메뉴 건너뛰기




Volumn 137, Issue 3, 2013, Pages 331-340

Murine models for pharmacological studies of the metabolic syndrome

Author keywords

Animal models; High fat diet; Keywords; Leptin; Metabolic syndrome

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; CHOLESTEROL; INSULIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; TRIACYLGLYCEROL;

EID: 84874115254     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.11.004     Document Type: Review
Times cited : (121)

References (218)
  • 1
    • 77954272440 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides
    • M. Abe, T. Toyohara, A. Ishii, T. Suzuki, N. Noguchi, and Y. Akiyama The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides Drug Metab Pharmacokinet 25 3 2010 274 282
    • (2010) Drug Metab Pharmacokinet , vol.25 , Issue.3 , pp. 274-282
    • Abe, M.1    Toyohara, T.2    Ishii, A.3    Suzuki, T.4    Noguchi, N.5    Akiyama, Y.6
  • 2
    • 65949113140 scopus 로고    scopus 로고
    • Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa)
    • A. Agouni, A.H. Lagrue-Lak-Hal, H.A. Mostefai, A. Tesse, P. Mulder, and P. Rouet Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa) PLoS One 4 5 2009 e5557
    • (2009) PLoS One , vol.4 , Issue.5 , pp. 5557
    • Agouni, A.1    Lagrue-Lak-Hal, A.H.2    Mostefai, H.A.3    Tesse, A.4    Mulder, P.5    Rouet, P.6
  • 5
    • 0032698952 scopus 로고    scopus 로고
    • Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells)
    • B. Ahren, and P.J. Havel Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells) Am J Physiol 277 4 Pt 2 1999 R959 R966
    • (1999) Am J Physiol , vol.277 , Issue.4 PART 2
    • Ahren, B.1    Havel, P.J.2
  • 6
    • 80053407853 scopus 로고    scopus 로고
    • GLUT2 accumulation in enterocyte apical and intracellular membranes: A study in morbidly obese human subjects and ob/ob and high fat-fed mice
    • A. Ait-Omar, M. Monteiro-Sepulveda, C. Poitou, M. Le Gall, A. Cotillard, and J. Gilet GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice Diabetes 60 10 2011 2598 2607
    • (2011) Diabetes , vol.60 , Issue.10 , pp. 2598-2607
    • Ait-Omar, A.1    Monteiro-Sepulveda, M.2    Poitou, C.3    Le Gall, M.4    Cotillard, A.5    Gilet, J.6
  • 7
    • 0034218936 scopus 로고    scopus 로고
    • Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats
    • K.A. Al-Barazanji, J.R. Arch, R.E. Buckingham, and M. Tadayyon Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats Obes Res 8 4 2000 317 323
    • (2000) Obes Res , vol.8 , Issue.4 , pp. 317-323
    • Al-Barazanji, K.A.1    Arch, J.R.2    Buckingham, R.E.3    Tadayyon, M.4
  • 8
    • 0038527321 scopus 로고    scopus 로고
    • The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats
    • N.L. Alderson, M.E. Chachich, N.N. Youssef, R.J. Beattie, M. Nachtigal, and S.R. Thorpe The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats Kidney Int 63 6 2003 2123 2133
    • (2003) Kidney Int , vol.63 , Issue.6 , pp. 2123-2133
    • Alderson, N.L.1    Chachich, M.E.2    Youssef, N.N.3    Beattie, R.J.4    Nachtigal, M.5    Thorpe, S.R.6
  • 9
    • 0029808766 scopus 로고    scopus 로고
    • Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity
    • M. Alonso-Galicia, M.W. Brands, D.H. Zappe, and J.E. Hall Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity Hypertension 28 6 1996 1047 1054
    • (1996) Hypertension , vol.28 , Issue.6 , pp. 1047-1054
    • Alonso-Galicia, M.1    Brands, M.W.2    Zappe, D.H.3    Hall, J.E.4
  • 10
    • 0032897297 scopus 로고    scopus 로고
    • The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats
    • K.M. Anderson, A.D. Eckhart, R.N. Willette, and W.J. Koch The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats Hypertension 33 1 Pt 2 1999 402 407
    • (1999) Hypertension , vol.33 , Issue.1 PART 2 , pp. 402-407
    • Anderson, K.M.1    Eckhart, A.D.2    Willette, R.N.3    Koch, W.J.4
  • 11
    • 50249165923 scopus 로고    scopus 로고
    • Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats
    • L.L. Atkinson, C. McDonald-Dyck, C. Benkoczi, and D.T. Finegood Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats Diabetes Obes Metab 10 9 2008 780 790
    • (2008) Diabetes Obes Metab , vol.10 , Issue.9 , pp. 780-790
    • Atkinson, L.L.1    McDonald-Dyck, C.2    Benkoczi, C.3    Finegood, D.T.4
  • 12
    • 0025435330 scopus 로고
    • Adrenoceptor-mediated control of glucose homeostasis in obese hyperglycaemic (ob/ob) mice
    • C.J. Bailey, and P.R. Flatt Adrenoceptor-mediated control of glucose homeostasis in obese hyperglycaemic (ob/ob) mice Diabetes Res 14 2 1990 87 91
    • (1990) Diabetes Res , vol.14 , Issue.2 , pp. 87-91
    • Bailey, C.J.1    Flatt, P.R.2
  • 13
    • 17844373625 scopus 로고    scopus 로고
    • Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    • S.H. Bates, R.N. Kulkarni, M. Seifert, and M.G. Myers Jr. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis Cell Metab 1 3 2005 169 178
    • (2005) Cell Metab , vol.1 , Issue.3 , pp. 169-178
    • Bates, S.H.1    Kulkarni, R.N.2    Seifert, M.3    Myers, Jr.M.G.4
  • 14
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • S.H. Bates, W.H. Stearns, T.A. Dundon, M. Schubert, A.W. Tso, and Y. Wang STAT3 signalling is required for leptin regulation of energy balance but not reproduction Nature 421 6925 2003 856 859
    • (2003) Nature , vol.421 , Issue.6925 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5    Wang, Y.6
  • 15
    • 0032936546 scopus 로고    scopus 로고
    • The effect of moxonidine on feeding and body fat in obese Zucker rats: Role of hypothalamic NPY neurones
    • C. Bing, P. King, L. Pickavance, M. Brown, D. Ziegler, and E. Kaan The effect of moxonidine on feeding and body fat in obese Zucker rats: role of hypothalamic NPY neurones Br J Pharmacol 127 1 1999 35 42
    • (1999) Br J Pharmacol , vol.127 , Issue.1 , pp. 35-42
    • Bing, C.1    King, P.2    Pickavance, L.3    Brown, M.4    Ziegler, D.5    Kaan, E.6
  • 16
    • 67650001888 scopus 로고    scopus 로고
    • Synergistic effect of the human GLP-1 analogue liraglutide and a dual PPARalpha/gamma agonist on glycaemic control in Zucker diabetic fatty rats
    • C.L. Brand, E.D. Galsgaard, D. Tornehave, J. Romer, C.F. Gotfredsen, and K. Wassermann Synergistic effect of the human GLP-1 analogue liraglutide and a dual PPARalpha/gamma agonist on glycaemic control in Zucker diabetic fatty rats Diabetes Obes Metab 11 8 2009 795 803
    • (2009) Diabetes Obes Metab , vol.11 , Issue.8 , pp. 795-803
    • Brand, C.L.1    Galsgaard, E.D.2    Tornehave, D.3    Romer, J.4    Gotfredsen, C.F.5    Wassermann, K.6
  • 17
    • 27844457564 scopus 로고    scopus 로고
    • Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity
    • J. Buchanan, P.K. Mazumder, P. Hu, G. Chakrabarti, M.W. Roberts, and U.J. Yun Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity Endocrinology 146 12 2005 5341 5349
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5341-5349
    • Buchanan, J.1    Mazumder, P.K.2    Hu, P.3    Chakrabarti, G.4    Roberts, M.W.5    Yun, U.J.6
  • 21
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • H. Chen, O. Charlat, L.A. Tartaglia, E.A. Woolf, X. Weng, and S.J. Ellis Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice Cell 84 3 1996 491 495
    • (1996) Cell , vol.84 , Issue.3 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6
  • 22
    • 79953200515 scopus 로고    scopus 로고
    • Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats
    • B. Chen, A. Moore, L.V. Escobedo, M.S. Koletsky, D. Hou, and R.J. Koletsky Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats Exp Biol Med (Maywood) 236 3 2011 309 314
    • (2011) Exp Biol Med (Maywood) , vol.236 , Issue.3 , pp. 309-314
    • Chen, B.1    Moore, A.2    Escobedo, L.V.3    Koletsky, M.S.4    Hou, D.5    Koletsky, R.J.6
  • 23
    • 0037224527 scopus 로고    scopus 로고
    • Muscle lipid metabolism and insulin secretion are altered in insulin-resistant rats fed a high sucrose diet
    • A. Chicco, M.E. D'Alessandro, L. Karabatas, C. Pastorale, J.C. Basabe, and Y.B. Lombardo Muscle lipid metabolism and insulin secretion are altered in insulin-resistant rats fed a high sucrose diet J Nutr 133 1 2003 127 133
    • (2003) J Nutr , vol.133 , Issue.1 , pp. 127-133
    • Chicco, A.1    D'Alessandro, M.E.2    Karabatas, L.3    Pastorale, C.4    Basabe, J.C.5    Lombardo, Y.B.6
  • 24
    • 77955054237 scopus 로고    scopus 로고
    • Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet
    • J. Chidambaram, and A. Carani Venkatraman Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet Food Chem Toxicol 48 8-9 2010 2021 2029
    • (2010) Food Chem Toxicol , vol.48 , Issue.89 , pp. 2021-2029
    • Chidambaram, J.1    Carani Venkatraman, A.2
  • 25
    • 33845875499 scopus 로고    scopus 로고
    • Vascular lipotoxicity: Endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats
    • I. Chinen, M. Shimabukuro, K. Yamakawa, N. Higa, T. Matsuzaki, and K. Noguchi Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats Endocrinology 148 1 2007 160 165
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 160-165
    • Chinen, I.1    Shimabukuro, M.2    Yamakawa, K.3    Higa, N.4    Matsuzaki, T.5    Noguchi, K.6
  • 26
    • 6344282522 scopus 로고    scopus 로고
    • The yellow agouti mutation alters some but not all responses to diet and exercise
    • S. Chiu, J.S. Fisler, G.M. Espinal, P.J. Havel, J.S. Stern, and C.H. Warden The yellow agouti mutation alters some but not all responses to diet and exercise Obes Res 12 8 2004 1243 1255
    • (2004) Obes Res , vol.12 , Issue.8 , pp. 1243-1255
    • Chiu, S.1    Fisler, J.S.2    Espinal, G.M.3    Havel, P.J.4    Stern, J.S.5    Warden, C.H.6
  • 27
    • 0014848832 scopus 로고
    • Glucose tolerance and time sequence of adiposity, hyperinsulinemia and hyperglycemia in obese-hyperglycemic mice (obob)
    • C. Chlouverakis, E.F. Dade, and R.A. Batt Glucose tolerance and time sequence of adiposity, hyperinsulinemia and hyperglycemia in obese-hyperglycemic mice (obob) Metabolism 19 9 1970 687 693
    • (1970) Metabolism , vol.19 , Issue.9 , pp. 687-693
    • Chlouverakis, C.1    Dade, E.F.2    Batt, R.A.3
  • 28
    • 34447640712 scopus 로고    scopus 로고
    • The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats
    • S.H. Choi, Z.S. Zhao, Y.J. Lee, S.K. Kim, D.J. Kim, and C.W. Ahn The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats Diabetes Metab Res Rev 23 5 2007 411 418
    • (2007) Diabetes Metab Res Rev , vol.23 , Issue.5 , pp. 411-418
    • Choi, S.H.1    Zhao, Z.S.2    Lee, Y.J.3    Kim, S.K.4    Kim, D.J.5    Ahn, C.W.6
  • 29
    • 77950613528 scopus 로고    scopus 로고
    • FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
