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Volumn 16, Issue 8, 2009, Pages 667-684

Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome

Author keywords

Chronic inflammation; Nitric oxide bioavailability; Regulation of skeletal muscle perfusion; Rodent models of obesity; Vascular reactivity; Vascular remodeling

Indexed keywords

ATORVASTATIN; GEMFIBROZIL; INTERLEUKIN 10; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PROBUCOL; RANTES; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 70350678737     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.3109/10739680903133722     Document Type: Article
Times cited : (31)

References (52)
  • 1
    • 21644446065 scopus 로고    scopus 로고
    • Nitric oxide modulates vascular infl ammation and intimal hyperplasia in insulin resistance and the metabolic syndrome
    • Barbato JE, Zuckerbraun BS, Overhaus M, Raman KG, Tzeng E. (2005). Nitric oxide modulates vascular infl ammation and intimal hyperplasia in insulin resistance and the metabolic syndrome. Am J Physiol Heart Circ Physiol 289:H228-H236.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Barbato, J.E.1    Zuckerbraun, B.S.2    Overhaus, M.3    Raman, K.G.4    Tzeng, E.5
  • 2
    • 0027233548 scopus 로고
    • Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats
    • Baumbach GL, Hajdu MA. (1993). Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats. Hypertension 21:816-826.
    • (1993) Hypertension , vol.21 , pp. 816-826
    • Baumbach, G.L.1    Hajdu, M.A.2
  • 3
    • 33745002232 scopus 로고    scopus 로고
    • The nonlipid effects of statins on endothelial function
    • Beckman JA, Creager MA. (2006). The nonlipid effects of statins on endothelial function. Trends Cardiovasc Med 16:156-162.
    • (2006) Trends Cardiovasc Med , vol.16 , pp. 156-162
    • Beckman, J.A.1    Creager, M.A.2
  • 4
    • 33747173757 scopus 로고    scopus 로고
    • High-dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response
    • Boodhwani M, Nakai Y, Voisine P, Feng J, Li J, Mieno S, et al. (2006). High-dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response. Circulation 114:I402-I408.
    • (2006) Circulation , vol.114
    • Boodhwani, M.1    Nakai, Y.2    Voisine, P.3    Feng, J.4    Li, J.5    Mieno, S.6
  • 5
    • 0017347635 scopus 로고
    • The Zucker-fatty rat: A review
    • Bray GA. (1977). The Zucker-fatty rat: a review. Fed Proc 36:148-153.
    • (1977) Fed Proc , vol.36 , pp. 148-153
    • Bray, G.A.1
  • 6
    • 0031830994 scopus 로고    scopus 로고
    • Impaired adaptive vascular growth in hyper-cholesterolemic rabbit
    • Bucay M, Nguy J, Barrios R, Chen CH, Henry PD. (1998). Impaired adaptive vascular growth in hyper-cholesterolemic rabbit. Atherosclerosis 139:243-251.
    • (1998) Atherosclerosis , vol.139 , pp. 243-251
    • Bucay, M.1    Nguy, J.2    Barrios, R.3    Chen, C.H.4    Henry, P.D.5
  • 7
    • 15444366991 scopus 로고    scopus 로고
    • Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes, and infl ammation
    • Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. (2005). Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and infl ammation. Circulation 111:1448-1454.
    • (2005) Circulation , vol.111 , pp. 1448-1454
    • Dandona, P.1    Aljada, A.2    Chaudhuri, A.3    Mohanty, P.4    Garg, R.5
  • 8
    • 10744232357 scopus 로고    scopus 로고
    • Differential effects of simvastatin and atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I are consistent across hypercholesterolemic patient subgroups
    • Davidson MH, Ose L, Frohlich J, Scott RS, Dujovne CA, Escobar ID, et al. (2003). Differential effects of simvastatin and atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I are consistent across hypercholesterolemic patient subgroups. Clin Cardiol. 26:509-514.
