Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor

Fertility and Sterility

Volumn 79, Issue 3, 2003, Pages 628-631

  Shozu, Makio ^a   Murakami, Kouichi ^a   Segawa, Tomoya ^a   Kasai, Tadayuki ^a   Inoue, Masaki ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Aromatase inhibitors; Fadrozole; Leiomyoma; Urinary retention

Indexed keywords

AROMATASE INHIBITOR; ESTROGEN; FADROZOLE; FOLLITROPIN; LUTEINIZING HORMONE;

ADULT; ARTICLE; CASE REPORT; CLIMACTERIUM; CLINICAL FEATURE; CLINICAL PRACTICE; DETERIORATION; DIAGNOSTIC IMAGING; ECHOGRAPHY; ESTROGEN BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HOT FLUSH; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MEASUREMENT; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RECURRENT DISEASE; SYMPTOM; TREATMENT OUTCOME; TUMOR VOLUME; URINE RETENTION; UTERUS MYOMA;

EID: 0037338121     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(02)04761-1     Document Type: Article

References (31)

1. Haney A.F. Clinical decision making regarding leiomyomata what we need in the next millennium . Environ Health Perspect. 108:(Suppl 5):2000;835-839.
2. Adamson G.D. Treatment of uterine fibroids current findings with gonadotropin-releasing hormone agonists . Am J Obstet Gynecol. 166:1992;746-751.
3. Demopoulos R.I., Mesia A.F. Effects of leuprolide acetate on treatment of leiomyomata - clues to mechanisms of action. Adv Anat Pathol. 5:1998;129-136.
4. Stewart E.A. Uterine fibroids. Lancet. 357:2001;293-298.
5. Shaw R.W. New approaches to the management of fibroids. Curr Opin Obstet Gynecol. 3:1991;859-864.
6. Kettel L.M., Murphy A.A., Morales A.J., Rivier J., Vale W., Yen S.S. Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist. Fertil Steril. 60:1993;642-646.
7. Felberbaum R.E., Germer U., Ludwig M., Riethmuller-Winzen H., Heise S., Buttge I., et al. Treatment of uterine fibroids with a slow-release formulation of the gonadotrophin releasing hormone antagonist Cetrorelix. Hum Reprod. 13:1998;660-668.
8. De Leo V., Morgante G., Lanzetta D., D'Antona D., Bertieri R.S. Danazol administration after gonadotrophin-releasing hormone analogue reduces rebound of uterine myomas. Hum Reprod. 12:1997;357-360.
9. Coutinho E.M., Goncalves M.T. Long-term treatment of leiomyomas with gestrinone. Fertil Steril. 51:1989;939-946.
10. Murphy A.A., Kettel L.M., Morales A.J., Roberts V.J., Yen S.S. Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J Clin Endocrinol Metab. 76:1993;513-517.
11. Walker C.L., Burroughs K.D., Davis B., Sowell K., Everitt J.I., Fuchs-Young R. Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma. J Soc Gynecol Investig. 7:2000;249-256.
12. Andersen J., DyReyes V.M., Barbieri R.L., Coachman D.M., Miksicek R.J. Leiomyoma primary cultures have elevated transcriptional response to estrogen compared with autologous myometrial cultures. J Soc Gynecol Invest. 2:1995;542-551.
13. Palomba S., Sammartino A., Di Carlo C., Affinito P., Zullo F., Nappi C. Effects of raloxifene treatment on uterine leiomyomas in postmenopausal women. Fertil Steril. 76:2001;38-43.
14. Kurose T., Hando T., Shiota A. Clinical usefulness of GnRH agonist therapy for premenopausal women with uterine leiomyoma. [in Japanese] Nippon Sanka Fujinka Gakkai Zasshi. 47:1995;35-41.
15. Nicholson T.A., Pelage J.P., Ettles D.F. Fibroid calcification after uterine artery embolization ultrasonographic appearance and pathology . J Vasc Interv Radiol. 12:2001;443-446.
16. Iveson T.J., Smith I.E., Ahern J., Smithers D.A., Trunet P.F., Dowsett M. Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in postmenopausal patients with advanced breast cancer. Cancer Res. 53:1993;266-270.
17. Lee M.J., Kazer R.R. Massive ascites after leuprolide acetate administration for the treatment of leiomyomata uteri. Fertil Steril. 58:1992;416-418.
18. Harding S.G., Pesce A., McMillan L. Symptomatic ascites complicating GnRH analogue use for myoma shrinkage. Br J Obstet Gynaecol. 100:1993;1054-1056.
19. Friedman A.J. Acute urinary retention after gonadotropin-releasing hormone agonist treatment for leiomyomata uteri. Fertil Steril. 59:1993;677-678.
20. Hansen L.M., Batzer F.R., Corson S.L., Bello S. Obesity and GnRH action. Report of a case with contribution by peripherally derived estrogens. J Reprod Med. 42:1997;247-250.
21. Sumitani H., Shozu M., Segawa T., Murakami K., Yang H.J., Shimada K., et al. In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism. Endocrinol. 141:2000;3852-3861.
22. Shozu M., Sumitani H., Segawa T., Yang H.J., Murakami K., Inoue M. Leuprorelin acetate inhibits the expression of aromatase P450 in leiomyoma cells through modification of the transcriptional activity of the glucocorticoid receptor. J Clin Endocrinol Metab. 86:2001;5405-5411.
23. Shozu M., Sumitani H., Segawa T., Yang H.J., Murakami K., Kasai T., et al. Over-expression of aromatase P-450 in leiomyoma tissues is driven through the promoter I.4 of aromatase P-450. J Clin Endocrinol Metab. 87:2002;2540-2548.
24. Selvaraj N., Shetty G., Vijayalakshmi K., Bhatnagar A.S., Moudgal N.R. Effect of blocking oestrogen synthesis with a new generation aromatase inhibitor CGS 16949A on follicular maturation induced by pregnant mare serum gonadotrophin in the immature rat. J Endocrinol. 142:1994;563-570.
25. Moudgal N.R., Shetty G., Selvaraj N., Bhatnagar A.S. Use of a specific aromatase inhibitor for determining whether there is a role for oestrogen in follicle/oocyte maturation, ovulation and preimplantation embryo development. J Reprod Fertil Suppl. 50:1996;69-81.
26. Palter S.F., Tavares A.B., Hourvitz A., Veldhuis J.D., Adashi E.Y. Are estrogens of import to primate/human ovarian folliculogenesis? Endocr Rev. 22:2001;389-424.
27. Mitwally M.F., Casper R.F. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril. 75:2001;305-309.
28. Selvaraj N., Bhatnagar A.S., Moudgal N.R. Is there a role for estrogen in follicular maturation in the primate? Endocrine. 3:1995;245-249.
29. Shozu M., Akasofu K., Harada T., Kubota Y. A new cause of female pseudohermaphroditism placental aromatase deficiency . J Clin Endocrinol Metab. 72:1991;560-566.
30. Conte F.A., Grumbach M.M., Ito Y., Fisher C.R., Simpson E.R. A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom). J Clin Endocrinol Metab. 78:1994;1287-1292.
31. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab. 80:1995;3689-3698.