Inhibition of proliferation and transforming growth factor β3 protein expression by peroxisome proliferators-activated receptor γ ligands in human uterine leiomyoma cells

Chinese Medical Journal

Volumn 121, Issue 2, 2008, Pages 166-171

  Zhang, Chun Hua ^a   Wen, Ze Qing ^a   Li, Jian Feng ^a   Li, Chang Zhong ^a   Shi, Min ^a   Yang, Gui Wen ^b   Lan, Shou Min ^a   Zhu, Yong ^c   Wang, Fei ^a   Zhang, Yao Jing ^a   Wang, Ying Ying ^a   Zhang, Hui ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG NORMAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Leiomyoma; Peroxisome proliferators activated receptor ; Transforming growth factor 3; Uterus

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; TRANSFORMING GROWTH FACTOR BETA3;

ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; INCUBATION TIME; MITOSIS INHIBITION; MOLECULAR INTERACTION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; UTERUS MYOMA;

EID: 39049095841     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200801020-00014     Document Type: Article

References (23)

1. Houston KD, Hunter DS, Hodges LC, Walker CL. Uterine leiomyomas: mechanisms of tumorigenesis. Toxicol Pathol 2001; 29: 100-104.
2. Sozen I, Arici A. Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata. Fertil Steril 2002; 78: 1-12.
3. Hoffman PJ, Milliken DB, Gregg LC, Davis RR, Gregg JP. Molecular characterization of uterine fibrosis and its implication for underlying mechanisms of pathogenesis. Fertil Steril 2004; 82: 639-649.
4. Arslan AA, Gold LI, Mittal K, Mittal K, Suen TC, Belitskaya-Levy I, et al. Gene expression studies provide clues to the pathogenesis of uterine leiomyoma, new evidence and a systematic review. Hum Reprod 2005; 20: 852-863.
5. Arici A, Sozen I. Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertil Steril 2000; 73: 1006-1011.
6. Lee BS, Nowak RA. Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta3 (TGF-β3) and altered responses to the antiproliferative effects of TGF beta. J Clin Endocrinol Metab 2001; 86: 913-920.
7. Eucker J, Sterz J, Krebbel H, Zavrski I, Kaiser M, Zang C, et al. Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. Anticancer Drugs 2006; 17: 763-769.
8. Yasui Y, Hosokawa M, Kohno H, Tanaka T, Miyashita K. Troglitazone and 9-cis, 11-trans, 13-trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. Chemotherapy 2006; 52: 220-225.
9. Houston KD, Copland JA, Broaddus RR, Broaddus RR, Gottardis MM, Fischer SM, et al. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. Cancer Res 2003; 63: 1221-1227.
10. De Falco M, Staibano S, D'Armiento FP, Mascolo M, Salvatore G, Busiello A, et al. Preoperative treatment of uterine leiomyomas: clinical findings and expression of transforming growth factor-beta3 and connective tissue growth factor. J Soc Gynecol Investig 2006; 13: 297-303.
11. Matsuo H, Maruo T, Samoto T. Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone. J Clin Endocrinol Metab 1997; 82: 293-299.
12. Yamada T, Nakago S, Kurachi O, Wang J, Takekida S, Matsuo H, et al. Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cells. Hum Reprod 2004; 19: 815-821.
13. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci U S A 1986; 83: 2496-2500.
14. Welshons WV, Wolf MF, Murphy CS, Jordan VC. Estrogenic activity of phenol red. Mol Cell Endocrinol 1988; 57: 169-178.
15. Dani C, Smith AG, Dessolin S, Leroy P, Staccini L, Villageois P, et al. Differentiation of embryonic stem cells into adipocytes in vitro. J Cell 1997; 110: 1279-1285.
16. Li MY, Lee TW, Yim AP, Chen GG. Function of PPARgamma and its ligands in lung cancer. Crit Rev Clin Lab 2006; 43: 183-202.
17. Chen W, Yang CC, Sheu HM, Seltmann H, Zouboulis CC. Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol 2003; 121: 441-447.
18. Yu D, Murdoch SJ, Parikh SJ, Marcovina SM, Cobitz A, Chen H, et al. Rosiglitazone increases LDL particle size and buoyancy and decreases C-reactive protein in patients with type 2 diabetes on statin therapy. Diab Vasc Dis Res 2006; 3: 189-196.
19. Rios-Vazquez R, Marzoa-Rivas R, Gil-Ortega I, Kaski JC. Peroxisome proliferator-activated receptor-gamma agonists for managemeat and prevention of vascular disease in patients with and without diabetes mellitus. Am J Cardiovasc Drugs 2006; 6: 231-242.
20. Liu Y, Meng Y, Liu H, Li J, Fu J, Liu Y, et al. Growth inhibition and differentiation induced by peroxisome proliferator activated receptor gamma ligand rosiglitazone in human melanoma cell line a375. Med Oncol 2006; 23: 393-402.
21. Aiello A, Pandini G, Frasca F, Conte E, Murabito A, Sacco A, et al. Peroxisomal proliferator activated receptor-gamma agonists induce partial reversion of epithelial mesenchymal transition in antaplastic thyroid cancer cells. Endocrinology 2006; 147: 4463-4475.
22. Wolanska M, Jaworski S. Epidermal growth factor (EGF) in uterine leiomyoma during tumour growth. Ginekol Pol 2005; 76: 643-647.
23. Xu J, Luo X, Chegini N. Differential expression, regulation, and induction of Smads, transforming growth factor-beta signal transduction pathway in leiomyoma and myometrial smooth muscle cells and alteration by gonadotropin-releasing hormone analog. J Clin Endocrinol Metab 2003; 88: 1350-1361.