Uterine smooth-muscle tumours: Practical approach to diagnosis

Current Diagnostic Pathology

Volumn 10, Issue 2, 2004, Pages 140-156

  Al Nafussi, A ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Leiomyomas; Leiomyosarcomas; Smooth muscle tumours; Variants

Indexed keywords

GONADORELIN AGONIST;

HISTOPATHOLOGY; HORMONAL THERAPY; HUMAN; LEIOMYOMA; LEIOMYOMATOSIS; MOLECULAR RECOGNITION; MUSCLE DEVELOPMENT; MUSCLE TUMOR; MYOMETRIUM; PATHOLOGIST; REVIEW; TUMOR DIAGNOSIS; UTERINE ARTERY EMBOLIZATION; UTERINE SMOOTH MUSCLE TUMOR; UTERUS MYOMA; UTERUS TUMOR;

EID: 1942501823     PISSN: 09686053     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-6053(03)00072-3     Document Type: Article

References (109)

1. Adesola KA, Ogunniyi SO. Hysterectomies in Nigerians: histopathological analysis of cases seen in ile-ife. Niger Postgrad Med J 2001;8:37-40.
2. Stewart EA. Uterine fibroids. Lancet 2001;357:293-8.
3. Cramer SF, Horiszny JA, Leppert P. Epidemiology of uterine leiomyomas. With an etiologic hypothesis. J Reprod Med 1995;40:595-600.
4. Jones MW, Norris HJ. Clinicopathologic study of 28 uterine leiomyosarcomas with metastasis. Int J Gynecol Pathol 1995;14:243-9.
5. Leibsohn S, d'Ablaing G, Mishell Jr. DR, Schlaerth JB. Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas. Am J Obstet Gynecol 1990;162:968-74.
6. Van Dinh T, Woodruff JD. Leiomyosarcoma of the uterus. Am J Obstet Gynecol 1982;144:817-23.
7. Gisser SD, Young I. Neurilemoma-like uterine myomas: an ultrastructural reaffirmation of their non-schwannian nature. Am J Obstet Gynecol 1977;129:389-92.
8. Wilkinson N, Rollason TP. Recent advances in the pathology of smooth muscle tumours of the uterus. Histopathology 2001;39:331-41.
9. Benda JA. Pathology of smooth muscle tumors of the uterine corpus. Clin Obstet Gynecol 2001;44:350-63.
10. Perrone TL, Dehner P. Prognostically favorable mitotically active' smooth-muscle tumors of the uterus. A clinicopathologic study of ten cases. Am J Surg Pathol 1988;12:1-8.
11. O'Connor DM, Norris HJ. Mitotically active leiomyomas of the uterus. Hum Pathol 1990;21:223-7.
12. Dgani R, Piura B, Ben Baruch G, et al. Clinical-pathological study of uterine leiomyomas with high mitotic activity. Acta Obstet Gynecol Scand 1998;77:74-7.
13. Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 1994;18:535-58.
14. Prayson RA, Hart WR. Mitotically active leiomyomas of the uterus. Am J Clin Pathol 1992;97:14-20.
15. McCluggage WG, Bharucha H. Cellular leiomyoma mimicking endometrial stromal neoplasm in association with GnRH agonist goserelin. Histopathology 1999;34:184-6.
16. Liao X, Wang Y, Yue C, Liu Y, Wang H, Dai L, et al. Highly cellular leiomyoma of uterus: a comparative morphologic and immunohistochemical study of endometrial stromal tumors. Zhonghua Bing Li Xue Za Zhi 2002;31:396-400.
17. Oliva E, Clement PB, Young RH. Endometrial stromal tumors: an update on a group of tumors with a protean phenotype. Adv Anat Pathol 2000;7:257-81.
18. Kempson RL, Hendrickson MR. Smooth muscle, endometrial stromal, and mixed Mullerian tumors of the uterus. Mod Pathol 2000;13:328-42.
19. Fukunaga M, Ushigome S. Uterine bizarre lipoleiomyoma. Pathol Int 1998;48:562-5.
20. Downes KA, Hart WR. Bizarre leiomyomas of the uterus: a comprehensive pathologic study of 24 cases with long-term follow-up. Am J Surg Pathol 1997;21:1261-70.
