Activin-A and myostatin response and steroid regulation in human myometrium: Disruption of their signalling in uterine fibroid

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 3, 2011, Pages 755-765

  Ciarmela, Pasquapina ^a   Bloise, Enrrico ^b   Gray, Peter C ^c   Carrarelli, Patrizia ^b   Islam, Md Soriful ^a   De Pascalis, Flavio ^b   Severi, Filiberto Maria ^b   Vale, Wylie ^c   Castellucci, Mario ^a   Petraglia, Felice ^b  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; ACTIVIN A; ACTIVIN RECEPTOR; BETA ACTIN; CRIPTO; EPIDERMAL GROWTH FACTOR; ESTROGEN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FOLLISTATIN; FOLLISTATIN RELATED PROTEIN; FOLLITROPIN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESSENGER RNA; MYOSTATIN; PROGESTERONE; SEX HORMONE; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYSTERECTOMY; MENOPAUSE; MENSTRUAL CYCLE; MYOMETRIUM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEROID METABOLISM; TISSUE CULTURE; UTERUS MYOMA;

ACTIVIN RECEPTORS; ACTIVINS; ADULT; BLOTTING, WESTERN; ENDOMETRIUM; EPIDERMAL GROWTH FACTOR; FEMALE; FOLLISTATIN; FOLLISTATIN-RELATED PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LEIOMYOMA; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYOMETRIUM; MYOSTATIN; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; STEROIDS; TISSUE CULTURE TECHNIQUES;

EID: 79952302811     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0501     Document Type: Article

References (39)