    • S. Cipriani, A. Mencarelli, G. Palladino, and S. Fiorucci FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats J Lipid Res 51 4 2010 771 784
    • (2010) J Lipid Res , vol.51 , Issue.4 , pp. 771-784
    • Cipriani, S.1    Mencarelli, A.2    Palladino, G.3    Fiorucci, S.4
  • 30
    • 84859534676 scopus 로고    scopus 로고
    • Metformin prevents the development of chronic heart failure in the SHHF rat model
    • A. Cittadini, R. Napoli, M.G. Monti, D. Rea, S. Longobardi, and P.A. Netti Metformin prevents the development of chronic heart failure in the SHHF rat model Diabetes 61 4 2012 944 953
    • (2012) Diabetes , vol.61 , Issue.4 , pp. 944-953
    • Cittadini, A.1    Napoli, R.2    Monti, M.G.3    Rea, D.4    Longobardi, S.5    Netti, P.A.6
  • 31
    • 0023177645 scopus 로고
    • Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats
    • M.P. Cleary, B. Kasiske, M.P. O'Donnell, and W.F. Keane Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats Atherosclerosis 66 1-2 1987 107 112
    • (1987) Atherosclerosis , vol.66 , Issue.12 , pp. 107-112
    • Cleary, M.P.1    Kasiske, B.2    O'Donnell, M.P.3    Keane, W.F.4
  • 32
    • 0036179334 scopus 로고    scopus 로고
    • Gender difference in diet-induced obesity hypertension: Implication of renal alpha2-adrenergic receptors
    • G. Coatmellec-Taglioni, J.P. Dausse, Y. Giudicelli, and C. Ribiere Gender difference in diet-induced obesity hypertension: implication of renal alpha2-adrenergic receptors Am J Hypertens 15 2 Pt 1 2002 143 149
    • (2002) Am J Hypertens , vol.15 , Issue.2 PART 1 , pp. 143-149
    • Coatmellec-Taglioni, G.1    Dausse, J.P.2    Giudicelli, Y.3    Ribiere, C.4
  • 33
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • D.L. Coleman Effects of parabiosis of obese with diabetes and normal mice Diabetologia 9 4 1973 294 298
    • (1973) Diabetologia , vol.9 , Issue.4 , pp. 294-298
    • Coleman, D.L.1
  • 34
    • 0014076277 scopus 로고
    • Studies with the mutation, diabetes, in the mouse
    • D.L. Coleman, and K.P. Hummel Studies with the mutation, diabetes, in the mouse Diabetologia 3 2 1967 238 248
    • (1967) Diabetologia , vol.3 , Issue.2 , pp. 238-248
    • Coleman, D.L.1    Hummel, K.P.2
  • 35
    • 0015864927 scopus 로고
    • The influence of genetic background on the expression of the obese (Ob) gene in the mouse
    • D.L. Coleman, and K.P. Hummel The influence of genetic background on the expression of the obese (Ob) gene in the mouse Diabetologia 9 4 1973 287 293
    • (1973) Diabetologia , vol.9 , Issue.4 , pp. 287-293
    • Coleman, D.L.1    Hummel, K.P.2
  • 36
    • 0019442536 scopus 로고
    • Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex
    • E. Colle, R.D. Guttmann, and T. Seemayer Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex J Exp Med 154 4 1981 1237 1242
    • (1981) J Exp Med , vol.154 , Issue.4 , pp. 1237-1242
    • Colle, E.1    Guttmann, R.D.2    Seemayer, T.3
  • 38
    • 0036066483 scopus 로고    scopus 로고
    • The concept of selective leptin resistance: Evidence from agouti yellow obese mice
    • M.L. Correia, W.G. Haynes, K. Rahmouni, D.A. Morgan, W.I. Sivitz, and A.L. Mark The concept of selective leptin resistance: evidence from agouti yellow obese mice Diabetes 51 2 2002 439 442
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 439-442
    • Correia, M.L.1    Haynes, W.G.2    Rahmouni, K.3    Morgan, D.A.4    Sivitz, W.I.5    Mark, A.L.6
  • 39
    • 0029763177 scopus 로고    scopus 로고
    • The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals
    • I. Cusin, F. Rohner-Jeanrenaud, A. Stricker-Krongrad, and B. Jeanrenaud The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals Diabetes 45 10 1996 1446 1450
    • (1996) Diabetes , vol.45 , Issue.10 , pp. 1446-1450
    • Cusin, I.1    Rohner-Jeanrenaud, F.2    Stricker-Krongrad, A.3    Jeanrenaud, B.4
  • 40
    • 0031928230 scopus 로고    scopus 로고
    • Interactions of captopril and verapamil on glucose tolerance and insulin action in an animal model of insulin resistance
    • D.B. Dal Ponte, D.L. Fogt, S. Jacob, and E.J. Henriksen Interactions of captopril and verapamil on glucose tolerance and insulin action in an animal model of insulin resistance Metabolism 47 8 1998 982 987
    • (1998) Metabolism , vol.47 , Issue.8 , pp. 982-987
    • Dal Ponte, D.B.1    Fogt, D.L.2    Jacob, S.3    Henriksen, E.J.4
  • 41
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • X. Ding, N.K. Saxena, S. Lin, N.A. Gupta, and F.A. Anania Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice Hepatology 43 1 2006 173 181
    • (2006) Hepatology , vol.43 , Issue.1 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 42
    • 0036294862 scopus 로고    scopus 로고
    • Relationship between insulin resistance and muscle triglyceride content in nonobese and obese experimental models of insulin resistance syndrome
    • J. Divisova, L. Kazdova, M. Hubova, and E. Meschisvili Relationship between insulin resistance and muscle triglyceride content in nonobese and obese experimental models of insulin resistance syndrome Ann N Y Acad Sci 967 2002 440 445
    • (2002) Ann N y Acad Sci , vol.967 , pp. 440-445
    • Divisova, J.1    Kazdova, L.2    Hubova, M.3    Meschisvili, E.4
  • 43
    • 0034123037 scopus 로고    scopus 로고
    • Development of hypertension in a rat model of diet-induced obesity
    • A.D. Dobrian, M.J. Davies, R.L. Prewitt, and T.J. Lauterio Development of hypertension in a rat model of diet-induced obesity Hypertension 35 4 2000 1009 1015
    • (2000) Hypertension , vol.35 , Issue.4 , pp. 1009-1015
    • Dobrian, A.D.1    Davies, M.J.2    Prewitt, R.L.3    Lauterio, T.J.4
  • 44
    • 33745230441 scopus 로고    scopus 로고
    • Renal injury: Similarities and differences in male and female rats with the metabolic syndrome
    • J.H. Dominguez, P. Wu, J.W. Hawes, M. Deeg, J. Walsh, and S.C. Packer Renal injury: similarities and differences in male and female rats with the metabolic syndrome Kidney Int 69 11 2006 1969 1976
    • (2006) Kidney Int , vol.69 , Issue.11 , pp. 1969-1976
    • Dominguez, J.H.1    Wu, P.2    Hawes, J.W.3    Deeg, M.4    Walsh, J.5    Packer, S.C.6
  • 45
    • 22144460505 scopus 로고    scopus 로고
    • A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury
    • E.F. du Toit, M. Nabben, and A. Lochner A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury Basic Res Cardiol 100 4 2005 346 354
    • (2005) Basic Res Cardiol , vol.100 , Issue.4 , pp. 346-354
    • Du Toit, E.F.1    Nabben, M.2    Lochner, A.3
  • 46
    • 36348946386 scopus 로고    scopus 로고
    • Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling
    • K.L. Ellacott, J.G. Murphy, D.L. Marks, and R.D. Cone Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling Endocrinology 148 12 2007 6186 6194
    • (2007) Endocrinology , vol.148 , Issue.12 , pp. 6186-6194
    • Ellacott, K.L.1    Murphy, J.G.2    Marks, D.L.3    Cone, R.D.4
  • 47
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • V. Emilsson, Y.L. Liu, M.A. Cawthorne, N.M. Morton, and M. Davenport Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion Diabetes 46 2 1997 313 316
    • (1997) Diabetes , vol.46 , Issue.2 , pp. 313-316
    • Emilsson, V.1    Liu, Y.L.2    Cawthorne, M.A.3    Morton, N.M.4    Davenport, M.5
  • 48
    • 34547473573 scopus 로고    scopus 로고
    • Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome
    • P. Ernsberger, J.L. Johnson, T. Rosenthal, D. Mirelman, and R.J. Koletsky Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome Am J Hypertens 20 8 2007 866 874
    • (2007) Am J Hypertens , vol.20 , Issue.8 , pp. 866-874
    • Ernsberger, P.1    Johnson, J.L.2    Rosenthal, T.3    Mirelman, D.4    Koletsky, R.J.5
  • 49
    • 0028004330 scopus 로고
    • Refeeding hypertension in obese spontaneously hypertensive rats
    • P. Ernsberger, R.J. Koletsky, J.S. Baskin, and M. Foley Refeeding hypertension in obese spontaneously hypertensive rats Hypertension 24 6 1994 699 705
    • (1994) Hypertension , vol.24 , Issue.6 , pp. 699-705
    • Ernsberger, P.1    Koletsky, R.J.2    Baskin, J.S.3    Foley, M.4
  • 50
    • 0030013287 scopus 로고    scopus 로고
    • Sympathetic nervous system in salt-sensitive and obese hypertension: Amelioration of multiple abnormalities by a central sympatholytic agent
    • P. Ernsberger, R.J. Koletsky, L.A. Collins, and D. Bedol Sympathetic nervous system in salt-sensitive and obese hypertension: amelioration of multiple abnormalities by a central sympatholytic agent Cardiovasc Drugs Ther 10 Suppl. 1 1996 275 282
    • (1996) Cardiovasc Drugs Ther , vol.10 , Issue.SUPPL. 1 , pp. 275-282
    • Ernsberger, P.1    Koletsky, R.J.2    Collins, L.A.3    Bedol, D.4
  • 51
    • 0032786129 scopus 로고    scopus 로고
    • Molecular pathology in the obese spontaneous hypertensive Koletsky rat: A model of syndrome X
    • P. Ernsberger, R.J. Koletsky, and J.E. Friedman Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X Ann N Y Acad Sci 892 1999 272 288
    • (1999) Ann N y Acad Sci , vol.892 , pp. 272-288
    • Ernsberger, P.1    Koletsky, R.J.2    Friedman, J.E.3
  • 52
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 385 6612 1997 165 168
    • (1997) Nature , vol.385 , Issue.6612 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 53
    • 0034456475 scopus 로고    scopus 로고
    • The central melanocortin system can directly regulate serum insulin levels
    • W. Fan, D.M. Dinulescu, A.A. Butler, J. Zhou, D.L. Marks, and R.D. Cone The central melanocortin system can directly regulate serum insulin levels Endocrinology 141 9 2000 3072 3079
    • (2000) Endocrinology , vol.141 , Issue.9 , pp. 3072-3079
    • Fan, W.1    Dinulescu, D.M.2    Butler, A.A.3    Zhou, J.4    Marks, D.L.5    Cone, R.D.6
  • 54
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • H. Fei, H.J. Okano, C. Li, G.H. Lee, C. Zhao, and R. Darnell Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues Proc Natl Acad Sci U S A 94 13 1997 7001 7005
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.13 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.H.4    Zhao, C.5    Darnell, R.6
  • 55
    • 71149095260 scopus 로고    scopus 로고
    • Lipase maturation factor 1: Its expression in Zucker diabetic rats, and effects of metformin and fenofibrate
    • F. Forcheron, A. Basset, P. Del Carmine, and M. Beylot Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate Diabetes Metab 35 6 2009 452 457
    • (2009) Diabetes Metab , vol.35 , Issue.6 , pp. 452-457
    • Forcheron, F.1    Basset, A.2    Del Carmine, P.3    Beylot, M.4
  • 56
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 6704 1998 763 770
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 57
