Mifepristone: Clinical application in general gynecology

Clinical Obstetrics and Gynecology

Volumn 39, Issue 2, 1996, Pages 451-460

  Morales, Arlene J ^a,c   Kettel, L Michael ^a   Murphy, Ana A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; MIFEPRISTONE; PROGESTERONE RECEPTOR;

APPETITE DISORDER; CONTRACEPTION; DOSE RESPONSE; DRUG RECEPTOR BINDING; ECTOPIC PREGNANCY; ENDOMETRIOSIS; FATIGUE; HALITOSIS; HORMONAL REGULATION; HOT FLUSH; HUMAN; NAUSEA; PREMENSTRUAL SYNDROME; REVIEW; UTERUS BLEEDING; UTERUS MYOMA;

BIOLOGY; DELIVERY OF HEALTH CARE; ENDOCRINE SYSTEM; ENDOMETRIAL EFFECTS; ENDOMETRIUM; GENITALIA; GENITALIA, FEMALE; GYNECOLOGY; HEALTH; HEALTH SERVICES; HORMONE ANTAGONISTS; HORMONES; LITERATURE REVIEW; MEDICINE; PHYSIOLOGY; RU-486--ADMINISTRACTION AND DOSAGE; RU-486--THERAPEUTIC USE; TREATMENT; UROGENITAL SYSTEM; UTERINE EFFECTS; UTERUS;

ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; GENITAL DISEASES, FEMALE; HORMONE ANTAGONISTS; HUMANS; LEIOMYOMA; MENSTRUAL CYCLE; MIFEPRISTONE; UTERINE NEOPLASMS;

EID: 0029931137     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003081-199606000-00018     Document Type: Review

References (33)

