Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: A randomized controlled trial

Obstetrics and Gynecology

Volumn 108, Issue 6, 2006, Pages 1381-1387

  Fiscella, Kevin ^a   Eisinger, Steven H ^a   Meldrum, Sean ^a   Feng, Changyong ^a   Fisher, Susan G ^a   Guzick, David S ^a  

^a Department of Family Medicine Research Program ^*

Author keywords

[No Author keywords available]

Indexed keywords

MIFEPRISTONE; PLACEBO;

ADULT; AMENORRHEA; ANEMIA; ARTICLE; CANCER DIAGNOSIS; CANCER PAIN; CANCER SIZE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG CAPSULE; ECHOGRAPHY; ENDOMETRIUM HYPERPLASIA; FATIGUE; FEMALE; HEADACHE; HISTOPATHOLOGY; HOT FLUSH; HUMAN; LEIOMYOMA; LIBIDO DISORDER; LIVER DYSFUNCTION; LOW DRUG DOSE; MOOD CHANGE; NAUSEA; NERVOUSNESS; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SHORT FORM 36; SIDE EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR BLEEDING; UTERINE FIBROID SYMPTOMS QUALITY OF LIFE QUESTIONNAIRE; UTERUS BLEEDING; UTERUS MYOMA; VOMITING; WEAKNESS;

ADULT; FEMALE; HORMONE ANTAGONISTS; HUMANS; LEIOMYOMATOSIS; MIDDLE AGED; MIFEPRISTONE; ORGAN SIZE; PAIN; QUALITY OF LIFE; TREATMENT OUTCOME; UTERINE NEOPLASMS; UTERUS;

EID: 33845402183     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000243776.23391.7b     Document Type: Article

References (19)

1. Day BD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol 2003;188:100-7.
2. Wegienka G, Baird DD, Hertz-Picciotto I, Harlow SD, Steege JF, Hill MC, et al. Self-reported heavy bleeding associated with uterine leiomyomata. Obstet Gynecol 2003;101:431-7.
3. Lippman SA, Warner M, Samuels S, Olive D, Vercellini P, Eskenazi B. Uterine fibroids and gynecologic pain symptoms in a population-based study. Fertil Steril 2003;80:1488-94.
4. Becker ER, Spalding J, DuChane J, Horowitz IR. Inpatient surgical treatment patterns for patients with uterine fibroids in the United States, 1998-2002. J Nat Med Assoc 2005;97:1336-42.
5. Steinauer J, Pritts EA, Jackson R, Jacoby AF. Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol 2004;103:1331-6.
6. Eisinger SH, Meldrum S, Fiscella K, le Roux HD, Guzick DS. Low-dose mifepristone for uterine leiomyomata. Obstet Gynecol 2003;101:243-50.
7. Spies JB, Coyne K, Guaou GN, Boyle D, Skyrnarz-Murphy K, Gonzalves SM. The UFS-QOL, a new disease-specific symptom and health-related quality of life questionnaire for leiomyomata. Obstet Gynecol 2002;99:290-300.
8. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473-83.
9. Katz J, Melzack R. Measurement of pain. Surg Clin North Am 1999;79:231-52.
10. Janssen CA, Scholten PC, Heintz AP. A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss. Obstet Gynecol 1995;85:977-82.
11. Baird DT, Brown A, Critchley HO, Williams AR, Lin S, Cheng L. Effect of long-term treatment with low-dose mifepristone on the endometrium. Hum Reprod 2003;18:61-8.
12. Management of uterine fibroids. AHRQ Publication No. 01-E051. Rockville (MD): Agency for Healthcare Research and Quality. Evidence Report/Technology Assessment: Number 34. Available at: http://www.ahrq.gov/clinic/epcsums/ utersumm.htm. Retrieved September 14, 2006.
13. Spies JB, Warren EH, Mathias SD, Walsh SM, Roth AR, Pentecost MJ. Uterine fibroid embolization: measurement of health-related quality of life before and after therapy. J Vasc Intervent Radiol 1999;10:1293-303.
14. Eisinger SH, Bonfiglio T, Fiscella K, Meldrum S, Guzick DS. Twelve-month safety and efficacy of low-dose mifepristone for uterine myomas. J Min Invas Gynecol 12:227-33.
15. Murphy AA, Kettel LM, Morales AJ, Roberts VJ, Yen SS. Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J Clin Endocrinol Metab 1993;76:513-7.
16. Reinsch RC, Murphy AA, Morales AJ, Yen SS. The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: a prospective, randomized study. Am J Obstet Gynecol 1994;170:1623-7.
17. Yang Y, Zheng S, Li K. Treatment of uterine leiomyoma by two different doses of mifepristone. Chin J Obstet Gynecol 1996;31:624-6.
18. Zeng C, Gu M, Huang H. A clinical control study on the treatment of uterine leiomyoma with gonadotrophin releasing hormone agonist or mifepristone [in Chinese]. Chin J Obstet Gynecol 1998;33:490-2.
19. Greene MF. Fatal infections associated with mifepristone-induced abortion. N Engl J Med 2005;353:2317-8.