    scopus 로고
    • MiR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5
    • Chuang TD, Panda H, Luo X, Chegini N. miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5. Endocr Relat Cancer. 2012;19:541-556.
    • (2012) Endocr Relat Cancer. , vol.19 , pp. 541-556
    • Chuang, T.D.1    Panda, H.2    Luo, X.3    Chegini, N.4
  • 42
    • 84861210601 scopus 로고    scopus 로고
    • MiR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8
    • Chuang TD, Luo X, Panda H, Chegini N. miR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8. Mol Endocrinol. 2012;26:1028-1042.
    • (2012) Mol Endocrinol. , vol.26 , pp. 1028-1042
    • Chuang, T.D.1    Luo, X.2    Panda, H.3    Chegini, N.4
  • 43
    • 79952302811 scopus 로고    scopus 로고
    • Activin-A and myostatin response and steroid regulation in human myometrium: Disruption of their signalling in uterine fibroid
    • Ciarmela P, Bloise E, Gray PC, et al. Activin-A and myostatin response and steroid regulation in human myometrium: disruption of their signalling in uterine fibroid. J Clin Endocrinol Metab. 2011;96:755-765.
    • (2011) J Clin Endocrinol Metab. , vol.96 , pp. 755-765
    • Ciarmela, P.1    Bloise, E.2    Gray, P.C.3
  • 44
    • 0036295025 scopus 로고    scopus 로고
    • Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata
    • DOI 10.1016/S0015-0282(02)03154-0, PII S0015028202031540
    • Sozen I, Arici A. Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata. Fertil Steril. 2002;78:1-12. (Pubitemid 34722662)
    • (2002) Fertility and Sterility , vol.78 , Issue.1 , pp. 1-12
    • Sozen, I.1    Arici, A.2
  • 45
    • 42449090272 scopus 로고    scopus 로고
    • Activin-A in myometrium: Characterization of the actions on myometrial cells
    • DOI 10.1210/en.2007-0692
    • Ciarmela P, Wiater E, Vale W. Activin-A in myometrium: characterization of the actions on myometrial cells. Endocrinology. 2008;149:2506-2516. (Pubitemid 351574535)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2506-2516
    • Ciarmela, P.1    Wiater, E.2    Vale, W.3
  • 46
    • 59649119051 scopus 로고    scopus 로고
    • Presence, actions, and regulation of myostatin in rat uterus and myometrial cells
    • Ciarmela P, Wiater E, Smith SM, Vale W. Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Endocrinology. 2009;150:906-914.
    • (2009) Endocrinology. , vol.150 , pp. 906-914
    • Ciarmela, P.1    Wiater, E.2    Smith, S.M.3    Vale, W.4
  • 47
    • 0033279281 scopus 로고    scopus 로고
    • Complex interactions between sex steroids and cytokines in the human pregnant myometrium: Evidence for an autocrine signaling system at term
    • DOI 10.1210/en.140.6.2533
    • Hatthachote P, Gillespie JI. Complex interactions between sex steroids and cytokines in the human pregnant myometrium: evidence for an autocrine signaling system at term. Endocrinology. 1999;140:2533-2540. (Pubitemid 32245130)
    • (1999) Endocrinology , vol.140 , Issue.6 , pp. 2533-2540
    • Hatthachote, P.1    Gillespie, J.I.2
  • 48
    • 39049148410 scopus 로고    scopus 로고
    • Interleukin-6-174G/C polymorphism in breast cancer and uterine leiomyoma patients: A population-based case control study
    • Litovkin KV, Domenyuk VP, Bubnov VV, Zaporozhan VN. Interleukin-6-174G/C polymorphism in breast cancer and uterine leiomyoma patients: a population-based case control study. Exp Oncol. 2007;29:295-298. (Pubitemid 351236319)
    • (2007) Experimental Oncology , vol.29 , Issue.4 , pp. 295-298
    • Litovkin, K.V.1    Domenyuk, V.P.2    Bubnov, V.V.3    Zaporozhan, V.N.4
  • 49
    • 14244263713 scopus 로고    scopus 로고
    • Gene expression profiling of leiomyoma and myometrial smooth muscle cells in response to transforming growth factor-β
    • DOI 10.1210/en.2004-1377
    • Luo X, Ding L, Xu J, Chegini N. Gene expression profiling of leiomyoma and myometrial smooth muscle cells in response to transforming growth factor-β. Endocrinology. 2005;146:1097-1118. (Pubitemid 40289299)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1097-1118
    • Luo, X.1    Ding, L.2    Xu, J.3    Chegini, N.4
  • 50
    • 8744246378 scopus 로고    scopus 로고
    • Gonadotropin releasing hormone and transforming growth factor β activate mitogen-activated protein kinase/extracellularly regulated kinase and differentially regulate fibronectin, type I collagen, and plasminogen activator inhibitor-1 expression in leiomyoma and myometrial smooth muscle cells
    • DOI 10.1210/jc.2004-0161
    • Ding L, Xu J, Luo X, Chegini N. Gonadotropin releasing hormone and transforming growth factor β activate mitogen-activated protein kinase/extracellularly regulated kinase and differentially regulate fibronectin, type I collagen, and plasminogen activator inhibitor-1 expression in leiomyoma and myometrial smooth muscle cells. J Clin Endocrinol Metab. 2004;89:5549-5557. (Pubitemid 39518439)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.11 , pp. 5549-5557
    • Ding, L.1    Xu, J.2    Luo, X.3    Chegini, N.4
  • 51
    • 0035017526 scopus 로고    scopus 로고
    • Tumor necrosis factor-α expression in human uterine leiomyoma and its down-regulation by progesterone
    • DOI 10.1210/jc.86.5.2275
    • Kurachi O, Matsuo H, Samoto T, Maruo T. Tumor necrosis factor-α expression in human uterine leiomyoma and its down-regulation by progesterone. J Clin Endocrinol Metab. 2001;86:2275-2280. (Pubitemid 32472952)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.5 , pp. 2275-2280
    • Kurachi, O.1    Matsuo, H.2    Samoto, T.3    Maruo, T.4
  • 52
    • 50149084714 scopus 로고    scopus 로고
    • Expression of mRNA for chemokines and chemokine receptors in tissues of the myometrium and uterine leiomyoma
    • Syssoev KA, Kulagina NV, Chukhlovin AB, Morozova EB, Totolian AA. Expression of mRNA for chemokines and chemokine receptors in tissues of the myometrium and uterine leiomyoma. Bull Exp Biol Med. 2008;145:84-89.