1. Batista MC, Cartledge TP, Zellmer AW, Nieman LK, Merriam GR, Loriaux DL. Evidence for a critical role of progesterone in the regulation of the midcycle gonadotropin surge and ovulation. J Clin Endocrinol Metab. 1992;74:565-570.
2. Steunkel C, Garzo G, Morris S, Liu JH, Yen SSC. Effects of the antiprogesterone RU 486 in the early follicular phase of the menstrual cycle. Fertil Steril. 1990;53:642-646.
3. Liu JH, Garzo G, Morris S, Steunkel CA, Ulmann A, Yen SSC. Disruption of follicular maturation and delay of ovulation after administration of the antiprogesterone RU 486. J Clin Endocrinol Metab. 1987;65: 1135-1140.
4. Luukkainen T, Heikinheimo O. Inhibition of folliculogenesis and ovulation by the antiprogesterone RU 486. Fertil Steril. 1988;49:961-963.
5. Swahn ML, Bygdeman M, Cekan S,Xing S, Masironi B, Johannisson E. The effect of RU 486 administered during the early luteal phase on bleeding pattern, hormone parameters and endometrium. Human Reprod. 1990;5:402-408.
6. Schaison G, George M, Lestrat N, Baulieu E. Effects of the antiprogesterone steroid RU 486 during midluteal phase in normal women. J Clin Endocrinol Metab. 1985;61: 484-489.
7. Garzo VG, Liu JH, Ulmann A, Baulieu E, Yen SSC. Effects of an anti-progesterone (RU 486) on the hypothalamic-hypophyseal-ovarian-endometrial axis during the luteal phase of the menstrual cycle. J Clin Endocrinol Metab. 1988;66:508-517.
8. Ledger WL, Sweeting VM, Hillier H, Baird DT. Inhibition of ovulation by low dose mifepristone (RU 486). Human Reprod. 1992;7:945-950.
9. Croxatto HB, Salvatierra AM Croxatto HD, Fuentealba B. Effects of continuous treatment with low dose mifepristone throughout one menstrual cycle. Human Reprod. 1993;8:201-207.
10. Kettel LM, Murphy AA, Mortola JF, Liu JH, Ulmann A, Yen SSC. Endocrine responses to long-term administration of the antiprogesterone RU 486 in patients with pelvic endometriosis. Fertil Steril. 1991;56: 402-407.
11. Murphy AA, Kettel LM, Morales AJ, Roberts VJ, Yen SSC. Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J Clin Endocrinol Metab. 1993;76:513-517.
12. Murphy AA, Kettel LM, Morales AJ, Roberts V, Parmley T, Yen SSC. Endometrial effects of long term, low dose administration of RU-486. Fertil Steril. 1995;63:761-766.
13. Greene KE, Kettel LM, Yen SSC. Interruption of endometrial maturation without hormonal changes by an antiprogesterone during the first half of the luteal phase of the menstrual cycle: a contraceptive potential. Fertil Steril. 1992;58:338-343.
14. Neulen J, Williams RF, Hodgen GD. RU 486: induction of dose dependent elevations of estradiol receptor in endometrium from ovariectomized monkeys. J Clin Endocrinol Metab. 1990;71:1074-1075.
15. Wolf JP, Hsiu JG, Anderson TL, Ulmann A, Baulieu EE, Hodgen GD. Noncompetitive antiestrogen effect of RU 486 in blocking the estrogen-stimulate luteinizing hormone surge and proliferative action of estradiol on endometrium in castrate monkey. Fertil Steril. 1989;52:1055-1060.
16. Slayden OD, Brenner R. RU 486 action after estrogen priming in the endometrium and oviducts of Rhesus monkeys (macaca mulattta). J Clin Endocrinol Metab. 1994:78: 440-448.
17. Bukowski J, Hsiu JG, Williams RF, Goodman AL, Hodgen GD. Membrane Metalloendopeptidase (Enkephalinase) in Cynomolgus Monkey Endometruim : During Menstrual Cycle and After Treatment with RU 486. Presented at the American Society of Reproductive Medicine. 51st Annual Meeting. Seattle, Washington, October 9-12, 1995. Abstract #O-023.
18. Kettel LM, Murphy AA, Morales AJ, Ulmann A, Baulieu EE, Yen SSC. Treatment of endometriosis with the antiprogesterone mifepristone (RU-486). Fertil Steril. 1996;69:23-28.
19. Kawaguchi K, Fujii S, Konishi I, Nanbu Y, Nonogaki H, Mori T. Mitotic activity in uterine leiomyomata during the menstrual cycle. Am J Obstet Gynecol. 1989;160:637-641.
20. Soules MR, McCarty KS. Leiomyomatas: steroid receptor content. Am J Obstet Gynecol. 1982:143:6-11.
21. Friedman AJ, Barbieri RL, Doubliet PM, Fine C, Schiff I. A randomized double blind trial of a GnRH agonist with or without medroxyprogesterone in the treatment of leiomyomata uteri. Fertil Steril. 1988;49: 404-409.
22. Carr BR, Marshburn PB, Weatherall PT, Bradshaw KD, Breslau NA, Byrd W, Roark M, Steinkampf MP. An evaluation of the effect of GnRH analogs and medroxyprogesterone acetate on uterine leiomyomata volume by MRI: a prospective double blind placebo-controlled crossover trial. J Clin Endocrinol Metab. 1993;76:1217-1223.
23. Murphy AA, Morales AJ, Kettel LM, Yen SSC. Regression of uterine leiomyomata to the antiprogesterone RU 486: dose response effect. Fertil Steril. 1995;64:187-190.
24. Murphy AA, Morales AJ, Sincich C. In vitro effects of RU 486 on leiomyomata and myometrium. Society of Gynecological Investigation. San Antonio, Texas. Abstract, 1992.
25. Reinsch RC, Murphy AA, Morales AJ, Yen SSC. The effects of RU-486 and leuprolide acetate on uterine artery blood glow in the fibroid uterus: a prospective randomized study. Am J Obstet Gynecol. 1994;170: 1623-1628.
26. Matta WHM, Stabile I, Shaw RW, Campbell S. Doppler assessment of uterine blood flow changes in patients with fibroid receiving the GnRH buserelin. Fertil Steril. 1988;49: 1083-1085.
27. Halbreich U. Treatment of premenstrual syndromes with progesterone antagonists (i.e. RU 486): political and methodological issues. Psychiatry. 1990;53:407-409.
28. Schmidt PJ, Nieman LK, Grover GN, Muller KL, Merriam GR, Rubiow DR. Lack of effect of induced menses on symptoms in women with premenstrual syndrome. N Eng J Med. 1991;324:1174-1179.
29. Chan AF, Mortola JF, Wood SH, Yen SSC. Persistence of premenstrual syndrome during low-dose administration of the progesterone antagonist RU 486. Obstet Gynecol. 1994;84:1001-1005.
30. Paris FX, Henry-Suchet J, Tesquier L, Dacquin G, Pez JP, Loysel T, Loffredo V, Toger M, DeBrux J. Effect of an antiprogesterone (RU 486) on extra-uterine pregnancy. Revue Francaise de Gynecologie et D'Obstetrique. 1986;81:607-609.
31. Kenigsberg D, Porte J, Jull M, Spitz IM. Medical treatment of residual ectopic pregnancy: RU 486 and methotrexate. Fertil Steril. 1987;47:702-703.
32. Dietl J. Drug therapy of extrauterine pregnancy. Geburtshilfe und Frauenheilkunde. 1992;52:133-138.
33. Paris FX, Henry-Suchet J, Tesquier L, Loysel T, Pez HP, Loffredo V, Roger M, De Brux J. The value of an antiprogesterone steroid in the treatment of extra-uterine pregnancy. Preliminary results. Revue Francaise de Gynecologie et D'Obstetrique. 1986;81:33-35.