21. Klunder KB, Svanholm H, Frimodt-Moller PC. Uterine bizarre leiomyoma. Acta Obstet Gynecol Scand 1982;61:121-3.
22. Myles JL, Hart WR. Apoplectic leiomyomas of the uterus. A clinicopathologic study of five distinctive hemorrhagic leiomyomas associated with oral contraceptive usage. Am J Surg Pathol 1985;9:798-805.
23. Norris HJ, Hilliard GD, Irey NS. Hemorrhagic cellular leiomyomas ("apoplectic leiomyoma") of the uterus associated with pregnancy and oral contraceptives. Int J Gynecol Pathol 1988;7:212-24.
24. Logani KB, Agarwal K, Mukherjee J, Goyal R. Lipoleiomyoma of uterus: an uncommon lesion. J Indian Med Assoc 1998;96:321.
25. Fukunaga M, Ushigome S. Uterine bizarre lipoleiomyoma. Pathol Int 1998;48:562-5.
26. Shintaku M. Lipoleiomyomatous tumors of the uterus: a heterogeneous group? Histopathological study of five cases. Pathol Int 1996;46:498-502.
27. Gentile R, Zarri M, De Lucchi F, Bellone F, Lapertosa G. Lipoleiomyoma of the uterus. Pathologica 1996;88:132-4.
28. Lin M, Hanai J. Atypical lipoleiomyoma of the uterus. Acta Pathol Jpn 1991;41:164-9.
29. Clement PB, Young RH, Scully RE. Intravenous leiomyomatosis of the uterus A clinicopathological analysis of 16 cases with unusual histologic features. Am J Surg Pathol 1988;12:932-45.
30. Konichezky M, Reif R, Bukovsky I. Benign angiomyoma of the uterus with unusual macroscopic appearance. Int J Gynaecol Obstet 1980;18:4-6.
31. Jameson CF. Angiomyoma of the uterus in a patient with tuberous sclerosis. Histopathology 1990;16:202-3.
32. Schmid C, Beham A, Kratochvil P. Haematopoiesis in a degenerating uterine leiomyoma. Arch Gynecol Obstet 1990;248:81-6.
33. Vang R, Medeiros LJ, Samoszuk M, Deavers MT. Uterine leiomyomas with eosinophils: a clinicopathologic study of 3 cases. Int J Gynecol Pathol 2001;20:239-43.
34. Robboy SJ, Bentley RC, Butnor K, Anderson MC. Pathology and pathophysiotogy of uterine smooth-muscle tumors. Environ Health Perspect. 2000;108(Suppl 5):779-84.
35. Ceyhan K, Simsir C, Dolen I, Calyskan E, Umudum H. Multinodular hydropic leiomyoma of the uterus with perinodular hydropic degeneration and extrauterine extension. Pathol Int 2002;52:540-3.
36. Jordan LB, Al Nafussi A, Beattie G. Cotyledonoid hydropic intravenous leiomyomatosis: a new variant leiomyoma. Histopathology 2002;40:245-52.
37. Amant F, Gabriel C, Timmerman D, Vergote I. Pseudo-Meigs' syndrome caused by a hydropic degenerating uterine leiomyoma with elevated CA 125. Gynecol Oncol 2001;83:153-7.
38. Coad JE, Sulaiman RA, Das K, Staley N. Perinodular hydropic degeneration of a uterine leiomyoma: a diagnostic challenge. Hum Pathol 1997;28:249-51.
39. Sreenan JJ, Prayson RA, Biscotti CV, Thornton MH, Easley KA, Hart WR. Histopathologic findings in 107 uterine leiomyomas treated with leuprolide acetate compared with 126 controls. Am J Surg Pathol 1996;20:427-32.
40. Clement PB, Young RH, Scully RE. Diffuse, perinodular, and other patterns of hydropic degeneration within and adjacent to uterine leiomyomas. Problems in differential diagnosis. Am J Surg Pathol 1992;16:26-32.
41. Mulvany NJ, Slavin JL, Ostor AG, Fortune DW. Intravenous leiomyomatosis of the uterus: a clinicopathologic study of 22 cases. Int J Gynecol Pathol 1994;13:1-9.
42. Ueda H, Togashi K, Konishi I, et al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics 1999;19 Spec No:S131-S145.
43. Lai FM, Wong FW, Allen PW. Diffuse uterine leiomyomatosis with hemorrhage. Arch Pathol Lab Med 1991;115:834-7.
