-
1
-
-
70449129500
-
Recent patents on the pichia pastoris expression system, expanding the toolbox for recombinant protein production
-
Bollok M, Resina D, Valero F, Ferrer P. Recent patents on the pichia pastoris expression system, expanding the toolbox for recombinant protein production. Recent Pat Biotechnol 2009, 3:192-201.
-
(2009)
Recent Pat Biotechnol
, vol.3
, pp. 192-201
-
-
Bollok, M.1
Resina, D.2
Valero, F.3
Ferrer, P.4
-
2
-
-
84856272158
-
Protein secretion in Pichia pastoris and advances in protein production
-
10.1007/s00253-011-3654-z, 22057543
-
Damasceno LM, Huang C-J, Batt C. Protein secretion in Pichia pastoris and advances in protein production. Appl Microbiol Biotechnol 2012, 93:31-39. 10.1007/s00253-011-3654-z, 22057543.
-
(2012)
Appl Microbiol Biotechnol
, vol.93
, pp. 31-39
-
-
Damasceno, L.M.1
Huang, C.-J.2
Batt, C.3
-
3
-
-
84855932983
-
Recombinant protein production in yeasts
-
10.1007/978-1-61779-433-9_17, 22160907
-
Mattanovich D, Branduardi P, Dato L, Gasser B, Sauer M, Porro D. Recombinant protein production in yeasts. Methods Mol Biol 2012, 824:329-358. 10.1007/978-1-61779-433-9_17, 22160907.
-
(2012)
Methods Mol Biol
, vol.824
, pp. 329-358
-
-
Mattanovich, D.1
Branduardi, P.2
Dato, L.3
Gasser, B.4
Sauer, M.5
Porro, D.6
-
4
-
-
77951228730
-
Stepwise engineering of a Pichia pastoris D-amino acid oxidase whole cell catalyst
-
10.1186/1475-2859-9-24, 2873405, 20420682
-
Abad S, Nahalka J, Bergler G, Arnold SA, Speight R, Fotheringham I, Nidetzky B, Glieder A. Stepwise engineering of a Pichia pastoris D-amino acid oxidase whole cell catalyst. Microb Cell Fact 2010, 9:24-35. 10.1186/1475-2859-9-24, 2873405, 20420682.
-
(2010)
Microb Cell Fact
, vol.9
, pp. 24-35
-
-
Abad, S.1
Nahalka, J.2
Bergler, G.3
Arnold, S.A.4
Speight, R.5
Fotheringham, I.6
Nidetzky, B.7
Glieder, A.8
-
5
-
-
70449530436
-
Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation
-
10.1016/j.ymben.2009.08.006, 19716429
-
Schroer K, Luef KP, Hartner FS, Glieder A, Pscheidt B. Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation. Metab Eng 2010, 12:8-17. 10.1016/j.ymben.2009.08.006, 19716429.
-
(2010)
Metab Eng
, vol.12
, pp. 8-17
-
-
Schroer, K.1
Luef, K.P.2
Hartner, F.S.3
Glieder, A.4
Pscheidt, B.5
-
6
-
-
3042652967
-
Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris
-
10.1111/j.1432-1033.2004.04176.x, 15182362
-
Solà A, Maaheimo H, Ylönen K, Ferrer P, Szyperski T. Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris. Eur J Biochem 2004, 271:2462-2470. 10.1111/j.1432-1033.2004.04176.x, 15182362.
-
(2004)
Eur J Biochem
, vol.271
, pp. 2462-2470
-
-
Solà, A.1
Maaheimo, H.2
Ylönen, K.3
Ferrer, P.4
Szyperski, T.5
-
7
-
-
33846268057
-
Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates
-
10.1099/mic.0.29263-0, 17185557
-
Solà A, Jouhten P, Maaheimo H, Szyperski T, Ferrer P. Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates. Microbiology 2007, 153:281-290. 10.1099/mic.0.29263-0, 17185557.
-
(2007)
Microbiology
, vol.153
, pp. 281-290
-
-
Solà, A.1
Jouhten, P.2
Maaheimo, H.3
Szyperski, T.4
Ferrer, P.5
-
8
-
-
77954040575
-
Genome-scale metabolic reconstruction an in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement
-
10.1186/1475-2859-9-50, 2908565, 20594333
-
Chung BKS, Selvarasu S, Camattari A, Ryu J, Lee H, Ahn J, Lee H, Lee D. Genome-scale metabolic reconstruction an in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement. Microb Cell Fact 2010, 9:50. 10.1186/1475-2859-9-50, 2908565, 20594333.
