Steroid hormones and leiomyomas

Obstetrics and Gynecology Clinics of North America

Volumn 33, Issue 1, 2006, Pages 59-67

  Marsh, Erica E ^a   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; AROMATASE INHIBITOR; CLOMIFENE; CLOMIFENE CITRATE; ESTROGEN; GONADORELIN AGONIST; GROWTH FACTOR; HORMONE RECEPTOR; MIFEPRISTONE; ONAPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR MODULATOR; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STEROID HORMONE; STEROID HORMONE ANTAGONIST; TAMOXIFEN;

CLINICAL TRIAL; DRUG EFFICACY; HUMAN; LEIOMYOMA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH; TUMOR RECURRENCE; UTERUS BLEEDING;

FEMALE; GONADAL STEROID HORMONES; HUMANS; LEIOMYOMA; UTERINE NEOPLASMS;

EID: 33644504488     PISSN: 08898545     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ogc.2005.12.001     Document Type: Review

References (60)

1. E.A. Stewart Uterine fibroids Lancet 357 2001 293 298
2. L.M. Marshall, D. Spiegelman, and R.L. Barbieri Variation in the incidence of uterine leiomyoma among premenopausal women by age and race Obstet Gynecol 90 1997 967 973
3. A.H. Ligon, and C.C. Morton Leiomyomata: heritability and cytogenetic studies Hum Reprod Update 7 2001 8 14
4. N. Pandis, S. Heim, and G. Bardi Chromosome analysis of 96 uterine leiomyomas Cancer Genet Cytogenet 55 1991 11 18
5. D.E. Townsend, R.S. Sparkes, and M.C. Baluda Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis by glucose-6-phosphate dehydrogenase Am J Obstet Gynecol 107 1970 1168 1173
6. Z. Gao, H. Matsuo, and Y. Wang Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cells J Clin Endocrinol Metab 86 2001 5593 5599
7. A. Arici, and I. Sozen Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma Am J Obstet Gynecol 188 2003 76 83
8. A. Arici, and I. Sozen Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation Fertil Steril 73 2000 1006 1011
9. T. Maruo, H. Matsuo, and T. Samoto Effects of progesterone on uterine leiomyoma growth and apoptosis Steroids 65 2000 585 592
10. S.L. Cole An internist's observations of patients on long-term contraception J Reprod Med 5 1970 175 178
11. C.L. Walker Role of hormonal and reproductive factors in the etiology and treatment of uterine leiomyoma Recent Prog Horm Res 57 2002 277 294
12. A.M. Rywlin, R.J. Simmons, and M.J. Robinson Leiomyoma of vagina recurrent in pregnancy: a case with apparent hormone dependency South Med J 62 1969 1449 1451
13. A.H. John, and R. Martin Growth of leiomyomata with estrogen-progestogen therapy J Reprod Med 6 1971 56 58
14. T. Frankel, and F. Benjamin Rapid enlargement of a uterine fibroid after clomiphene therapy J Obstet Gynaecol Br Commonw 80 1973 764
15. M.J. Puukka, K.K. Kontula, and A.J. Kauppila Estrogen receptor in human myoma tissue Mol Cell Endocrinol 6 1976 35 44
16. K. Ochiai Cycle variation and distribution in the concentration of cytosol estrogen and progesterone receptors in the normal human uterus and myoma Nippon Sanka Fujinka Gakkai Zasshi 32 1980 945 952
17. E.A. Wilson, F. Yang, and E.D. Rees Estradiol and progesterone binding in uterine leiomyomata and in normal uterine tissues Obstet Gynecol 55 1980 20 24
18. T. Tamaya, J. Fujimoto, and H. Okada Comparison of cellular levels of steroid receptors in uterine leiomyoma and myometrium Acta Obstet Gynecol Scand 64 1985 307 309
19. J. Andersen, and R.L. Barbieri Abnormal gene expression in uterine leiomyomas J Soc Gynecol Investig 2 1995 663 672
20. S. Palomba, T. Sena, and M. Morelli Effect of different doses of progestin on uterine leiomyomas in postmenopausal women Eur J Obstet Gynecol Reprod Biol 102 2002 199 201
21. M.S. Rein, R.L. Barbieri, and A.J. Friedman Progesterone: a critical role in the pathogenesis of uterine myomas Am J Obstet Gynecol 172 1995 14 18
22. K.D. Houston, D.S. Hunter, and L.C. Hodges Uterine leiomyomas: mechanisms of tumorigenesis Toxicol Pathol 29 2001 100 104
23. S. Li, and J. McLachlan Estrogen-associated genes in uterine leiomyoma Ann N Y Acad Sci 948 2001 112 120
24. N. Chegini, C. Ma, and X.M. Tang Effects of GnRH analogues, add-back steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression Mol Hum Reprod 8 2002 1071 1078
25. H. Matsuo, O. Kurachi, and Y. Shimomura Molecular bases for the actions of ovarian sex steroids in the regulation of proliferation and apoptosis of human uterine leiomyoma Oncology 57 Suppl 2 1999 49 58
26. Y.Y. Hsieh, C.C. Chang, and F.J. Tsai Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma Fertil Steril 79 2003 96 99
27. K.D. Houston, J.A. Copland, and R.R. Broaddus Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma Cancer Res 63 2003 1221 1227
28. C.C. Coddington, R.L. Collins, and T.H. Shawker Long-acting gonadotropin hormone-releasing hormone analog used to treat uteri Fertil Steril 45 1986 624 629
29. S.R. Howe, M.M. Gottardis, and J.I. Everitt Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo Endocrinology 136 1995 4996 5003
30. R. Fuchs-Young, S. Howe, and L. Hale Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators Mol Carcinog 17 1996 151 159