    • (2008) Bull Exp Biol Med. , vol.145 , pp. 84-89
    • Syssoev, K.A.1    Kulagina, N.V.2    Chukhlovin, A.B.3    Morozova, E.B.4    Totolian, A.A.5
  • 53
    • 0032101202 scopus 로고    scopus 로고
    • Expression and hormonal regulation of monocyte chemotactic protein-1 in myometrium and leiomyomata
    • DOI 10.1016/S0015-0282(98)00072-7, PII S0015028298000727
    • Sozen I, Olive DL, Arici A. Expression and hormonal regulation of monocyte chemotactic protein-1 in myometrium and leiomyomata. Fertil Steril. 1998;69:1095-1102. (Pubitemid 28274900)
    • (1998) Fertility and Sterility , vol.69 , Issue.6 , pp. 1095-1102
    • Sozen, I.1    Olive, D.L.2    Arici, A.3
  • 54
    • 0031764883 scopus 로고    scopus 로고
    • Extracellular matrix components in uterine leiomyoma and their alteration during the tumour growth
    • Wolańska M, Sobolewski K, Drozdzewicz M, Bańkowski E. Extracellular matrix components in uterine leiomyoma and their alteration during the tumour growth. Mol Cell Biochem. 1998;189: 145-152. (Pubitemid 28556559)
    • (1998) Molecular and Cellular Biochemistry , vol.189 , Issue.1-2 , pp. 145-152
    • Wolanska, M.1    Sobolewski, K.2    Drozdzewicz, M.3    Bankowski, E.4
  • 55
    • 0034001575 scopus 로고    scopus 로고
    • Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
    • DOI 10.1016/S0015-0282(00)00418-0, PII S0015028200004180
    • Arici A, Sozen I. Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertil Steril. 2000;73:1006-1011. (Pubitemid 30227527)
    • (2000) Fertility and Sterility , vol.73 , Issue.5 , pp. 1006-1011
    • Arici, A.1    Sozen, I.2
  • 56
    • 70450205241 scopus 로고    scopus 로고
    • Transforming growth factor β3 regulates the versican variants in the extracellular matrixrich uterine leiomyomas
    • Norian JM, Malik M, Parker CY, et al. Transforming growth factor β3 regulates the versican variants in the extracellular matrixrich uterine leiomyomas. Reprod Sci. 2009;16:1153-1164.
    • (2009) Reprod Sci. , vol.16 , pp. 1153-1164
    • Norian, J.M.1    Malik, M.2    Parker, C.Y.3
  • 57
    • 77951528114 scopus 로고    scopus 로고
    • Why leiomyomas are called fibroids: The central role of extracellular matrix in symptomatic women
    • Malik M, Norian J, McCarthy-Keith D, Britten J, Catherino WH. Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women. Semin Reprod Med. 2010;28:169-179.
    • (2010) Semin Reprod Med. , vol.28 , pp. 169-179
    • Malik, M.1    Norian, J.2    McCarthy-Keith, D.3    Britten, J.4    Catherino, W.H.5
  • 59
    • 84860511488 scopus 로고    scopus 로고
    • Role of stem cells in human uterine leiomyoma growth
    • Ono M, Qiang W, Serna VA, et al. Role of stem cells in human uterine leiomyoma growth. PloS One. 2012;7:e36935.
    • (2012) PloS One. , vol.7
    • Ono, M.1    Qiang, W.2    Serna, V.A.3
  • 60
    • 84865676565 scopus 로고    scopus 로고
    • Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells
    • Mas A, Cervelló I, Gil-Sanchis C, et al. Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells. Fertil Steril. 2012;98:741-751.e6.
    • (2012) Fertil Steril. , vol.98
    • Mas, A.1    Cervelló, I.2    Gil-Sanchis, C.3
  • 61
    • 0028306250 scopus 로고
    • Gonadotropin-releasing hormone and its analogs
    • Conn PD, Crowley MW Jr. Gonadotropin-releasing hormone and its analogs. Annu Rev Med. 1994;45:391-405.
    • (1994) Annu Rev Med. , vol.45 , pp. 391-405
    • Conn, P.D.1    Crowley Jr., M.W.2
  • 63
    • 0036213910 scopus 로고    scopus 로고
    • Relationship between platelet-derived growth factor expression in leiomyomas and uterine volume changes after gonadotropin-releasing hormone agonist treatment
    • DOI 10.1053/hupa.2002.31298
    • Di Lieto A, De Rosa G, De Falco M, et al. Relationship between platelet-derived growth factor expression in leiomyomas and uterine volume changes after gonadotropin-releasing hormone agonist treatment. Hum Pathol. 2002;33:220-224. (Pubitemid 34298738)
    • (2002) Human Pathology , vol.33 , Issue.2 , pp. 220-224
    • Di Lieto, A.1    De Rosa, G.2    De Falco, M.3    Iannotti, F.4    Staibano, S.5    Pollio, F.6    Scaramellino, M.7    Salvatore, G.8
  • 64
    • 13444273035 scopus 로고    scopus 로고
    • Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas
    • Di Lieto A, De Falco M, Pollio F, et al. Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas. J Soc Gynecol Investig. 2005;12:123.
    • (2005) J Soc Gynecol Investig. , vol.12 , pp. 123
    • Di Lieto, A.1    De Falco, M.2    Pollio, F.3
  • 65
    • 0242298197 scopus 로고    scopus 로고
    • The expression of Smads and transforming growth factor beta receptors in leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy
    • DOI 10.1016/j.mce.2003.08.007
    • Chegini N, Luo X, Ding L, Ripley D. The expression of Smads and transforming growth factor β receptors in leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy. Mol Cell Endocrinol. 2003;209:9-16. (Pubitemid 37353078)
    • (2003) Molecular and Cellular Endocrinology , vol.209 , Issue.1-2 , pp. 9-16
    • Chegini, N.1    Luo, X.2    Ding, L.3    Ripley, D.4
  • 66
    • 0037390966 scopus 로고    scopus 로고
    • Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy
    • Chegini N, Verala J, Luo X, Xu J, Williams RS. Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy. J Soc Gynecol Investig. 2003;10:161.