-
(2010)
Microb Cell Fact
, vol.9
, pp. 50
-
-
Chung, B.K.S.1
Selvarasu, S.2
Camattari, A.3
Ryu, J.4
Lee, H.5
Ahn, J.6
Lee, H.7
Lee, D.8
-
9
-
-
64549104846
-
The effect of temperature on the proteome of recombinant Pichia pastoris research articles
-
10.1021/pr8007623, 19216534
-
Dragosits M, Stadlmann J, Albiol J, Baumann K, Maurer M, Gasser B, Sauer M, Altmann F, Ferrer P, Mattanovich D. The effect of temperature on the proteome of recombinant Pichia pastoris research articles. J Proteome Res 2009, 8:1380-1392. 10.1021/pr8007623, 19216534.
-
(2009)
J Proteome Res
, vol.8
, pp. 1380-1392
-
-
Dragosits, M.1
Stadlmann, J.2
Albiol, J.3
Baumann, K.4
Maurer, M.5
Gasser, B.6
Sauer, M.7
Altmann, F.8
Ferrer, P.9
Mattanovich, D.10
-
10
-
-
67650089521
-
Genome, secretome and glucose transport highlight unique features of the protein production host Pichia pastoris
-
10.1186/1475-2859-8-29, 2702363, 19490607
-
Mattanovich D, Graf AB, Stadlmann J, Dragosits M, Redl A, Maurer M, Kleinheinz M, Sauer M, Altmann F, Gasser B. Genome, secretome and glucose transport highlight unique features of the protein production host Pichia pastoris. Microb Cell Fact 2009, 8:29. 10.1186/1475-2859-8-29, 2702363, 19490607.
-
(2009)
Microb Cell Fact
, vol.8
, pp. 29
-
-
Mattanovich, D.1
Graf, A.B.2
Stadlmann, J.3
Dragosits, M.4
Redl, A.5
Maurer, M.6
Kleinheinz, M.7
Sauer, M.8
Altmann, F.9
Gasser, B.10
-
11
-
-
85028098288
-
Development of quantitative metabolomics for Pichia pastoris
-
3291848, 22448155
-
Carnicer M, Canelas AB, Pierick A, Zeng Z, Dam J, Albiol J, Ferrer P, Heijnen JJ, Gulik W. Development of quantitative metabolomics for Pichia pastoris. Metabolomics 2011, 8:284-298. 3291848, 22448155.
-
(2011)
Metabolomics
, vol.8
, pp. 284-298
-
-
Carnicer, M.1
Canelas, A.B.2
Pierick, A.3
Zeng, Z.4
Dam, J.5
Albiol, J.6
Ferrer, P.7
Heijnen, J.J.8
Gulik, W.9
-
12
-
-
77954743150
-
Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production
-
Sohn SB, Graf AB, Kim TY, Gasser B, Maurer M, Ferrer P, Mattanovich D, Lee SY. Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production. Biotechnol J 2010, 5:701-715.
-
(2010)
Biotechnol J
, vol.5
, pp. 701-715
-
-
Sohn, S.B.1
Graf, A.B.2
Kim, T.Y.3
Gasser, B.4
Maurer, M.5
Ferrer, P.6
Mattanovich, D.7
Lee, S.Y.8
-
13
-
-
0002983218
-
Metabolism of one-carbon compounds
-
New York: Academic, Harrison JS, Rose AH, 2
-
Harder M, Veenhuis M. Metabolism of one-carbon compounds. The Yeasts. Volume 3 (Metabolism and physiology of Yeast) 1989, 289-316. New York: Academic, Harrison JS, Rose AH, 2.
-
(1989)
The Yeasts. Volume 3 (Metabolism and physiology of Yeast)
, pp. 289-316
-
-
Harder, M.1
Veenhuis, M.2
-
14
-
-
14744299579
-
Recent advances in the expression of foreign genes in Pichia pastoris
-
Cregg JM, Vedvick TS, Rasehke WC. Recent advances in the expression of foreign genes in Pichia pastoris. Biothecnology 1993, 2:905-910.
-
(1993)
Biothecnology
, vol.2
, pp. 905-910
-
-
Cregg, J.M.1
Vedvick, T.S.2
Rasehke, W.C.3
-
15
-
-
33748915125
-
Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters, a review
-
10.1186/1475-2859-5-17, 1564409, 16600031
-
Cos O, Ramón R, Montesinos JL, Valero F. Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters, a review. Microb Cell Fact 2006, 5:17. 10.1186/1475-2859-5-17, 1564409, 16600031.
-
(2006)
Microb Cell Fact
, vol.5
, pp. 17
-
-
Cos, O.1
Ramón, R.2
Montesinos, J.L.3
Valero, F.4
-
16
-
-
0035703883
-
Non-repressing carbon sources for alcohol oxidase (AOX1) promoter of Pichia pastoris
-
Inan M, Meagher MM. Non-repressing carbon sources for alcohol oxidase (AOX1) promoter of Pichia pastoris. J Biosci Bioeng 2001, 92:585-589.
-
(2001)
J Biosci Bioeng
, vol.92
, pp. 585-589
-
-
Inan, M.1
Meagher, M.M.2
-
17
-
-
34447292394
-
A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris
-
10.1016/j.jbiotec.2007.05.019, 17614154
-
Jungo C, Schenk J, Pasquier M, Marison IW, von Stockar U. A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris. J Biotechnol 2007, 131:57-66. 10.1016/j.jbiotec.2007.05.019, 17614154.