    • 25644451236 scopus 로고    scopus 로고
    • Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice
    • H. Fujita, H. Fujishima, J. Koshimura, M. Hosoba, N. Yoshioka, and T. Shimotomai Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice Endocr J 52 4 2005 427 433
    • (2005) Endocr J , vol.52 , Issue.4 , pp. 427-433
    • Fujita, H.1    Fujishima, H.2    Koshimura, J.3    Hosoba, M.4    Yoshioka, N.5    Shimotomai, T.6
  • 58
    • 0028318273 scopus 로고
    • Little or no expression of the cholecystokinin-A receptor gene in the pancreas of diabetic rats (Otsuka Long-Evans Tokushima Fatty = OLETF rats)
    • A. Funakoshi, K. Miyasaka, A. Jimi, T. Kawanai, Y. Takata, and A. Kono Little or no expression of the cholecystokinin-A receptor gene in the pancreas of diabetic rats (Otsuka Long-Evans Tokushima Fatty = OLETF rats) Biochem Biophys Res Commun 199 2 1994 482 488
    • (1994) Biochem Biophys Res Commun , vol.199 , Issue.2 , pp. 482-488
    • Funakoshi, A.1    Miyasaka, K.2    Jimi, A.3    Kawanai, T.4    Takata, Y.5    Kono, A.6
  • 60
    • 15444380712 scopus 로고    scopus 로고
    • Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight
    • B.R. Gedulin, S.E. Nikoulina, P.A. Smith, G. Gedulin, L.L. Nielsen, and A.D. Baron Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight Endocrinology 146 4 2005 2069 2076
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 2069-2076
    • Gedulin, B.R.1    Nikoulina, S.E.2    Smith, P.A.3    Gedulin, G.4    Nielsen, L.L.5    Baron, A.D.6
  • 61
    • 77955971998 scopus 로고    scopus 로고
    • Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction
    • D. Gomez-Garre, M.L. Gonzalez-Rubio, P. Munoz-Pacheco, A. Caro-Vadillo, P. Aragoncillo, and A. Fernandez-Cruz Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction Eur J Heart Fail 12 9 2010 903 912
    • (2010) Eur J Heart Fail , vol.12 , Issue.9 , pp. 903-912
    • Gomez-Garre, D.1    Gonzalez-Rubio, M.L.2    Munoz-Pacheco, P.3    Caro-Vadillo, A.4    Aragoncillo, P.5    Fernandez-Cruz, A.6
  • 62
    • 59849125655 scopus 로고    scopus 로고
    • Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    • A.C. Goncalves, J. Tank, A. Diedrich, A. Hilzendeger, R. Plehm, and M. Bader Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction Hypertension 53 2 2009 387 392
    • (2009) Hypertension , vol.53 , Issue.2 , pp. 387-392
    • Goncalves, A.C.1    Tank, J.2    Diedrich, A.3    Hilzendeger, A.4    Plehm, R.5    Bader, M.6
  • 63
    • 70350678737 scopus 로고    scopus 로고
    • Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome
    • A.G. Goodwill, S.J. Frisbee, P.A. Stapleton, M.E. James, and J.C. Frisbee Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome Microcirculation 16 8 2009 667 684
    • (2009) Microcirculation , vol.16 , Issue.8 , pp. 667-684
    • Goodwill, A.G.1    Frisbee, S.J.2    Stapleton, P.A.3    James, M.E.4    Frisbee, J.C.5
  • 64
    • 34548313696 scopus 로고    scopus 로고
    • Impaired coronary function in Wistar Ottawa Karlsburg W rats - A new model of the metabolic syndrome
    • O. Grisk, T. Frauendorf, T. Schluter, I. Kloting, B. Kuttler, and A. Krebs Impaired coronary function in Wistar Ottawa Karlsburg W rats - a new model of the metabolic syndrome Pflugers Arch 454 6 2007 1011 1021
    • (2007) Pflugers Arch , vol.454 , Issue.6 , pp. 1011-1021
    • Grisk, O.1    Frauendorf, T.2    Schluter, T.3    Kloting, I.4    Kuttler, B.5    Krebs, A.6
  • 65
    • 24344483109 scopus 로고    scopus 로고
    • Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I
    • M.L. Gruen, M.R. Plummer, W. Zhang, K.A. Posey, M.F. Linton, and S. Fazio Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I J Lipid Res 46 9 2005 2007 2014
    • (2005) J Lipid Res , vol.46 , Issue.9 , pp. 2007-2014
    • Gruen, M.L.1    Plummer, M.R.2    Zhang, W.3    Posey, K.A.4    Linton, M.F.5    Fazio, S.6
  • 66
    • 0027270597 scopus 로고
    • Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats
    • A. Handberg, L. Kayser, P.E. Hoyer, M. Voldstedlund, H.P. Hansen, and J. Vinten Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats Diabetologia 36 6 1993 481 486
    • (1993) Diabetologia , vol.36 , Issue.6 , pp. 481-486
    • Handberg, A.1    Kayser, L.2    Hoyer, P.E.3    Voldstedlund, M.4    Hansen, H.P.5    Vinten, J.6
  • 67
    • 0001567542 scopus 로고
    • Two new congenic strains for nutrition and obesity research
    • C.T. Hansen two new congenic strains for nutrition and obesity research Fed Proc Fed Am Soc Exp Biol 42 1983 537
    • (1983) Fed Proc Fed Am Soc Exp Biol , vol.42 , pp. 537
    • Hansen, C.T.1
  • 68
    • 79959675075 scopus 로고    scopus 로고
    • Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
    • M.R. Hayes, S.E. Kanoski, A.L. Alhadeff, and H.J. Grill Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats Obesity (Silver Spring) 19 7 2011 1342 1349
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.7 , pp. 1342-1349
    • Hayes, M.R.1    Kanoski, S.E.2    Alhadeff, A.L.3    Grill, H.J.4
  • 69
    • 0016726198 scopus 로고
    • Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle
    • D.A. Hems, E.A. Rath, and T.R. Verrinder Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle Biochem J 150 2 1975 167 173
    • (1975) Biochem J , vol.150 , Issue.2 , pp. 167-173
    • Hems, D.A.1    Rath, E.A.2    Verrinder, T.R.3
  • 70
    • 0030708654 scopus 로고    scopus 로고
    • Antihypertensive agent moxonidine enhances muscle glucose transport in insulin-resistant rats
    • E.J. Henriksen, S. Jacob, D.L. Fogt, E.B. Youngblood, and J. Godicke Antihypertensive agent moxonidine enhances muscle glucose transport in insulin-resistant rats Hypertension 30 6 1997 1560 1565
    • (1997) Hypertension , vol.30 , Issue.6 , pp. 1560-1565
    • Henriksen, E.J.1    Jacob, S.2    Fogt, D.L.3    Youngblood, E.B.4    Godicke, J.5
  • 72
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • K.P. Hummel, M.M. Dickie, and D.L. Coleman Diabetes, a new mutation in the mouse Science 153 740 1966 1127 1128
    • (1966) Science , vol.153 , Issue.740 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 74
    • 0029895421 scopus 로고    scopus 로고
    • Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat
    • M. Iida, T. Murakami, K. Ishida, A. Mizuno, M. Kuwajima, and K. Shima Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat Biochem Biophys Res Commun 222 1 1996 19 26
    • (1996) Biochem Biophys Res Commun , vol.222 , Issue.1 , pp. 19-26
    • Iida, M.1    Murakami, T.2    Ishida, K.3    Mizuno, A.4    Kuwajima, M.5    Shima, K.6
  • 75
    • 0030590070 scopus 로고    scopus 로고
    • Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat
    • M. Iida, T. Murakami, K. Ishida, A. Mizuno, M. Kuwajima, and K. Shima Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat Biochem Biophys Res Commun 224 2 1996 597 604
    • (1996) Biochem Biophys Res Commun , vol.224 , Issue.2 , pp. 597-604
    • Iida, M.1    Murakami, T.2    Ishida, K.3    Mizuno, A.4    Kuwajima, M.5    Shima, K.6
  • 76
    • 0030459456 scopus 로고    scopus 로고
    • High-fat diet-induced hyperglycemia and obesity in mice: Differential effects of dietary oils
    • S. Ikemoto, M. Takahashi, N. Tsunoda, K. Maruyama, H. Itakura, and O. Ezaki High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils Metabolism 45 12 1996 1539 1546
    • (1996) Metabolism , vol.45 , Issue.12 , pp. 1539-1546
    • Ikemoto, S.1    Takahashi, M.2    Tsunoda, N.3    Maruyama, K.4    Itakura, H.5    Ezaki, O.6
  • 77
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • A.M. Ingalls, M.M. Dickie, and G.D. Snell Obese, a new mutation in the house mouse J Hered 41 12 1950 317 318
    • (1950) J Hered , vol.41 , Issue.12 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 78
    • 0029011693 scopus 로고
    • Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion?
    • K. Ishida, A. Mizuno, Z. Min, T. Sano, and K. Shima Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion? Metabolism 44 7 1995 940 945
    • (1995) Metabolism , vol.44 , Issue.7 , pp. 940-945
    • Ishida, K.1    Mizuno, A.2    Min, Z.3    Sano, T.4    Shima, K.5
  • 79
    • 77749233936 scopus 로고    scopus 로고
    • Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome
    • N. Ishizaka, M. Hongo, G. Matsuzaki, K. Furuta, K. Saito, and R. Sakurai Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome Hypertens Res 33 3 2010 263 268
    • (2010) Hypertens Res , vol.33 , Issue.3 , pp. 263-268
    • Ishizaka, N.1    Hongo, M.2    Matsuzaki, G.3    Furuta, K.4    Saito, K.5    Sakurai, R.6
  • 80
    • 0032437482 scopus 로고    scopus 로고
    • Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB)
    • T. Ishizuka, P. Ernsberger, S. Liu, D. Bedol, T.M. Lehman, and R.J. Koletsky Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB) J Nutr 128 12 1998 2299 2306
    • (1998) J Nutr , vol.128 , Issue.12 , pp. 2299-2306
    • Ishizuka, T.1    Ernsberger, P.2    Liu, S.3    Bedol, D.4    Lehman, T.M.5    Koletsky, R.J.6
  • 81
    • 80053035829 scopus 로고    scopus 로고
    • Activation of Akt kinase accompanies increased cardiac resistance to ischemia/reperfusion in rats after short-term feeding with lard-based high-fat diet and increased sucrose intake
    • M. Ivanova, P. Janega, J. Matejikova, P. Simoncikova, D. Pancza, and T. Ravingerova Activation of Akt kinase accompanies increased cardiac resistance to ischemia/reperfusion in rats after short-term feeding with lard-based high-fat diet and increased sucrose intake Nutr Res 31 8 2011 631 643
    • (2011) Nutr Res , vol.31 , Issue.8 , pp. 631-643
    • Ivanova, M.1    Janega, P.2    Matejikova, J.3    Simoncikova, P.4    Pancza, D.5    Ravingerova, T.6
  • 82
    • 0033596979 scopus 로고    scopus 로고
    • The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats
    • S. Jacob, D.L. Fogt, G.J. Dietze, and E.J. Henriksen The beta2-adrenergic modulator celiprolol reduces insulin resistance in obese Zucker rats Life Sci 64 22 1999 2071 2079
    • (1999) Life Sci , vol.64 , Issue.22 , pp. 2071-2079
    • Jacob, S.1    Fogt, D.L.2    Dietze, G.J.3    Henriksen, E.J.4
  • 83
    • 33644915528 scopus 로고    scopus 로고
    • Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats
    • P. Janiak, J.P. Bidouard, C. Cadrouvele, B. Poirier, L. Gouraud, and Y. Grataloup Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats Eur J Pharmacol 534 1-3 2006 271 279
    • (2006) Eur J Pharmacol , vol.534 , Issue.13 , pp. 271-279
    • Janiak, P.1    Bidouard, J.P.2    Cadrouvele, C.3    Poirier, B.4    Gouraud, L.5    Grataloup, Y.6
  • 84
    • 11144290197 scopus 로고    scopus 로고
    • The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model