1. Harrison CA, Gray PC, Vale WW, Robertson DM 2005 Antagonists of activin signaling: mechanisms and potential biological applications. Trends Endocrinol Metab 16:73-78 (Pubitemid 40270853)
2. McPherron AC, Lawler AM, Lee SJ 1997 Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature 387:83-90 (Pubitemid 27202654)
3. Mathews LS, Vale WW 1991 Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65:973-982
4. Attisano L, Wrana JL, Montalvo E, Massagué J 1996 Activation of signalling by the activin receptor complex. Mol Cell Biol 16:1066-1073 (Pubitemid 26061678)
5. Derynck R, Zhang Y, Feng XH 1998 Smads: transcriptional activators of TGF-β responses. Cell 95:737-740 (Pubitemid 29014453)
6. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L 2003 Myostatin signals through a transforming growth factor β-like signaling pathway to block adipogenesis. Mol Cell Biol 23:7230-7242 (Pubitemid 37211004)
7. Bilezikjian LM, Corrigan AZ, Blount AL, Chen Y, Vale WW 2001 Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-β signaling in anterior pituitary cells. Endocrinology 142:1065-1072 (Pubitemid 32202815)
8. Zhu X, Topouzis S, Liang LF, Stotish RL 2004 Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism. Cytokine 26:262-272
9. Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, Wolfman NM, Qiu Y 2002 The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. J Biol Chem 277:40735-40741 (Pubitemid 35215657)
10. Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R 1998 FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. Oncogene 16:2949-2954 (Pubitemid 28383280)
11. Tsuchida K, Arai KY, Kuramoto Y, Yamakawa N, Hasegawa Y, Sugino H 2000 Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-β family. J Biol Chem 275:40788-40796 (Pubitemid 32054898)
12. Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico MG 1989 Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J 8:1987-1991
13. Gray PC, Harrison CA, Vale W 2003 Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proc Natl Acad Sci USA 100:5193-5198 (Pubitemid 36542681)
14. Kelber JA, Shani G, Booker EC, Vale WW, Gray PC 2008 Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal. J Biol Chem 283:4490-4500
15. Gray PC, Shani G, Aung K, Kelber J, Vale W 2006 Cripto binds transforming growth factor β (TGF-β) and inhibits TGF-β signaling. Mol Cell Biol 26:9268-9278 (Pubitemid 44904422)
16. Ciarmela P, Wiater E, Smith SM, Vale W 2009 Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Endocrinology 150:906-914
17. Ciarmela P, Wiater E, Vale W 2008 Activin-A in myometrium: characterization of the actions on myometrial cells. Endocrinology 149:2506-2516 (Pubitemid 351574535)
18. Flake GP, Andersen J, Dixon D 2003 Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 111:1037-1054 (Pubitemid 36826884)
19. Walker CL, Stewart EA 2005 Uterine fibroids: the elephant in the room. Science 308:1589-1592 (Pubitemid 40807499)
20. Everitt JI, Wolf DC, Howe SR, Goldsworthy TL, Walker C 1995 Rodent model of reproductive tract leiomyomata. Clinical and pathological features. Am J Pathol 146:1556-1567
21. Laping NJ, Everitt JI, Frazier KS, Burgert M, Portis MJ, Cadacio C, Gold LI, Walker CL 2007 Tumor-specific efficacy of transforming growth factor-β RI inhibition in Eker rats. Clin Cancer Res 13:3087-3099
22. Catherino WH, Prupas C, Tsibris JC, Leppert PC, Payson M, Nieman LK, Segars JH 2003 Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. Fertil Steril 80:282-290 (Pubitemid 36959782)
23. Catherino WH, Segars JH 2003 Microarray analysis in fibroids: which gene list is the correct list? Fertil Steril 80:293-294
24. Hodge JC, Morton CC 2007 Genetic heterogeneity among uterine leiomyomata: insights into malignant progression. Hum Mol Genet 16(Spec No 1):R7-R13 (Pubitemid 47241838)
25. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjöblom P, Norgren A, Lindblom B 1998 Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 83:4092-4096 (Pubitemid 28513601)
26. Sakaguchi H, Fujimoto J, Aoki I, Tamaya T 2003 Expression of estrogen receptor α and β in myometrium of premenopausal and postmenopausal women. Steroids 68:11-19 (Pubitemid 35418301)
27. Saito S, Sidis Y, Mukherjee A, Xia Y, Schneyer A 2005 Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. Endocrinology 146:5052-5062 (Pubitemid 41653017)
28. Ciarmela P, Florio P, Toti P, Franchini A, Maguer-Satta V, Ginanneschi C, Ottaviani E, Petraglia F 2003 Human placenta and fetal membranes express follistatin-related gene mRNA and protein. J Endocrinol Invest 26:641-645 (Pubitemid 37270695)
29. Florio P, Ciarmela P, Toti P, Maguer-Satta V, Rimokh R, Buonocore G, Rossi M, Gioffrè W, Petraglia F 2004 Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide. Mol Cell Endocrinol 218:129-135 (Pubitemid 38569933)
30. Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer-Satta V, Rimokh R, Altomare A, Tosi P, Petraglia F 2004 Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma. Eur J Endocrinol 151:251-257 (Pubitemid 39207021)
31. Bloise E, Couto HL, Massai L, Ciarmela P, Mencarelli M, Borges LE, Muscettola M, Grasso G, Amaral VF, Cassali GD, Petraglia F, Reis FM 2009 Differential expression of follistatin and FLRG in human breast proliferative disorders. BMC Cancer 9:320
32. Chegini N, Zhao Y, Williams RS, Flanders KC 1994 Human uterine tissue throughout the menstrual cycle expresses transforming growth factor-β1 (TGF β1), TGF β2, TGF β3, and TGF β type II receptor messenger ribonucleic acid and protein and contains [125I]TGF β1-binding sites. Endocrinology 135:439-449
33. Chegini N, Luo X, Ding L, Ripley D 2003 The expression of Smads and transforming growth factor β receptors in leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy. Mol Cell Endocrinol 209:9-16 (Pubitemid 37353078)
34. Saloman DS, Bianco C, Ebert AD, Khan NI, De Santis M, Normanno N, Wechselberger C, Seno M, Williams K, Sanicola M, Foley S, Gullick WJ, Persico G 2000 The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer. Endocr Relat Cancer 7:199-226 (Pubitemid 32172272)
35. Calvanese L, Saporito A, Oliva R, D' Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L 2009 Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor. J Pept Sci 15:175-183
36. Strizzi L, Bianco C, Hirota M, Watanabe K, Mancino M, Hamada S, Raafat A, Lawson S, Ebert AD, D'Antonio A, Losito S, Normanno N, Salomon DS 2007 Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice. J Pathol 211:36-44 (Pubitemid 46092027)
37. Rossi MJ, Chegini N, Masterson BJ 1992 Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro. Endocrinology 130:1716-1727
38. Tang XM, Rossi MJ, Masterson BJ, Chegini N 1994 Insulin-like growth factor I (IGF-I), IGF-I receptors, and IGF binding proteins 1-4 in human uterine tissue: tissue localization and IGF-I action in endometrial stromal and myometrial smooth muscle cells in vitro. Biol Reprod 50:1113-1125 (Pubitemid 24116048)
39. Tang XM, Dou Q, Zhao Y, McLean F, Davis J, Chegini N 1997 The expression of transforming growth factor-βs and TGF-β receptor mRNA and protein and the effect of TGF-βs on human myometrial smooth muscle cells in vitro. Mol Hum Reprod 3:233-240 (Pubitemid 127509480)