-
(2007)
J Biotechnol
, vol.131
, pp. 57-66
-
-
Jungo, C.1
Schenk, J.2
Pasquier, M.3
Marison, I.W.4
von Stockar, U.5
-
18
-
-
34247347868
-
Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris
-
10.1016/j.jbiotec.2007.02.025, 17399833
-
Ramón R, Ferrer P, Valero F. Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris. J Biotechnol 2007, 130:39-46. 10.1016/j.jbiotec.2007.02.025, 17399833.
-
(2007)
J Biotechnol
, vol.130
, pp. 39-46
-
-
Ramón, R.1
Ferrer, P.2
Valero, F.3
-
19
-
-
77950340182
-
Optimization of the heterologous production of a Rhizopus oryzae lipase in Pichia pastoris system using mixed substrates on controlled fed-batch bioprocess
-
Arnau C, Ramón R, Casas C, Valero F. Optimization of the heterologous production of a Rhizopus oryzae lipase in Pichia pastoris system using mixed substrates on controlled fed-batch bioprocess. Enzyme Microb Technol 2010, 46:494-500.
-
(2010)
Enzyme Microb Technol
, vol.46
, pp. 494-500
-
-
Arnau, C.1
Ramón, R.2
Casas, C.3
Valero, F.4
-
20
-
-
78149252300
-
Quantitative physiology of Pichia pastoris during glucose-limited high-cell density fed-batch cultivation for recombinant protein production
-
10.1002/bit.22836, 20552674
-
Heyland J, Fu J, Blank LM, Schmid A. Quantitative physiology of Pichia pastoris during glucose-limited high-cell density fed-batch cultivation for recombinant protein production. Biotechnol Bioeng 2010, 107:357-368. 10.1002/bit.22836, 20552674.
-
(2010)
Biotechnol Bioeng
, vol.107
, pp. 357-368
-
-
Heyland, J.1
Fu, J.2
Blank, L.M.3
Schmid, A.4
-
21
-
-
84855419801
-
Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production
-
10.1016/j.ymben.2011.11.002, 22115737
-
Driouch H, Melzer G, Wittmann C. Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production. Metab Eng 2012, 14:47-58. 10.1016/j.ymben.2011.11.002, 22115737.
-
(2012)
Metab Eng
, vol.14
, pp. 47-58
-
-
Driouch, H.1
Melzer, G.2
Wittmann, C.3
-
22
-
-
84860649085
-
Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures
-
10.1186/1475-2859-11-57, 3443025, 22569166
-
Jordà J, Jouhten P, Cámara E, Maaheimo H, Albiol J, Ferrer P. Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures. Microb Cell Fact 2012, 11:57. 10.1186/1475-2859-11-57, 3443025, 22569166.
-
(2012)
Microb Cell Fact
, vol.11
, pp. 57
-
-
Jordà, J.1
Jouhten, P.2
Cámara, E.3
Maaheimo, H.4
Albiol, J.5
Ferrer, P.6
-
23
-
-
0029146299
-
Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism
-
10.1111/j.1432-1033.1995.tb20829.x, 7556192
-
Szyperski T. Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism. Eur J Biochem 1995, 232:433-448. 10.1111/j.1432-1033.1995.tb20829.x, 7556192.
-
(1995)
Eur J Biochem
, vol.232
, pp. 433-448
-
-
Szyperski, T.1
-
24
-
-
0030050268
-
Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
-
10.1002/(SICI)1097-0290(19960120)49:2<111::AID-BIT1>3.0.CO;2-T, 18623562
-
Marx A, de Graaf AA, Wiechert W, Eggeling L. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol Bioeng 1996, 49:111-129. 10.1002/(SICI)1097-0290(19960120)49:2<111::AID-BIT1>3.0.CO;2-T, 18623562.
-
(1996)
Biotechnol Bioeng
, vol.49
, pp. 111-129
-
-
Marx, A.1
de Graaf, A.A.2
Wiechert, W.3
Eggeling, L.4
-
25
-
-
0033107837
-
Quantification of intracellular metabolic fluxes from fractional enrichment and 13C-13C coupling constraints on the isotopomer distribution in labeled biomass components
-
10.1006/mben.1999.0114, 10935929
-
Schmidt K, Nørregaard LC, Pedersen B, Meissner A, Duus JO, Nielsen JO, Villadsen J. Quantification of intracellular metabolic fluxes from fractional enrichment and 13C-13C coupling constraints on the isotopomer distribution in labeled biomass components. Metab Eng 1999, 1:166-179. 10.1006/mben.1999.0114, 10935929.