    • (2003) Clin Cardiol , vol.26 , pp. 509-514
    • Davidson, M.H.1    Ose, L.2    Frohlich, J.3    Scott, R.S.4    Dujovne, C.A.5    Escobar, I.D.6
  • 10
    • 33645094374 scopus 로고    scopus 로고
    • Statins: Potential new indications in infl ammatory conditions
    • Endres M. (2006). Statins: potential new indications in infl ammatory conditions. Atheroscler Suppl. 7:31-35.
    • (2006) Atheroscler Suppl , vol.7 , pp. 31-35
    • Endres, M.1
  • 11
    • 26044461187 scopus 로고    scopus 로고
    • Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on high-sensitivity C-reactive protein levels
    • Field KM. (2005). Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on high-sensitivity C-reactive protein levels. Pharma-cotherapy 25:1365-1377.
    • (2005) Pharma-cotherapy , vol.25 , pp. 1365-1377
    • Field, K.M.1
  • 13
    • 33646366713 scopus 로고    scopus 로고
    • Impaired hemorrhage tolerance in the obese Zucker rat model of metabolic syndrome
    • Frisbee JC. (2006). Impaired hemorrhage tolerance in the obese Zucker rat model of metabolic syndrome. J Appl Physiol 100:465-473.
    • (2006) J Appl Physiol , vol.100 , pp. 465-473
    • Frisbee, J.C.1
  • 14
    • 33646397829 scopus 로고    scopus 로고
    • Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
    • Frisbee JC. (2006). Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats. Am J Physiol Heart Circ Physiol 290:H2066-H2074.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Frisbee, J.C.1
  • 15
    • 23044449830 scopus 로고    scopus 로고
    • Reduced nitric oxide bioavaila-bility contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome
    • Frisbee JC. (2005). Reduced nitric oxide bioavaila-bility contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 289:R307-R316.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289
    • Frisbee, J.C.1
  • 16
    • 23744440521 scopus 로고    scopus 로고
    • Hypertension-independent micro-vascular rarefaction in the obese Zucker rat model of the metabolic syndrome
    • Frisbee JC. (2005). Hypertension-independent micro-vascular rarefaction in the obese Zucker rat model of the metabolic syndrome. Microcirculation. 12:383-392.
    • (2005) Microcirculation , vol.12 , pp. 383-392
    • Frisbee, J.C.1
  • 17
    • 3242734728 scopus 로고    scopus 로고
    • Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats
    • Frisbee JC. (2004). Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. J Appl Physiol 97:764-772.
    • (2004) J Appl Physiol , vol.97 , pp. 764-772
    • Frisbee, J.C.1
  • 18
    • 0142126900 scopus 로고    scopus 로고
    • Impaired skeletal muscle perfu-sion in obese Zucker rats
    • Frisbee JC. (2003). Impaired skeletal muscle perfu-sion in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 285:R1124-R1134.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Frisbee, J.C.1
  • 19
    • 0038338728 scopus 로고    scopus 로고
    • Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats
    • Frisbee JC. (2003). Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats. Am J Physiol Heart Circ Physiol 285:H104-H111.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Frisbee, J.C.1
  • 20
    • 32544443164 scopus 로고    scopus 로고
    • Effi cacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia
    • Ginsberg HN. (2006). Effi cacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia. J Clin Endocrinol Metab 91:383-392.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 383-392
    • Ginsberg, H.N.1
  • 21
    • 0025311088 scopus 로고
    • Microvessel changes in hypertension measured by Griffonia simplicifolia i lectin
    • Greene AS, Lombard JH, Cowley AW, Jr, Hansen-Smith FM. (1990). Microvessel changes in hypertension measured by Griffonia simplicifolia I lectin. Hypertension 15:779-783.
    • (1990) Hypertension , vol.15 , pp. 779-783
    • Greene, A.S.1    Lombard, J.H.2    Cowley, A.W.3    Jr Hansen-Smith, F.M.4
  • 22
    • 0030757725 scopus 로고    scopus 로고
    • Regulation of ob gene and over expression in obesity
    • Guerre-Millo M. (1997). Regulation of ob gene and over expression in obesity. Biomed Pharmacother. 51:318-323.