    • S. Jesmin, I. Sakuma, Y. Hattori, A. Kitabatake, and T. Miyauchi The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model J Cardiovasc Pharmacol 44 Suppl. 1 2004 S49 S53
    • (2004) J Cardiovasc Pharmacol , vol.44 , Issue.SUPPL. 1
    • Jesmin, S.1    Sakuma, I.2    Hattori, Y.3    Kitabatake, A.4    Miyauchi, T.5
  • 85
    • 1842479703 scopus 로고    scopus 로고
    • Bezafibrate on lipids and glucose metabolism in obese diabetic Otsuka Long-Evans Tokushima fatty rats
    • D. Jia, M. Yamamoto, M. Otani, and M. Otsuki Bezafibrate on lipids and glucose metabolism in obese diabetic Otsuka Long-Evans Tokushima fatty rats Metabolism 53 4 2004 405 413
    • (2004) Metabolism , vol.53 , Issue.4 , pp. 405-413
    • Jia, D.1    Yamamoto, M.2    Otani, M.3    Otsuki, M.4
  • 86
    • 84863525189 scopus 로고    scopus 로고
    • Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats
    • V. Jindal, D. Dhingra, S. Sharma, M. Parle, and R.K. Harna Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats J Pharmacol Pharmacother 2 2 2011 80 84
    • (2011) J Pharmacol Pharmacother , vol.2 , Issue.2 , pp. 80-84
    • Jindal, V.1    Dhingra, D.2    Sharma, S.3    Parle, M.4    Harna, R.K.5
  • 87
    • 0015473277 scopus 로고
    • Cellularity of adipose depots in six strains of genetically obese mice
    • P.R. Johnson, and J. Hirsch Cellularity of adipose depots in six strains of genetically obese mice J Lipid Res 13 1 1972 2 11
    • (1972) J Lipid Res , vol.13 , Issue.1 , pp. 2-11
    • Johnson, P.R.1    Hirsch, J.2
  • 88
    • 77952705847 scopus 로고    scopus 로고
    • Variation in characteristics of islets of Langerhans in insulin-resistant, diabetic and non-diabetic-rat strains
    • H.B. Jones, D. Nugent, and R. Jenkins Variation in characteristics of islets of Langerhans in insulin-resistant, diabetic and non-diabetic-rat strains Int J Exp Pathol 91 3 2010 288 301
    • (2010) Int J Exp Pathol , vol.91 , Issue.3 , pp. 288-301
    • Jones, H.B.1    Nugent, D.2    Jenkins, R.3
  • 89
    • 24144484876 scopus 로고    scopus 로고
    • The metabolic syndrome: Time for a critical appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • R. Kahn, J. Buse, E. Ferrannini, and M. Stern The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes Diabetes Care 28 9 2005 2289 2304
    • (2005) Diabetes Care , vol.28 , Issue.9 , pp. 2289-2304
    • Kahn, R.1    Buse, J.2    Ferrannini, E.3    Stern, M.4
  • 90
    • 62249130886 scopus 로고    scopus 로고
    • Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats
    • M. Kaihara, Y. Nakamura, T. Sugimoto, H.A. Uchida, H. Norii, and Y. Hanayama Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans- Tokushima Fatty rats Acta Med Okayama 63 1 2009 35 42
    • (2009) Acta Med Okayama , vol.63 , Issue.1 , pp. 35-42
    • Kaihara, M.1    Nakamura, Y.2    Sugimoto, T.3    Uchida, H.A.4    Norii, H.5    Hanayama, Y.6
  • 91
    • 0033395851 scopus 로고    scopus 로고
    • Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
    • A.J. Kastin, W. Pan, L.M. Maness, R.J. Koletsky, and P. Ernsberger Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor Peptides 20 12 1999 1449 1453
    • (1999) Peptides , vol.20 , Issue.12 , pp. 1449-1453
    • Kastin, A.J.1    Pan, W.2    Maness, L.M.3    Koletsky, R.J.4    Ernsberger, P.5
  • 92
    • 0026722931 scopus 로고
    • Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain
    • K. Kawano, T. Hirashima, S. Mori, Y. Saitoh, M. Kurosumi, and T. Natori Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain Diabetes 41 11 1992 1422 1428
    • (1992) Diabetes , vol.41 , Issue.11 , pp. 1422-1428
    • Kawano, K.1    Hirashima, T.2    Mori, S.3    Saitoh, Y.4    Kurosumi, M.5    Natori, T.6
  • 93
    • 70350317887 scopus 로고    scopus 로고
    • Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis
    • T. Kawasaki, K. Igarashi, T. Koeda, K. Sugimoto, K. Nakagawa, and S. Hayashi Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis J Nutr 139 11 2009 2067 2071
    • (2009) J Nutr , vol.139 , Issue.11 , pp. 2067-2071
    • Kawasaki, T.1    Igarashi, K.2    Koeda, T.3    Sugimoto, K.4    Nakagawa, K.5    Hayashi, S.6
  • 94
    • 0027222062 scopus 로고
    • Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein
    • M. Kern, T.A. Loomis, E.B. Tapscott, and G.L. Dohm Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein Int J Biochem 25 9 1993 1257 1261
    • (1993) Int J Biochem , vol.25 , Issue.9 , pp. 1257-1261
    • Kern, M.1    Loomis, T.A.2    Tapscott, E.B.3    Dohm, G.L.4
  • 95
    • 71949103387 scopus 로고    scopus 로고
    • Impact of simvastatin on adipose tissue: Pleiotropic effects in vivo
    • T. Khan, M.P. Hamilton, D.I. Mundy, S.C. Chua, and P.E. Scherer Impact of simvastatin on adipose tissue: pleiotropic effects in vivo Endocrinology 150 12 2009 5262 5272
    • (2009) Endocrinology , vol.150 , Issue.12 , pp. 5262-5272
    • Khan, T.1    Hamilton, M.P.2    Mundy, D.I.3    Chua, S.C.4    Scherer, P.E.5
  • 96
    • 0033974348 scopus 로고    scopus 로고
    • The adipoinsular axis: Effects of leptin on pancreatic beta-cells
    • T.J. Kieffer, and J.F. Habener The adipoinsular axis: effects of leptin on pancreatic beta-cells Am J Physiol Endocrinol Metab 278 1 2000 E1 E14
    • (2000) Am J Physiol Endocrinol Metab , vol.278 , Issue.1
    • Kieffer, T.J.1    Habener, J.F.2
  • 97
    • 0029004532 scopus 로고
    • Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur
    • M.L. Klebig, J.E. Wilkinson, J.G. Geisler, and R.P. Woychik Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur Proc Natl Acad Sci U S A 92 11 1995 4728 4732
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.11 , pp. 4728-4732
    • Klebig, M.L.1    Wilkinson, J.E.2    Geisler, J.G.3    Woychik, R.P.4
  • 98
    • 0033956846 scopus 로고    scopus 로고
    • The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding
    • K. Kobayashi, T.M. Forte, S. Taniguchi, B.Y. Ishida, K. Oka, and L. Chan The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding Metabolism 49 1 2000 22 31
    • (2000) Metabolism , vol.49 , Issue.1 , pp. 22-31
    • Kobayashi, K.1    Forte, T.M.2    Taniguchi, S.3    Ishida, B.Y.4    Oka, K.5    Chan, L.6
  • 99
    • 0015891045 scopus 로고
    • Obese spontaneously hypertensive rats - A model for study of atherosclerosis
    • S. Koletsky Obese spontaneously hypertensive rats - a model for study of atherosclerosis Exp Mol Pathol 19 1 1973 53 60
    • (1973) Exp Mol Pathol , vol.19 , Issue.1 , pp. 53-60
    • Koletsky, S.1
  • 100
    • 0015891045 scopus 로고
    • Obese spontaneously hypertensive rats - A model for study of atherosclerosis
    • S. Koletsky Obese spontaneously hypertensive rats - a model for study of atherosclerosis Exp Mol Pathol 19 1 1973 53 60
    • (1973) Exp Mol Pathol , vol.19 , Issue.1 , pp. 53-60
    • Koletsky, S.1
  • 101
    • 0016778960 scopus 로고
    • Animal model: Obese hypertensive rat
    • S. Koletsky Animal model: obese hypertensive rat Am J Pathol 81 2 1975 463 466
    • (1975) Am J Pathol , vol.81 , Issue.2 , pp. 463-466
    • Koletsky, S.1
  • 102
    • 0016750056 scopus 로고
    • Pathologic findings and laboratory data in a new strain of obese hypertensive rats
    • S. Koletsky Pathologic findings and laboratory data in a new strain of obese hypertensive rats Am J Pathol 80 1 1975 129 142
    • (1975) Am J Pathol , vol.80 , Issue.1 , pp. 129-142
    • Koletsky, S.1
  • 103
    • 0017224914 scopus 로고
    • Effect of low calorie diet on the hyperlipidemia, hypertension, and life span of genetically obese rats
    • S. Koletsky, and D.I. Puterman Effect of low calorie diet on the hyperlipidemia, hypertension, and life span of genetically obese rats Proc Soc Exp Biol Med 151 2 1976 368 371
    • (1976) Proc Soc Exp Biol Med , vol.151 , Issue.2 , pp. 368-371
    • Koletsky, S.1    Puterman, D.I.2
  • 104
    • 0025261239 scopus 로고
    • Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice
    • L. Koranyi, D. James, M. Mueckler, and M.A. Permutt Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice J Clin Invest 85 3 1990 962 967
    • (1990) J Clin Invest , vol.85 , Issue.3 , pp. 962-967
    • Koranyi, L.1    James, D.2    Mueckler, M.3    Permutt, M.A.4
  • 105
    • 0032910313 scopus 로고    scopus 로고
    • Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats
    • I. Kosegawa, S. Chen, T. Awata, K. Negishi, and S. Katayama Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats Clin Exp Hypertens 21 3 1999 199 211
    • (1999) Clin Exp Hypertens , vol.21 , Issue.3 , pp. 199-211
    • Kosegawa, I.1    Chen, S.2    Awata, T.3    Negishi, K.4    Katayama, S.5
  • 106
    • 0029976031 scopus 로고    scopus 로고
    • Metformin decreases blood pressure and obesity in OLETF rats via improvement of insulin resistance
    • I. Kosegawa, S. Katayama, C. Kikuchi, H. Kashiwabara, K. Negishi, and J. Ishii Metformin decreases blood pressure and obesity in OLETF rats via improvement of insulin resistance Hypertens Res 19 1 1996 37 41
    • (1996) Hypertens Res , vol.19 , Issue.1 , pp. 37-41
    • Kosegawa, I.1    Katayama, S.2    Kikuchi, C.3    Kashiwabara, H.4    Negishi, K.5    Ishii, J.6
  • 107
    • 0031580692 scopus 로고    scopus 로고
    • WOK.1W rats. A potential animal model of the insulin resistance syndrome
    • P. Kovacs, B. Voigt, S. Berg, L. Vogt, and I. Kloting WOK.1W rats. A potential animal model of the insulin resistance syndrome Ann N Y Acad Sci 827 1997 94 99
    • (1997) Ann N y Acad Sci , vol.827 , pp. 94-99
    • Kovacs, P.1    Voigt, B.2    Berg, S.3    Vogt, L.4    Kloting, I.5
  • 108
    • 0037021505 scopus 로고    scopus 로고
    • The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    • H.M. Lakka, D.E. Laaksonen, T.A. Lakka, L.K. Niskanen, E. Kumpusalo, and J. Tuomilehto The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men JAMA 288 21 2002 2709 2716
    • (2002) JAMA , vol.288 , Issue.21 , pp. 2709-2716
    • Lakka, H.M.1    Laaksonen, D.E.2    Lakka, T.A.3    Niskanen, L.K.4    Kumpusalo, E.5    Tuomilehto, J.6
  • 109
    • 40749136975 scopus 로고    scopus 로고
    • Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats
    • P.J. Larsen, E.M. Wulff, C.F. Gotfredsen, C.L. Brand, J. Sturis, and N. Vrang Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats Diabetes Obes Metab 10 4 2008 301 311
    • (2008) Diabetes Obes Metab , vol.10 , Issue.4 , pp. 301-311
    • Larsen, P.J.1    Wulff, E.M.2    Gotfredsen, C.F.3    Brand, C.L.4    Sturis, J.5    Vrang, N.6
  • 111
    • 4744356246 scopus 로고    scopus 로고
    • Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments
    • J.M. Lenhard, D.K. Croom, and D.T. Minnick Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments Biochem Biophys Res Commun 324 1 2004 92 97