-
(1999)
Metab Eng
, vol.1
, pp. 166-179
-
-
Schmidt, K.1
Nørregaard, L.C.2
Pedersen, B.3
Meissner, A.4
Duus, J.O.5
Nielsen, J.O.6
Villadsen, J.7
-
26
-
-
0037335931
-
Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS
-
10.1046/j.1432-1033.2003.03448.x, 12603321
-
Fischer E, Sauer U. Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS. Eur J Biochem 2003, 270:880-891. 10.1046/j.1432-1033.2003.03448.x, 12603321.
-
(2003)
Eur J Biochem
, vol.270
, pp. 880-891
-
-
Fischer, E.1
Sauer, U.2
-
27
-
-
0035101471
-
Metabolic isotopomer labeling systems Part I, global dynamic behavior
-
10.1016/S0025-5564(00)00059-6, 11166321
-
Wiechert W, Wurzel M. Metabolic isotopomer labeling systems Part I, global dynamic behavior. Math Biosci 2001, 169:173-205. 10.1016/S0025-5564(00)00059-6, 11166321.
-
(2001)
Math Biosci
, vol.169
, pp. 173-205
-
-
Wiechert, W.1
Wurzel, M.2
-
28
-
-
33846061120
-
Metabolic networks in motion, 13C-based flux analysis
-
1682028, 17102807
-
Sauer U. Metabolic networks in motion, 13C-based flux analysis. Mol Syst Biol 2006, 2:62. 1682028, 17102807.
-
(2006)
Mol Syst Biol
, vol.2
, pp. 62
-
-
Sauer, U.1
-
29
-
-
79958703818
-
Stationary versus non-stationary (13)C-MFA, a comparison using a consistent dataset
-
10.1016/j.jbiotec.2010.07.008, 20638432
-
Noack S, Nöh K, Moch M, Oldiges M, Wiechert W. Stationary versus non-stationary (13)C-MFA, a comparison using a consistent dataset. J Biotechnol 2011, 154:179-190. 10.1016/j.jbiotec.2010.07.008, 20638432.
-
(2011)
J Biotechnol
, vol.154
, pp. 179-190
-
-
Noack, S.1
Nöh, K.2
Moch, M.3
Oldiges, M.4
Wiechert, W.5
-
30
-
-
84876302772
-
Measurement of intracellular metabolites of primary metabolism and adenine nucleotides in chemostat cultivated Penicillium chrysogenum
-
Nasution U, van Gulik WM, Kleijn RJ, van Winden WA. Measurement of intracellular metabolites of primary metabolism and adenine nucleotides in chemostat cultivated Penicillium chrysogenum. InterScience 2006, 94:166.
-
(2006)
InterScience
, vol.94
, pp. 166
-
-
Nasution, U.1
van Gulik, W.M.2
Kleijn, R.J.3
van Winden, W.A.4
-
31
-
-
74049130331
-
Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels
-
10.1186/1475-2859-8-65, 2799386, 20003217
-
Carnicer M, Baumann K, Töplitz I, Sánchez-Ferrando F, Mattanovich D, Ferrer P, Albiol J. Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels. Microb Cell Fact 2009, 8:65. 10.1186/1475-2859-8-65, 2799386, 20003217.
-
(2009)
Microb Cell Fact
, vol.8
, pp. 65
-
-
Carnicer, M.1
Baumann, K.2
Töplitz, I.3
Sánchez-Ferrando, F.4
Mattanovich, D.5
Ferrer, P.6
Albiol, J.7
-
32
-
-
42549132542
-
Hypoxic fed-batch cultivation of Pichia pastoris increases specific and volumetric productivity of recombinant proteins
-
10.1002/bit.21763, 18078287
-
Baumann K, Maurer M, Dragosits M, Cos O, Ferrer P, Mattanovich D. Hypoxic fed-batch cultivation of Pichia pastoris increases specific and volumetric productivity of recombinant proteins. Biotechnol Bioeng 2008, 100:177-183. 10.1002/bit.21763, 18078287.
-
(2008)
Biotechnol Bioeng
, vol.100
, pp. 177-183
-
-
Baumann, K.1
Maurer, M.2
Dragosits, M.3
Cos, O.4
Ferrer, P.5
Mattanovich, D.6
-
33
-
-
33744455445
-
Experimental design principles for isotopically instationary C labeling experiments
-
10.1002/bit.20803, 16598793
-
Nöh K, Wiechert W. Experimental design principles for isotopically instationary C labeling experiments. Biotechnol Bioeng 2006, 94:234-251. 10.1002/bit.20803, 16598793.
-
(2006)
Biotechnol Bioeng
, vol.94
, pp. 234-251
-
-
Nöh, K.1
Wiechert, W.2
-
34
-
-
0035923330
-
Improved rapid sampling for in vivo kinetics of intracellular metabolites in Saccharomyces cerevisiae
-
10.1002/bit.10048, 11668440
-
Lange HC, Eman MR, van Zuijlen G, Visser D, van Dam JC, Frank J, de Mattos MJ, Heijnen JJ. Improved rapid sampling for in vivo kinetics of intracellular metabolites in Saccharomyces cerevisiae. Biotechnol Bioeng 2001, 75:406-415. 10.1002/bit.10048, 11668440.
