Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats

Journal of Pharmacology and Pharmacotherapeutics

Volumn 2, Issue 2, 2011, Pages 80-84

  Jindal, Vaneeta ^a   Dhingra, Dinesh ^a   Sharma, Sunil ^a   Parle, Milind ^a   Harna, Rajinder Kumar ^b  

^a GURU JAMBHESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY   (India)

^b CIVIL HOSPITAL   (India)

Author keywords

Cafeteria diet; hyperlipidemia; obesity; sulpiride; Tamarindus indica

Indexed keywords

ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; TAMARINDUS INDICA EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; FEMALE; FRUIT; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; OBESITY; PHYTOCHEMISTRY; RAT; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

EID: 84863525189     PISSN: 0976500X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0976-500X.81896     Document Type: Article

References (29)

1. Garruti G, Cotecchia S, Giampetruzzi F, Giorgino F, Giorgino R. Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome. J Gastrointestin Liver Dis 2008;17:193-8.
2. Ryan DH, Bray GA, Helmcke F, Sander G, Volaufova J, Greenway F, et al. Serial echocardiographic and clinical evaluation of valvular regurgitation before, during and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine. Obes Res 2000;7:313-22.
3. Ghosh D, Maiti R, Das UK. Attenuation of hyperglycemia and hyper lipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biol Pharm Bull 2005;28:1172-6.
4. Ushanandini S, Nagaraju S, Harish KK, Vedavathi M, Machiah DK, Kemparaju K, et al. The anti-snake venom properties of Tamarindus indica (leguminosae) seed extract. Phytother Res 2006;20:851-8.
5. Pimple B P, Kadam P V, Badgujar NS, Bafna AR, Patil MJ. Protective effect of Tamarindus indica linn against paracetamol-induced hepatotoxicity in rats. Indian J Pharm Sci 2007;69:827-31.
6. Martinello F, Soares SM, Franco JJ, Santos AC, Sugohara A, Garcia SB, et al. Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters. Food Chem Toxicol 2006;44:810-8.
7. Ranjan R, Swarup D, Patra RC, Chandra V. Tamarindus indica L. and Moringa oleifera M. extract administration ameliorates fluoride toxicity in rabbits. Indian J Exp Biol 2009;47:900-5.
8. Khalid S, Shaik Mossadeq WM, Israf DA, Hashim P, Rejab S, Shaberi AM, et al. In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Med Princ Pract 2010;19:255-9.
9. Ali N, Shah S W. Spasmolytic activity of fruits of Tamarindus indica L. J Young Pharmacists 2010;2:261-4.
10. Khan RA, Siddiqui S F, Azhar E, Ahmed S P. Preliminary screening of methanol and butanol extracts of Tamarindus indica for antiemetic activity. J Basic Applied Sci 2005;1:51-4.
11. Muthu SE, Nandakumar S, Roa UA. The effect of methanolic extract of Tamarindus indica on the growth of clinical isolates of Burkholderia pseudomallei. Indian J Med Res 2005;122:525-8.
12. Dighe NS, Pattan SR, Nirmal SA, Kalkotwar RS, Gaware VM, Hole MB. Analgesic activity of Tamarindus indica. Res J Pharmacog Phytochem 2009;1:69-71.
13. Souza A, Aka KJ. Spasmogenic effect of the aqueous extract of Tamarindus indica L caesalpiniaceae on the contractile activity of guinea-pig Taenia coli. Afr J Tradit Complement Altern Med 2007;4:261-6.
14. Morton J F, Miami FL. Tamarind fruits of warm climates. In: Fruits of warm climates. Editor: J.F. Morton, Miami, Florida, USA. 1987.p115-21.
15. Ukwuani AN, Abukakar MG, Shehu RA, Hassan LG. Antiobesity effects of pulp extract Tamarindus indica in albino rat. Asian J Biochem 2008;3:221-7.
16. Kaur G, Kulkarni SK. Antiobesity effect of a polyherbal formulation, OB-200G in female rats fed on cafeteria and atherogenic diets. Indian J Pharmacol 2000;32:294-9.
17. Baptista T, Lacruz A, Acosta A, Colasante C, de Quijada M, de Mendoza S, et al. Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats. Appetite 2000;34:77-86.
18. Sclafani A, Springer D. Dietary obesity in adult rat: Similarities to hypothalamic and human obesities. Physiol Behav 1976;17:461-71.
19. Bull NL. Studies of dietary habits, food consumption and nutrient intake of adolescents and young adults. World Rev Nutr Diet 1988;57:24-74.
20. Rothwell NJ, Stock MJ, Warwick B P. The effect of high fat and high carbohydrate cafeteria diets on diet-induced thermogenesis in the rat. Int J Obes 1983;7:263-70.
21. Sclafani A, Xenakis S. Sucrose and polysaccharide-induced obesity in the rat. Physiol Behav 1984;32:169-75.
22. Rolls BJ, Van Duijvenvoorde PM, Rowe EA. Variety in the diet enhances intake in a meal and contributes to the development of obesity in the rat. Physiol Behav 1983;31:21-7.
23. Naim M, Brand JG, Kare MR, Carpenter RG. Energy intake weight gain and fat deposition in rat fed with flavored, nutritionally controlled diets in a mutichoice ('cafeteria') design. J Nutr 1985;115:1447-58.
24. Barr HG, Mckracken KJ. High efficiency of energy utilization in 'cafeteria' and force fed rats kept at 29°C. Br J Nutr 1984;51:379-87.
25. Wang GJ. Brain dopamine and obesity. Lancet 2001;357:354-7.
26. Baptista T, Lacruz A, Pàez X, Hernàndez L, Beaulieu S. The antipsychotic drug sulpiride does not affect bodyweight in male rats. Is insulin resistance involved? Eur J Pharmacol 2002;447:91-8.
27. Baptista T, Contreras Q, Teneud L, Albornoz MA, Ximena pljez AA, Anny Lacruz MQ, et al. Mechanism of the neuroleptic-induced obesity in female rats. Prog Neuropsychopharmacol Biol Psychiatry 1998;22:187-98.
28. Parada MA, Hernandez L, Paez X, Baptista T, Parada PD, De Quijada M. Mechanism of the body weight increase induced by systemic sulpiride. Pharmacol Biochem Behav 1989;33:45-50.
29. Wagstaff AJ, Fitton A, Benfield P. Sulpiride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in schizophrenia. CNS Drugs 1994;2:313-33.