31. M.A. Lumsden, C.P. West, and D.T. Baird Tamoxifen prolongs luteal phase in premenopausal women but has no effect on the size of uterine fibroids Clin Endocrinol (Oxf) 31 1989 335 343
32. M.A. Lumsden, C.P. West, and H. Hillier Estrogenic action of tamoxifen in women treated with luteinizing hormone-releasing hormone agonists (goserelin)-lack of shrinkage of uterine fibroids Fertil Steril 52 1989 924 929
33. P.V. Dilts Jr, M.P. Hopkins, and A.E. Chang Rapid growth of leiomyoma in patient receiving tamoxifen Am J Obstet Gynecol 166 1 Pt 1 1992 167 168
34. J. Kang, L. Baxi, and D. Heller Tamoxifen-induced growth of leiomyomas: a case report J Reprod Med 41 1996 119 120
35. K.B. Porter, J.C. Tsibris, and G.W. Porter Effects of raloxifene in a guinea pig model for leiomyomas Am J Obstet Gynecol 179 1998 1283 1287
36. S. Palomba, A. Sammartino, and C. Di Carlo Effects of raloxifene treatment on uterine leiomyomas in postmenopausal women Fertil Steril 76 2001 38 43
37. S. Palomba, F. Orio Jr, and M. Morelli Raloxifene administration in premenopausal women with uterine leiomyomas: a pilot study J Clin Endocrinol Metab 87 2002 3603 3608
38. S. Palomba, T. Russo, and F. Orio Jr Effectiveness of combined GnRH analogue plus raloxifene administration in the treatment of uterine leiomyomas: a prospective, randomized, single-blind, placebo-controlled clinical trial Hum Reprod 17 2002 3213 3219
39. S. Palomba, F. Orio Jr, and T. Russo Long-term effectiveness and safety of GnRH agonist plus raloxifene administration in women with uterine leiomyomas Hum Reprod 19 2004 1308 1314
40. E.J. Folkerd, C.J. Newton, and K. Davidson Aromatase activity in uterine leiomyomata J Steroid Biochem Mol Biol 20 1984 1195 1200
41. T. Yamamoto, K. Takamori, and H. Okada Effect of aminoglutethimide on androstenedione aromatase activity in human uterine leiomyoma Horm Metab Res 17 1985 548 549
42. S.E. Bulun, E.R. Simpson, and R.A. Word Expression of the CYP19 gene and its product aromatase cytochrome P450 in human leiomyoma tissues and cells in culture J Clin Endocrinol Metab 78 1994 736 743
43. H. Sumitani, M. Shozu, and T. Segawa In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism Endocrinology 141 2000 3852 3861
44. J.A. Otubu, V.C. Buttram, and N.F. Besch Unconjugated steroids in leiomyomas and tumor-bearing myometrium Am J Obstet Gynecol 143 1982 130 133
45. J.R. Pasqualini, E. Cornier, and J. Grenier Effect of decapeptyl, an agonistic analog of gonadotropin-releasing hormone on estrogens, estrogen sulfates, and progesterone receptors in leiomyoma and myometrium Fertil Steril 53 1990 1012 1017
46. M. Shozu, H. Sumitani, and T. Segawa Overexpression of aromatase P450 in leiomyoma tissue is driven primarily through promoter I.4 of the aromatase P450 gene (CYP19) J Clin Endocrinol Metab 87 2002 2540 2548
47. M. Shozu, K. Murakami, and T. Segawa Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor Fertil Steril 79 2003 628 631
48. M. Nisolle, S. Gillerot, and F. Casanas-Roux Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy Hum Reprod 14 1999 2844 2850
49. X. Wu, H. Wang, and K. Englund Expression of progesterone receptors A and B and insulin-like growth factor-I in human myometrium and fibroids after treatment with a gonadotropin-releasing hormone analogue Fertil Steril 78 2002 985 993
50. T. Maruo, H. Matsuo, and Y. Shimomura Effects of progesterone on growth factor expression in human uterine leiomyoma Steroids 68 2003 817 824
51. L.R. Viegas, G.P. Vicent, and J.L. Baranao Steroid hormones induce bcl-X gene expression through direct activation of distal promoter P4 J Biol Chem 279 11 2004 9831 9839
52. M.R. Moore, J.L. Zhou, and K.A. Blankenship A sequence in the 5′ flanking region confers progestin responsiveness on the human c-myc gene J Steroid Biochem Mol Biol 62 1997 243 252
53. X. Wu, A. Blanck, and M. Olovsson Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause J Steroid Biochem Mol Biol 80 2002 77 83
54. M. Lessl, M. Klotzbuecher, and S. Schoen Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium J Clin Endocrinol Metab 82 1997 2596 2600
55. O. Kurachi, H. Matsuo, and T. Samoto Tumor necrosis factor-alpha expression in human uterine leiomyoma and its down-regulation by progesterone J Clin Endocrinol Metab 86 2001 2275 2280
56. T. Yamada, S. Nakago, and O. Kurachi Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cells Hum Reprod 19 2004 815 821
57. D.K. Mahajan, and S.N. London Mifepristone (RU486): a review Fertil Steril 68 1997 967 976
58. A.A. Murphy, L.M. Kettel, and A.J. Morales Regression of uterine leiomyomata in response to the antiprogesterone RU 486 J Clin Endocrinol Metab 76 1993 513 517
59. J. Steinauer, E.A. Pritts, and R. Jackson Systematic review of mifepristone for the treatment of uterine leiomyomata Obstet Gynecol 103 2004 1331 1336
60. D. DeManno, W. Elger, and R. Garg Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy Steroids 68 2003 1019 1032