-
(2001)
Biotechnol Bioeng
, vol.75
, pp. 406-415
-
-
Lange, H.C.1
Eman, M.R.2
van Zuijlen, G.3
Visser, D.4
van Dam, J.C.5
Frank, J.6
de Mattos, M.J.7
Heijnen, J.J.8
-
35
-
-
0032125853
-
Mechanical disruption of Pichia pastoris yeast to recover the recombinant glycoprotein Bm86
-
Canales M, Buxadó JA, Heynngnezz L, Enriquez A. Mechanical disruption of Pichia pastoris yeast to recover the recombinant glycoprotein Bm86. Enzyme Microb Technol 1998, 23:58-63.
-
(1998)
Enzyme Microb Technol
, vol.23
, pp. 58-63
-
-
Canales, M.1
Buxadó, J.A.2
Heynngnezz, L.3
Enriquez, A.4
-
36
-
-
1442326111
-
MIRACLE, mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites
-
10.1002/bit.10907, 14966803
-
Mashego MR, Wu L, van Dam JC, Ras C, Vinke JL, van Winden WA, van Gulik WM, Heijnen JJ. MIRACLE, mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites. Biotechnol Bioeng 2004, 85:620-628. 10.1002/bit.10907, 14966803.
-
(2004)
Biotechnol Bioeng
, vol.85
, pp. 620-628
-
-
Mashego, M.R.1
Wu, L.2
van Dam, J.C.3
Ras, C.4
Vinke, J.L.5
van Winden, W.A.6
van Gulik, W.M.7
Heijnen, J.J.8
-
37
-
-
11144324238
-
Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13 C-labeled cell extracts as internal standards
-
10.1016/j.ab.2004.09.001, 15620880
-
Wu L, Mashego MR, Dam JCV, Proell AM, Vinke JL, Ras C, van Winden WA, van Gulik WM, Heijnen JJ. Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13 C-labeled cell extracts as internal standards. Anal Biochem 2005, 336:164-171. 10.1016/j.ab.2004.09.001, 15620880.
-
(2005)
Anal Biochem
, vol.336
, pp. 164-171
-
-
Wu, L.1
Mashego, M.R.2
Dam, J.C.V.3
Proell, A.M.4
Vinke, J.L.5
Ras, C.6
van Winden, W.A.7
van Gulik, W.M.8
Heijnen, J.J.9
-
38
-
-
33749448867
-
Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions
-
10.1016/j.ymben.2006.05.006, 16890470
-
Nöh K, Wahl A, Wiechert W. Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions. Metab Eng 2006, 8:554-577. 10.1016/j.ymben.2006.05.006, 16890470.
-
(2006)
Metab Eng
, vol.8
, pp. 554-577
-
-
Nöh, K.1
Wahl, A.2
Wiechert, W.3
-
39
-
-
77956255989
-
Intracellular metabolite determination in the presence of extracellular abundance, Application to the penicillin biosynthesis pathway in Penicillium chrysogenum
-
10.1002/bit.22786, 20506508
-
Douma RD, de Jonge LP, Jonker CTH, Seifar RM, Heijnen JJ, van Gulik WM. Intracellular metabolite determination in the presence of extracellular abundance, Application to the penicillin biosynthesis pathway in Penicillium chrysogenum. Biotechnol Bioeng 2010, 107:105-115. 10.1002/bit.22786, 20506508.
-
(2010)
Biotechnol Bioeng
, vol.107
, pp. 105-115
-
-
Douma, R.D.1
de Jonge, L.P.2
Jonker, C.T.H.3
Seifar, R.M.4
Heijnen, J.J.5
van Gulik, W.M.6
-
40
-
-
69749110125
-
Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics
-
10.1021/ac900999t, 19653633
-
Canelas AB, ten Pierick A, Ras C, Seifar RM, van Dam JC, van Gulik WM, Heijnen JJ. Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics. Anal Chem 2009, 81:7379-7389. 10.1021/ac900999t, 19653633.
-
(2009)
Anal Chem
, vol.81
, pp. 7379-7389
-
-
Canelas, A.B.1
ten Pierick, A.2
Ras, C.3
Seifar, R.M.4
van Dam, J.C.5
van Gulik, W.M.6
Heijnen, J.J.7
-
41
-
-
0842343470
-
New tools for mass isotopomer data evaluation in 13C flux analysis, Mass isotope correction, data consistency checking, and precursor relationships
-
Wahl SA, Dauner M, Wiechert W. New tools for mass isotopomer data evaluation in 13C flux analysis, Mass isotope correction, data consistency checking, and precursor relationships. Biotechnol Bioeng 2004, 3:259-268.