    • (2003) J Soc Gynecol Investig. , vol.10 , pp. 161
    • Chegini, N.1    Verala, J.2    Luo, X.3    Xu, J.4    Williams, R.S.5
  • 67
    • 12244291229 scopus 로고    scopus 로고
    • Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma
    • DOI 10.1016/S1071-5576(02)00184-3, PII S1071557602001843
    • Chegini N, Kornberg L. Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma. J Soc Gynecol Investig. 2003;10:21-26. (Pubitemid 36051094)
    • (2003) Journal of the Society for Gynecologic Investigation , vol.10 , Issue.1 , pp. 21-26
    • Chegini, N.1    Kornberg, L.2
  • 68
    • 0036204393 scopus 로고    scopus 로고
    • Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells
    • Wang Y, Matsuo H, Kurachi O, Maruo T. Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells. Eur J Endocrinol. 2002;146:447.
    • (2002) Eur J Endocrinol. , vol.146 , pp. 447
    • Wang, Y.1    Matsuo, H.2    Kurachi, O.3    Maruo, T.4
  • 69
    • 1042303663 scopus 로고    scopus 로고
    • Molecular mechanisms involved in GnRH analogue-related apoptosis for uterine leiomyomas
    • Bifulco G, Miele C, Pellicano M, et al. Molecular mechanisms involved in GnRH analogue-related apoptosis for uterine leiomyomas. Mol Hum Reprod. 2004;10:43.
    • (2004) Mol Hum Reprod. , vol.10 , pp. 43
    • Bifulco, G.1    Miele, C.2    Pellicano, M.3
  • 70
    • 0024421225 scopus 로고
    • A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy
    • Friedman AJ, Rein MS, Harrison-Atlas D, Garfield JM, Doubilet PM. A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy. Fertil Steril. 1989;52:728.
    • (1989) Fertil Steril. , vol.52 , pp. 728
    • Friedman, A.J.1    Rein, M.S.2    Harrison-Atlas, D.3    Garfield, J.M.4    Doubilet, P.M.5
  • 71
    • 0023908227 scopus 로고
    • Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: Assessment by magnetic resonance imaging
    • Andreyko JL, Blumenfeld Z, Marshall LA, Monroe SE, Hricak H, Jaffe RB. Use of an agonistic analog of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging. Am J Obstet Gynecol. 1988;158:903.
    • (1988) Am J Obstet Gynecol. , vol.158 , pp. 903
    • Andreyko, J.L.1    Blumenfeld, Z.2    Marshall, L.A.3    Monroe, S.E.4    Hricak, H.5    Jaffe, R.B.6
  • 72
    • 0024374379 scopus 로고
    • A placebo-controlled trial of a depot gonadotropin-releasing hormone analogue (leuprolide) in the treatment of uterine leiomyomata
    • Schlaff WD, Zerhouni EA, Huth JA, Chen J, Damewood MD, Rock JA. A placebo-controlled trial of a depot gonadotropin-releasing hormone analogue (leuprolide) in the treatment of uterine leiomyomata. Obstet Gynecol. 1989;74:856.
    • (1989) Obstet Gynecol. , vol.74 , pp. 856
    • Schlaff, W.D.1    Zerhouni, E.A.2    Huth, J.A.3    Chen, J.4    Damewood, M.D.5    Rock, J.A.6
  • 73
    • 0029047827 scopus 로고
    • GnRH agonist and iron versus placebo and iron in the anemic patient before surgery for leiomyomas: A randomized controlled trial
    • Leuprolide Acetate Study Group
    • Stovall TG, Muneyyirci-Delale O, Summitt RL Jr, Scialli AR. GnRH agonist and iron versus placebo and iron in the anemic patient before surgery for leiomyomas: a randomized controlled trial. Leuprolide Acetate Study Group. Obstet Gynecol. 1995;86: 65-71.
    • (1995) Obstet Gynecol , vol.86 , pp. 65-71
    • Stovall, T.G.1    Muneyyirci-Delale, O.2    Summitt Jr., R.L.3    Scialli, A.R.4
  • 74
    • 0036806165 scopus 로고    scopus 로고
    • Efficacy of pre-operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: A systematic review
    • DOI 10.1016/S1470-0328(02)01925-0, PII S1470032802019250
    • Lethaby A, Vollenhoven B, Sowter M. Efficacy of pre-operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: a systematic review. BJOG. 2002;109:1097-1108. (Pubitemid 35287078)
    • (2002) BJOG: An International Journal of Obstetrics and Gynaecology , vol.109 , Issue.10 , pp. 1097-1108
    • Lethaby, A.1    Vollenhoven, B.2    Sowter, M.3
  • 75
    • 0038511958 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone agonist treatment before abdominal myomectomy: A controlled trial
    • DOI 10.1016/S0015-0282(03)00362-5
    • Vercellini P, Trespìdi L, Zaina B, Vicentini S, Stellato G, Crosignani PG. Gonadotropin-releasing hormone agonist treatment before abdominal myomectomy: a controlled trial. Fertil Steril. 2003;79:1390-1395. (Pubitemid 36687886)
    • (2003) Fertility and Sterility , vol.79 , Issue.6 , pp. 1390-1395
    • Vercellini, P.1    Trespidi, L.2    Zaina, B.3    Vicentini, S.4    Stellato, G.5    Crosignani, P.G.6
  • 76
    • 33749504718 scopus 로고    scopus 로고
    • The levonorgestrel intrauterine system: Long-term contraception and therapeutic effects
    • Sitruk-Ware R, Inki P. The levonorgestrel intrauterine system: long-term contraception and therapeutic effects. Womens Health (Lond Engl). 2005;1:171-182.
    • (2005) Womens Health (Lond Engl). , vol.1 , pp. 171-182
    • Sitruk-Ware, R.1    Inki, P.2
  • 77
    • 77955577648 scopus 로고    scopus 로고
    • Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells
    • Xu Q, Qiu L, Zhu L, Luo L, Xu C. Levonorgestrel inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Contraception. 2010;82:301-308.
