Human uterine leiomyomata express higher levels of peroxisome proliferator-activated receptor γ, retinoid X receptor α, and all-trans retinoic acid than myometrium

Cancer Research

Volumn 59, Issue 22, 1999, Pages 5737-5744

  Tsibris, John C M ^a,b   Porter, Kathy B ^a,d   Jazayeri, Allahyar ^a,d   Tzimas, Georg ^c,e   Nau, Heinz ^c,f   Huang, Hong ^a,g   Kuparadze, Khatuna ^a,h   Porter, Gregory W ^a,d   O'Brien, William F ^a   Spellacy, William N ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d TEXAS TECH UNIVERSITY   (United States)

^e Tzimas Dimolios Co   (Greece)

^f UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^g UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^h Zhordania Inst of Hum Reproduction   (Georgia)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RETINOIC ACID; RETINOID X RECEPTOR; TROGLITAZONE;

ANIMAL TISSUE; ARTICLE; FOLLICULAR PHASE; GUINEA PIG; HUMAN; HUMAN TISSUE; HYSTERECTOMY; LEIOMYOMA; LEIOMYOMATOSIS; MENSTRUAL CYCLE; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERUS TUMOR;

ANIMALS; CARCINOGENS; CHROMANS; DRUG IMPLANTS; ESTRADIOL; FEMALE; GUINEA PIGS; HUMANS; LEIOMYOMATOSIS; MENSTRUAL CYCLE; MYOMETRIUM; NEOPLASM PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRETINOIN; UTERINE NEOPLASMS;