-
(2004)
Biotechnol Bioeng
, vol.3
, pp. 259-268
-
-
Wahl, S.A.1
Dauner, M.2
Wiechert, W.3
-
42
-
-
26244452731
-
Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence
-
10.1111/j.1742-4658.2005.04907.x, 16176270
-
Kleijn RJ, van Winden WA, van Gulik WM, Heijnen JJ. Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence. FEBS J 2005, 272:4970-4982. 10.1111/j.1742-4658.2005.04907.x, 16176270.
-
(2005)
FEBS J
, vol.272
, pp. 4970-4982
-
-
Kleijn, R.J.1
van Winden, W.A.2
van Gulik, W.M.3
Heijnen, J.J.4
-
43
-
-
33745433792
-
Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data
-
Kümmel A, Panke S, Heinemann M. Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data. Mol Syst Biol 2006, 2:1-10.
-
(2006)
Mol Syst Biol
, vol.2
, pp. 1-10
-
-
Kümmel, A.1
Panke, S.2
Heinemann, M.3
-
44
-
-
42549159856
-
anNET, a tool for network-embedded thermodynamic analysis of quantitative metabolome data
-
Zamboni N, Kümmel A, Heinemann M. anNET, a tool for network-embedded thermodynamic analysis of quantitative metabolome data. BMC Bioinforma 2008, 9:199.
-
(2008)
BMC Bioinforma
, vol.9
, pp. 199
-
-
Zamboni, N.1
Kümmel, A.2
Heinemann, M.3
-
45
-
-
79955137362
-
An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data
-
10.1016/j.ymben.2011.02.005, 21354323
-
Canelas AB, Ras C, ten Pierick A, van Gulik WM, Heijnen JJ. An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data. Metab Eng 2011, 13:294-306. 10.1016/j.ymben.2011.02.005, 21354323.
-
(2011)
Metab Eng
, vol.13
, pp. 294-306
-
-
Canelas, A.B.1
Ras, C.2
ten Pierick, A.3
van Gulik, W.M.4
Heijnen, J.J.5
-
46
-
-
33845238737
-
Systematic assignment of thermodynamic constraints in metabolic network models
-
Kümmel A, Panke S, Heinemann M. Systematic assignment of thermodynamic constraints in metabolic network models. BMC Bioinforma 2006, 7:512.
-
(2006)
BMC Bioinforma
, vol.7
, pp. 512
-
-
Kümmel, A.1
Panke, S.2
Heinemann, M.3
-
47
-
-
80052067544
-
Intracellular pH is a tightly controlled signal in yeast
-
Orij R, Brul S, Smits GJ. Intracellular pH is a tightly controlled signal in yeast. Biochim Biophys Acta 1810, 2011:933-944.
-
(1810)
Biochim Biophys Acta
, vol.2011
, pp. 933-944
-
-
Orij, R.1
Brul, S.2
Smits, G.J.3
-
48
-
-
0020812944
-
Application of macroscopic balances to the identification of gross measurement errors
-
10.1002/bit.260250906, 18574815
-
Wang NS, Stephanopoulos G. Application of macroscopic balances to the identification of gross measurement errors. Biotechnol Bioeng 1983, 25:2177-2208. 10.1002/bit.260250906, 18574815.
-
(1983)
Biotechnol Bioeng
, vol.25
, pp. 2177-2208
-
-
Wang, N.S.1
Stephanopoulos, G.2
-
49
-
-
0028764687
-
Linear constraint relations in biochemical reaction systems, I. Classification of the calculability and the balanceability of conversion rates
-
10.1002/bit.260430103, 18613305
-
Heijden VD. Linear constraint relations in biochemical reaction systems, I. Classification of the calculability and the balanceability of conversion rates. Biotechnol Bioeng 1994, 43:3-10. 10.1002/bit.260430103, 18613305.
-
(1994)
Biotechnol Bioeng
, vol.43
, pp. 3-10
-
-
Heijden, V.D.1
-
50
-
-
84857732977
-
Data reconciliation and error detection
-
Boca Raton: CRC Press, Smolke C, 8
-
Verheijen PJT. Data reconciliation and error detection. The Metabolic Pathway Engineering Handbook 2010, 8.1-8.13. Boca Raton: CRC Press, Smolke C, 8.
-
(2010)
The Metabolic Pathway Engineering Handbook
-
-
Verheijen, P.J.T.1
-
51
-
-
78049451371
-
Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae
-
10.1016/j.ymben.2010.08.003, 20816840
-
Wisselink HW, Cipollina C, Oud B, Crimi B, Heijnen JJ, Pronk JT, van Maris AJA. Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. Metab Eng 2010, 12:537-551. 10.1016/j.ymben.2010.08.003, 20816840.