    • (2004) Biochem Biophys Res Commun , vol.324 , Issue.1 , pp. 92-97
    • Lenhard, J.M.1    Croom, D.K.2    Minnick, D.T.3
  • 112
    • 0012785395 scopus 로고    scopus 로고
    • Metformin reverses fatty liver disease in obese, leptin-deficient mice
    • H.Z. Lin, S.Q. Yang, C. Chuckaree, F. Kuhajda, G. Ronnet, and A.M. Diehl Metformin reverses fatty liver disease in obese, leptin-deficient mice Nat Med 6 9 2000 998 1003
    • (2000) Nat Med , vol.6 , Issue.9 , pp. 998-1003
    • Lin, H.Z.1    Yang, S.Q.2    Chuckaree, C.3    Kuhajda, F.4    Ronnet, G.5    Diehl, A.M.6
  • 113
    • 79954848932 scopus 로고    scopus 로고
    • Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury
    • L. Llacuna, A. Fernandez, C.V. Montfort, N. Matias, L. Martinez, and F. Caballero Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury J Hepatol 54 5 2011 1002 1010
    • (2011) J Hepatol , vol.54 , Issue.5 , pp. 1002-1010
    • Llacuna, L.1    Fernandez, A.2    Montfort, C.V.3    Matias, N.4    Martinez, L.5    Caballero, F.6
  • 114
    • 44949143027 scopus 로고    scopus 로고
    • Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases
    • K. Maedler, F.T. Schulthess, C. Bielman, T. Berney, C. Bonny, and M. Prentki Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases FASEB J 22 6 2008 1905 1913
    • (2008) FASEB J , vol.22 , Issue.6 , pp. 1905-1913
    • Maedler, K.1    Schulthess, F.T.2    Bielman, C.3    Berney, T.4    Bonny, C.5    Prentki, M.6
  • 115
    • 77952668649 scopus 로고    scopus 로고
    • Model of intestinal chylomicron over-production and ezetimibe treatment: Impact on the retention of cholesterol in arterial vessels
    • R. Mangat, S. Warnakula, Y. Wang, J.C. Russell, R. Uwiera, and D.F. Vine Model of intestinal chylomicron over-production and ezetimibe treatment: impact on the retention of cholesterol in arterial vessels Atheroscler Suppl 11 1 2010 17 24
    • (2010) Atheroscler Suppl , vol.11 , Issue.1 , pp. 17-24
    • Mangat, R.1    Warnakula, S.2    Wang, Y.3    Russell, J.C.4    Uwiera, R.5    Vine, D.F.6
  • 116
    • 0023522562 scopus 로고
    • Hepatic glycogen synthase phosphatase and phosphorylase phosphatase activities are increased in obese (fa/fa) hyperinsulinemic Zucker rats: Effects of glyburide administration
    • R.N. Margolis Hepatic glycogen synthase phosphatase and phosphorylase phosphatase activities are increased in obese (fa/fa) hyperinsulinemic Zucker rats: effects of glyburide administration Life Sci 41 24 1987 2615 2622
    • (1987) Life Sci , vol.41 , Issue.24 , pp. 2615-2622
    • Margolis, R.N.1
  • 117
    • 0033512117 scopus 로고    scopus 로고
    • Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
    • A.L. Mark, R.A. Shaffer, M.L. Correia, D.A. Morgan, C.D. Sigmund, and W.G. Haynes Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice J Hypertens 17 12 Pt 2 1999 1949 1953
    • (1999) J Hypertens , vol.17 , Issue.12 PART 2 , pp. 1949-1953
    • Mark, A.L.1    Shaffer, R.A.2    Correia, M.L.3    Morgan, D.A.4    Sigmund, C.D.5    Haynes, W.G.6
  • 118
    • 0001717747 scopus 로고
    • SHHF/Mcc-cp rat: Model of obesity, non insulin-dependent diabetes, and congestive heart failure
    • S.A. McCune, P.B. Baker, and H.F. Stills SHHF/Mcc-cp rat: model of obesity, non insulin-dependent diabetes, and congestive heart failure ILAR News 32 1990 23 27
    • (1990) ILAR News , vol.32 , pp. 23-27
    • McCune, S.A.1    Baker, P.B.2    Stills, H.F.3
  • 119
    • 0031807955 scopus 로고    scopus 로고
    • Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats
    • J.D. McKendrick, E. Salas, G.P. Dube, J. Murat, J.C. Russell, and M.W. Radomski Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats Br J Pharmacol 124 2 1998 361 369
    • (1998) Br J Pharmacol , vol.124 , Issue.2 , pp. 361-369
    • McKendrick, J.D.1    Salas, E.2    Dube, G.P.3    Murat, J.4    Russell, J.C.5    Radomski, M.W.6
  • 120
    • 44949112526 scopus 로고    scopus 로고
    • Adiponectin receptors: Expression in Zucker diabetic rats and effects of fenofibrate and metformin
    • C. Metais, F. Forcheron, P. Abdallah, A. Basset, P. Del Carmine, and G. Bricca Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin Metabolism 57 7 2008 946 953
    • (2008) Metabolism , vol.57 , Issue.7 , pp. 946-953
    • Metais, C.1    Forcheron, F.2    Abdallah, P.3    Basset, A.4    Del Carmine, P.5    Bricca, G.6
  • 121
  • 122
    • 0027302022 scopus 로고
    • The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein
    • E.J. Michaud, S.J. Bultman, L.J. Stubbs, and R.P. Woychik The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein Genes Dev 7 7A 1993 1203 1213
    • (1993) Genes Dev , vol.7 , Issue.7 A , pp. 1203-1213
    • Michaud, E.J.1    Bultman, S.J.2    Stubbs, L.J.3    Woychik, R.P.4
  • 123
    • 0027256438 scopus 로고
    • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
    • M.W. Miller, D.M. Duhl, H. Vrieling, S.P. Cordes, M.M. Ollmann, and B.M. Winkes Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation Genes Dev 7 3 1993 454 467
    • (1993) Genes Dev , vol.7 , Issue.3 , pp. 454-467
    • Miller, M.W.1    Duhl, D.M.2    Vrieling, H.3    Cordes, S.P.4    Ollmann, M.M.5    Winkes, B.M.6
  • 124
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin
    • T.M. Mizuno, S.P. Kleopoulos, H.T. Bergen, J.L. Roberts, C.A. Priest, and C.V. Mobbs Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin Diabetes 47 2 1998 294 297
    • (1998) Diabetes , vol.47 , Issue.2 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 125
    • 33845325347 scopus 로고    scopus 로고
    • Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
    • T.H. Moran, and S. Bi Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors Philos Trans R Soc Lond B Biol Sci 361 1471 2006 1211 1218
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , Issue.1471 , pp. 1211-1218
    • Moran, T.H.1    Bi, S.2
  • 126
    • 6944246101 scopus 로고    scopus 로고
    • Role of early insulin secretion in postglucose-loading hyperglycaemia and postfat-loading hyperlipidaemia: Comparing nateglinide and glibenclamide for acute effects on insulin secretion in OLETF rats
    • Y. Mori, Y. Kitahara, K. Miura, T. Mine, and N. Tajima Role of early insulin secretion in postglucose-loading hyperglycaemia and postfat-loading hyperlipidaemia: comparing nateglinide and glibenclamide for acute effects on insulin secretion in OLETF rats Diabetes Obes Metab 6 6 2004 422 431
    • (2004) Diabetes Obes Metab , vol.6 , Issue.6 , pp. 422-431
    • Mori, Y.1    Kitahara, Y.2    Miura, K.3    Mine, T.4    Tajima, N.5
  • 127
    • 22244433844 scopus 로고    scopus 로고
    • Short-term effect of bezafibrate on the expression of adiponectin mRNA in the adipose tissues: A study in spontaneously type 2 diabetic rats with visceral obesity
    • Y. Mori, F. Oana, A. Matsuzawa, S. Akahane, and N. Tajima Short-term effect of bezafibrate on the expression of adiponectin mRNA in the adipose tissues: a study in spontaneously type 2 diabetic rats with visceral obesity Endocrine 25 3 2004 247 251
    • (2004) Endocrine , vol.25 , Issue.3 , pp. 247-251
    • Mori, Y.1    Oana, F.2    Matsuzawa, A.3    Akahane, S.4    Tajima, N.5
  • 128
    • 33746216259 scopus 로고    scopus 로고
    • Effects of mitiglinide on glucose-induced insulin release into the portal vein and fat-induced triglyceride elevation in prediabetic and diabetic OLETF rats
    • Y. Mori, K. Ojima, Y. Fuujimori, I. Aoyagi, H. Kusama, and Y. Yamazaki Effects of mitiglinide on glucose-induced insulin release into the portal vein and fat-induced triglyceride elevation in prediabetic and diabetic OLETF rats Endocrine 29 2 2006 309 315
    • (2006) Endocrine , vol.29 , Issue.2 , pp. 309-315
    • Mori, Y.1    Ojima, K.2    Fuujimori, Y.3    Aoyagi, I.4    Kusama, H.5    Yamazaki, Y.6
  • 129
    • 0022344591 scopus 로고
    • Energy intake, weight gain and fat deposition in rats fed flavored, nutritionally controlled diets in a multichoice ("cafeteria") design
    • M. Naim, J.G. Brand, M.R. Kare, and R.G. Carpenter Energy intake, weight gain and fat deposition in rats fed flavored, nutritionally controlled diets in a multichoice ("cafeteria") design J Nutr 115 11 1985 1447 1458
    • (1985) J Nutr , vol.115 , Issue.11 , pp. 1447-1458
    • Naim, M.1    Brand, J.G.2    Kare, M.R.3    Carpenter, R.G.4
  • 130
    • 34047199047 scopus 로고    scopus 로고
    • Bezafibrate regulates the expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes
    • S. Nakano, Y. Inada, H. Masuzaki, T. Tanaka, S. Yasue, and T. Ishii Bezafibrate regulates the expression and enzyme activity of 11beta- hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes Am J Physiol Endocrinol Metab 292 4 2007 E1213 E1222
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.4
    • Nakano, S.1    Inada, Y.2    Masuzaki, H.3    Tanaka, T.4    Yasue, S.5    Ishii, T.6
  • 131
    • 0028281559 scopus 로고
    • Characterization of plasma lipids in genetically obese mice: The mutants obese, diabetes, fat, tubby, and lethal yellow
    • P.M. Nishina, S. Lowe, J. Wang, and B. Paigen Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow Metabolism 43 5 1994 549 553
    • (1994) Metabolism , vol.43 , Issue.5 , pp. 549-553
    • Nishina, P.M.1    Lowe, S.2    Wang, J.3    Paigen, B.4
  • 132
    • 34447118168 scopus 로고    scopus 로고
    • Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins
    • K.S. Oh, E.Y. Kim, M. Yoon, and C.M. Lee Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins Exp Mol Med 39 3 2007 385 394
    • (2007) Exp Mol Med , vol.39 , Issue.3 , pp. 385-394
    • Oh, K.S.1    Kim, E.Y.2    Yoon, M.3    Lee, C.M.4
  • 133
    • 0023931351 scopus 로고
    • Effects of fenofibrate, gemfibrozil and nicotinic acid on plasma lipoprotein levels in normal and hyperlipidemic mice. A proposed model for drug screening
    • P. Olivier, M.O. Plancke, D. Marzin, V. Clavey, J. Sauzieres, and J.C. Fruchart Effects of fenofibrate, gemfibrozil and nicotinic acid on plasma lipoprotein levels in normal and hyperlipidemic mice. A proposed model for drug screening Atherosclerosis 70 1-2 1988 107 114
    • (1988) Atherosclerosis , vol.70 , Issue.12 , pp. 107-114
    • Olivier, P.1    Plancke, M.O.2    Marzin, D.3    Clavey, V.4    Sauzieres, J.5    Fruchart, J.C.6
  • 136
    • 38349057333 scopus 로고    scopus 로고
    • Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes
    • C.L. Oltman, T.L. Kleinschmidt, E.P. Davidson, L.J. Coppey, D.D. Lund, and M.A. Yorek Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes Vascul Pharmacol 48 1 2008 47 53
    • (2008) Vascul Pharmacol , vol.48 , Issue.1 , pp. 47-53
    • Oltman, C.L.1    Kleinschmidt, T.L.2    Davidson, E.P.3    Coppey, L.J.4    Lund, D.D.5    Yorek, M.A.6