EID: 0033571775     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Carlson, K. J., Nichols, D. H., and Schiff, I. Indications for hysterectomy. N. Engl. J. Med., 328: 856-860, 1993.
2. Lepine, L. A., Hillis, S D., Marchbanks, P. A., Koonin, L. M., Morrow, B., Kieke, B. A., and Wilcox, L. S. Hysterectomy surveillance: United States, 1980-1993. Mor. Mortal. WkIy Rep. CDC Surveill. Summ., 46: 1-15, 1997.
3. Lemay, A., and Maheux, R. GnRH agonists in the management of uterine leiomyoma. Infert. Reprod. Med. Clin. N. Am., 7: 33-55, 1996.
4. Bulun, S. E., Simpson, E. R., and Word, R. A. Expression of CYP 19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissue and cells in culture. J. Clin. Endocrinol. Metab., 7: 736-743, 1994.
5. Everitt, J. I., Wolf, D. C., Howe, S. R., Goldsworthy, T. L., and Walker, C. Rodent model of reproductive tract leiomyomata: clinical and pathology features. Am. J. Pathol., 146: 1556-1567, 1995.
6. Romagnolo, B., Molina, T., Leroy, G., Blin, C., Porteux, A., Thomasset, M., Vandewalle, A., Kahn, A., and Perret, T. Estradiol-dependent uterine leiomyomas in transgenic mice. J. Clin. Invest., 98: 777-784, 1996.
7. Webster, M. A., Martin-Soudant, N., Nepveu, A., Cardiff, R. D., and Muller, W. J. The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members. Oncogene, 16: 1963-1972, 1998.
8. Tsibris, J. C. M., Porter, K. B., Nicosia, S. F., Porter, G. W., O'Brien, W. F., and Spellacy, W. N. Retinoic acid involvement in leiomyoma development: an animal model. J. Soc. Gynecol. Invest., 3 (Suppl. 2): 29A, 1996.
9. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. The nuclear receptor superfamily: the second decade. Cell, 83: 835-839, 1995.
10. Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev., 8: 1224-1234, 1994.
11. Spiegelman, B. M. PPARγ in monocytes: less pain, any gain? Cell, 93: 153-155, 1998.
12. Willson, T. M., and Wahli, W. Peroxisome proliferator-activated receptor agonists. Curr. Opin. Chem. Biol., 1: 235-241, 1997.
13. Spiegelman, B. M. PPARγ. Adipocyte regulator and thiazolidinedione receptor. Diabetes, 47: 507-514, 1998.
14. Kliewer, S. A., and Willson, T. M. The nuclear receptor PPARγ: bigger than fat. Curr. Opin. Genet. Dev., 8: 576-581, 1998.
15. Mueller, E., Sarraf, P., Tontonoz, P., Evans, R. M., Martin, K. J., Zhang, M., Fletcher, C., Singer, S., and Spiegelman, B. M. Terminal differentiation of human breast cancer through PPARγ. Mol. Cell, 1: 465-470, 1998.
16. Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H., and Evans, R. M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell, 93: 229-240, 1998.
17. Kim, J. B., Wright, H. M., Wright, M., and Spiegelman, B. M. ADD1/SREBP1 activates PPARγ through the production of endogenous ligand. Proc. Natl. Acad. Sci. USA, 95: 4333-4337, 1998.
18. Sarraf, P., Mueller, E., Jones, D., King, F. J., DeAngelo, D. J., Partridge, J. B., Holden, S. A., Chen, L. B., Singer, S., Fletcher, C., and Spiegelman, B. M. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med., 4: 1046-1052, 1998.
19. Tsibris, J., Porter, K., Jazayeri, A., Nicosia, S., Porter, G., O'Brien, W., and Spellacy, W. Effect of troglitazone, an inducer of the peroxisome proliferator-activated receptor y (PPARγ), on uterine leiomyoma development in the guinea pig model. J. Soc. Gynecol. Invest., 5 (Suppl. 1): 180A, 1998.
20. Furukawa, Y., Uenoyama, S., Ohta, M., Tsunoba, A., Griffin, J. D., and Saito, M. Transforming growth factor-β inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-1. J. Biol. Chem., 267: 17121-17127, 1992.
21. Porter, K. B., Tsibris, J. C. M., Nicosia, S. V., Murphy, J. M., O'Brien, W. F., Rao, P., and Spellacy, W. N. Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect? Biol. Reprod., 52: 824-832, 1995.
22. Porter, K. B., Tsibris, J. C. M., Porter, G. W., O'Brien, W. F., and Spellacy, W. N. Use of endoscopic and ultrasound techniques in the guinea pig model. Lab. Anim. Sci., 47: 537-539, 1997.
23. Collins, M. D., Eckhoff, C., Chahoud, I., Bochert, G., and Nau, H. 4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse. Arch. Toxicol., 66: 652-659, 1992.
24. Scott, W. J., Jr., Walter, R., Tzimas, G., Sass, J. O., Nau, H., and Collins, M. D. Endogenous status of retinoids and their cytosolic binding proteins in limb buds of chick vs. mouse embryos. Dev. Biol., 165: 397-409, 1994.
25. Tzimas, G., Sass, J. O., Wittfoht, W., Elmazar, M. M., Ehlers, K., and Nau, H. Identification of 9,13-di-cis-retinoic acid as a major plasma metabolite of 9-cis-retinoic acid and limited transfer of 9-cis-retinoic acid and 9,13-di-cis-retinoic acid to the mouse and rat embryos. Drug Metab. Dispos., 22: 928-936, 1994.