    • (2010) Contraception. , vol.82 , pp. 301-308
    • Xu, Q.1    Qiu, L.2    Zhu, L.3    Luo, L.4    Xu, C.5
  • 78
    • 83055194361 scopus 로고    scopus 로고
    • Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma
    • Kriplani A, Awasthi D, Kulshrestha V, Agarwal N. Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma. Int J Gynaecol Obstet. 2012;116;35-38.
    • (2012) Int J Gynaecol Obstet , vol.116 , pp. 35-38
    • Kriplani, A.1    Awasthi, D.2    Kulshrestha, V.3    Agarwal, N.4
  • 80
    • 11444265410 scopus 로고    scopus 로고
    • The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: A prospective controlled trial
    • DOI 10.1159/000080932
    • Soysal S, Soysal ME. The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial. Gynecol Obstet Invest. 2005;59:29-35. (Pubitemid 40082294)
    • (2005) Gynecologic and Obstetric Investigation , vol.59 , Issue.1 , pp. 29-35
    • Soysal, S.1    Soysal, M.E.2
  • 81
    • 77952669802 scopus 로고    scopus 로고
    • Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes
    • Murat Naki M, Tekcan C, Ozcan N, Cebi M. Levonorgestrel-releasing intrauterine device insertion ameliorates leiomyoma-dependent menorrhagia among women of reproductive age without a significant regression in the uterine and leiomyoma volumes. Fertil Steril. 2010;94:371-374.
    • (2010) Fertil Steril. , vol.94 , pp. 371-374
    • Murat Naki, M.1    Tekcan, C.2    Ozcan, N.3    Cebi, M.4
  • 82
    • 0031051692 scopus 로고    scopus 로고
    • RU486 (mifepristone): Mechanisms of action and clinical uses
    • Cadepond PF, Ulmann MD, Baulieu MD. RU486 (mifepristone): mechanisms of action and clinical uses. Annu Rev Med. 1997;48: 129-156.
    • (1997) Annu Rev Med. , vol.48 , pp. 129-156
    • Cadepond, P.F.1    Ulmann, M.D.2    Baulieu, M.D.3
  • 83
    • 0029936893 scopus 로고    scopus 로고
    • RU486 suppresses prolactin production in explant cultures of leiomyoma and myometrium
    • Stewart EA, Austin DJ, Jain P, Penglase MD, Nowak RA. RU486 suppresses prolactin production in explant cultures of leiomyoma and myometrium. Fertil Steril. 1996;65:1119-1124. (Pubitemid 26158626)
    • (1996) Fertility and Sterility , vol.65 , Issue.6 , pp. 1119-1124
    • Stewart, E.A.1    Austin, D.J.2    Jain, P.3    Penglase, M.D.4    Nowak, R.A.5
  • 84
    • 77955672097 scopus 로고    scopus 로고
    • LAT1 regulates growth of uterine leiomyoma smooth muscle cells
    • Xia L, Coon JS, Su E, et al. LAT1 regulates growth of uterine leiomyoma smooth muscle cells. Reprod Sci. 2010;17:791-797.
    • (2010) Reprod Sci. , vol.17 , pp. 791-797
    • Xia, L.1    Coon, J.S.2    Su, E.3
  • 85
    • 70449090348 scopus 로고    scopus 로고
    • Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells
    • Luo X, Yin P, Reierstad S, et al. Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells. J Clin Endocrinol Metab. 2009;94:4533-4539.
    • (2009) J Clin Endocrinol Metab. , vol.94 , pp. 4533-4539
    • Luo, X.1    Yin, P.2    Reierstad, S.3
  • 86
    • 76749167058 scopus 로고    scopus 로고
    • Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells
    • Yin P, Lin Z, Reierstad S, et al. Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells. Cancer Res. 2010;70:1722-1730.
    • (2010) Cancer Res. , vol.70 , pp. 1722-1730
    • Yin, P.1    Lin, Z.2    Reierstad, S.3
  • 88
    • 0029049613 scopus 로고
    • Regression of uterine leiomyomata to the antiprogesterone RU486: Dose-response effect
    • Murphy AA, Morales AJ, Kettel LM, Yen SS. Regression of uterine leiomyomata to the antiprogesterone RU486: dose-response effect. Fertil Steril. 1995;64:187.
    • (1995) Fertil Steril. , vol.64 , pp. 187
    • Murphy, A.A.1    Morales, A.J.2    Kettel, L.M.3    Yen, S.S.4
  • 90
    • 33845402183 scopus 로고    scopus 로고
    • Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: A randomized controlled trial
    • Fiscella K, Eisinger SH, Meldrum S, Feng C, Fisher SG, Guzick DS. Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial. Obstet Gynecol. 2006;108:1381.
    • (2006) Obstet Gynecol. , vol.108 , pp. 1381
    • Fiscella, K.1    Eisinger, S.H.2    Meldrum, S.3    Feng, C.4    Fisher, S.G.5    Guzick, D.S.6
  • 94
    • 66549088116 scopus 로고    scopus 로고
    • Low-dose mifepristone in treatment of uterine leiomyoma: A randomised double-blind placebo-controlled clinical trial
    • Bagaria M, Suneja A, Vaid NB, Guleria K, Mishra K. Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trial. Aust N Z J Obstet Gynaecol. 2009;49:77-83.
    • (2009) Aust N Z J Obstet Gynaecol. , vol.49 , pp. 77-83
    • Bagaria, M.1    Suneja, A.2    Vaid, N.B.3    Guleria, K.4    Mishra, K.5
  • 95
    • 0029931137 scopus 로고    scopus 로고
    • Mifepristone: Clinical application in general gynecology
    • DOI 10.1097/00003081-199606000-00018
    • Morales AJ, Kettel LM, Murphy AA. Mifepristone: clinical application in general gynecology. Clin Obstet Gynecol. 1996;39:451-460. (Pubitemid 26143722)
    • (1996) Clinical Obstetrics and Gynecology , vol.39 , Issue.2 , pp. 451-460
    • Morales, A.J.1    Kettel, L.M.2    Murphy, A.A.3
  • 97
    • 33745855890 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFβ3 and their receptors in cultured uterine leiomyoma cells
    • DOI 10.1093/humrep/del035
    • Wang J, Ohara N, Wang Z, et al. A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFb3 and their receptors in cultured uterine leiomyoma cells. Hum Reprod. 2006;21:1869-1877. (Pubitemid 44028263)
    • (2006) Human Reproduction , vol.21 , Issue.7 , pp. 1869-1877
    • Wang, J.1    Ohara, N.2    Wang, Z.3    Chen, W.4    Morikawa, A.5    Sasaki, H.6    De Manno, D.A.7    Chwalisz, K.8    Maruo, T.9
  • 98
    • 33846995100 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells
    • Sasaki H, Ohara N, Xu Q, et al. A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. J Clin Endocrinol Metab. 2007;92:616-623.