44. Palomba S, Sammartino A, Di Carlo C, Affinito P, Zullo F, Nappi C. Effects of raloxifene treatment on uterine leiomyomas in postmenopausal women. Fertil Steril 2001;76:38-43.
45. Deligdisch L, Hirschmann S, Altchek A. Pathologic changes in gonadotropin releasing hormone agonist analogue treated uterine leiomyomata. Fertil Steril 1997;67:837-41.
46. Wang PH, Yang AH, Yuan CC, Lee WL, Chao HT. Uterine myoma after cessation of gonadotropin-releasing hormone agonist: ultrasound and histopathologic findings. Zhonghua Yi Xue Za Zhi 1998;61:625-9.
47. Vu K, Greenspan DL, Wu TC, Zacur HA, Kurman RJ. Cellular proliferation, estrogen receptor, progesterone receptor, and bcl-2 expression in GnRH agonist-treated uterine leiomyomas. Hum Pathol 1998;29:359-63.
48. Nicholson TA, Pelage JP, Ettles DF. Fibroid calcification after uterine artery embolization: ultrasonographic appearance and pathology. J Vasc Interv Radiol 2001;12:443-6.
49. McCluggage WG, Ellis PK, McClure N, Walker WJ, Jackson PA, Manek S. Pathologic features of uterine leiomyomas following uterine artery embolization. Int J Gynecol Pathol 2000;19:342-7.
50. Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth-muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol 1994;18:535-58.
51. Mayerhofer K, Obermair A, Windbichler, et al. Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases. Gynecol Oncol 1999;74:196-201.
52. Prayson RA, Goldblum JR, Hart WR. Epithelioid smooth-muscle tumors of the uterus: a clinicopathologic study of 18 patients. Am J Surg Pathol 1997;21:383-91.
53. Kyriazis AP, Kyriazis AA. Uterine leiomyoblastoma (epithelioid leiomyoma) neoplasm of low-grade malignancy. A histopathologic study. Arch Pathol Lab Med 1992;116:1189-91.
54. Mittal K, Demopoulos RI. MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001;32:984-7.
55. Hsieh CH, Lin H, Huang CC, Huang EY, Chang SY, Chang Chien CC. Leiomyosarcoma of the uterus: a clinicopathologic study of 21 cases. Acta Obstet Gynecol Scand 2003;82:74-81.
56. Buscema J, Carpenter SE, Rosenshein NB, Woodruff JD. Epithelioid leiomyosarcoma of the uterus. Cancer 1986;57:1192-6.
57. Nguyen GK, Russell L, Honore L, Vriends R. Epithelioid leiomyosarcoma of the uterus with oncocytic change. Pathol Res Pract 2001;197:643-6.
58. Levine PH, Mittal K. Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. Int J Surg Pathol 2002;10:231-6.
59. Fukuda T, Ohnishi Y. Histological and immunohistochemical observations of dedifferentiated leiomyosarcoma of the uterus. Acta Pathol Jpn 1991;41:466-72.
60. Kagami S, Kashimura M, Toki N, Katuhata Y. Myxoid leiomyosarcoma of the uterus with subsequent pregnancy and delivery. Gynecol Oncol 2002;85:538-42.
61. Takano Y, Morimura Y, Yamada H, Yanagida K, Sato A, Suzuki O, Suzuki T. Myxoid leiomyosarcoma of the uterus. Fukushima J Med Sci 2000;46:41-7.
62. Chang E, Shim SI. Myxoid leiomyosarcoma of the uterus: a case report and review of the literature. J Korean Med Sci 1998;13:559-62.
63. Prayson RA, Hart WR. Pathologic considerations of uterine smooth-muscle tumors. Obstet Gynecol Clin North Am 1995;22:637-57.
64. Schneider D, Halperin R, Segal M, Maymon R, Bukovsky I. Myxoid leiomyosarcoma of the uterus with unusual malignant histologic pattern: a case report. Gynecol Oncol 1995;59:156-8.
65. Kunzel KE, Mills NZ, Muderspach LI, d'Ablaing III G. Myxoid leiomyosarcoma of the uterus. Gynecol Oncol 1993;48:277-80.