  • 137
    • 77953783839 scopus 로고    scopus 로고
    • Preventing increased blood pressure in the obese Zucker rat improves severity of stroke
    • J.M. Osmond, J.D. Mintz, and D.W. Stepp Preventing increased blood pressure in the obese Zucker rat improves severity of stroke Am J Physiol Heart Circ Physiol 299 1 2010 H55 H61
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , Issue.1
    • Osmond, J.M.1    Mintz, J.D.2    Stepp, D.W.3
  • 138
    • 75649086459 scopus 로고    scopus 로고
    • Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat
    • M. Otani, M. Yamamoto, M. Harada, and M. Otsuki Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat Br J Pharmacol 159 2 2010 462 473
    • (2010) Br J Pharmacol , vol.159 , Issue.2 , pp. 462-473
    • Otani, M.1    Yamamoto, M.2    Harada, M.3    Otsuki, M.4
  • 139
    • 0028921885 scopus 로고
    • Loss of sensitivity to cholecystokinin stimulation of isolated pancreatic acini from genetically diabetic rats
    • M. Otsuki, T. Akiyama, H. Shirohara, S. Nakano, K. Furumi, and I. Tachibana Loss of sensitivity to cholecystokinin stimulation of isolated pancreatic acini from genetically diabetic rats Am J Physiol 268 3 Pt 1 1995 E531 E536
    • (1995) Am J Physiol , vol.268 , Issue.3 PART 1
    • Otsuki, M.1    Akiyama, T.2    Shirohara, H.3    Nakano, S.4    Furumi, K.5    Tachibana, I.6
  • 140
    • 0035008129 scopus 로고    scopus 로고
    • Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats
    • J.M. Overton, T.D. Williams, J.B. Chambers, and M.E. Rashotte Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats Am J Physiol Regul Integr Comp Physiol 280 4 2001 R1007 R1015
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.280 , Issue.4
    • Overton, J.M.1    Williams, T.D.2    Chambers, J.B.3    Rashotte, M.E.4
  • 141
    • 79952213256 scopus 로고    scopus 로고
    • Rodent models for metabolic syndrome research
    • S.K. Panchal, and L. Brown Rodent models for metabolic syndrome research J Biomed Biotechnol 2011 2011 351982
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 351982
    • Panchal, S.K.1    Brown, L.2
  • 142
    • 0033020021 scopus 로고    scopus 로고
    • Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats
    • S.C. Park, M.J. Radin, T. Hoepf, and S.A. McCune Comparison of verapamil and felodipine treatment on lipid and glucose metabolism in obese female SHHF/Mcc-facp rats Proc Soc Exp Biol Med 221 3 1999 224 233
    • (1999) Proc Soc Exp Biol Med , vol.221 , Issue.3 , pp. 224-233
    • Park, S.C.1    Radin, M.J.2    Hoepf, T.3    McCune, S.A.4
  • 143
    • 0002803911 scopus 로고
    • Zucker Diabetic Fatty rat as a model for non-insulin-dependent diabetes mellitus
    • R.G. Peterson, W.N. Shaw, M.-A. Neel, L.A. Little, and J. Eichberg Zucker Diabetic Fatty rat as a model for non-insulin-dependent diabetes mellitus ILAR J 32 3 1990 16 19
    • (1990) ILAR J , vol.32 , Issue.3 , pp. 16-19
    • Peterson, R.G.1    Shaw, W.N.2    Neel, M.-A.3    Little, L.A.4    Eichberg, J.5
  • 144
    • 0000426949 scopus 로고
    • Treatment of obese female and male SHHF/Mcc-fa(cp) rats with antihypertensive drugs, nifedipine and enalapril: Effects on body weight, fat distribution, insulin resistance and systolic pressure
    • M.J. Radin, Y.Y. Chu, T.M. Hoepf, and S.A. McCune Treatment of obese female and male SHHF/Mcc-fa(cp) rats with antihypertensive drugs, nifedipine and enalapril: effects on body weight, fat distribution, insulin resistance and systolic pressure Obes Res 1 6 1993 433 442
    • (1993) Obes Res , vol.1 , Issue.6 , pp. 433-442
    • Radin, M.J.1    Chu, Y.Y.2    Hoepf, T.M.3    McCune, S.A.4
  • 145
    • 0026542619 scopus 로고
    • Effects of enalapril and clonidine on glomerular structure, function, and atrial natriuretic peptide receptors in SHHF/Mcc-cp rats
    • M.J. Radin, J.E. Jenkins, S.A. McCune, R.R. Jurin, and R.L. Hamlin Effects of enalapril and clonidine on glomerular structure, function, and atrial natriuretic peptide receptors in SHHF/Mcc-cp rats J Cardiovasc Pharmacol 19 3 1992 464 472
    • (1992) J Cardiovasc Pharmacol , vol.19 , Issue.3 , pp. 464-472
    • Radin, M.J.1    Jenkins, J.E.2    McCune, S.A.3    Jurin, R.R.4    Hamlin, R.L.5
  • 146
    • 0035542973 scopus 로고    scopus 로고
    • Leptin signaling pathways in the central nervous system: Interactions between neuropeptide y and melanocortins
    • K. Rahmouni, and W.G. Haynes Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins Bioessays 23 12 2001 1095 1099
    • (2001) Bioessays , vol.23 , Issue.12 , pp. 1095-1099
    • Rahmouni, K.1    Haynes, W.G.2
  • 147
    • 0036179425 scopus 로고    scopus 로고
    • Selective resistance to central neural administration of leptin in agouti obese mice
    • K. Rahmouni, W.G. Haynes, D.A. Morgan, and A.L. Mark Selective resistance to central neural administration of leptin in agouti obese mice Hypertension 39 2 Pt 2 2002 486 490
    • (2002) Hypertension , vol.39 , Issue.2 PART 2 , pp. 486-490
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 148
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • G.M. Reaven Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 12 1988 1595 1607
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 150
    • 0042767611 scopus 로고    scopus 로고
    • Variation in type 2 diabetes-related traits in mouse strains susceptible to diet-induced obesity
    • M. Rossmeisl, J.S. Rim, R.A. Koza, and L.P. Kozak Variation in type 2 diabetes-related traits in mouse strains susceptible to diet-induced obesity Diabetes 52 8 2003 1958 1966
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1958-1966
    • Rossmeisl, M.1    Rim, J.S.2    Koza, R.A.3    Kozak, L.P.4
  • 151
    • 0021814354 scopus 로고
    • Energy balance and brown fat activity in rats fed cafeteria diets or high-fat, semisynthetic diets at several levels of intake
    • N.J. Rothwell, M.J. Stock, and B.P. Warwick Energy balance and brown fat activity in rats fed cafeteria diets or high-fat, semisynthetic diets at several levels of intake Metabolism 34 5 1985 474 480
    • (1985) Metabolism , vol.34 , Issue.5 , pp. 474-480
    • Rothwell, N.J.1    Stock, M.J.2    Warwick, B.P.3
  • 152
    • 0009557662 scopus 로고
    • Jcr:LA-corpulent Rat: A strain with spontaneous vascular and myocardial disease
    • J.C. Russel, and D. G., K. Jcr:LA-corpulent Rat: A strain with spontaneous vascular and myocardial disease ILAR J 32 3 1990
    • (1990) ILAR J , vol.32 , Issue.3
    • Russel, J.C.1    G, K.D.2
  • 153
    • 0025495639 scopus 로고
    • Effects of advancing age and severe food restriction on pathological processes in the insulin resistant JCR:LA-corpulent rat
    • J.C. Russell, D.G. Koeslag, V. Manickavel, R.M. Amy, and P.J. Dolphin Effects of advancing age and severe food restriction on pathological processes in the insulin resistant JCR:LA-corpulent rat Diabetes Res 15 2 1990 53 62
    • (1990) Diabetes Res , vol.15 , Issue.2 , pp. 53-62
    • Russell, J.C.1    Koeslag, D.G.2    Manickavel, V.3    Amy, R.M.4    Dolphin, P.J.5
  • 154
    • 0024548105 scopus 로고
    • Effects of chronic ethanol consumption in atherosclerosis-prone JCR:LA-corpulent rat
    • J.C. Russell, R.M. Amy, V. Manickavel, and P.J. Dolphin Effects of chronic ethanol consumption in atherosclerosis-prone JCR:LA-corpulent rat Arteriosclerosis 9 1 1989 122 128
    • (1989) Arteriosclerosis , vol.9 , Issue.1 , pp. 122-128
    • Russell, J.C.1    Amy, R.M.2    Manickavel, V.3    Dolphin, P.J.4
  • 155
    • 0030960457 scopus 로고    scopus 로고
    • Cardioprotective and hypolipidemic effects of nisoldipine in the JCR:LA-cp rat
    • J.C. Russell, P.J. Dolphin, S.E. Graham, and R.M. Amy Cardioprotective and hypolipidemic effects of nisoldipine in the JCR:LA-cp rat J Cardiovasc Pharmacol 29 5 1997 586 592
    • (1997) J Cardiovasc Pharmacol , vol.29 , Issue.5 , pp. 586-592
    • Russell, J.C.1    Dolphin, P.J.2    Graham, S.E.3    Amy, R.M.4
  • 156
    • 0028299395 scopus 로고
    • Abnormal insulin and glucose metabolism in the JCR:LA-corpulent rat
    • J.C. Russell, S. Graham, and M. Hameed Abnormal insulin and glucose metabolism in the JCR:LA-corpulent rat Metabolism 43 5 1994 538 543
    • (1994) Metabolism , vol.43 , Issue.5 , pp. 538-543
    • Russell, J.C.1    Graham, S.2    Hameed, M.3
  • 157
    • 0029089272 scopus 로고
    • Sexual dimorphism in the metabolic response to the calcium channel antagonists, diltiazem and clentiazem, by hyperlipidemic JCR:LA-cp rats
    • J.C. Russell, S.E. Graham, B. Stewart, and P.J. Dolphin Sexual dimorphism in the metabolic response to the calcium channel antagonists, diltiazem and clentiazem, by hyperlipidemic JCR:LA-cp rats Biochim Biophys Acta 1258 2 1995 199 205
    • (1995) Biochim Biophys Acta , vol.1258 , Issue.2 , pp. 199-205
    • Russell, J.C.1    Graham, S.E.2    Stewart, B.3    Dolphin, P.J.4
  • 158
    • 77955625847 scopus 로고    scopus 로고
    • Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome
    • J.C. Russell, S.E. Kelly, A. Diane, Y. Wang, R. Mangat, and S. Novak Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome Am J Physiol Gastrointest Liver Physiol 299 2 2010 G507 G516
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , Issue.2
    • Russell, J.C.1    Kelly, S.E.2    Diane, A.3    Wang, Y.4    Mangat, R.5    Novak, S.6
  • 159
    • 0024306038 scopus 로고
    • Plasma lipid secretion and clearance in hyperlipidemic JCR:LA-corpulent rats
    • J.C. Russell, D.G. Koeslag, R.M. Amy, and P.J. Dolphin Plasma lipid secretion and clearance in hyperlipidemic JCR:LA-corpulent rats Arteriosclerosis 9 6 1989 869 876
    • (1989) Arteriosclerosis , vol.9 , Issue.6 , pp. 869-876
    • Russell, J.C.1    Koeslag, D.G.2    Amy, R.M.3    Dolphin, P.J.4
  • 160
    • 80051545800 scopus 로고    scopus 로고
    • Diet-induced obesity suppresses ghrelin in rat gastrointestinal tract and serum
    • I. Sahin, S. Aydin, Y. Ozkan, A.F. Dagli, K.O. Akin, and S.P. Guzel Diet-induced obesity suppresses ghrelin in rat gastrointestinal tract and serum Mol Cell Biochem 355 1-2 2011 299 308
    • (2011) Mol Cell Biochem , vol.355 , Issue.12 , pp. 299-308
    • Sahin, I.1    Aydin, S.2    Ozkan, Y.3    Dagli, A.F.4    Akin, K.O.5    Guzel, S.P.6
  • 161
    • 0030907617 scopus 로고    scopus 로고
    • Improving effect of carteolol on bodyweight and carbohydrate and lipid metabolic responses in the OLETF rat
    • Y. Saitoh, T. Tani, Y. Asahi, Z. Man, K. Kawano, and H. Ikunaga Improving effect of carteolol on bodyweight and carbohydrate and lipid metabolic responses in the OLETF rat Clin Exp Pharmacol Physiol 24 5 1997 321 325
    • (1997) Clin Exp Pharmacol Physiol , vol.24 , Issue.5 , pp. 321-325