    • (2007) J Clin Endocrinol Metab. , vol.92 , pp. 616-623
    • Sasaki, H.1    Ohara, N.2    Xu, Q.3
  • 99
    • 33646067165 scopus 로고    scopus 로고
    • A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells
    • Chen W, Ohara N, Wang J, et al. A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. J Clin Endocrinol Metab. 2006;91:1296-1304.
    • (2006) J Clin Endocrinol Metab. , vol.91 , pp. 1296-1304
    • Chen, W.1    Ohara, N.2    Wang, J.3
  • 101
    • 44249127287 scopus 로고    scopus 로고
    • Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer
    • Morikawa A, Ohara N, Xu Q, et al. Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer. Hum Reprod. 2008;23:944-951.
    • (2008) Hum Reprod. , vol.23 , pp. 944-951
    • Morikawa, A.1    Ohara, N.2    Xu, Q.3
  • 102
    • 34249712002 scopus 로고    scopus 로고
    • A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata
    • DOI 10.1016/j.fertnstert.2006.11.094, PII S001502820604533X
    • Chwalisz K, Larsen L, Mattia-Goldberg C, Edmonds A, Elger W, Winkel CA. A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata. Fertil Steril. 2007;87:1399-1412. (Pubitemid 46829155)
    • (2007) Fertility and Sterility , vol.87 , Issue.6 , pp. 1399-1412
    • Chwalisz, K.1    Larsen, L.2    Mattia-Goldberg, C.3    Edmonds, A.4    Elger, W.5    Winkel, C.A.6
  • 103
    • 57349169309 scopus 로고    scopus 로고
    • Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy
    • Wilkens J, Chwalisz K, Han C, et al. Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy. J Clin Endocrinol Metab. 2008;93:4664.
    • (2008) J Clin Endocrinol Metab. , vol.93 , pp. 4664
    • Wilkens, J.1    Chwalisz, K.2    Han, C.3
  • 104
    • 0345735757 scopus 로고    scopus 로고
    • Development of the selective progesterone receptor modulator CDB-2914 for clinical indications
    • DOI 10.1016/S0039-128X(03)00118-1
    • Blithe DL, Nieman LK, Blye RP, Stratton P, Passaro M. Development of the selective progesterone receptor modulator CDB-2914 for clinical indications. Steroids. 2003;68:1013-1017. (Pubitemid 37532426)
    • (2003) Steroids , vol.68 , Issue.10-13 , pp. 1013-1017
    • Blithe, D.L.1    Nieman, L.K.2    Blye, R.P.3    Stratton, P.4    Passaro, M.5
  • 105
    • 0347627640 scopus 로고    scopus 로고
    • Pharmacologic properties of CDB (VA)-2914
    • Gainer EE, Ulmann A. Pharmacologic properties of CDB (VA)-2914. Steroids. 2003;68:1005-1011.
    • (2003) Steroids. , vol.68 , pp. 1005-1011
    • Gainer, E.E.1    Ulmann, A.2
  • 106
    • 14044251610 scopus 로고    scopus 로고
    • Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5′-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells
    • DOI 10.1210/jc.2004-1569
    • Xu Q, Takekida S, Ohara N, et al. Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly (adenosine 5′-diphosphate- ribose) polymerase expression in cultured human uterine leiomyoma cells. J Clin Endocrinol Metab. 2005;90:953-961. (Pubitemid 40279221)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.2 , pp. 953-961
    • Xu, Q.1    Takekida, S.2    Ohara, N.3    Chen, W.4    Sitruk-Ware, R.5    Johansson, E.D.B.6    Maruo, T.7
  • 107
    • 77951593752 scopus 로고    scopus 로고
    • Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth
    • Yoshida S, Ohara N, Xu Q, et al. Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth. Semin Reprod Med. 2010;28:260-273.
    • (2010) Semin Reprod Med. , vol.28 , pp. 260-273
    • Yoshida, S.1    Ohara, N.2    Xu, Q.3
  • 108
    • 33749545197 scopus 로고    scopus 로고
    • Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells
    • DOI 10.1093/humrep/del159
    • Xu Q, Ohara N, Chen W, et al. Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Hum Reprod. 2006;21:2408-2416. (Pubitemid 44530620)
    • (2006) Human Reproduction , vol.21 , Issue.9 , pp. 2408-2416
    • Xu, Q.1    Ohara, N.2    Chen, W.3    Liu, J.4    Sasaki, H.5    Morikawa, A.6    Sitruk-Ware, R.7    Johansson, E.D.B.8    Maruo, T.9
  • 109
    • 40949109661 scopus 로고    scopus 로고
    • Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells
    • DOI 10.1093/molehr/gan004
    • Xu Q, Ohara N, Liu J, et al. Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells. Mol Hum Reprod. 2008;14:181-191. (Pubitemid 351404891)
    • (2008) Molecular Human Reproduction , vol.14 , Issue.3 , pp. 181-191
    • Xu, Q.1    Ohara, N.2    Liu, J.3    Amano, M.4    Sitruk-Ware, R.5    Yoshida, S.6    Maruo, T.7
  • 110
    • 77957750090 scopus 로고    scopus 로고
    • Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system
    • Maruo T, Ohara N, Yoshida S, et al. Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system. Contraception. 2010;82:435-441.
    • (2010) Contraception. , vol.82 , pp. 435-441
    • Maruo, T.1    Ohara, N.2    Yoshida, S.3
  • 112
    • 78751569564 scopus 로고    scopus 로고
    • Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: A randomized, double-blind, placebo-controlled, phase IIb study
    • Nieman LK, Blocker W, Nansel T, et al. Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study. Fertil Steril. 2011;95:767-772.e761-e762.