-
(2010)
Metab Eng
, vol.12
, pp. 537-551
-
-
Wisselink, H.W.1
Cipollina, C.2
Oud, B.3
Crimi, B.4
Heijnen, J.J.5
Pronk, J.T.6
van Maris, A.J.A.7
-
52
-
-
78649701348
-
Limitations in xylose-fermenting Saccharomyces cerevisiae, made evident through comprehensive metabolite profiling and thermodynamic analysis
-
10.1128/AEM.01787-10, 2976174, 20889786
-
Klimacek M, Krahulec S, Sauer U, Nidetzky B. Limitations in xylose-fermenting Saccharomyces cerevisiae, made evident through comprehensive metabolite profiling and thermodynamic analysis. Appl Environ Microbiol 2010, 76:7566-7574. 10.1128/AEM.01787-10, 2976174, 20889786.
-
(2010)
Appl Environ Microbiol
, vol.76
, pp. 7566-7574
-
-
Klimacek, M.1
Krahulec, S.2
Sauer, U.3
Nidetzky, B.4
-
54
-
-
46249123194
-
Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady-state and highly dynamic conditions
-
10.1002/bit.21813, 18383140
-
Canelas AB, van Gulik WM, Heijnen JJ. Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady-state and highly dynamic conditions. Biotechnol Bioeng 2008, 100:734-743. 10.1002/bit.21813, 18383140.
-
(2008)
Biotechnol Bioeng
, vol.100
, pp. 734-743
-
-
Canelas, A.B.1
van Gulik, W.M.2
Heijnen, J.J.3
-
55
-
-
59149092918
-
Dynamic 13C-tracer study of storage carbohydrate pools in aerobic glucose-limited Saccharomyces cerevisiae confirms a rapid steady-state turnover and fast mobilization during a modest stepup in the glucose uptake rate
-
10.1111/j.1567-1364.2008.00465.x, 19220865
-
Aboka FO, Heijnen JJ, van Winden WA. Dynamic 13C-tracer study of storage carbohydrate pools in aerobic glucose-limited Saccharomyces cerevisiae confirms a rapid steady-state turnover and fast mobilization during a modest stepup in the glucose uptake rate. FEMS Yeast Res 2009, 9:191-201. 10.1111/j.1567-1364.2008.00465.x, 19220865.
-
(2009)
FEMS Yeast Res
, vol.9
, pp. 191-201
-
-
Aboka, F.O.1
Heijnen, J.J.2
van Winden, W.A.3
-
56
-
-
84867745157
-
Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis
-
10.1186/1475-2859-11-140, 3538697, 23098235
-
Zhao Z, ten Pierick A, de Jonge L, Heijnen JJ, Wahl A. Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis. Microb Cell Fact 2012, 11:140. 10.1186/1475-2859-11-140, 3538697, 23098235.
-
(2012)
Microb Cell Fact
, vol.11
, pp. 140
-
-
Zhao, Z.1
ten Pierick, A.2
de Jonge, L.3
Heijnen, J.J.4
Wahl, A.5
-
57
-
-
0035170286
-
Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae
-
10.1111/j.1574-6976.2001.tb00570.x, 11152939
-
Bakker BM, Overkamp KM, van Maris AJ, Kötter P, Luttik MA, van Dijken JP, Pronk JT. Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae. FEMS Microbiol Rev 2001, 25:15-37. 10.1111/j.1574-6976.2001.tb00570.x, 11152939.
-
(2001)
FEMS Microbiol Rev
, vol.25
, pp. 15-37
-
-
Bakker, B.M.1
Overkamp, K.M.2
van Maris, A.J.3
Kötter, P.4
Luttik, M.A.5
van Dijken, J.P.6
Pronk, J.T.7
-
58
-
-
68849090311
-
Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans
-
10.1096/fj.08-127985, 19289605
-
Strijbis K, van Roermund CWT, Hardy GP, van den Burg J, Bloem K, de Haan J, van Vlies N, Wanders RJA, Vaz FM, Distel B. Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans. FASEB J 2009, 23:2349-2359. 10.1096/fj.08-127985, 19289605.
-
(2009)
FASEB J
, vol.23
, pp. 2349-2359
-
-
Strijbis, K.1
van Roermund, C.W.T.2
Hardy, G.P.3
van den Burg, J.4
Bloem, K.5
de Haan, J.6
van Vlies, N.7
Wanders, R.J.A.8
Vaz, F.M.9
Distel, B.10
-
59
-
-
67149116767
-
Genome sequence of the recombinant protein production host Pichia pastoris
-
10.1038/nbt.1544, 19465926
-
Schutter KD, Lin Y, Tiels P, Hecke AV, Glinka S, Peer YVD, Callewaert N, Weber-Lehmann J, Rouze P. Genome sequence of the recombinant protein production host Pichia pastoris. Nat Biotechnol 2009, 27:561-566. 10.1038/nbt.1544, 19465926.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 561-566
-
-
Schutter, K.D.1
Lin, Y.2
Tiels, P.3
Hecke, A.V.4
Glinka, S.5
Peer, Y.V.D.6
Callewaert, N.7
Weber-Lehmann, J.8
Rouze, P.9
-
60
-
-
77958044182
-
A multi-level study of recombinant Pichia pastoris in different oxygen conditions
-
10.1186/1752-0509-4-141, 2987880, 20969759
-
Baumann K, Carnicer M, Dragosits M, Graf AB, Stadlmann J, Jouhten P, Maaheimo H, Gasser B, Albiol J, Mattanovich D, Ferrer P. A multi-level study of recombinant Pichia pastoris in different oxygen conditions. BMC Syst Biol 2010, 4:141. 10.1186/1752-0509-4-141, 2987880, 20969759.