    • (1997) Biomed Pharmacother , vol.51 , pp. 318-323
    • Guerre-Millo, M.1
  • 24
    • 1842583832 scopus 로고    scopus 로고
    • Effects of conventional and aggressive statin treatment on markers of endothelial function and infl ammation
    • Hognestad A, Aukrust P, Wergeland R, Stokke O, Gullestad L, Semb AG, et al. (2004). Effects of conventional and aggressive statin treatment on markers of endothelial function and infl ammation. Clin Cardiol 27:199-203.
    • (2004) Clin Cardiol , vol.27 , pp. 199-203
    • Hognestad, A.1    Aukrust, P.2    Wergeland, R.3    Stokke, O.4    Gullestad, L.5    Semb, A.G.6
  • 25
    • 0035312651 scopus 로고    scopus 로고
    • Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks
    • John S, Delles C, Jacobi J, Schlaich M P, Schneider M, Schmitz G, et al. (2001). Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. J Am Coll Cardiol 37:1351-1358.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1351-1358
    • John, S.1    Delles, C.2    Jacobi, J.3    Schlaich, M.P.4    Schneider, M.5    Schmitz, G.6
  • 26
    • 33645307415 scopus 로고    scopus 로고
    • Treatment of hypercholesterolemia in patients with metabolic syndrome: How do different statins compare?
    • Knopp RH, Paramsothy P. (2006). Treatment of hypercholesterolemia in patients with metabolic syndrome: how do different statins compare? Nat Clin Pract Endocrinol Metab 2:136-137.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 136-137
    • Knopp, R.H.1    Paramsothy, P.2
  • 27
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U, La Fata V, Plutzky J, Liao JK. (1998). Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97:1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 28
    • 0037180771 scopus 로고    scopus 로고
    • Infl ammation in atherosclerosis
    • Libby P. (2002). Infl ammation in atherosclerosis. Nature 420:868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 29
    • 0038577223 scopus 로고    scopus 로고
    • Minireview: Adiposity, infl ammation, and atherogenesis
    • Lyon CJ, Law RE, Hsueh WA. (2003). Minireview: adiposity, infl ammation, and atherogenesis. Endocrinology 144:2195-2200.
    • (2003) Endocrinology , vol.144 , pp. 2195-2200
    • Lyon, C.J.1    Law, R.E.2    Hsueh, W.A.3
  • 30
    • 0034747925 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein-1 expression in early lesions from hypercholesterolemic swine independently of their effect on plasma cholesterol levels
    • Martinez-Gonzalez J, Alfon J, Berrozpe M, Badimon L. (2001). HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein-1 expression in early lesions from hypercholesterolemic swine independently of their effect on plasma cholesterol levels. Atherosclerosis 159:27-33.
    • (2001) Atherosclerosis , vol.159 , pp. 27-33
    • Martinez-Gonzalez, J.1    Alfon, J.2    Berrozpe, M.3    Badimon, L.4
  • 31
    • 23944466455 scopus 로고    scopus 로고
    • Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions
    • Mason RP, Walter MF, Day CA, Jacob RF. (2005). Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions. Am J Cardiol 96:11F-23F .
    • (2005) Am J Cardiol , vol.96
    • Mason, R.P.1    Walter, M.F.2    Day, C.A.3    Jacob, R.F.4
  • 32
    • 33746234763 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome
    • Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, et al. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 2006;99:69-77.
    • (2006) Circ Res , vol.99 , pp. 69-77
    • Picchi, A.1    Gao, X.2    Belmadani, S.3    Potter, B.J.4    Focardi, M.5    Chilian, W.M.6
  • 33
    • 2942519273 scopus 로고    scopus 로고
    • Low-grade systemic infl am-mation impairs arterial stiffness in newly diagnosed hypercholesterolaemia
    • Pirro M, Schillaci G, Savarese G, Gemelli F, Vaudo G, Siepi D, et al. (2004). Low-grade systemic infl am-mation impairs arterial stiffness in newly diagnosed hypercholesterolaemia. Eur J Clin Invest 34:335-341.