    • (2011) Fertil Steril. , vol.95 , pp. 767-772
    • Nieman, L.K.1    Blocker, W.2    Nansel, T.3
  • 113
    • 84856568733 scopus 로고    scopus 로고
    • Ulipristal acetate versus placebo for fibroid treatment before surgery
    • Donnez J, Tatarchuk TF, Bouchard P, et al. Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med. 2012;366:409-420.
    • (2012) N Engl J Med. , vol.366 , pp. 409-420
    • Donnez, J.1    Tatarchuk, T.F.2    Bouchard, P.3
  • 114
    • 84856563732 scopus 로고    scopus 로고
    • Ulipristal acetate versus leuprolide acetate for uterine fibroids
    • Donnez J, Tomaszewski J, Vázquez F, et al. Ulipristal acetate versus leuprolide acetate for uterine fibroids. N Engl J Med. 2012;366:421-432.
    • (2012) N Engl J Med. , vol.366 , pp. 421-432
    • Donnez, J.1    Tomaszewski, J.2    Vázquez, F.3
  • 115
    • 2142701431 scopus 로고    scopus 로고
    • In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone
    • DOI 10.1016/j.jsbmb.2003.12.004, PII S0960076004000184
    • Attardi BJ, Burgenson J, Hild SA, Reel JR. In vitro antiprogestational/ antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004;88:277-288. (Pubitemid 38553759)
    • (2004) Journal of Steroid Biochemistry and Molecular Biology , vol.88 , Issue.3 , pp. 277-288
    • Attardi, B.J.1    Burgenson, J.2    Hild, S.A.3    Reel, J.R.4
  • 116
    • 77952110601 scopus 로고    scopus 로고
    • The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells
    • Luo X, Yin P, Coon VJ, Cheng YH, Wiehle RD, Bulun SE. The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Fertil Steril. 2010;93:2668-2673.
    • (2010) Fertil Steril. , vol.93 , pp. 2668-2673
    • Luo, X.1    Yin, P.2    Coon, V.J.3    Cheng, Y.H.4    Wiehle, R.D.5    Bulun, S.E.6
  • 117
    • 80051988006 scopus 로고    scopus 로고
    • Cdb-4124 does not cause apoptosis in cultured fibroid cells
    • Roeder H, Jayes F, Feng L, Leppert PC. Cdb-4124 does not cause apoptosis in cultured fibroid cells. Reprod Sci. 2011;18:850-857.
    • (2011) Reprod Sci. , vol.18 , pp. 850-857
    • Roeder, H.1    Jayes, F.2    Feng, L.3    Leppert, P.C.4
  • 119
    • 34948896920 scopus 로고    scopus 로고
    • Aromatase inhibitor therapy for uterine bleeding in a postmenopausal woman with leiomyomata
    • DOI 10.1097/gme.0b013e318054e2be
    • Kaunitz AM. Aromatase inhibitor therapy for uterine bleeding in a postmenopausal woman with leiomyomata. Menopause. 2007;14:941-943. (Pubitemid 47517596)
    • (2007) Menopause , vol.14 , Issue.5 , pp. 941-943
    • Kaunitz, A.M.1
  • 120
    • 57849113658 scopus 로고    scopus 로고
    • Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients
    • Hilário SG, Bozzini N, Borsari R, Baracat EC. Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients. Fertil Steril. 2009;91:240-243.
    • (2009) Fertil Steril. , vol.91 , pp. 240-243
    • Hilário, S.G.1    Bozzini, N.2    Borsari, R.3    Baracat, E.C.4
  • 121
    • 0037338121 scopus 로고    scopus 로고
    • Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor
    • DOI 10.1016/S0015-0282(02)04761-1
    • Shozu M, Murakami K, Segawa T, Kasai T, Inoue M. Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor. Fertil Steril. 2003;79:628-631. (Pubitemid 36293465)
    • (2003) Fertility and Sterility , vol.79 , Issue.3 , pp. 628-631
    • Shozu, M.1    Murakami, K.2    Segawa, T.3    Kasai, T.4    Inoue, M.5
  • 123
    • 72749091561 scopus 로고    scopus 로고
    • A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status
    • Parsanezhad ME, Azmoon M, Alborzi S, et al. A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. Fertil Steril. 2010;93:192-198.
    • (2010) Fertil Steril. , vol.93 , pp. 192-198
    • Parsanezhad, M.E.1    Azmoon, M.2    Alborzi, S.3
  • 125
    • 77649190601 scopus 로고    scopus 로고
    • Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice
    • Zhang D, Al-Hendy M, Richard-Davis G, et al. Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice. Am J Obstet Gynecol. 2010;202:289.e1-289.e9.
    • (2010) Am J Obstet Gynecol. , vol.202
    • Zhang, D.1    Al-Hendy, M.2    Richard-Davis, G.3
  • 127
    • 0031738215 scopus 로고    scopus 로고
    • Pirfenidone: A novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production
    • DOI 10.1210/jc.83.1.219
    • Lee BS, Margolin SB, Nowak RA. Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production. J Clin Endocrinol Metab. 1998;83:219-223. (Pubitemid 28498339)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.1 , pp. 219-223
    • Lee, B.-S.1    Margolin, S.B.2    Nowak, R.A.3
  • 128
    • 77957272596 scopus 로고    scopus 로고
    • Novel, orally active selective progesterone receptor modulator CP8947 inhibits leiomyoma cell proliferation without adversely affecting endometrium or myometrium
    • Catherino WH, Malik M, Driggers P, Chappel S, Segars J, Davis J. Novel, orally active selective progesterone receptor modulator CP8947 inhibits leiomyoma cell proliferation without adversely affecting endometrium or myometrium. J Steroid Biochem Mol Biol. 2010;122:279-286.
    • (2010) J Steroid Biochem Mol Biol. , vol.122 , pp. 279-286
    • Catherino, W.H.1    Malik, M.2    Driggers, P.3    Chappel, S.4    Segars, J.5    Davis, J.6
  • 131
    • 19944427608 scopus 로고    scopus 로고
    • Ciglitizone inhibits cell proliferation in human uterine leiomyoma via activation of store-operated Ca2+ channels
    • Kim BY, Cho CH, Song DK, et al. Ciglitizone inhibits cell proliferation in human uterine leiomyoma via activation of store-operated Ca2+ channels. Am J Physiol Cell Physiol. 2005;288:C389-C395.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Kim, B.Y.1    Cho, C.H.2    Song, D.K.3
  • 133
    • 0033818915 scopus 로고    scopus 로고
    • Halofuginone: From veterinary use to human therapy
    • Pines M, Vlodavsky I, Nagler A. Halofuginone: from veterinary use to human therapy. Drug Dev Res. 2000;50:371-378.