66. Kaleli S, Calay Z, Ceydeli N, Aydynly K, Kosebay D. A huge abdominal mass mimicking ovarian cancer: p53-negative but aneuploid myxoid leiomyosarcoma of the uterus. Eur J Obstet Gynecol Reprod Biol 2001;100:96-9.
67. Coard KC, Fletcher H M. Leiomyosarcoma of the uterus with a florid intravascular component ("intravenous leiomyosarcomatosis"). Int J Gynecol Pathol 2002;21:182-5.
68. Aru A, Norup P, Bjerregaard B, Andreasson B, Horn T. Osteoclast-like giant cells in leiomyomatous tumors of the uterus. A case report and review of the literature. Acta Obstet Gynecol Scand 2001;80:371-4.
69. Watanabe K, Hiraki H, Ohishi M, Mashiko K, Saginoya H, Suzuki T. Uterine leiomyosarcoma with osteoclast-like giant cells: histopathological and cytological observations. Pathol Int 1996;46:656-60.
70. Karpuz V, Joris F, Letovanec N, Branchmanski F, Kapanci Y. Metastizing low-grade clear cell leiomyosarcoma of the uterus. Pathol Int 1998;48:82-5.
71. Silva EG, Tornos C, Ordonez NG, Morris M. Uterine leiomyosarcoma with clear cell areas. Int J Gynecol Pathol 1995;14:174-8.
72. Bapat K, Brustein S. Uterine sarcoma with liposarcomatous differentiation: report of a case and review of the literature. Int J Gynaecol Obstet 1989;28:71-5.
73. Nagel H, Brinck U, Luthje D, Fuzesi L. Plexiform leiomyoma of the uterus in a patient with breast carcinoma: case report and review of the literature. Pathology 1999;31:292-4.
74. Han HS, Park IA, Kim SH, Lee HP. The clear cell variant of epithelioid intravenous leiomyomatosis of the uterus: report of a case. Pathol Int 1998;48:892-6.
75. Hyde KE, Geisinger KR, Marshall RB, Jones TL. The clear-cell variant of uterine epithelioid leiomyoma. An immunohistologic and ultrastructural study. Arch Pathol Lab Med 1989;113:551-3.
76. Brooks JJ, Wells GB, Yeh IT, LiVolsi VA. Bizarre epithelioid lipoleiomyoma of the uterus. Int J Gynecol Pathol 1992;11:144-9.
77. Eltabbakh GH, Samter GT. Sex cord tumors of the uterus. Int J Gynaecol Obstet 1995;48:113-4.
78. Horn LC, Fischer U, Friedrich T, Baier D. Myxoid uterine leiomyoma with focal lymphangioma-like pattern. Zentralbl Gynakol 2001;123:655-8.
79. Cruz M, Murakami T, Tsuda K, et al. Myxoid leiomyoma of the uterus: CT and MRI features. Abdom Imaging 2001;26:98-101.
80. Ueda H, Togashi K, Konishi I et al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics 1999;19 Spec No:S131-S145.
81. Shimokama T, Watanabe T. Leiomyoma exhibiting a marked granular change: granular cell leiomyoma versus granular cell schwannoma. Hum Pathol 1992;23:327-31.
82. Robles-Frias A, Severin CE, Robles-Frias MJ, Garrido JL. Diffuse uterine leiomyomatosis with ovarian and parametrial involvement. Obstet Gynecol 2001;97(5 Pt 2): 834-5.
83. Baschinsky DY, Isa A, Niemann TH, Prior TW, Lucas JG, Frankel WL. Diffuse leiomyomatosis of the uterus: a case report with clonality analysis. Hum Pathol 2000;31:1429-32.
84. Mulvany NY, Ostor AG, Ross I. Diffuse leiomyomatosis of the uterus. Histopathology 1995;27:175-9.
85. Domnitz SW, Roth JA, Corwin LJ. Diffuse leiomyomatosis of the uterus in pregnancy. A case report. J Reprod Med 1994;39:61-6.
86. Beattie GJ, Williams AR, Duncan A, Smart GE. Diffuse leiomyomatosis of the uterus with local pelvic spread. Acta Obstet Gynecol Scand 1993;72:492-4.
87. Matsumoto K, Yamamoto T, Hisayoshi T, Asano G. Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae-like cyst formation. Pathol Int 2001;51:396-401.