26. Arnhold, T., Tzimas, G., Wittfoht, W., Plonait, S., and Nau, H. Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption. Life Sci., 59: PL169-PL177, 1996.
27. Tzimas, G., Collins, M. D., Bürgin, H., Hummler, H., and Nau, H. Embryotoxic doses of vitamin A to rabbits result in low plasma but high embryonic concentrations of all-trans-retinoic acid: risk of vitamin A exposure in humans. J. Nutr., 126: 2159-2171, 1996.
28. Nagaya, T., Murata, Y., Yamaguchi, S., Nomura, Y., Ohmori, S., Fujieda, M., Katunuma, N., Yen, P. M., Chin, W. W., and Seo, H. Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor a by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action. J. Biol. Chem., 273: 33166-33173, 1998.
29. Nomura, Y., Nagaya, T., Yamaguchi, S., Katunuma, N., and Seo, H. Cleavage of RXRa by a lysosomal enzyme, cathepsin L-type protease. Biochem. Biophys. Res. Commun., 254: 388-394, 1999.
30. Auboeuf, D., Rieusset, J., Fajas, L., Vallier, P., Frering, V., Riou, J. P., Staels, B., Auwerx, J., Laville, M., and Vidal, H. Tissue distribution and quantitation of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans. Diabetes, 46: 1319-1327, 1997.
31. Gittoes, N. J., McCabe, C. J., Sheppard, M. C., and Franklyn, J. A Retinoid X receptor y mRNA expression is reduced in recurrent non-functioning pituitary adenomas. Clin. Endocrinol., 48: 425-433, 1998.
32. Mukherjee, R., Davies, P. J. A., Crombie, D. L., Bischoff, E. D., Cesario, R. M., Jow, L., Hamann, L. G., Boehm, M. F., Mondon, C. E., Nadzan, A. M., Paterniti, J. R., Jr., and Heyman, R. A. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature (Lond.), 386: 407-410, 1997.
33. Ma, H., Sprechter, H. W., and Kolattukudy, P. E. Estrogen-induced production of a peroxisome proliferator activated receptor (PPAR) ligand in a PPARγ-expressing tissue. J. Biol. Chem., 273: 30131-30138, 1998.
34. Marshall, L. M., Spiegelman, D., Manson, J. E., Goldman, M. B., Barbieri, R. L., Stampfer, M. J., Willett, W. C., and Hunter, D. J. Risk of uterine leiomyomata among premenopausal women in relation to body size and cigarette smoking. Epidemiology, 9: 511-517, 1998.
35. Dilworth, F. J., Fromental-Ramain, C., Remboutsika, E., Benecke, A., and Chambon, P. Ligand-dependent activation of transcription in vitro by retinoic acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc. Natl. Acad. Sci. USA, 96: 1995-2000, 1999.
36. Knudson, A. G. Hereditary cancer: two hits revisited. J. Cancer Res. Clin. Oncol., 122: 135-140, 1996.
37. Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B. R., Kliewer, S. A., Lehmann, J. M., and Morris, D. C. Peroxisome proliferator-activated receptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol. Pharmacol., 50: 1087-1094, 1996.
38. Lee, S-K., Choi, H-S., Song, M-R., Lee, M-O., and Lee J. W. Estrogen receptor, a common interaction partner for a subset of nuclear receptors. Mol. Endocrinol., 12: 1184-1192, 1998.
39. Song, M-R., Lee, S-K., Seo, Y-W., Choi, H-S., Lee, J. W., and Lee, M-O. Differential modulation of transcriptional activity of oestrogen receptors by direct protein-protein interactions with retinoid receptors. Biochem. J., 336: 711-717, 1998.
40. Anzano, M. A., Byers, S. W., Smith, I. M., Peer, C. W., Mullen, L. T., Brown, C. C., Roberts, A. B., and Sporn, M. B. Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen. Cancer Res., 54: 4614-4617, 1994.
41. Keller, H., Givel, F., Perroud, M., and Wahli, W. Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol. Endocrinol., 9: 794-804, 1995.
42. Nuňez, S. B., Medin, J. A., Braissant, O., Kemp, L., Wahli, W., Ozato, K., and Segars, J. H. Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor. Mol. Cell. Endocrinol., 127: 27-40, 1997.
43. Kawaguchi, D., Fujii, S., Konishi, I., Nanbu, Y., Nonagaki, H., and Mori, T. Mitotic activity in uterine leiomyomas during the menstrual cycle. Am. J. Obstet. Gynecol., 160: 637-641, 1989.
44. Porter, K. B., Tsibris, J. C. M., Porter, G. W., Fuchs-Young, R., Nicosia, S. V., O'Brien, W. F., and Spellacy, W. N. Effects of raloxifene in a guinea pig model for leiomyomata. Am. J. Obstet. Gynecol., 179: 1283-1287, 1998.
45. Porter, K. B., Tsibris, J. C. M., Porter, G., O'Brien, W. F., and Spellacy, W. N. The effect of selective estrogen receptor modulator LY353381 (SERM) and Tamoxifen (Tam) on abdominal leiomyoma (L) growth in the guinea pig model, as determined by ultrasonography. J. Soc. Gynecol. Invest., 6 (Suppl. 1): 229A, 1999.
46. Chiba, H., Clifford, J., Metzger, D., and Chambon, P. Specific and redundant functions of retinoid X receptor/retinoid acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells. J. Cell Biol., 139: 735-747, 1997.