    • Saitoh, Y.1    Tani, T.2    Asahi, Y.3    Man, Z.4    Kawano, K.5    Ikunaga, H.6
  • 162
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • R. Saladin, P. De Vos, M. Guerre-Millo, A. Leturque, J. Girard, and B. Staels Transient increase in obese gene expression after food intake or insulin administration Nature 377 6549 1995 527 529
    • (1995) Nature , vol.377 , Issue.6549 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3    Leturque, A.4    Girard, J.5    Staels, B.6
  • 163
    • 0015851492 scopus 로고
    • Plasma lipoproteins and the synthesis and turnover of plasma triglyceride in normal and genetically obese mice
    • D.M. Salmon, and D.A. Hems Plasma lipoproteins and the synthesis and turnover of plasma triglyceride in normal and genetically obese mice Biochem J 136 3 1973 551 563
    • (1973) Biochem J , vol.136 , Issue.3 , pp. 551-563
    • Salmon, D.M.1    Hems, D.A.2
  • 164
    • 79957482239 scopus 로고    scopus 로고
    • Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: Comparison to high-fat diet
    • B.P. Sampey, A.M. Vanhoose, H.M. Winfield, A.J. Freemerman, M.J. Muehlbauer, and P.T. Fueger Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet Obesity (Silver Spring) 19 6 2011 1109 1117
    • (2011) Obesity (Silver Spring) , vol.19 , Issue.6 , pp. 1109-1117
    • Sampey, B.P.1    Vanhoose, A.M.2    Winfield, H.M.3    Freemerman, A.J.4    Muehlbauer, M.J.5    Fueger, P.T.6
  • 165
    • 4344717030 scopus 로고    scopus 로고
    • Effects of long-term captopril and l-arginine treatment on ventilation and blood pressure in obese male SHHF rats
    • E.H. Schlenker, C.K. Kost Jr., and M.M. Likness Effects of long-term captopril and l-arginine treatment on ventilation and blood pressure in obese male SHHF rats J Appl Physiol 97 3 2004 1032 1039
    • (2004) J Appl Physiol , vol.97 , Issue.3 , pp. 1032-1039
    • Schlenker, E.H.1    Kost, Jr.C.K.2    Likness, M.M.3
  • 166
    • 0345276712 scopus 로고    scopus 로고
    • Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats
    • E.H. Schlenker, T. Tamura, and A.M. Gerdes Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats J Appl Physiol 95 6 2003 2292 2298
    • (2003) J Appl Physiol , vol.95 , Issue.6 , pp. 2292-2298
    • Schlenker, E.H.1    Tamura, T.2    Gerdes, A.M.3
  • 167
    • 0037631821 scopus 로고    scopus 로고
    • Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy
    • R.E. Schmidt, D.A. Dorsey, L.N. Beaudet, and R.G. Peterson Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy Am J Pathol 163 1 2003 21 28
    • (2003) Am J Pathol , vol.163 , Issue.1 , pp. 21-28
    • Schmidt, R.E.1    Dorsey, D.A.2    Beaudet, L.N.3    Peterson, R.G.4
  • 170
    • 79960094781 scopus 로고    scopus 로고
    • Glucagon plays an important role in the modification of insulin secretion by leptin
    • H. Shimizu, T. Tsuchiya, K. Ohtani, K. Shimomura, I.S. Oh, and Y. Ariyama Glucagon plays an important role in the modification of insulin secretion by leptin Islets 3 4 2011 150 154
    • (2011) Islets , vol.3 , Issue.4 , pp. 150-154
    • Shimizu, H.1    Tsuchiya, T.2    Ohtani, K.3    Shimomura, K.4    Oh, I.S.5    Ariyama, Y.6
  • 171
    • 79954631160 scopus 로고    scopus 로고
    • The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes
    • M. Shimoda, Y. Kanda, S. Hamamoto, K. Tawaramoto, M. Hashiramoto, and M. Matsuki The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes Diabetologia 54 5 2011 1098 1108
    • (2011) Diabetologia , vol.54 , Issue.5 , pp. 1098-1108
    • Shimoda, M.1    Kanda, Y.2    Hamamoto, S.3    Tawaramoto, K.4    Hashiramoto, M.5    Matsuki, M.6
  • 173
    • 0033548092 scopus 로고    scopus 로고
    • Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    • D.L. Silver, X.C. Jiang, and A.R. Tall Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover J Biol Chem 274 7 1999 4140 4146
    • (1999) J Biol Chem , vol.274 , Issue.7 , pp. 4140-4146
    • Silver, D.L.1    Jiang, X.C.2    Tall, A.R.3
  • 174
    • 79961150432 scopus 로고    scopus 로고
    • Mesenteric resistance arteries in type 2 diabetic db/db mice undergo outward remodeling
    • F.M. Souza-Smith, P.S. Katz, A.J. Trask, J.A. Stewart Jr., K.C. Lord, and K.J. Varner Mesenteric resistance arteries in type 2 diabetic db/db mice undergo outward remodeling PLoS One 6 8 2011 e23337
    • (2011) PLoS One , vol.6 , Issue.8 , pp. 23337
    • Souza-Smith, F.M.1    Katz, P.S.2    Trask, A.J.3    Stewart, Jr.J.A.4    Lord, K.C.5    Varner, K.J.6
  • 175
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • D. Spanswick, M.A. Smith, V.E. Groppi, S.D. Logan, and M.L. Ashford Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels Nature 390 6659 1997 521 525
    • (1997) Nature , vol.390 , Issue.6659 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 176
    • 0029911348 scopus 로고    scopus 로고
    • Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone
    • S. Sreenan, J. Sturis, W. Pugh, C.F. Burant, and K.S. Polonsky Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone Am J Physiol 271 4 Pt 1 1996 E742 E747
    • (1996) Am J Physiol , vol.271 , Issue.4 PART 1
    • Sreenan, S.1    Sturis, J.2    Pugh, W.3    Burant, C.F.4    Polonsky, K.S.5
  • 177
    • 0020597577 scopus 로고
    • The major histocompatibility complex and insulin-dependent diabetes in BB rats
    • O. Stark, I. Kloting, K. Reiher, and K.D. Kohnert The major histocompatibility complex and insulin-dependent diabetes in BB rats Acta Biol Med Ger 41 12 1982 1129 1133
    • (1982) Acta Biol Med Ger , vol.41 , Issue.12 , pp. 1129-1133
    • Stark, O.1    Kloting, I.2    Reiher, K.3    Kohnert, K.D.4
  • 180
    • 45849110636 scopus 로고    scopus 로고
    • Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet
    • J. Sugatani, M. Osabe, T. Wada, K. Yamakawa, Y. Yamazaki, and T. Takahashi Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet Eur J Nutr 47 4 2008 192 200
    • (2008) Eur J Nutr , vol.47 , Issue.4 , pp. 192-200
    • Sugatani, J.1    Osabe, M.2    Wada, T.3    Yamakawa, K.4    Yamazaki, Y.5    Takahashi, T.6
  • 181
    • 0029065480 scopus 로고
    • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice
    • R.S. Surwit, M.N. Feinglos, J. Rodin, A. Sutherland, A.E. Petro, and E.C. Opara Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice Metabolism 44 5 1995 645 651
    • (1995) Metabolism , vol.44 , Issue.5 , pp. 645-651
    • Surwit, R.S.1    Feinglos, M.N.2    Rodin, J.3    Sutherland, A.4    Petro, A.E.5    Opara, E.C.6
  • 182
    • 79957586597 scopus 로고    scopus 로고
    • Effects of exercise, diet, and their combination on metabolic-syndrome- related parameters in OLETF rats
    • M. Suzuki, D. Shindo, M. Kimura, and H. Waki Effects of exercise, diet, and their combination on metabolic-syndrome-related parameters in OLETF rats Int J Sport Nutr Exerc Metab 21 3 2011 222 232
    • (2011) Int J Sport Nutr Exerc Metab , vol.21 , Issue.3 , pp. 222-232
    • Suzuki, M.1    Shindo, D.2    Kimura, M.3    Waki, H.4
  • 183
    • 47949106019 scopus 로고    scopus 로고
    • Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts
    • I. Tabbi-Anneni, J. Buchanan, R.C. Cooksey, and E.D. Abel Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts Endocrinology 149 8 2008 4043 4050
    • (2008) Endocrinology , vol.149 , Issue.8 , pp. 4043-4050
    • Tabbi-Anneni, I.1    Buchanan, J.2    Cooksey, R.C.3    Abel, E.D.4
  • 184
    • 0030267744 scopus 로고    scopus 로고
    • Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat
    • K. Takaya, Y. Ogawa, J. Hiraoka, K. Hosoda, Y. Yamori, and K. Nakao Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat Nat Genet 14 2 1996 130 131
    • (1996) Nat Genet , vol.14 , Issue.2 , pp. 130-131
    • Takaya, K.1    Ogawa, Y.2    Hiraoka, J.3    Hosoda, K.4    Yamori, Y.5    Nakao, K.6
  • 185
    • 0030570741 scopus 로고    scopus 로고
    • Molecular cloning of rat leptin receptor isoform complementary DNAs - Identification of a missense mutation in Zucker fatty (fa/fa) rats
    • K. Takaya, Y. Ogawa, N. Isse, T. Okazaki, N. Satoh, and H. Masuzaki Molecular cloning of rat leptin receptor isoform complementary DNAs - identification of a missense mutation in Zucker fatty (fa/fa) rats Biochem Biophys Res Commun 225 1 1996 75 83
    • (1996) Biochem Biophys Res Commun , vol.225 , Issue.1 , pp. 75-83
    • Takaya, K.1    Ogawa, Y.2    Isse, N.3    Okazaki, T.4    Satoh, N.5    Masuzaki, H.6
  • 186
    • 0030845706 scopus 로고    scopus 로고
    • Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats
    • S. Takiguchi, Y. Takata, A. Funakoshi, K. Miyasaka, K. Kataoka, and Y. Fujimura Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats Gene 197 1-2 1997 169 175
    • (1997) Gene , vol.197 , Issue.12 , pp. 169-175
    • Takiguchi, S.1    Takata, Y.2    Funakoshi, A.3    Miyasaka, K.4    Kataoka, K.5    Fujimura, Y.6
  • 187
    • 80053109889 scopus 로고    scopus 로고
    • Differential effect of statins on diabetic nephropathy in db/db mice
    • Y. Tamura, T. Murayama, M. Minami, M. Yokode, and H. Arai Differential effect of statins on diabetic nephropathy in db/db mice Int J Mol Med 28 5 2011 683 687
    • (2011) Int J Mol Med , vol.28 , Issue.5 , pp. 683-687
    • Tamura, Y.1    Murayama, T.2    Minami, M.3    Yokode, M.4    Arai, H.5
  • 188
    • 0017175777 scopus 로고
    • Hepatic cholesterol metabolism in vitro in the obese spontaneously hypertensive, hyperlipemic and atherosclerotic rat
    • E. Tan, A. Butkus, and S. Koletsky Hepatic cholesterol metabolism in vitro in the obese spontaneously hypertensive, hyperlipemic and atherosclerotic rat Exp Mol Pathol 25 2 1976 142 151
    • (1976) Exp Mol Pathol , vol.25 , Issue.2 , pp. 142-151
    • Tan, E.1    Butkus, A.2    Koletsky, S.3
  • 189
    • 50249180295 scopus 로고    scopus 로고
    • Effects of combined PPARgamma and PPARalpha agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat
    • J. Tanabe, N. Tamasawa, M. Yamashita, K. Matsuki, H. Murakami, and J. Matsui Effects of combined PPARgamma and PPARalpha agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat Diabetes Obes Metab 10 9 2008 772 779
    • (2008) Diabetes Obes Metab , vol.10 , Issue.9 , pp. 772-779
    • Tanabe, J.1    Tamasawa, N.2    Yamashita, M.3    Matsuki, K.4    Murakami, H.5    Matsui, J.6
  • 190
    • 0034794044 scopus 로고    scopus 로고
    • Exercise adds to metformin and acarbose efficacy in db/db mice
    • T. Tang, and M.J. Reed Exercise adds to metformin and acarbose efficacy in db/db mice Metabolism 50 9 2001 1049 1053
    • (2001) Metabolism , vol.50 , Issue.9 , pp. 1049-1053
    • Tang, T.1    Reed, M.J.2
  • 191
    • 77952771123 scopus 로고    scopus 로고
    • Effects of glucagon like peptide-1 treatment on the alveolar capillary basal lamina in Otsuka Long-Evans Tokushima Fatty rats