    • (2004) Eur J Clin Invest , vol.34 , pp. 335-341
    • Pirro, M.1    Schillaci, G.2    Savarese, G.3    Gemelli, F.4    Vaudo, G.5    Siepi, D.6
  • 34
    • 26844564725 scopus 로고    scopus 로고
    • The potential relevance of the multiple lipid-independent (pleiotropic) effects of statins in the management of acute coronary syndromes
    • Ray KK, Cannon C P. (2005). The potential relevance of the multiple lipid-independent (pleiotropic) effects of statins in the management of acute coronary syndromes. J Am Coll Cardiol 46:1425-1433.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1425-1433
    • Ray, K.K.1    Cannon, C.P.2
  • 35
    • 0037811929 scopus 로고    scopus 로고
    • Rescue of hypercholesterole-mia-related impairment of angiogenesis by oral folate supplementation
    • Sasaki K, Duan J, Murohara T, Ikeda H, Shintani S, Shimada T, et al. (2003). Rescue of hypercholesterole-mia-related impairment of angiogenesis by oral folate supplementation. J Am Coll Cardiol 42:364-372.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 364-372
    • Sasaki, K.1    Duan, J.2    Murohara, T.3    Ikeda, H.4    Shintani, S.5    Shimada, T.6
  • 36
    • 2542443477 scopus 로고    scopus 로고
    • Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis
    • Sata M, Nishimatsu H, Osuga J, Tanaka K, Ishizaka N, Ishibashi S, et al. (2004). Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis. Hypertension 43:1214-1220.
    • (2004) Hypertension , vol.43 , pp. 1214-1220
    • Sata, M.1    Nishimatsu, H.2    Osuga, J.3    Tanaka, K.4    Ishizaka, N.5    Ishibashi, S.6
  • 37
    • 0035109564 scopus 로고    scopus 로고
    • Simvastatin improves arterial compliance in the lower limb but not in the aorta
    • Shige H, Dart A, Nestel P. (2001). Simvastatin improves arterial compliance in the lower limb but not in the aorta. Atherosclerosis 155:245-250.
    • (2001) Atherosclerosis , vol.155 , pp. 245-250
    • Shige, H.1    Dart, A.2    Nestel, P.3
  • 39
    • 0034115408 scopus 로고    scopus 로고
    • The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia
    • Smilde TJ, van den Berkmortel F W, Wollersheim H, van Langen H, Kastelein JJ, Stalenhoef A F. (2000). The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. Eur J Clin Invest 30:473-480.
    • (2000) Eur J Clin Invest , vol.30 , pp. 473-480
    • Smilde, T.J.1    Van Den Berkmortel, F.W.2    Wollersheim, H.3    Van Langen, H.4    Kastelein, J.J.5    Stalenhoef, A.F.6
  • 40
    • 33746782930 scopus 로고    scopus 로고
    • Microvascular responses to hypercholesterolemia: The interactions between innate and adaptive immune responses
    • Stokes KY. (2006). Microvascular responses to hypercholesterolemia: the interactions between innate and adaptive immune responses. Antioxid Redox Signal 8:1141-1151.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1141-1151
    • Stokes, K.Y.1
  • 41
    • 0037183565 scopus 로고    scopus 로고
    • Hypercholesterolemia in minipigs impairs left ventricular response to stress: Association with decreased coronary fl ow reserve and reduced capillary density
    • Theilmeier G, Verhamme P, Dymarkowski S, Beck H, Bernar H, Lox M, et al. (2002). Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary fl ow reserve and reduced capillary density. Circulation 106:1140-1146.
    • (2002) Circulation , vol.106 , pp. 1140-1146
    • Theilmeier, G.1    Verhamme, P.2    Dymarkowski, S.3    Beck, H.4    Bernar, H.5    Lox, M.6
  • 42
    • 0042733747 scopus 로고    scopus 로고
    • Rat models of the metabolic syndrome
    • Tofovic S P, Jackson EK. (2003). Rat models of the metabolic syndrome. Meth Mol Med 86:29-46.