88. Andrade LA, Torresan RZ, Sales Jr. JF, Vicentini R, De Souza GA. Intravenous leiomyomatosis of the uterus. A report of three cases. Pathol Oncol Res 1998;4:44-7.
89. Marom D, Pitlik S, Sagie A, Ovadia Y, Bishara J. Intravenous leiomyomatosis with cardiac involvement in a pregnant woman. Am J Obstet Gynecol 1998;178:620-1.
90. Losch A, Kainz C, Gitsch G, Breitenecker G. Intravenous leiomyomatosis of the uterus. Gen Diagn Pathol 1995;141:75-9.
91. Nakayama Y, Kitamura S, Kawachi K, Kawata T, Fukutomi M, Hasegawa J, Morita R. Intravenous leiomyomatosis extending into the right atrium. Cardiovasc Surg 1994;2:642-5.
92. Matsumoto K, Nouga K, Yokoyama I, Ishii S, Wakabayashi G, Yoshida Y. Intravenous leiomyomatosis of the uterus. Eur J Vasc Surg 1994;8:377-8.
93. Peh WC, Cheung DL, Ngan H. Smooth-muscle tumors of the inferior vena cava and right heart. Clin Imaging 1993;17:117-23.
94. Esteban JM, Allen WM, Schaerf RH. Benign metastasizing leiomyoma of the uterus: histologic and immunohistochemical characterization of primary and metastatic lesions. Arch Pathol Lab Med 1999;123:960-2.
95. Huang PC, Chen JT, Chia-Man C, Kwan PC, Ho WL. Benign metastasizing leiomyoma of the lung: a case report. J Formos Med Assoc 2000;99:948-51.
96. Drake A, Dhundee J, Buckley CH, Woolas R. Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. BJOG 2001;108:661-4.
97. Altinok G, Usubutun A, Kucukali T, Gunalp S, Ayhan A. Disseminated peritoneal leiomyomatosis. A benign entity mimicking carcinomatosis. Arch Gynecol Obstet 2000;264:54-5.
98. Zotalis G, Nayar R, Hicks DG. Leiomyomatosis peritonealis disseminata, endometriosis, and multicystic mesothelioma: an unusual association. Int J Gynecol Pathol 1998;17:178-82.
99. Hardman III WJ, Majmudar B. Leiomyomatosis peritonealis disseminata: clinicopathologic analysis of five cases. South Med J 1996;89:291-4.
100. Bourgain C, Pierre E, De Vits A, Amy JJ, Kloppel G. Disseminated peritoneal leiomyomatosis. An unusual case. Pathol Res Pract 1994;190:500-4.
101. Nguyen GK. Disseminated leiomyomatosis peritonealis: report of a case in a postmenopausal woman. Can J Surg 1993;36:46-8.
102. Honore LH. Is cotyledonoid dissecting leiomyoma of the uterus (Sternberg tumor) identical with grapelike leiomyoma of the uterus? Am J Surg Pathol 1997;21:1257-8.
103. Fukunaga M, Ushigome S. Dissecting leiomyoma of the uterus with extrauterine extension. Histopathology 1998;32:160-4.
104. Kiaer H. Is cotyledonoid dissecting leiomyoma of the uterus (Sternberg tumor) identical with grapelike leiomyoma of the uterus? Am J Surg Pathol 1997;21:1257.
105. Roth LM, Reed RJ, Sternberg WH. Cotyledonoid dissecting leiomyoma of the uterus. The Sternberg tumor. Am J Surg Pathol 1996;20:1455-61.
106. Oliva E, Young RH, Amin MB, Clement PB. An immunohistochemical analysis of endometrial stromal and smooth-muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol 2002;26:403-12.
107. Poncelet C, Walker F, Madelenat P, et al. Expression of CD44 standard and isoforms V3 and V6 in uterine smooth-muscle tumors: a possible diagnostic tool for the diagnosis of leiomyosarcoma. Hum Pathol 2001;32:1190-6.
108. McCluggage WG, Sumathi VP, Maxwell P. CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 2001;39:273-8.
109. Rush DS, Tan J, Baergen RN, Soslow RA. h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma. Am J Surg Pathol 2001;25:253-8.