    • X. Tang, Y. Wang, X. Guo, S. Wang, L. Chai, and Y. Zhang Effects of glucagon like peptide-1 treatment on the alveolar capillary basal lamina in Otsuka Long-Evans Tokushima Fatty rats Beijing Da Xue Xue Bao 40 2 2008 178 180
    • (2008) Beijing da Xue Xue Bao , vol.40 , Issue.2 , pp. 178-180
    • Tang, X.1    Wang, Y.2    Guo, X.3    Wang, S.4    Chai, L.5    Zhang, Y.6
  • 192
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • L.A. Tartaglia The leptin receptor J Biol Chem 272 10 1997 6093 6096
    • (1997) J Biol Chem , vol.272 , Issue.10 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 193
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • L.A. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, and R. Devos Identification and expression cloning of a leptin receptor, OB-R Cell 83 7 1995 1263 1271
    • (1995) Cell , vol.83 , Issue.7 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3    Deng, N.4    Culpepper, J.5    Devos, R.6
  • 194
    • 77951287071 scopus 로고    scopus 로고
    • Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats
    • J. Toblli, G. Cao, C. Rivas, M. Munoz, J. Giani, and F. Dominici Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats J Hypertens 28 5 2010 1007 1019
    • (2010) J Hypertens , vol.28 , Issue.5 , pp. 1007-1019
    • Toblli, J.1    Cao, G.2    Rivas, C.3    Munoz, M.4    Giani, J.5    Dominici, F.6
  • 195
    • 0037357963 scopus 로고    scopus 로고
    • Cardiovascular protective role of a low-dose antihypertensive combination in obese Zucker rats
    • J.E. Toblli, G. DeRosa, C. Rivas, G. Cao, P. Piorno, and P. Pagano Cardiovascular protective role of a low-dose antihypertensive combination in obese Zucker rats J Hypertens 21 3 2003 611 620
    • (2003) J Hypertens , vol.21 , Issue.3 , pp. 611-620
    • Toblli, J.E.1    Derosa, G.2    Rivas, C.3    Cao, G.4    Piorno, P.5    Pagano, P.6
  • 196
    • 0035192862 scopus 로고    scopus 로고
    • 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats
    • S.P. Tofovic, R.K. Dubey, and E.K. Jackson 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats J Pharmacol Exp Ther 299 3 2001 973 977
    • (2001) J Pharmacol Exp Ther , vol.299 , Issue.3 , pp. 973-977
    • Tofovic, S.P.1    Dubey, R.K.2    Jackson, E.K.3
  • 197
    • 0042733747 scopus 로고    scopus 로고
    • Rat models of the metabolic syndrome
    • S.P. Tofovic, and E.K. Jackson Rat models of the metabolic syndrome Methods Mol Med 86 2003 29 46
    • (2003) Methods Mol Med , vol.86 , pp. 29-46
    • Tofovic, S.P.1    Jackson, E.K.2
  • 198
    • 0033936107 scopus 로고    scopus 로고
    • Renal function and structure in diabetic, hypertensive, obese ZDF × SHHF-hybrid rats
    • S.P. Tofovic, H. Kusaka, C.K. Kost Jr., and S. Bastacky Renal function and structure in diabetic, hypertensive, obese ZDF × SHHF-hybrid rats Ren Fail 22 4 2000 387 406
    • (2000) Ren Fail , vol.22 , Issue.4 , pp. 387-406
    • Tofovic, S.P.1    Kusaka, H.2    Kost, Jr.C.K.3    Bastacky, S.4
  • 199
    • 82355191481 scopus 로고    scopus 로고
    • Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet
    • V. Trak-Smayra, V. Paradis, J. Massart, S. Nasser, V. Jebara, and B. Fromenty Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet Int J Exp Pathol 92 6 2011 413 421
    • (2011) Int J Exp Pathol , vol.92 , Issue.6 , pp. 413-421
    • Trak-Smayra, V.1    Paradis, V.2    Massart, J.3    Nasser, S.4    Jebara, V.5    Fromenty, B.6
  • 200
    • 0033811405 scopus 로고    scopus 로고
    • Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg W (RT1u Haplotype) rat
    • J. van den Brandt, P. Kovacs, and I. Kloting Features of the metabolic syndrome in the spontaneously hypertriglyceridemic Wistar Ottawa Karlsburg W (RT1u Haplotype) rat Metabolism 49 9 2000 1140 1144
    • (2000) Metabolism , vol.49 , Issue.9 , pp. 1140-1144
    • Van Den Brandt, J.1    Kovacs, P.2    Kloting, I.3
  • 201
    • 0036088134 scopus 로고    scopus 로고
    • Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
    • H. Wang, L.H. Storlien, and X.F. Huang Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression Am J Physiol Endocrinol Metab 282 6 2002 E1352 E1359
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , Issue.6
    • Wang, H.1    Storlien, L.H.2    Huang, X.F.3
  • 203
    • 0343183905 scopus 로고    scopus 로고
    • Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats
    • T.C. Wascher, G. Wolkart, J.C. Russell, and F. Brunner Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats Diabetes 49 5 2000 803 809
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 803-809
    • Wascher, T.C.1    Wolkart, G.2    Russell, J.C.3    Brunner, F.4
  • 204
    • 36249017958 scopus 로고    scopus 로고
    • Insulin resistance, oxidative stress, and podocyte injury: Role of rosuvastatin modulation of filtration barrier injury
    • A. Whaley-Connell, V.G. DeMarco, G. Lastra, C. Manrique, R. Nistala, and S.A. Cooper Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury Am J Nephrol 28 1 2008 67 75
    • (2008) Am J Nephrol , vol.28 , Issue.1 , pp. 67-75
    • Whaley-Connell, A.1    Demarco, V.G.2    Lastra, G.3    Manrique, C.4    Nistala, R.5    Cooper, S.A.6
  • 205
    • 0030928574 scopus 로고    scopus 로고
    • Constitutive and impaired signaling of leptin receptors containing the Gln → Pro extracellular domain fatty mutation
    • D.W. White, D.W. Wang, S.C. Chua Jr., J.P. Morgenstern, R.L. Leibel, and H. Baumann Constitutive and impaired signaling of leptin receptors containing the Gln → Pro extracellular domain fatty mutation Proc Natl Acad Sci U S A 94 20 1997 10657 10662
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.20 , pp. 10657-10662
    • White, D.W.1    Wang, D.W.2    Chua, Jr.S.C.3    Morgenstern, J.P.4    Leibel, R.L.5    Baumann, H.6
  • 206
    • 0032925114 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats
    • R.N. Willette, N. Aiyar, T.L. Yue, M.P. Mitchell, J. Disa, and B.L. Storer In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats J Pharmacol Exp Ther 289 1 1999 48 53
    • (1999) J Pharmacol Exp Ther , vol.289 , Issue.1 , pp. 48-53
    • Willette, R.N.1    Aiyar, N.2    Yue, T.L.3    Mitchell, M.P.4    Disa, J.5    Storer, B.L.6
  • 207
    • 0032954960 scopus 로고    scopus 로고
    • Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic fatty rat model of type 2 diabetes
    • F.E. Yakubu-Madus, W.T. Johnson, K.M. Zimmerman, J. Dananberg, and M.I. Steinberg Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic fatty rat model of type 2 diabetes Diabetes 48 5 1999 1093 1100
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1093-1100
    • Yakubu-Madus, F.E.1    Johnson, W.T.2    Zimmerman, K.M.3    Dananberg, J.4    Steinberg, M.I.5
  • 208
    • 78650172207 scopus 로고    scopus 로고
    • Nifedipine prevents vascular endothelial dysfunction in a mouse model of obesity and type 2 diabetes, by improving eNOS dysfunction and dephosphorylation
    • E. Yamamoto, T. Nakamura, K. Kataoka, Y. Tokutomi, Y.F. Dong, and M. Fukuda Nifedipine prevents vascular endothelial dysfunction in a mouse model of obesity and type 2 diabetes, by improving eNOS dysfunction and dephosphorylation Biochem Biophys Res Commun 403 3-4 2010 258 263
    • (2010) Biochem Biophys Res Commun , vol.403 , Issue.34 , pp. 258-263
    • Yamamoto, E.1    Nakamura, T.2    Kataoka, K.3    Tokutomi, Y.4    Dong, Y.F.5    Fukuda, M.6
  • 209
    • 0030981063 scopus 로고    scopus 로고
    • Leptin receptor of Zucker fatty rat performs reduced signal transduction
    • T. Yamashita, T. Murakami, M. Iida, M. Kuwajima, and K. Shima Leptin receptor of Zucker fatty rat performs reduced signal transduction Diabetes 46 6 1997 1077 1080
    • (1997) Diabetes , vol.46 , Issue.6 , pp. 1077-1080
    • Yamashita, T.1    Murakami, T.2    Iida, M.3    Kuwajima, M.4    Shima, K.5
  • 210
    • 79953163093 scopus 로고    scopus 로고
    • Chronic administration of ezetimibe increases active glucagon-like peptide-1 and improves glycemic control and pancreatic beta cell mass in a rat model of type 2 diabetes
    • S.J. Yang, J.M. Choi, L. Kim, B.J. Kim, J.H. Sohn, and W.J. Kim Chronic administration of ezetimibe increases active glucagon-like peptide-1 and improves glycemic control and pancreatic beta cell mass in a rat model of type 2 diabetes Biochem Biophys Res Commun 407 1 2011 153 157
    • (2011) Biochem Biophys Res Commun , vol.407 , Issue.1 , pp. 153-157
    • Yang, S.J.1    Choi, J.M.2    Kim, L.3    Kim, B.J.4    Sohn, J.H.5    Kim, W.J.6
  • 211
    • 0017371691 scopus 로고
    • Genetics of obesity of Zucker rats and Koletsky rats
    • T.T. Yen, W.N. Shaw, and P.L. Yu Genetics of obesity of Zucker rats and Koletsky rats Heredity 38 3 1977 373 377
    • (1977) Heredity , vol.38 , Issue.3 , pp. 373-377
    • Yen, T.T.1    Shaw, W.N.2    Yu, P.L.3
  • 212
    • 78149470681 scopus 로고    scopus 로고
    • Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice
    • S. Yoshida, T. Ohishi, T. Matsui, H. Tanaka, H. Oshima, and Y. Yonetoku Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice Biochem Biophys Res Commun 402 2 2010 280 285
    • (2010) Biochem Biophys Res Commun , vol.402 , Issue.2 , pp. 280-285
    • Yoshida, S.1    Ohishi, T.2    Matsui, T.3    Tanaka, H.4    Oshima, H.5    Yonetoku, Y.6
  • 213
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • A.A. Young, B.R. Gedulin, S. Bhavsar, N. Bodkin, C. Jodka, and B. Hansen Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta) Diabetes 48 5 1999 1026 1034
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6
  • 214
    • 4143093784 scopus 로고    scopus 로고
    • Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model
    • Y. Yu, K. Ohmori, Y. Chen, C. Sato, H. Kiyomoto, and K. Shinomiya Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model J Am Coll Cardiol 44 4 2004 904 913
    • (2004) J Am Coll Cardiol , vol.44 , Issue.4 , pp. 904-913
    • Yu, Y.1    Ohmori, K.2    Chen, Y.3    Sato, C.4    Kiyomoto, H.5    Shinomiya, K.6
  • 216
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 6505 1994 425 432
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 217
    • 0013844370 scopus 로고
    • Hereditary obesity in the rat associated with hyperlipemia
    • L.M. Zucker Hereditary obesity in the rat associated with hyperlipemia Ann N Y Acad Sci 131 1 1965 447 458
    • (1965) Ann N y Acad Sci , vol.131 , Issue.1 , pp. 447-458
    • Zucker, L.M.1
  • 218
    • 77957216320 scopus 로고
    • Fatty, a new mutation in the rat
    • L.M. Zucker, and T.F. Zucker Fatty, a new mutation in the rat J Hered 52 1961 275
    • (1961) J Hered , vol.52 , pp. 275
    • Zucker, L.M.1    Zucker, T.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.