    • (2003) Meth Mol Med , vol.86 , pp. 29-46
    • Tofovic, S.P.1    Jackson, E.K.2
  • 43
  • 44
    • 0030853575 scopus 로고    scopus 로고
    • Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines
    • Van Belle E, Rivard A, Chen D, Silver M, Bunting S, Ferrara N, et al. (1997). Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation 96:2667-2674.
    • (1997) Circulation , vol.96 , pp. 2667-2674
    • Van Belle, E.1    Rivard, A.2    Chen, D.3    Silver, M.4    Bunting, S.5    Ferrara, N.6
  • 45
    • 0038115421 scopus 로고    scopus 로고
    • Correlates of endothelial function and their relationship with infl ammation in patients with familial hypercholesterolaemia
    • van Haelst PL, van Doormaal JJ, Asselbergs F W, van Roon AM, Veeger NJ, Henneman MM, et al. (2003). Correlates of endothelial function and their relationship with infl ammation in patients with familial hypercholesterolaemia. Clin Sci (Lond) 104:627-632.
    • (2003) Clin Sci (Lond) , vol.104 , pp. 627-632
    • Van Haelst, P.L.1    Van Doormaal, J.J.2    Asselbergs, F.W.3    Van Roon, A.M.4    Veeger, N.J.5    Henneman, M.M.6
  • 46
    • 32844472357 scopus 로고    scopus 로고
    • Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity
    • Vaziri ND, Xu ZG, Shahkarami A, Huang KT, Rodriguez-Iturbe B, Natarajan R. (2005). Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity. Kidney Int 68:2787-2793.
    • (2005) Kidney Int , vol.68 , pp. 2787-2793
    • Vaziri, N.D.1    Xu, Z.G.2    Shahkarami, A.3    Huang, K.T.4    Rodriguez-Iturbe, B.5    Natarajan, R.6
  • 47
    • 0032993428 scopus 로고    scopus 로고
    • The thiazolidinedione, rosiglita-zone, (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats
    • Walker AB, Chattington PD, Buckingham RE, Williams G. (1999). The thiazolidinedione, rosiglita-zone, (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes ;48:1448-1453.
    • (1999) Diabetes , vol.48 , pp. 1448-1453
    • Walker, A.B.1    Chattington, P.D.2    Buckingham, R.E.3    Williams, G.4
  • 49
    • 70350642409 scopus 로고    scopus 로고
    • Chronic hyperglycemia impairs functional vasodi-lation via increasing thromboxane receptor-mediated vasoconstriction
    • Aug [Epub ahead of print]
    • Xiang L, Naik JS, Abram SR, Hester RL . 2006. Chronic hyperglycemia impairs functional vasodi-lation via increasing thromboxane receptor-mediated vasoconstriction. Am J Physiol Heart Circ Physiol 11 Aug [Epub ahead of print] .
    • (2006) Am J Physiol Heart Circ Physiol , vol.11
    • Xiang, L.1    Naik, J.S.2    Abram, S.R.3    Hester, R.L.4
  • 51
    • 15544381276 scopus 로고    scopus 로고
    • Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats
    • Xiang L, Naik J, Hester RL. (2005). Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 288:R987-R991.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288
    • Xiang, L.1    Naik, J.2    Hester, R.L.3
  • 52
    • 31344467118 scopus 로고    scopus 로고
    • Are statins created equal? Evidence from randomized trials of prava-statin, simvastatin, and atorvastatin for cardio vascular disease prevention
    • Zhou Z, Rahme E, Pilote L. (2006) Are statins created equal? Evidence from randomized trials of prava-statin, simvastatin, and atorvastatin for cardio vascular disease prevention. Am Heart J 151:273-281
    • (2006) Am Heart J , vol.151 , pp. 273-281
    • Zhou, Z.1    Rahme, E.2    Pilote, L.3


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