-
(2010)
BMC Syst Biol
, vol.4
, pp. 141
-
-
Baumann, K.1
Carnicer, M.2
Dragosits, M.3
Graf, A.B.4
Stadlmann, J.5
Jouhten, P.6
Maaheimo, H.7
Gasser, B.8
Albiol, J.9
Mattanovich, D.10
Ferrer, P.11
-
61
-
-
1842473645
-
Impact of transamination reactions and protein turnover on labeling dynamics in (13)C-labeling experiments
-
10.1002/bit.20036, 15052641
-
Grotkjaer T, Akesson M, Christensen B, Gombert AK, Nielsen J. Impact of transamination reactions and protein turnover on labeling dynamics in (13)C-labeling experiments. Biotechnol Bioeng 2004, 86:209-216. 10.1002/bit.20036, 15052641.
-
(2004)
Biotechnol Bioeng
, vol.86
, pp. 209-216
-
-
Grotkjaer, T.1
Akesson, M.2
Christensen, B.3
Gombert, A.K.4
Nielsen, J.5
-
62
-
-
0026063215
-
Methanol oxidation and assimilation in Hansenula polymorpha
-
1130573, 1747123
-
Jones JG, Bellion E. Methanol oxidation and assimilation in Hansenula polymorpha. Biochem J 1991, 280:475-481. 1130573, 1747123.
-
(1991)
Biochem J
, vol.280
, pp. 475-481
-
-
Jones, J.G.1
Bellion, E.2
-
63
-
-
33846886702
-
Regulation of methanol utilisation pathway genes in yeasts
-
10.1186/1475-2859-5-39, 1781073, 17169150
-
Hartner FS, Glieder A. Regulation of methanol utilisation pathway genes in yeasts. Microb Cell Fact 2006, 5:39. 10.1186/1475-2859-5-39, 1781073, 17169150.
-
(2006)
Microb Cell Fact
, vol.5
, pp. 39
-
-
Hartner, F.S.1
Glieder, A.2
-
64
-
-
15044342010
-
Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts
-
10.1016/j.femsyr.2004.09.008, 15780654
-
Blank LM, Lehmbeck F, Sauer U. Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts. FEMS Yeast Res 2005, 5:545-558. 10.1016/j.femsyr.2004.09.008, 15780654.
-
(2005)
FEMS Yeast Res
, vol.5
, pp. 545-558
-
-
Blank, L.M.1
Lehmbeck, F.2
Sauer, U.3
-
65
-
-
70449441085
-
Sugar metabolism, redox balance and oxidative stress response in the respiratory yeast Kluyveromyces lactis
-
10.1186/1475-2859-8-46, 2754438, 19715615
-
González-Siso MI, García-Leiro A, Tarrío N, Cerdán ME. Sugar metabolism, redox balance and oxidative stress response in the respiratory yeast Kluyveromyces lactis. Microb Cell Fact 2009, 8:46. 10.1186/1475-2859-8-46, 2754438, 19715615.
-
(2009)
Microb Cell Fact
, vol.8
, pp. 46
-
-
González-Siso, M.I.1
García-Leiro, A.2
Tarrío, N.3
Cerdán, M.E.4
-
66
-
-
0026334731
-
Physiology of yeast in relation to biomass yields
-
Verduyn C. Physiology of yeast in relation to biomass yields. Biomedical and Life Science 1991, 60:325-353.
-
(1991)
Biomedical and Life Science
, vol.60
, pp. 325-353
-
-
Verduyn, C.1
-
67
-
-
84859199206
-
Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in-silico evaluation of their potentials
-
10.1186/1752-0509-6-24, 3364918, 22472172
-
Caspeta L, Shoaie S, Agren R, Nookaew I, Nielsen J. Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in-silico evaluation of their potentials. BMC Syst Biol 2012, 6:24. 10.1186/1752-0509-6-24, 3364918, 22472172.
-
(2012)
BMC Syst Biol
, vol.6
, pp. 24
-
-
Caspeta, L.1
Shoaie, S.2
Agren, R.3
Nookaew, I.4
Nielsen, J.5
-
68
-
-
0029689236
-
In vivo stationary flux analysis by 13C labeling experiments
-
Wiechert W, de Graaf AA. In vivo stationary flux analysis by 13C labeling experiments. Adv Biochem Eng Biotechnol 1996, 54:109-154.
-
(1996)
Adv Biochem Eng Biotechnol
, vol.54
, pp. 109-154
-
-
Wiechert, W.1
de Graaf, A.A.2
|