    • (2000) Drug Dev Res. , vol.50 , pp. 371-378
    • Pines, M.1    Vlodavsky, I.2    Nagler, A.3
  • 134
    • 77049102168 scopus 로고    scopus 로고
    • The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells
    • Grudzien MM, Low PS, Manning PC, Arredondo M, Belton RJ, Nowak RA. The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells. Fertil Steril. 2010;93:1290-1298.
    • (2010) Fertil Steril. , vol.93 , pp. 1290-1298
    • Grudzien, M.M.1    Low, P.S.2    Manning, P.C.3    Arredondo, M.4    Belton, R.J.5    Nowak, R.A.6
  • 136
    • 0018719291 scopus 로고
    • A double blind controlled trial of N-(3',4'-dimethoxycinnamoyl) anthranilic acid on children with bronchial asthma. N-5' study group in children
    • Shioda H. A double-blind controlled trial of N-(3, 4-dimethoxycinnamoyl) anthranilic acid on children with bronchial asthma. N-5 Study Group in Children. Allergy. 1979;34:213-219. (Pubitemid 10237256)
    • (1979) Allergy: European Journal of Allergy and Clinical Immunology , vol.34 , Issue.4 , pp. 213-219
    • Shioda, H.1    Nakayama, Y.2    Murano, J.3
  • 137
    • 0028148750 scopus 로고
    • Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts
    • Yamada H, Tajima S, Nishikawa T, Murad S, Pinnell SR. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem (Tokyo). 1994;116:892-897. (Pubitemid 24323674)
    • (1994) Journal of Biochemistry , vol.116 , Issue.4 , pp. 892-897
    • Yamada, H.1    Tajima, S.2    Nishikawa, T.3    Murad, S.4    Pinnell, S.R.5
  • 138
    • 0026452457 scopus 로고
    • The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts
    • Suzawa H, Kikuchi S, Arai N, Koda A. The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol. 1992;60:91.
    • (1992) Jpn J Pharmacol. , vol.60 , pp. 91
    • Suzawa, H.1    Kikuchi, S.2    Arai, N.3    Koda, A.4
  • 139
    • 0036288203 scopus 로고    scopus 로고
    • Anti-tumor effect of N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) on experimental pancreatic cancer
    • DOI 10.1272/jnms.69.224
    • Hiroi M, Onda M, Uchida E, Aimoto T. Anti-tumor effect of N-[3, 4-dimethoxycinnamoyl]-anthranilic acid (tranilast) on experimental pancreatic cancer. J Nippon Med Sch. 2002;69:224-234. (Pubitemid 34717634)
    • (2002) Journal of Nippon Medical School , vol.69 , Issue.3 , pp. 224-234
    • Hiroi, M.1    Onda, M.2    Uchida, E.3    Aimoto, T.4
  • 142
    • 84874833645 scopus 로고    scopus 로고
    • Antiproliferative effect of tranilast on human myometrial and leiomyoma cells
    • Islam MS, Protic O, Stortoni P, et al. Antiproliferative effect of tranilast on human myometrial and leiomyoma cells. Biol Biomed Rep. 2012;2:321-327.
    • (2012) Biol Biomed Rep. , vol.2 , pp. 321-327
    • Islam, M.S.1    Protic, O.2    Stortoni, P.3
  • 144
    • 0033571775 scopus 로고    scopus 로고
    • Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor γ, retinoid X receptor α, and all-trans retinoic acid than myometrium
    • Tsibris JC, Porter KB, Jazayeri A, et al. Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor γ, retinoid X receptor α, and all-trans retinoic acid than myometrium. Cancer Res. 1999;59:5737-5744.
    • (1999) Cancer Res. , vol.59 , pp. 5737-5744
    • Tsibris, J.C.1    Porter, K.B.2    Jazayeri, A.3
  • 145
    • 0029026709 scopus 로고
    • Retinoic acid inhibits estrogeninduced uterine stromal and myometrial cell proliferation
    • Boettger-Tong HL, Stancel GM. Retinoic acid inhibits estrogeninduced uterine stromal and myometrial cell proliferation. Endocrinology. 1995;136:2975-2983.
    • (1995) Endocrinology. , vol.136 , pp. 2975-2983
    • Boettger-Tong, H.L.1    Stancel, G.M.2
  • 146
    • 34249717950 scopus 로고    scopus 로고
    • Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure
    • DOI 10.1016/j.fertnstert.2006.11.093, PII S0015028206045341
    • Catherino WH, Malik M. Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure. Fertil Steril. 2007;87: 1388-1398. (Pubitemid 46829156)
    • (2007) Fertility and Sterility , vol.87 , Issue.6 , pp. 1388-1398
    • Catherino, W.H.1    Malik, M.2
  • 147
    • 49649086951 scopus 로고    scopus 로고
    • Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells
    • Malik M, Webb J, Catherino WH. Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells. Clin Endocrinol (Oxf). 2008;69:462-470.
    • (2008) Clin Endocrinol (Oxf). , vol.69 , pp. 462-470
    • Malik, M.1    Webb, J.2    Catherino, W.H.3
  • 148
    • 79955005067 scopus 로고    scopus 로고
    • All-trans-retinoic acid mediates changes in PI3K and retinoic acid signaling proteins of leiomyomas
    • Ben-Sasson H, Ben-Meir A, Shushan A, et al. All-trans-retinoic acid mediates changes in PI3K and retinoic acid signaling proteins of leiomyomas. Fertil Steril. 2011;95:2080-2086.
