All-trans-retinoic acid mediates changes in PI3K and retinoic acid signaling proteins of leiomyomas

Fertility and Sterility

Volumn 95, Issue 6, 2011, Pages 2080-2086

  Ben Sasson, Hadas ^a   Ben Meir, Assaf ^a   Shushan, Asher ^a   Karra, Laila ^a   Rojansky, Nathan ^a   Klein, Benjamin Y ^a   Levitzki, Rubina ^a   Ben Bassat, Hannah ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

all trans retinoic acid (ATRA); cell survival; Leiomyomas; PI3K Akt signaling; retinoic acid pathway

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1; CYCLIN D2; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; RETINOIC ACID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL PROLIFERATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MYOMETRIUM; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UTERUS MYOMA;

ADULT; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; LEIOMYOMA; MATCHED-PAIR ANALYSIS; MIDDLE AGED; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TRETINOIN; UTERINE NEOPLASMS;

EID: 79955005067     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.01.155     Document Type: Article

References (31)

1. W.H. Parker Etiology, symptomatology, and diagnosis of uterine myomas Fertil Steril 87 2007 725 736 (Pubitemid 46553757)
2. R.E. Blake Leiomyomata uteri: hormonal and molecular determinants of growth J Natl Med Assoc 99 2007 1170 1184 (Pubitemid 47614589)
3. M.H. Cheng, and P.H. Wang Uterine myoma: a condition amenable to medical therapy? Expert Opin Emerg Drugs 13 2008 119 133
4. J. Marill, N. Idres, C.C. Capron, E. Nguyen, and G.G. Chabot Retinoic acid metabolism and mechanism of action: a review Curr Drug Metab 4 2003 1 10 (Pubitemid 36131681)
5. M. Theodosiou, V. Laudet, and M. Schubert From carrot to clinic: an overview of the retinoic acid signaling pathway Cell Mol Life Sci 67 2010 1423 1445
6. G. Wolf Retinoic acid as cause of cell proliferation or cell growth inhibition depending on activation of one of two different nuclear receptors Nutr Rev 66 2008 55 59 (Pubitemid 351666662)
7. T.T. Schug, D.C. Berry, N.S. Shaw, S.N. Travis, and N. Noy Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors Cell 129 2007 723 733 (Pubitemid 46802374)
8. H. Boettger-Tong, G. Shipley, C.J. Hsu, and G.M. Stancel Cultured human uterine smooth muscle cells are retinoid responsive Proc Soc Exp Biol Med 215 1997 59 65
9. J.C. Tsibris, K.B. Porter, A. Jazayeri, G. Tzimas, H. Nau, and H. Huang Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor gamma, retinoid X receptor alpha, and all-trans retinoic acid than myometrium Cancer Res 59 1999 5737 5744
10. J.C. Tsibris, S. Maas, J.H. Segars, S.V. Nicosia, S.A. Enkemann, and W.F. O'Brien New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2 Biochem Biophys Res Commun 312 2003 249 254 (Pubitemid 37443953)
11. W.H. Catherino, and M. Malik Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure Fertil Steril 87 2007 1388 1398 (Pubitemid 46829156)
12. P.J. Hoffman, D.B. Milliken, L.C. Gregg, R.R. Davis, and J.P. Gregg Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis Fertil Steril 82 2004 639 649 (Pubitemid 39243186)
13. A.A. Arslan, L.I. Gold, K. Mittal, T.C. Suen, I. Belitskaya-Levy, and M.S. Tang Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review Hum Reprod 20 2005 852 863 (Pubitemid 40667828)
14. J. Liang, and J.M. Slingerland Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression Cell cycle 2 2003 339 345
15. T.F. Franke PI3K/Akt: getting it right matters Oncogene 27 2008 6473 6488
16. L. Karra, A. Shushan, A. Ben-Meir, N. Rojansky, B.Y. Klein, and D. Shveiky Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology Fertil Steril 93 2010 2646 2651
17. K.A. Kovács, F. Lengyel, Z. Vértes, J.L. Környei, P.M. Gocze, and B. Sumegi Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri J Steroid Biochem Mol Biol 103 2007 196 199 (Pubitemid 46149303)
18. L. Yu, K. Saile, C.D. Swartz, H. He, X. Zheng, and G.E. Kissling Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas Mol Med 14 2008 264 275 (Pubitemid 351785699)
19. G. López-Carballo, L. Moreno, S. Masiá, P. Pérez, and D. Barettino Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells J Biol Chem 277 2002 25297 25304 (Pubitemid 34951839)
20. K. Matkovic, F. Brugnoli, V. Bertagnolo, H. Banfic, and D. Visnjic The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells Leukemia 20 2006 941 951 (Pubitemid 43797283)
21. A. Shushan, N. Rojansky, N. Laufer, B.Y. Klein, Z. Shlomai, and R. Levitzki The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth Hum Reprod 19 2004 1957 1967 (Pubitemid 39236459)
22. H. Ben-Bassat, S. Rosenbaum-Mitrani, Z. Hartzstark, Z. Shlomai, N. Kleinberger-Doron, and A. Gazit Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes Cancer Res 57 1997 3741 3750 (Pubitemid 27381218)
23. D. Shveiky, A. Shushan, H. Ben Bassat, B.Y. Klein, A. Ben Meir, and R. Levitzky Acetaldehyde differentially affects the growth of uterine leiomyomata and myometrial cells in tissue cultures Fertil Steril 9 2009 575 579
24. J.C. Tsibris, J. Segars, D. Coppola, S. Mane, G.D. Wilbanks, and W.F. O'Brien Insights from gene arrays on the development and growth regulation of uterine leiomyomata Fertil Steril 78 2002 114 121 (Pubitemid 34722680)
25. K.M. Skubitz, and A.P. Skubitz Differential gene expression in uterine leiomyoma J Lab Clin Med 141 2003 297 308 (Pubitemid 36581910)
26. M. Zaitseva, B.J. Vollenhoven, and P.A. Rogers Retinoids regulate genes involved in retinoic acid synthesis and transport in human myometrial and fibroid smooth muscle cells Hum Reprod 23 2008 1076 1086 (Pubitemid 351757344)
27. E. Beurel, and R.S. Jope The paradoxical pro- and antiapoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways Prog Neurobiol 79 2006 173 189 (Pubitemid 44331500)
28. M.H. Kang, and C.P. Reynolds Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy Clin Cancer Res 15 2009 1126 1132
29. M. Malik, J. Webb, and W.H. Catherino Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells Clin Endocrinol (Oxf) 69 2008 462 470
30. S. Mangioni, P. Vigan, D. Lattuada, A. Abbiati, M. Vignali, and A.M. Di Blasio Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor J Clin Endocrinol Metab 90 2005 5349 5355 (Pubitemid 41262300)
31. D.J. Mulholland, S. Dedhar, H. Wu, and C.C. Nelson PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer Oncogene 25 2006 329 337 (Pubitemid 43117618)