    • (2011) Fertil Steril. , vol.95 , pp. 2080-2086
    • Ben-Sasson, H.1    Ben-Meir, A.2    Shushan, A.3
  • 149
    • 0038243870 scopus 로고    scopus 로고
    • Heparin inhibits the motility and proliferation of human myometrial and leiomyoma smooth muscle cells
    • Mason HR, Nowak RA, Morton CC, Castellot JJ Jr. Heparin inhibits the motility and proliferation of human myometrial and leiomyoma smooth muscle cells. Am J Pathol. 2003;162:1895-1904. (Pubitemid 36613047)
    • (2003) American Journal of Pathology , vol.162 , Issue.6 , pp. 1895-1904
    • Mason, H.R.1    Nowak, R.A.2    Morton, C.C.3    Castellot Jr., J.J.4
  • 150
    • 62749157517 scopus 로고    scopus 로고
    • Isoliquiritigenin induces G2 and Mphase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition
    • Park I, Park KK, Park JH, Chung WY. Isoliquiritigenin induces G2 and
    • (2009) Cancer Lett. , vol.277 , pp. 174-181
    • Park, I.1    Park, K.K.2    Park, J.H.3    Chung, W.Y.4
  • 152
    • 0036279287 scopus 로고    scopus 로고
    • Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review
    • Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol. 2002;40:1091-1097.
    • (2002) Food Chem Toxicol. , vol.40 , pp. 1091-1097
    • Surh, Y.J.1
  • 153
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: Preclinical and clinical studies
    • Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23: 363-398. (Pubitemid 36361976)
    • (2003) Anticancer Research , vol.23 , Issue.1 A , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 154
    • 65549164734 scopus 로고    scopus 로고
    • Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity
    • Swarnakar S, Paul S. Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity. Indian J Biochem Biophys. 2009;46:59-65.
    • (2009) Indian J Biochem Biophys. , vol.46 , pp. 59-65
    • Swarnakar, S.1    Paul, S.2
  • 155
    • 84874860816 scopus 로고    scopus 로고
    • Curcumin, a nutritional supplement with antineoplastic activity, selectively inhibits leiomyoma growth
    • Malik M, Britten J, Driggers P, Payson M, Segars JH, Catherino WH. Curcumin, a nutritional supplement with antineoplastic activity, selectively inhibits leiomyoma growth. Fertil Steril. 2007;88:S217.
    • (2007) Fertil Steril. , vol.88
    • Malik, M.1    Britten, J.2    Driggers, P.3    Payson, M.4    Segars, J.H.5    Catherino, W.H.6
  • 156
    • 79958026780 scopus 로고    scopus 로고
    • Inhibitory effect of curcumin on uterine leiomyoma cell proliferation
    • Tsuiji K, Takeda T, Li B, et al. Inhibitory effect of curcumin on uterine leiomyoma cell proliferation. Gynecol Endocrinol. 2011;27:512-517.
    • (2011) Gynecol Endocrinol. , vol.27 , pp. 512-517
    • Tsuiji, K.1    Takeda, T.2    Li, B.3
  • 157
    • 67349189224 scopus 로고    scopus 로고
    • Vitamin D inhibits myometrial and leiomyoma cell proliferation in vitro
    • Bläuer M, Rovio PH, Ylikomi T, Heinonen PK. Vitamin D inhibits myometrial and leiomyoma cell proliferation in vitro. Fertil Steril. 2009;91:1919-1925.
    • (2009) Fertil Steril. , vol.91 , pp. 1919-1925
    • Bläuer, M.1    Rovio, P.H.2    Ylikomi, T.3    Heinonen, P.K.4
  • 158
    • 78650417778 scopus 로고    scopus 로고
    • Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase
    • Sharan C, Halder SK, Thota C, Jaleel T, Nair S, Al-Hendy A. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O- methyltransferase. Fertil Steril. 2011;95:247-253.
    • (2011) Fertil Steril. , vol.95 , pp. 247-253
    • Sharan, C.1    Halder, S.K.2    Thota, C.3    Jaleel, T.4    Nair, S.5    Al-Hendy, A.6
  • 159
    • 79953859182 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D reduces TGF-β3-Induced fibrosis-related gene expression in human uterine leiomyoma cells
    • Halder SK, Goodwin JS, Al-Hendy A. 1,25-Dihydroxyvitamin D reduces TGF-β3-Induced fibrosis-related gene expression in human uterine leiomyoma cells. J Clin Endocrinol Metab. 2011;96: E754-E762.
    • (2011) J Clin Endocrinol Metab. , vol.96
    • Halder, S.K.1    Goodwin, J.S.2    Al-Hendy, A.3
  • 160
    • 84864017713 scopus 로고    scopus 로고
    • 1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model
    • Halder SK, Sharan C, Al-Hendy A. 1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model. Biol Reprod. 2012;86:116.
    • (2012) Biol Reprod. , vol.86 , pp. 116
    • Halder, S.K.1    Sharan, C.2    Al-Hendy, A.3
  • 161
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science. 1995;267:1782-1788.
    • (1995) Science. , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 162
    • 0033061032 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors as novel therapeutic agents
    • DOI 10.1016/S0163-7258(98)00066-7, PII S0163725898000667
    • Levitzki A. Protein tyrosine kinase inhibitors as novel therapeutic agents. Pharmacol Ther. 1999;82:231-239. (Pubitemid 29255918)
    • (1999) Pharmacology and Therapeutics , vol.82 , Issue.2-3 , pp. 231-239
    • Levitzki, A.1
  • 164
    • 33845742037 scopus 로고    scopus 로고
    • Inhibition of leiomyoma cell proliferation in vitro by genistein and the protein tyrosine kinase inhibitor TKS050
    • DOI 10.1016/j.fertnstert.2006.05.056, PII S0015028206030950
    • Shushan A, Ben-Bassat H, Mishani E, Laufer N, Klein BY, Rojansky N. Inhibition of leiomyoma cell proliferation in vitro by genistein and the protein tyrosine kinase inhibitor TKS050. Fertil Steril. 2007;87:127-135. (Pubitemid 46013862)
    • (2007) Fertility and Sterility , vol.87 , Issue.1 , pp. 127-135
    • Shushan, A.1    Ben-Bassat, H.2    Mishani, E.3    Laufer, N.4    Klein, B.Y.5    Rojansky, N.6
  • 165
    • 0032857422 scopus 로고    scopus 로고
    • Therapeutic uses of smad protein inhibitors: Selective inhibition of specific TGF-β activities
    • Laping NJ. Therapeutic uses of smad protein inhibitors: selective inhibition of specific TGF-β activities. IDrugs. 1999;2:907-914. (Pubitemid 29423412)
    • (1999) IDrugs , vol.2 , Issue.9 , pp. 907-914
    • Laping, N.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.